Search Results - "Goodson , Boyd M."
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NMR Hyperpolarization Techniques for Biomedicine
Published in Chemistry : a European journal (16-02-2015)“…Recent developments in NMR hyperpolarization have enabled a wide array of new in vivo molecular imaging modalities, ranging from functional imaging of the…”
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Heterogeneous Solution NMR Signal Amplification by Reversible Exchange
Published in Angewandte Chemie International Edition (14-07-2014)“…A novel variant of an iridium‐based organometallic catalyst was synthesized and used to enhance the NMR signals of pyridine in a heterogeneous phase by…”
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Irreversible Catalyst Activation Enables Hyperpolarization and Water Solubility for NMR Signal Amplification by Reversible Exchange
Published in The journal of physical chemistry. B (04-12-2014)“…Activation of a catalyst [IrCl(COD)(IMes)] (IMes = 1,3-bis(2,4,6-trimethylphenyl)imidazol-2-ylidene; COD = cyclooctadiene)] for signal amplification by…”
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The Feasibility of Formation and Kinetics of NMR Signal Amplification by Reversible Exchange (SABRE) at High Magnetic Field (9.4 T)
Published in Journal of the American Chemical Society (05-03-2014)“…1H NMR signal amplification by reversible exchange (SABRE) was observed for pyridine and pyridine-d 5 at 9.4 T, a field that is orders of magnitude higher than…”
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Nanoscale Catalysts for NMR Signal Enhancement by Reversible Exchange
Published in Journal of physical chemistry. C (02-04-2015)“…Two types of nanoscale catalysts were created to explore NMR signal enhancement via reversible exchange (SABRE) at the interface between heterogeneous and…”
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Spin Relays Enable Efficient Long-Range Heteronuclear Signal Amplification by Reversible Exchange
Published in Journal of physical chemistry. C (28-12-2017)“…A systematic experimental study is reported on the polarization transfer to distant spins, which do not directly bind to the polarization transfer complexes…”
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Hyperpolarization of “Neat” Liquids by NMR Signal Amplification by Reversible Exchange
Published in The journal of physical chemistry letters (21-05-2015)“…We report NMR Signal Amplification by Reversible Exchange (SABRE) hyperpolarization of the rare isotopes in “neat” liquids, each composed only of an otherwise…”
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Hyperpolarizing DNA Nucleobases via NMR Signal Amplification by Reversible Exchange
Published in Molecules (Basel, Switzerland) (25-01-2023)“…The present work investigates the potential for enhancing the NMR signals of DNA nucleobases by parahydrogen-based hyperpolarization. Signal amplification by…”
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Effects of a Tridentate Pincer Ligand on Parahydrogen Induced Polarization
Published in Chemphyschem (16-07-2021)“…The role of ligands in rhodium‐ and iridium‐catalyzed Parahydrogen Induced Polarization (PHIP) and SABRE (signal amplification by reversible exchange)…”
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Toward Cleavable Metabolic/pH Sensing “Double Agents” Hyperpolarized by NMR Signal Amplification by Reversible Exchange
Published in Chemistry : a European journal (25-07-2018)“…We show the simultaneous generation of hyperpolarized 13C‐labeled acetate and 15N‐labeled imidazole following spin‐relay of hyperpolarization and hydrolysis of…”
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Pilot Quality-Assurance Study of a Third-Generation Batch-Mode Clinical-Scale Automated Xenon-129 Hyperpolarizer
Published in Molecules (Basel, Switzerland) (16-02-2022)“…We present a pilot quality assurance (QA) study of a clinical-scale, automated, third-generation (GEN-3) Xe hyperpolarizer employing batch-mode spin-exchange…”
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Facile hyperpolarization chemistry for molecular imaging and metabolic tracking of [1–13C]pyruvate in vivo
Published in Journal of Magnetic Resonance Open (01-12-2023)“…•First demonstration of SABRE polarized [1–13C]pyruvate detected in vivo.•Metabolic conversion of pyruvate to lactate, alanine, and bicarbonate are…”
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Efficient SABRE-SHEATH Hyperpolarization of Potent Branched-Chain-Amino-Acid Metabolic Probe [1- 13 C]ketoisocaproate
Published in Metabolites (29-01-2023)“…Efficient C hyperpolarization of ketoisocaproate is demonstrated in natural isotopic abundance and [1- C]enriched forms via SABRE-SHEATH (Signal Amplification…”
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“Direct” 13C Hyperpolarization of 13C‐Acetate by MicroTesla NMR Signal Amplification by Reversible Exchange (SABRE)
Published in Angewandte Chemie International Edition (01-01-2020)“…Herein, we demonstrate “direct” 13C hyperpolarization of 13C‐acetate via signal amplification by reversible exchange (SABRE). The standard SABRE homogeneous…”
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Developing Hyperpolarized Butane Gas for Ventilation Lung Imaging
Published in Chemical & biomedical imaging (28-10-2024)“…NMR hyperpolarization dramatically improves the detection sensitivity of magnetic resonance through the increase in nuclear spin polarization. Because of the…”
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Sequence-Independent DNA Adsorption on Few-Layered Oxygen-Functionalized Graphene Electrodes: An Electrochemical Study for Biosensing Application
Published in Biosensors (Basel) (14-08-2021)“…DNA is strongly adsorbed on oxidized graphene surfaces in the presence of divalent cations. Here, we studied the effect of DNA adsorption on electrochemical…”
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Encapsulation of Small Gas Molecules by Cryptophane-111 in Organic Solution. 1. Size- and Shape-Selective Complexation of Simple Hydrocarbons
Published in The journal of physical chemistry. A, Molecules, spectroscopy, kinetics, environment, & general theory (10-12-2009)“…The reversible trapping of small hydrocarbons and other gases by cryptophane-111 (1) in organic solution was characterized with variable-temperature 1H NMR…”
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Over 20% 15N Hyperpolarization in Under One Minute for Metronidazole, an Antibiotic and Hypoxia Probe
Published in Journal of the American Chemical Society (06-07-2016)“…Direct NMR hyperpolarization of naturally abundant 15N sites in metronidazole is demonstrated using SABRE-SHEATH (Signal Amplification by Reversible Exchange…”
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Toward next-generation molecular imaging
Published in Proceedings of the National Academy of Sciences - PNAS (30-04-2024)Get full text
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Development and Implementation of a Two-Level Inquiry- and Project-Based Modular Approach to Teaching a Second-Semester Physical Chemistry Laboratory Course
Published in Journal of chemical education (09-05-2023)“…Over the past 20 years, significant effort has been devoted to advancing the modular approach to teaching chemistry laboratory courses. The development and…”
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