Search Results - "Goodwin, T"

Selectivity Studies and Free Energy Calculations of AKT Inhibitors by Zhong, Haizhen A, Goodwin, David T

“…Protein kinase B (PKB) or AKT protein is an important target for cancer treatment. Significant advances have been made in developing ATP-competitive inhibitors…”
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Investigating Performance Trends of Simulated Real-time Solar Flare Predictions: The Impacts of Training Windows, Data Volumes, and the Solar Cycle by Goodwin, Griffin T., Sadykov, Viacheslav M., Martens, Petrus C.

“…Abstract This study explores the behavior of machine-learning-based flare forecasting models deployed in a simulated operational environment. Using Georgia…”
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Free T4 immunoassays are flawed during pregnancy by Lee, Richard H., MD, Spencer, Carole A., PhD, Mestman, Jorge H., MD, Miller, Erin A., BS, Petrovic, Ivana, MS, Braverman, Lewis E., MD, Goodwin, T. Murphy, MD

“…Objective The purpose of this study was to evaluate the diagnostic accuracies of 2 free thyroxine immunoassays during pregnancy. Study Design Serum was…”
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Insights into the Biology of Hearing and Deafness Revealed by Single-Cell RNA Sequencing by Ranum, Paul T., Goodwin, Alexander T., Yoshimura, Hidekane, Kolbe, Diana L., Walls, William D., Koh, Jin-Young, He, David Z.Z., Smith, Richard J.H.

“…Single-cell RNA sequencing is a powerful tool by which to characterize the transcriptional profile of low-abundance cell types, but its application to the…”
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Molecular Endotyping of Pulmonary Fibrosis by Goodwin, Amanda T., MBChB, Jenkins, Gisli, PhD

“…Idiopathic pulmonary fibrosis (IPF) is a devastating and incurable progressive fibrotic lung condition associated with a significant disease burden. In recent…”
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Evaluation of outpatient treatment for non-hospitalised patients with COVID-19: The experience of a regional centre in the UK by Goodwin, Amanda T, Thompson, Jonathan S, Hall, Ian P

“…Antivirals, such as molnupiravir, and SARS-CoV-2 neutralising monoclonal antibodies (nMAbs), such as sotrovimab, reduced the risk of hospitalisation and death…”
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Shoulder dystocia: The unpreventable obstetric emergency with empiric management guidelines by Gherman, Robert B., Chauhan, Suneet, Ouzounian, Joseph G., Lerner, Henry, Gonik, Bernard, Goodwin, T. Murphy

“…Much of our understanding and knowledge of shoulder dystocia has been blurred by inconsistent and scientific studies that are of limited scientific quality. In…”
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RNA Interference Prevents Autosomal-Dominant Hearing Loss by Shibata, Seiji B., Ranum, Paul T., Moteki, Hideaki, Pan, Bifeng, Goodwin, Alexander T., Goodman, Shawn S., Abbas, Paul J., Holt, Jeffrey R., Smith, Richard J.H.

“…Hearing impairment is the most common sensory deficit. It is frequently caused by the expression of an allele carrying a single dominant missense mutation…”
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Outlier identification and monitoring of institutional or clinician performance: an overview of statistical methods and application to national audit data by Pavlou, Menelaos, Ambler, Gareth, Omar, Rumana Z, Goodwin, Andrew T, Trivedi, Uday, Ludman, Peter, de Belder, Mark

“…Institutions or clinicians (units) are often compared according to a performance indicator such as in-hospital mortality. Several approaches have been proposed…”
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Hyperemesis Gravidarum by Goodwin, T. Murphy, MD

“…Hyperemesis gravidarum occurs in 0.3% to 2% of pregnant women, although populations with significantly higher rates have been reported. In clinical practice,…”
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Detecting the earliest radiological signs of bisphosphonate-related osteonecrosis by Devlin, H., Greenwall-Cohen, J., Benton, J., Goodwin, T. L., Littlewood, A., Horner, K.

“…Key Points Highlights that general dental practitioner should ensure that all patients are dentally fit before they commence bisphosphonate treatment. Focal…”
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Impact of COVID-19 on cardiac procedure activity in England and associated 30-day mortality by Mohamed, Mohamed O, Banerjee, Amitava, Clarke, Sarah, de Belder, Mark, Patwala, Ashish, Goodwin, Andrew T, Kwok, Chun Shing, Rashid, Muhammad, Gale, Chris P, Curzen, Nick, Mamas, Mamas A

“…Abstract Aims Limited data exist on the impact of COVID-19 on national changes in cardiac procedure activity, including patient characteristics and clinical…”
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Intravenous rAAV2/9 injection for murine cochlear gene delivery by Shibata, Seiji B., Yoshimura, Hidekane, Ranum, Paul T., Goodwin, Alexander T., Smith, Richard J. H.

“…Gene therapy for genetic deafness is a promising approach by which to prevent hearing loss or to restore hearing after loss has occurred. Although a variety of…”
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Night and day: the comparative study of strepsirrhine primates reveals socioecological and phylogenetic patterns in olfactory signals by DELBARCO‐TRILLO, J, BURKERT, B.A, GOODWIN, T.E, DREA, C.M

“…Studies of chemical signals in vertebrates typically target single species; however, a broader understanding of olfactory communication may derive from…”
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Amplification of TGFβ Induced ITGB6 Gene Transcription May Promote Pulmonary Fibrosis by Tatler, Amanda L, Goodwin, Amanda T, Gbolahan, Olumide, Saini, Gauri, Porte, Joanne, John, Alison E, Clifford, Rachel L, Violette, Shelia M, Weinreb, Paul H, Parfrey, Helen, Wolters, Paul J, Gauldie, Jack, Kolb, Martin, Jenkins, Gisli

“…Idiopathic pulmonary fibrosis (IPF) is a devastating, progressive disease with poor survival rates and limited treatment options. Upregulation of αvβ6…”
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The knowledge mobilisation challenge: does producing evidence lead to its adoption within dentistry? by Goodwin, T. L., Brocklehurst, P. R., Williams, L.

“…Key Points Demonstrates that producing evidence in dentistry does not automatically translate into it being adopted or sustained within a clinical setting…”
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Associations between ambient air pollution and Hypertensive Disorders of Pregnancy by Mobasher, Zahra, Salam, Muhammad T., Goodwin, T.Murphy, Lurmann, Frederick, Ingles, Sue A., Wilson, Melissa L.

“…Exposure to ambient air pollution is linked to adverse pregnancy outcomes. Previous reports examining the relationship between ambient air pollution and…”
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Supportive care of patients with fibrosing interstitial lung disease: answering a great clinical need by Goodwin, Amanda T, Saini, Gauri

“…https://bit.ly/2ZAE2Ks…”
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In silico predictions of blood-brain barrier penetration: considerations to "keep in mind" by Goodwin, Jay T, Clark, David E

“…Within drug discovery, it is desirable to determine whether a compound will penetrate and distribute within the central nervous system (CNS) with the requisite…”
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Initial Experience in Adults with Complex Congenital Heart Disease Treated with Sacubitril/Valsartan for Heart Failure by Goodwin, T.L., Broda, C.R., Opina, A., Lam, W., Ermis, P.R.

“…Adults with congenital heart disease (ACHD) are an emerging population. Heart failure (HF) is a major cause of morbidity and mortality for ACHD…”
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