Search Results - "Gootz, Thomas"

The global problem of antibiotic resistance by Gootz, Thomas D

“…Amid the recent attention justly focused on the potential problem of microbial sources for weapons of bioterrorism, it is also apparent that human pathogens…”
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High-Level Carbapenem Resistance in a Klebsiella pneumoniae Clinical Isolate Is Due to the Combination of blaACT-1 β-Lactamase Production, Porin OmpK35/36 Insertional Inactivation, and Down-Regulation of the Phosphate Transport Porin PhoE by Kaczmarek, Frank M., Dib-Hajj, Fadia, Shang, Wenchi, Gootz, Thomas D.

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High-level carbapenem resistance in a Klebsiella pneumoniae clinical isolate is due to the combination of bla(ACT-1) beta-lactamase production, porin OmpK35/36 insertional inactivation, and down-regulation of the phosphate transport porin phoe by Kaczmarek, Frank M, Dib-Hajj, Fadia, Shang, Wenchi, Gootz, Thomas D

“…Clinical isolates of Klebsiella pneumoniae resistant to carbapenems and essentially all other antibiotics (multidrug resistant) are being isolated from some…”
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Genetic Organization of Transposase Regions Surrounding blaKPC Carbapenemase Genes on Plasmids from Klebsiella Strains Isolated in a New York City Hospital by Gootz, Thomas D, Lescoe, Mary Kay, Dib-Hajj, Fadia, Dougherty, Brian A, He, Wen, Della-Latta, Phyllis, Huard, Richard C

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Acinetobacter baumannii: an emerging multidrug-resistant threat by Gootz, Thomas D, Marra, Andrea

“…Amid the recent attention focused on the growing impact of methicillin-resistant Staphylococcus aureus and multidrug-resistant Pseudomonas aeruginosa…”
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The forgotten Gram-negative bacilli: What genetic determinants are telling us about the spread of antibiotic resistance by Gootz, Thomas D.

“…Gram-negative bacilli have become increasingly resistant to antibiotics over the past 2 decades due to selective pressure from the extensive use of antibiotics…”
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Genetic and Molecular Characterization of β-Lactamase-Negative Ampicillin-Resistant Haemophilus influenzae with Unusually High Resistance to Ampicillin by Kaczmarek, Frank S, Gootz, Thomas D, Dib-Hajj, Fadia, Shang, Wenchi, Hallowell, Shawn, Cronan, Melissa

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Inactivation of a class A and a class C β-lactamase by 6β-(hydroxymethyl)penicillanic acid sulfone by Papp-Wallace, Krisztina M., Bethel, Christopher R., Gootz, Thomas D., Shang, Wenchi, Stroh, Justin, Lau, William, McLeod, Dale, Price, Loren, Marfat, Anthony, Distler, Anne, Drawz, Sarah M., Chen, Hansong, Harry, Emily, Nottingham, Micheal, Carey, Paul R., Buynak, John D., Bonomo, Robert A.

“…β-Lactamase inhibitors (clavulanic acid, sulbactam, and tazobactam) contribute significantly to the longevity of the β-lactam antibiotics used to treat serious…”
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Preparation, Gram-Negative Antibacterial Activity, and Hydrolytic Stability of Novel Siderophore-Conjugated Monocarbam Diols by Flanagan, Mark E, Brickner, Steven J, Lall, Manjinder, Casavant, Jeffrey, Deschenes, Laura, Finegan, Steven M, George, David M, Granskog, Karl, Hardink, Joel R, Huband, Michael D, Hoang, Thuy, Lamb, Lucinda, Marra, Andrea, Mitton-Fry, Mark, Mueller, John P, Mullins, Lisa M, Noe, Mark C, O'Donnell, John P, Pattavina, David, Penzien, Joseph B, Schuff, Brandon P, Sun, Jianmin, Whipple, David A, Young, Jennifer, Gootz, Thomas D

“…A novel series of monocarbam compounds exhibiting promising antibacterial activity against multidrug resistant Gram-negative microorganisms is reported, along…”
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Enterococcal virulence determinants may be involved in resistance to clinical therapy by Marra, Andrea, Dib-Hajj, Fadia, Lamb, Lucinda, Kaczmarek, Frank, Shang, Wenchi, Beckius, Gretchen, Milici, Anthony J, Medina, Ivette, Gootz, Thomas D

“…Abstract The ability of enterococci to acquire resistance to antibiotics and form biofilms in vivo makes these infections, endocarditis in particular,…”
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Fluoroquinolone antibacterials: SAR, mechanism of action, resistance, and clinical aspects by Gootz, Thomas D., Brighty, Katherine E.

“…First page of article…”
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Global dissemination of beta-lactamases mediating resistance to cephalosporins and carbapenems by Gootz, Thomas D

“…While the main era of beta-lactam discovery programs is over, these agents continue to be the most widely prescribed antimicrobials in both community and…”
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Bacterial efflux pump inhibitors by Kamicker, Barbara J, Sweeney, Michael T, Kaczmarek, Frank, Dib-Hajj, Fadia, Shang, Wenchi, Crimin, Kim, Duignan, Joan, Gootz, Thomas D

“…Infections caused by multidrug-resistant Gram-negative pathogens play a major role in the morbidity and mortality of hospitalized patients. The rise of…”
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The current state of antibacterial research by Gootz, Thomas D

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Cloning and Functional Characterization of an NAD+-Dependent DNA Ligase from Staphylococcus aureus by Kaczmarek, F S, Zaniewski, R P, Gootz, T D, Danley, D E, Mansour, M N, Griffor, M, Kamath, A V, Cronan, M, Mueller, J, Sun, D, Martin, P K, Benton, B, McDowell, L, Biek, D, Schmid, M B

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New quinolone compounds from Pseudonocardia sp. with selective and potent anti-Helicobacter pylori activity: taxonomy of producing strain, fermentation, isolation, structural elucidation and biological activities by Dekker, K A, Inagaki, T, Gootz, T D, Huang, L H, Kojima, Y, Kohlbrenner, W E, Matsunaga, Y, McGuirk, P R, Nomura, E, Sakakibara, T, Sakemi, S, Suzuki, Y, Yamauchi, Y, Kojima, N

“…Eight novel quinolones with anti-Helicobacter pylori activity were isolated from the actinomycete Pseudonocardia sp. CL38489. The quinolones were very potent…”
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Anti-Toxoplasma gondii Activities and Structure-Activity Relationships of Novel Fluoroquinolones Related to Trovafloxacin by KHAN, A. A, ARAUJO, F. G, BRIGHTY, K. E, GOOTZ, T. D, REMINGTON, J. S

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Action of Quinolones against Staphylococcus aureus Topoisomerase IV:  Basis for DNA Cleavage Enhancement by Anderson, Virginia E, Zaniewski, Richard P, Kaczmarek, Frank S, Gootz, Thomas D, Osheroff, Neil

“…Topoisomerase IV is the primary cellular target for most quinolones in Gram-positive bacteria; however, its interaction with these agents is poorly understood…”
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Topoisomerase IV Catalysis and the Mechanism of Quinolone Action by Anderson, V E, Gootz, T D, Osheroff, N

“…Topoisomerase IV is a bacterial type II topoisomerase that is essential for proper chromosome segregation and is a target for quinolone-based antimicrobial…”
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CJ-12,954 and its congeners, new anti-Helicobacter pylori compounds produced by Phanerochaete velutina: fermentation, isolation, structural elucidation and biological activities by Dekker, K A, Inagaki, T, Gootz, T D, Kaneda, K, Nomura, E, Sakakibara, T, Sakemi, S, Sugie, Y, Yamauchi, Y, Yoshikawa, N, Kojima, N

“…Seven new phthalide compounds with anti-Helicobacter pylori activities were isolated from the basidiomycete Phanerochaete velutina CL6387. The two most potent…”
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