Novel Oxytocin Receptor Variants in Laboring Women Requiring High Doses of Oxytocin

Novel Oxytocin Receptor Variants in Laboring Women Requiring High Doses of Oxytocin

(Am J Obstet Gynecol. 2017;217(2):214.e1–214.e8)In the United States, oxytocin is administered to nearly half of women who give birth to either augment or induce labor. However, the required dosage of oxytocin varies widely among women, with a therapeutic window between 1 mU/min and >40 mU/min. V...

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Bibliographic Details
Published in:Obstetric anesthesia digest Vol. 38; no. 2; pp. 93 - 94
Main Authors: Reinl, E.L, Goodwin, Z.A, Raghuraman, N, Lee, G.Y, Jo, E.Y, Gezahegn, B.M, Pillai, M.K, Cahill, A.G, de Guzman Strong, C, England, S.K
Format: Journal Article
Language:English
Published: Copyright Wolters Kluwer Health, Inc. All rights reserved 01-06-2018
Online Access:Get full text
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Summary:(Am J Obstet Gynecol. 2017;217(2):214.e1–214.e8)In the United States, oxytocin is administered to nearly half of women who give birth to either augment or induce labor. However, the required dosage of oxytocin varies widely among women, with a therapeutic window between 1 mU/min and >40 mU/min. Variations in the oxytocin receptor gene may explain some women’s requirements for high or low doses of oxytocin. This study aimed to identify variants in the oxytocin receptor gene in women in labor who had high or low dosage requirements.
ISSN:0275-665X
1536-5395
DOI:10.1097/01.aoa.0000532289.07506.18