Search Results - "Goodyke, Austin"

Maize early endosperm growth and development: From fertilization through cell type differentiation by Leroux, Brian M, Goodyke, Austin J, Schumacher, Katelyn I, Abbott, Chelsi P, Clore, Amy M, Yadegari, Ramin, Larkins, Brian A, Dannenhoffer, Joanne M

“…• Premise of the study: Given the worldwide economic importance of maize endosperm, it is surprising that its development is not the most comprehensively…”
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The MDM2 inhibitor CGM097 combined with the BET inhibitor OTX015 induces cell death and inhibits tumor growth in models of neuroblastoma by Maser, Tyler, Zagorski, Joseph, Kelly, Shannon, Ostrander, Anna, Goodyke, Austin, Nagulapally, Abhinav, Bond, Jeffrey, Park, Yeonhee, Saulnier Sholler, Giselle

“…Background Neuroblastoma (NB) is the most common extracranial solid tumor in infants and children, with amplification of the oncogene MYCN being a hallmark of…”
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Determining the Gold Standard for Peripheral Nerve Management in Traumatic Amputations by Lucich, Elizabeth, Gorvetzian, Joseph, Goodyke, Austin, Braza, Matthew, Albazi, Evien, Ford, Ronald

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SARS-CoV-2 Genotyping Highlights the Challenges in Spike Protein Drift Independent of Other Essential Proteins by Prokop, Jeremy W, Alberta, Sheryl, Witteveen-Lane, Martin, Pell, Samantha, Farag, Hosam A, Bhargava, Disha, Vaughan, Robert M, Frisch, Austin, Bauss, Jacob, Bhatti, Humza, Arora, Sanjana, Subrahmanya, Charitha, Pearson, David, Goodyke, Austin, Westgate, Mason, Cook, Taylor W, Mitchell, Jackson T, Zieba, Jacob, Sims, Matthew D, Underwood, Adam, Hassouna, Habiba, Rajasekaran, Surender, Tamae Kakazu, Maximiliano A, Chesla, Dave, Olivero, Rosemary, Caulfield, Adam J

“…As of 2024, SARS-CoV-2 continues to propagate and drift as an endemic virus, impacting healthcare for years. The largest sequencing initiative for any species…”
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518 Identification of Tumor Infiltrating Leukocytes in Glioblastoma and Clinical Outcomes by Orozco, Andres Restrepo, Goodyke, Austin, Zagorski, Joseph, Vitaz, Todd

“…INTRODUCTION: Glioblastoma (GBM) accounts for 60% of all malignant brain tumors in adults with a dismal 5-year survival rate of 5%. Treatment challenges stem…”
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Differential gene expression of leaflet tissue in chronic ovine functional tricuspid regurgitation by Gaweda, Boguslaw, Goodyke, Austin, Prokop, Jeremy, Arora, Sanjana, Iwasieczko, Artur, Piekarska, Magda, Zagorski, Joseph, Widenka, Kazimierz, Rausch, Manuel K, Aguirre, Aitor, Timek, Tomasz A

“…Severe functional tricuspid regurgitation (FTR) is associated with subvalvular remodelling, but leaflet tissue alterations may also contribute. We set out to…”
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Valvular complex and tissue remodelling in ovine functional tricuspid regurgitation by Iwasieczko, Artur, Gaddam, Manikantam, Gaweda, Boguslaw, Goodyke, Austin, Mathur, Mrudang, Lin, Chien-Yu, Zagorski, Joseph, Solarewicz, Monica, Cohle, Stephen, Rausch, Manuel, Timek, Tomasz A

“…Abstract OBJECTIVES Pathophysiology of function tricuspid regurgitation (FTR) is incompletely understood. We set out to comprehensively evaluate geometric and…”
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Abstract 3190: DFMO preferentially drives cancer stem cells in neuroblastoma towards senescence by Avequin, Tracey, Goodyke, Austin, Zagorski, Joseph, Maser, Tyler, Sholler, Giselle L. Saulnier

“…Abstract Background: High-risk neuroblastoma (HRNB) is an aggressive form of the most common extracranial solid tumor cancer in children, often characterized…”
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MEDU-14. GENOMIC ANALYSIS OF ETMR GUIDES EFFICACIOUS DFMO DRUG COMBINATIONS by Goodyke, Austin, VanSickle, Elizabeth, Zagorski, Joseph, Beeravally, Abhinav, Sholler, Giselle Saulnier

“…Abstract Embryonal tumor with multilayered rosettes (ETMR), formerly termed ETANTR, is a rare pediatric tumor carrying a poor prognosis and occurring primarily…”
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SDPS-34 SCREENING TUMOR INFILTRATING LEUKOCYTES IN GLIOBLASTOMA REVEALS A CORRELATION WITH EGFR POSITIVE TUMOR CELLS WITH PROGNOSTIC IMPLICATIONS by Goodyke, Austin, Arora, Sanjana, Orozco, Andres Restrepo, Zagorski, Joseph, Vitaz, Todd

“…Abstract Glioblastoma (GBM) is a grade IV brain tumor that is difficult to manage and associated with high rates of relapse and mortality. Treatment failures…”
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Abstract 3191: The MDM2 inhibitor CGM097 synergizes with the BET inhibitor OTX015 to induce cell death in neuroblastoma cells by Maser, Tyler P., Zagorski, Joseph W., Goodyke, Austin J., VanSickle, Elizabeth A., Bond, Jeffrey P., Sholler, Giselle L. Saulnier

“…Abstract Background: Neuroblastoma (NB) is the most common extracranial solid tumor in infants and children, with amplification of the oncogene MYCN being a…”
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ETMR-18. TARGETING Lin28 IN ETMR WITH ODC1 INHIBITOR DFMO by Goodyke, Austin, Kelly, Shannon, Zagorski, Joseph, VanSickle, Elizabeth, Maser, Tyler, Sortwell, Caryl, Kemp, Christopher, Nagulapally, Abhinav, Dykema, Karl, Saulnier-Sholler, Giselle

“…Abstract Embryonal tumor with multilayered rosettes (ETMR), is an aggressive brain tumor primarily occurring in young patients (<4 years of age) and…”
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Bortezomib for the prevention and treatment of graft-versus-host disease after allogeneic hematopoietic stem cell transplantation by Al-Homsi, Ahmad Samer, Feng, Yuxin, Duffner, Ulrich, Al Malki, Monzr M, Goodyke, Austin, Cole, Kelli, Muilenburg, Marlee, Abdel-Mageed, Aly

“…Allogeneic hematopoietic stem cell transplantation is the standard treatment for a variety of benign and malignant conditions. However, graft-versus-host…”
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Ixazomib Impairs Dendritic Cell Function and T Cell Proliferation and Affects the Development of GvHD in a Schedule-Dependent Fashion by Feng, Yuxin, Goodyke, Austin, Muilenberg, Marlee, Cole, Kelli, Cannady, Kathleen, Shen, Anding, Al-Homsi, A. Samer

“…Background: Targeting T cells alone has yielded limited success in the prevention of graft-versus-host disease (GvHD) following allogeneic blood and marrow…”
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Ixazomib Suppresses Human Dendritic Cell and Modulates Murine Graft-Versus-Host Disease in a Schedule-Dependent Fashion by Al-Homsi, A Samer, Goodyke, Austin, Cole, Kelli, Muilenburg, Marlee, McLane, Michael, Abdel-Mageed, Sarah, Feng, Yuxin

“…Abstract There is an abiding need for innovative approaches for the prevention of graft-versus-host disease (GvHD) following allogeneic hematopoietic stem cell…”
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Post-Transplant Cyclophosphamide Overcomes Graft-Versus-Host Disease Aggravation Induced By Extended Administration of Proteasome Inhibitors by Al-Homsi, A. Samer, Goodyke, Austin, Cole, Kelli, Muilenburg, Marlee, McLane, Michael, Abdel-Mageed, Sarah, Abidi, Muneer H., Williams, Stephanie F.

“…The concept of suppressing dendritic cells (DCs) to prevent graft-versus-host disease (GvHD) following allogeneic hematopoietic stem cell transplantation…”
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Post-Transplantation Cyclophosphamide and Ixazomib Combination Rescues Mice Subjected to Experimental Graft-versus-Host Disease and Is Superior to Either Agent Alone by Al-Homsi, Ahmad Samer, Goodyke, Austin, McLane, Michael, Abdel-Mageed, Sarah, Cole, Kelli, Muilenburg, Marlee, Feng, Yuxin

“…Highlights • The combination of cyclophosphamide and ixazomib is effective in rescuing mice subjected to lethal graft-versus-host disease and is superior to…”
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Calcineurin and mTOR Inhibitor-Free Post-Transplantation Cyclophosphamide and Bortezomib Combination for Graft-Versus-Host Disease Prevention after Peripheral Blood Allogeneic Hematopoietic Stem Cell Transplantation: a Phase I-II Study by Al-Homsi, A Samer, Cole, Kelli, Muilenburg, Marlee, Goodyke, Austin, Abidi, Muneer, Duffner, Ulrich, Williams, Stephanie, Parker, Jessica, Abdel-Mageed, Aly

“…Highlights • PTC and bortezomib for the prevention of GvHD following peripheral blood AHSCT is feasible and safe • The calcineurin and mTOR inhibitor-free…”
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