Search Results - "Goody, Robin"

Pharmacological inhibition of a microRNA family in nonhuman primates by a seed-targeting 8-mer antimiR by Rottiers, Veerle, Obad, Susanna, Petri, Andreas, McGarrah, Robert, Lindholm, Marie W, Black, Joshua C, Sinha, Sumita, Goody, Robin J, Lawrence, Matthew S, deLemos, Andrew S, Hansen, Henrik F, Whittaker, Steve, Henry, Steve, Brookes, Rohn, Najafi-Shoushtari, S Hani, Chung, Raymond T, Whetstine, Johnathan R, Gerszten, Robert E, Kauppinen, Sakari, Näär, Anders M

“…MicroRNAs (miRNAs) regulate many aspects of human biology. They target mRNAs for translational repression or degradation through base pairing with 3'…”
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Elezanumab, a human anti-RGMa monoclonal antibody, promotes neuroprotection, neuroplasticity, and neurorecovery following a thoracic hemicompression spinal cord injury in non-human primates by Jacobson, Peer B., Goody, Robin, Lawrence, Matthew, Mueller, Bernhard K., Zhang, Xiaomeng, Hooker, Bradley A., Pfleeger, Kimberly, Ziemann, Adam, Locke, Charles, Barraud, Quentin, Droescher, Mathias, Bernhard, Joerg, Popp, Andreas, Boeser, Preethne, Huang, Lili, Mollon, Jennifer, Mordashova, Yulia, Cui, Yi-Fang, Savaryn, John P., Grinnell, Christine, Dreher, Ingeborg, Gold, Michael, Courtine, Grégoire, Mothe, Andrea, Tator, Charles H., Guest, James D.

“…Spinal cord injury (SCI) is a devastating condition characterized by loss of function, secondary to damaged spinal neurons, disrupted axonal connections, and…”
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Antiangiogenic activity of aganirsen in nonhuman primate and rodent models of retinal neovascular disease after topical administration by Cloutier, Frank, Lawrence, Matthew, Goody, Robin, Lamoureux, Stéphanie, Al-Mahmood, Salman, Colin, Sylvie, Ferry, Antoine, Conduzorgues, Jean-Pascal, Hadri, Amel, Cursiefen, Claus, Udaondo, Patricia, Viaud, Eric, Thorin, Eric, Chemtob, Sylvain

“…Aganirsen, an antisense oligonucleotide inhibiting insulin receptor substrate (IRS)-1 expression, has been shown to promote the regression of pathologic…”
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Optimization of laser-induced choroidal neovascularization in African green monkeys by Goody, Robin J., Hu, Wenzheng, Shafiee, Afshin, Struharik, Michael, Bartels, Stephen, López, Francisco J., Lawrence, Matthew S.

“…We developed and validated a new nonhuman primate model of laser-induced choroidal neovascularization (CNV) that addresses study design limitations prevalent…”
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Clinical chemistry and hematology values in a Caribbean population of African green monkeys by Liddie, Shervin, Goody, Robin J., Valles, Rodrigo, Lawrence, Matthew S.

“…Background  Hematology and clinical chemistry (HCC) reference values are critical in veterinary practice and in vivo pre‐clinical research, enabling detection…”
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Novel Strategy for Treatment of Viral Central Nervous System Infection by Using a Cell-Permeating Inhibitor of c-Jun N-Terminal Kinase by BECKHAM, J. David, GOODY, Robin J, CLARKE, Penny, BONNY, Christophe, TYLER, Kenneth L

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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The use of the African green monkey as a preclinical model for ocular pharmacokinetic studies by Glogowski, Shellise, Ward, Keith W, Lawrence, Matthew S, Goody, Robin J, Proksch, Joel W

“…This investigation evaluated the ocular and systemic pharmacokinetics of besifloxacin in African green monkeys compared with cynomolgus monkeys following…”
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Apoptotic death of striatal neurons induced by human immunodeficiency virus-1 Tat and gp120: Differential involvement of caspase-3 and endonuclease G by Singh, Indrapal N, Goody, Robin J, Dean, Celeste, Ahmad, Nael M, Lutz, Sarah E, Knapp, Pamela E, Nath, Avindra, Hauser, Kurt F

“…Human immunodeficiency virus-1 (HIV-1) infection affects the striatum, resulting in gliosis and neuronal losses. To determine whether HIV-1 proteins induce…”
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Reovirus infection of the CNS enhances iNOS expression in areas of virus-induced injury by Goody, Robin J., Hoyt, Cristen C., Tyler, Kenneth L.

“…Nitric oxide (NO) has been implicated as a contributor to the host's innate defense against viral infections including those affecting the CNS. Reovirus…”
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Experimental Reovirus-Induced Acute Flaccid Paralysis and Spinal Motor Neuron Cell Death by Goody, Robin J, Schittone, Stephanie A, Tyler, Kenneth L

“…Acute flaccid paralysis (AFP) describes the loss of motor function in 1 or more limbs commonly associated with viral infection and destruction of motor neurons…”
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JAK-STAT signaling pathways are activated in the brain following reovirus infection by Goody, Robin J, Beckham, J David, Rubtsova, Kira, Tyler, Kenneth L

“…Reovirus infection provides a classic experimental model system for studying the pathogenesis of viral infections of the central nervous system (CNS), with…”
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Nonstructural Protein σ1s Is a Determinant of Reovirus Virulence and Influences the Kinetics and Severity of Apoptosis Induction in the Heart and Central Nervous System by HOYT, Cristen C, RICHARDSON-BURNS, Sarah M, GOODY, Robin J, ROBINSON, Bridget A, DEBIASI, Roberta L, TYLER, Kenneth L

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Quantitative autoradiographic mapping of opioid receptors in the brain of δ-opioid receptor gene knockout mice by Goody, Robin J, Oakley, Sarah M, Filliol, Dominique, Kieffer, Brigitte L, Kitchen, Ian

“…Using quantitative receptor autoradiography we have determined if deletion of the δ-opioid receptor gene ( Oprd1) results in compensatory changes in the…”
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Selective vulnerability of cerebellar granule neuroblasts and their progeny to drugs with abuse liability by Hauser, Kurt F, Khurdayan, Valeriya K, Goody, Robin J, Nath, Avindra, Saria, Alois, Pauly, James R

“…Cerebellar development is shaped by the interplay of genetic and numerous environmental factors. Recent evidence suggests that cerebellar maturation is acutely…”
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Primate model of chronic retinal neovascularization and vascular leakage by Patel, Chintan, Goody, Robin, Hu, Wenzheng, Kurian, Anish, James, Donnicia, Torres, Richard, Christie, Lori-Ann, Hohman, Thomas, Lawrence, Matthew

“…The purpose of this study was to characterize and develop a primate model of chronic retinal neovascularization and vascular leakage that can be employed to…”
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Experimental Reovirus-lnduced Acute Flaccid Paralysis and Spinal Motor Neuron Cell Death by GOODY, Robin J, SCHITTONE, Stephanie A, TYLER, Kenneth L

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Decoy Peptides that Bind Dynorphin Noncovalently Prevent NMDA Receptor-Mediated Neurotoxicity by Woods, Amina S, Kaminski, Rafal, Oz, Murat, Wang, Yun, Hauser, Kurt, Goody, Robin, Wang, Hay-Yan J, Jackson, Shelley N, Zeitz, Peter, Zeitz, Karla P, Zolkowska, Dorota, Schepers, Raf, Nold, Michael, Danielson, Jens, Gräslund, Astrid, Vukojevic, Vladana, Bakalkin, Georgy, Basbaum, Allan, Shippenberg, Toni

“…Prodynorphin-derived peptides elicit various pathological effects including neurological dysfunction and cell death. These actions are reduced by…”
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Nonstructural Protein capital sigma 1s Is a Determinant of Reovirus Virulence and Influences the Kinetics and Severity of Apoptosis Induction in the Heart and Central Nervous System by Hoyt, Cristen C, Richardson-Burns, Sarah M, Goody, Robin J, Robinson, Bridget A, Debiasi, Roberta L, Tyler, Kenneth L

“…The mechanisms by which viruses kill susceptible cells in target organs and ultimately produce disease in the infected host remain poorly understood. Dependent…”
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Nonstructural protein sigma1s is a determinant of reovirus virulence and influences the kinetics and severity of apoptosis induction in the heart and central nervous system by Hoyt, Cristen C, Richardson-Burns, Sarah M, Goody, Robin J, Robinson, Bridget A, Debiasi, Roberta L, Tyler, Kenneth L

“…The mechanisms by which viruses kill susceptible cells in target organs and ultimately produce disease in the infected host remain poorly understood. Dependent…”
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Influence of maternal milk on functional activation of delta-opioid receptors in postnatal rats by Goody, R J, Kitchen, I

“…Weaning rat pups at day 21 activates a delta-opioid receptor that mediates swim-stress-induced analgesia (swim SIA). We have addressed the possibility that…”
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