Search Results - "Goodwin, Craig"

Combination Therapies with CDK4/6 Inhibitors to Treat KRAS-Mutant Pancreatic Cancer by Goodwin, Craig M, Waters, Andrew M, Klomp, Jennifer E, Javaid, Sehrish, Bryant, Kirsten L, Stalnecker, Clint A, Drizyte-Miller, Kristina, Papke, Bjoern, Yang, Runying, Amparo, Amber M, Ozkan-Dagliyan, Irem, Baldelli, Elisa, Calvert, Valerie, Pierobon, Mariaelena, Sorrentino, Jessica A, Beelen, Andrew P, Bublitz, Natalie, Lüthen, Mareen, Wood, Kris C, Petricoin, Emanuel F, Sers, Christine, McRee, Autumn J, Cox, Adrienne D, Der, Channing J

“…Mutational loss of CDKN2A (encoding p16INK4A) tumor-suppressor function is a key genetic step that complements activation of KRAS in promoting the development…”
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Concurrent Inhibition of IGF1R and ERK Increases Pancreatic Cancer Sensitivity to Autophagy Inhibitors by Stalnecker, Clint A, Grover, Kajal R, Edwards, A Cole, Coleman, Michael F, Yang, Runying, DeLiberty, Jonathan M, Papke, Björn, Goodwin, Craig M, Pierobon, Mariaelena, Petricoin, Emanuel F, Gautam, Prson, Wennerberg, Krister, Cox, Adrienne D, Der, Channing J, Hursting, Stephen D, Bryant, Kirsten L

“…The aggressive nature of pancreatic ductal adenocarcinoma (PDAC) mandates the development of improved therapies. As KRAS mutations are found in 95% of PDAC and…”
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Discovery of 2‑Indole-acylsulfonamide Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors Using Fragment-Based Methods by Pelz, Nicholas F, Bian, Zhiguo, Zhao, Bin, Shaw, Subrata, Tarr, James C, Belmar, Johannes, Gregg, Claire, Camper, DeMarco V, Goodwin, Craig M, Arnold, Allison L, Sensintaffar, John L, Friberg, Anders, Rossanese, Olivia W, Lee, Taekyu, Olejniczak, Edward T, Fesik, Stephen W

“…Myeloid cell leukemia-1 (Mcl-1) is a member of the Bcl-2 family of proteins responsible for the regulation of programmed cell death. Amplification of Mcl-1 is…”
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Low-Dose Vertical Inhibition of the RAF-MEK-ERK Cascade Causes Apoptotic Death of KRAS Mutant Cancers by Ozkan-Dagliyan, Irem, Diehl, J. Nathaniel, George, Samuel D., Schaefer, Antje, Papke, Bjoern, Klotz-Noack, Kathleen, Waters, Andrew M., Goodwin, Craig M., Gautam, Prson, Pierobon, Mariaelena, Peng, Sen, Gilbert, Thomas S.K., Lin, Kevin H., Dagliyan, Onur, Wennerberg, Krister, Petricoin, Emanuel F., Tran, Nhan L., Bhagwat, Shripad V., Tiu, Ramon V., Peng, Sheng-Bin, Herring, Laura E., Graves, Lee M., Sers, Christine, Wood, Kris C., Cox, Adrienne D., Der, Channing J.

“…We address whether combinations with a pan-RAF inhibitor (RAFi) would be effective in KRAS mutant pancreatic ductal adenocarcinoma (PDAC). Chemical library and…”
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Discovery of Tricyclic Indoles That Potently Inhibit Mcl‑1 Using Fragment-Based Methods and Structure-Based Design by Burke, Jason P, Bian, Zhiguo, Shaw, Subrata, Zhao, Bin, Goodwin, Craig M, Belmar, Johannes, Browning, Carrie F, Vigil, Dominico, Friberg, Anders, Camper, DeMarco V, Rossanese, Olivia W, Lee, Taekyu, Olejniczak, Edward T, Fesik, Stephen W

“…Myeloid cell leukemia-1 (Mcl-1) is an antiapoptotic member of the Bcl-2 family of proteins that is overexpressed and amplified in many cancers. Overexpression…”
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Detection of phenotype‐specific therapeutic vulnerabilities in breast cells using a CRISPR loss‐of‐function screen by Barkovskaya, Anna, Goodwin, Craig M., Seip, Kotryna, Hilmarsdottir, Bylgja, Pettersen, Solveig, Stalnecker, Clint, Engebraaten, Olav, Briem, Eirikur, Der, Channing J., Moestue, Siver A., Gudjonsson, Thorarinn, Mælandsmo, Gunhild M., Prasmickaite, Lina

“…Cellular phenotype plasticity between the epithelial and mesenchymal states has been linked to metastasis and heterogeneous responses to cancer therapy, and…”
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Concurrent Inhibition of ERK and Farnesyltransferase Suppresses the Growth of HRAS Mutant Head and Neck Squamous Cell Carcinoma by Javaid, Sehrish, Schaefer, Antje, Goodwin, Craig M, Nguyen, Victoria V, Massey, Frances L, Pierobon, Mariaelena, Gambrell-Sanders, Da'Jhnae, Waters, Andrew M, Lambert, Kathryn N, Diehl, J Nathaniel, Hobbs, G Aaron, Wood, Kris C, Petricoin, Emanuel F, Der, Channing J, Cox, Adrienne D

“…Human papilloma virus (HPV)-negative head and neck squamous cell carcinoma (HNSCC) is a common cancer worldwide with an unmet need for more effective, less…”
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Defining the KRAS- and ERK-dependent transcriptome in KRAS-mutant cancers by Klomp, Jeffrey A, Klomp, Jennifer E, Stalnecker, Clint A, Bryant, Kirsten L, Edwards, A Cole, Drizyte-Miller, Kristina, Hibshman, Priya S, Diehl, J Nathaniel, Lee, Ye S, Morales, Alexis J, Taylor, Khalilah E, Peng, Sen, Tran, Nhan L, Herring, Laura E, Prevatte, Alex W, Barker, Natalie K, Hover, Laura D, Hallin, Jill, Chowdhury, Saikat, Coker, Oluwadara, Lee, Hey Min, Goodwin, Craig M, Gautam, Prson, Olson, Peter, Christensen, James G, Shen, John P, Kopetz, Scott, Graves, Lee M, Lim, Kian-Huat, Wang-Gillam, Andrea, Wennerberg, Krister, Cox, Adrienne D, Der, Channing J

“…How the oncogene drives cancer growth remains poorly understood. Therefore, we established a systemwide portrait of KRAS- and extracellular signal-regulated…”
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Discovery and biological characterization of potent myeloid cell leukemia‐1 inhibitors by Lee, Taekyu, Bian, Zhiguo, Zhao, Bin, Hogdal, Leah J., Sensintaffar, John L., Goodwin, Craig M., Belmar, Johannes, Shaw, Subrata, Tarr, James C., Veerasamy, Nagarathanam, Matulis, Shannon M., Koss, Brian, Fischer, Melissa A., Arnold, Allison L., Camper, DeMarco V., Browning, Carrie F., Rossanese, Olivia W., Budhraja, Amit, Opferman, Joseph, Boise, Lawrence H., Savona, Michael R., Letai, Anthony, Olejniczak, Edward T., Fesik, Stephen W.

“…Myeloid cell leukemia 1 (Mcl‐1) is an antiapoptotic member of the Bcl‐2 family of proteins that when overexpressed is associated with high tumor grade, poor…”
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RHOA L57V drives the development of diffuse gastric cancer through IGF1R-PAK1-YAP1 signaling by Schaefer, Antje, Hodge, Richard G, Zhang, Haisheng, Hobbs, G Aaron, Dilly, Julien, Huynh, Minh V, Goodwin, Craig M, Zhang, Feifei, Diehl, J Nathaniel, Pierobon, Mariaelena, Baldelli, Elisa, Javaid, Sehrish, Guthrie, Karson, Rashid, Naim U, Petricoin, Emanuel F, Cox, Adrienne D, Hahn, William C, Aguirre, Andrew J, Bass, Adam J, Der, Channing J

“…Cancer-associated mutations in the guanosine triphosphatase (GTPase) RHOA are found at different locations from the mutational hotspots in the structurally and…”
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CHK1 protects oncogenic KRAS-expressing cells from DNA damage and is a target for pancreatic cancer treatment by Klomp, Jennifer E, Lee, Ye S, Goodwin, Craig M, Papke, Björn, Klomp, Jeff A, Waters, Andrew M, Stalnecker, Clint A, DeLiberty, Jonathan M, Drizyte-Miller, Kristina, Yang, Runying, Diehl, J Nathaniel, Yin, Hongwei H, Pierobon, Mariaelena, Baldelli, Elisa, Ryan, Meagan B, Li, Siqi, Peterson, Jackson, Smith, Amber R, Neal, James T, McCormick, Aaron K, Kuo, Calvin J, Counter, Christopher M, Petricoin, 3rd, Emanuel F, Cox, Adrienne D, Bryant, Kirsten L, Der, Channing J

“…We apply genetic screens to delineate modulators of KRAS mutant pancreatic ductal adenocarcinoma (PDAC) sensitivity to ERK inhibitor treatment, and we identify…”
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Vertical Inhibition of the RAF-MEK-ERK Cascade Induces Myogenic Differentiation, Apoptosis, and Tumor Regression in H/NRAS Q61X Mutant Rhabdomyosarcoma by Garcia, Natalia, Del Pozo, Vanessa, Yohe, Marielle E, Goodwin, Craig M, Shackleford, Terry J, Wang, Long, Baxi, Kunal, Chen, Yidong, Rogojina, Anna T, Zimmerman, Sara M, Peer, Cody J, Figg, William D, Ignatius, Myron S, Wood, Kris C, Houghton, Peter J, Vaseva, Angelina V

“…Oncogenic RAS signaling is an attractive target for fusion-negative rhabdomyosarcoma (FN-RMS). Our study validates the role of the ERK MAPK effector pathway in…”
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Vertical Inhibition of the RAF–MEK–ERK Cascade Induces Myogenic Differentiation, Apoptosis, and Tumor Regression in H/NRASQ61X Mutant Rhabdomyosarcoma by Garcia, Natalia, Del Pozo, Vanessa, Yohe, Marielle E., Goodwin, Craig M., Shackleford, Terry J., Wang, Long, Baxi, Kunal, Chen, Yidong, Rogojina, Anna T., Zimmerman, Sara M., Peer, Cody J., Figg, William D., Ignatius, Myron S., Wood, Kris C., Houghton, Peter J., Vaseva, Angelina V.

“…Abstract Oncogenic RAS signaling is an attractive target for fusion-negative rhabdomyosarcoma (FN-RMS). Our study validates the role of the ERK MAPK effector…”
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Functional and biological heterogeneity of KRAS Q61 mutations by Huynh, Minh V, Hobbs, G Aaron, Schaefer, Antje, Pierobon, Mariaelena, Carey, Leiah M, Diehl, J Nathaniel, DeLiberty, Jonathan M, Thurman, Ryan D, Cooke, Adelaide R, Goodwin, Craig M, Cook, Joshua H, Lin, Lin, Waters, Andrew M, Rashid, Naim U, Petricoin, 3rd, Emanuel F, Campbell, Sharon L, Haigis, Kevin M, Simeone, Diane M, Lyssiotis, Costas A, Cox, Adrienne D, Der, Channing J

“…Missense mutations at the three hotspots in the guanosine triphosphatase (GTPase) RAS-Gly , Gly , and Gln (commonly known as G12, G13, and Q61,…”
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VCP/p97, a pleiotropic protein regulator of the DNA damage response and proteostasis, is a potential therapeutic target in KRAS -mutant pancreatic cancer by Lee, Ye S, Klomp, Jennifer E, Stalnecker, Clint A, Goodwin, Craig M, Gao, Yanzhe, Droby, Gaith N, Vaziri, Cyrus, Bryant, Kirsten L, Der, Channing J, Cox, Adrienne D

“…We and others have recently shown that proteins involved in the DNA damage response (DDR) are critical for -mutant pancreatic ductal adenocarcinoma (PDAC) cell…”
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Targeting the ERK mitogen-activated protein kinase cascade for the treatment of KRAS-mutant pancreatic cancer by Diehl, J Nathaniel, Hibshman, Priya S, Ozkan-Dagliyan, Irem, Goodwin, Craig M, Howard, Sarah V, Cox, Adrienne D, Der, Channing J

“…Mutational activation of the KRAS oncogene is found in ~95% of pancreatic ductal adenocarcinoma (PDAC), the major form of pancreatic cancer. With substantial…”
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Abstract 3551: Discovery of orally bioavailable novel Mcl-1 inhibitors that exhibit selective anti-proliferative activity in Mcl-1 sensitive cancer cell lines by Lee, Taekyu, Bian, Zhiguo, Belmar, Johannes, Shaw, Subrata, Tarr, James C., Zhao, Bin, Pelz, Nick, Camper, DeMarco, Goodwin, Craig M., Arnold, Allison L., Sensintaffar, John L., Browning, Carrie F., Rossanese, Olivia W., Olejniczak, Edward T., Fesik, Stephen W.

“…Abstract Myeloid cell leukemia-1 (Mcl-1) is a member of the Bcl-2 family of proteins that regulate apoptosis. Amplification of Mcl-1 is found in various…”
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Barriers to device longevity and reuse: A vintage device empirical study by Goodwin, Craig, Woolley, Sandra

“…•Barriers to app installation impede device longevity.•Relatively few apps could be downloaded directly onto a vintage device.•Many apps could be downloaded…”
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Binding energies for alkane molecules on a carbon surface from gas–solid chromatography and molecular mechanics by Rybolt, Thomas R., Wells, Christina E., Thomas, Howard E., Goodwin, Craig M., Blakely, Jennifer L., Turner, James D.

“…Gas–solid chromatography was used to determine B 2 s (gas–solid virial coefficient) values for 12 alkanes (10 branched and 2 cyclic) interacting with a carbon…”
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Riparian Restoration in the Western United States: Overview and Perspective by Goodwin, Craig N., Hawkins, Charles P., Kershner, Jeffrey L.

“…This historical and conceptual overview of riparian ecosystem restoration discusses how riparian ecosystems have been defined, describes the hydrologic,…”
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