Search Results - "Goodship, Allen E"

Beneficial effects of autologous bone marrow-derived mesenchymal stem cells in naturally occurring tendinopathy by Smith, Roger Kenneth Whealands, Werling, Natalie Jayne, Dakin, Stephanie Georgina, Alam, Rafiqul, Goodship, Allen E, Dudhia, Jayesh

“…Tendon injuries are a common age-related degenerative condition where current treatment strategies fail to restore functionality and normal quality of life…”
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Repair of Torn Avascular Meniscal Cartilage Using Undifferentiated Autologous Mesenchymal Stem Cells: From In Vitro Optimization to a First‐in‐Human Study by Whitehouse, Michael R., Howells, Nicholas R., Parry, Michael C., Austin, Eric, Kafienah, Wael, Brady, Kyla, Goodship, Allen E., Eldridge, Jonathan D., Blom, Ashley W., Hollander, Anthony P.

“…Meniscal cartilage tears are common and predispose to osteoarthritis (OA). Most occur in the avascular portion of the meniscus where current repair techniques…”
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Low-magnitude high-frequency mechanical signals accelerate and augment endochondral bone repair: Preliminary evidence of efficacy by Goodship, Allen E., Lawes, Timothy J., Rubin, Clinton T.

“…Fracture healing can be enhanced by load bearing, but the specific components of the mechanical environment which can augment or accelerate the process remain…”
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Development of a soft tissue seal around bone-anchored transcutaneous amputation prostheses by Pendegrass, Catherine J., Goodship, Allen E., Blunn, Gordon W.

“…Conventional amputation prosthetics are problematic because they rely on the stump–socket interface for attachment. Intraosseous transcutaneous amputation…”
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Noninvasive Raman Spectroscopy of Human Tissue in vivo by Matousek, Pavel, Draper, Edward R. C., Goodship, Allen E., Clark, Ian P., Ronayne, Kate L., Parker, Anthony W.

“…We report the first transcutaneous Raman spectrum of human bone in vivo obtained at skin-safe laser illumination levels. The spectrum of thumb distal phalanx…”
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Bone marrow mesenchymal stem cells do not enhance intra-synovial tendon healing despite engraftment and homing to niches within the synovium by Khan, Mohammad R, Dudhia, Jayesh, David, Frederic H, De Godoy, Roberta, Mehra, Vedika, Hughes, Gillian, Dakin, Stephanie G, Carr, Andrew J, Goodship, Allen E, Smith, Roger K W

“…Intra-synovial tendon injuries display poor healing, which often results in reduced functionality and pain. A lack of effective therapeutic options has led to…”
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Evidence from Raman Spectroscopy of a Putative Link Between Inherent Bone Matrix Chemistry and Degenerative Joint Disease by Kerns, Jemma G., Gikas, Panagiotis D., Buckley, Kevin, Shepperd, Adam, Birch, Helen L., McCarthy, Ian, Miles, Jonathan, Briggs, Timothy W. R., Keen, Richard, Parker, Anthony W., Matousek, Pavel, Goodship, Allen E.

“…Objective Osteoarthritis (OA) is a common debilitating disease that results in degeneration of cartilage and bone in the synovial joints. Subtle changes in the…”
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Response of a Collagenase-Induced Tendon Injury to Treatment with a Polysulphated Glycosaminoglycan (Adequan) by Oryan, Ahmad, Goodship, Allen E., Silver, Ian A.

“…This study explored the hypothesis that local administration of a polysulphated glycosaminoglycan (PSGAG) in the early phase of healing of a standard…”
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Gap junction protein expression and cellularity: comparison of immature and adult equine digital tendons by Stanley, Rachael L., Fleck, Roland A., Becker, David L., Goodship, Allen E., Ralphs, Jim R., Patterson‐Kane, Janet C.

“…Injury to the energy‐storing superficial digital flexor tendon is common in equine athletes and is age‐related. Tenocytes in the superficial digital flexor…”
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Aspartic Acid Racemization and Collagen Degradation Markers Reveal an Accumulation of Damage in Tendon Collagen That Is Enhanced with Aging by Thorpe, Chavaunne T., Streeter, Ian, Pinchbeck, Gina L., Goodship, Allen E., Clegg, Peter D., Birch, Helen L.

“…Little is known about the rate at which protein turnover occurs in living tendon and whether the rate differs between tendons with different physiological…”
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The Wnt5a Receptor, Receptor Tyrosine Kinase‐Like Orphan Receptor 2, Is a Predictive Cell Surface Marker of Human Mesenchymal Stem Cells with an Enhanced Capacity for Chondrogenic Differentiation by Dickinson, Sally C., Sutton, Catherine A., Brady, Kyla, Salerno, Anna, Katopodi, Theoni, Williams, Rhys L., West, Christopher C., Evseenko, Denis, Wu, Ling, Pang, Suzanna, Ferro de Godoy, Roberta, Goodship, Allen E., Péault, Bruno, Blom, Ashley W., Kafienah, Wael, Hollander, Anthony P.

“…Multipotent mesenchymal stem cells (MSCs) have enormous potential in tissue engineering and regenerative medicine. However, until now, their development for…”
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Adaptive band target entropy minimization: Optimization for the decomposition of spatially offset Raman spectra of bone by Churchwell, John H., Sowoidnich, Kay, Chan, Oliver, Goodship, Allen E., Parker, Anthony W., Matousek, Pavel

“…We report a novel variant of band target entropy minimization (BTEM), adaptive band target entropy minimization (A‐BTEM), which offers an improved ability to…”
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Evaluation of the Effects of Synovial Multipotent Cells on Deep Digital Flexor Tendon Repair in a Large Animal Model of Intra‐Synovial Tendinopathy by Khan, Mohammad R., Smith, Roger K., David, Frederic, Lam, Richard, Hughes, Gillian, Godoy, Roberta, Carr, Andrew J., Goodship, Allen E., Dudhia, Jayesh

“…ABSTRACT Intra‐synovial tendon injuries are a common orthopedic problem with limited treatment options. The synovium is a specialized connective tissue forming…”
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Spatially offset Raman spectroscopy for photon migration studies in bones with different mineralization levels by Sowoidnich, Kay, Churchwell, John H, Buckley, Kevin, Goodship, Allen E, Parker, Anthony W, Matousek, Pavel

“…The ability of Spatially Offset Raman Spectroscopy (SORS) to obtain chemically specific information from below the sample surface makes it a promising…”
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Peak strain magnitudes and rates in the tibia exceed greatly those in the skull: An in vivo study in a human subject by Hillam, Richard A, Goodship, Allen E, Skerry, Tim M

“…Abstract Bone mass and architecture are the result of a genetically determined baseline structure, modified by the effect of internal hormonal/biochemical…”
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Towards the in vivo prediction of fragility fractures with Raman spectroscopy by Buckley, Kevin, Kerns, Jemma G., Vinton, Jacqueline, Gikas, Panagiotis D., Smith, Christian, Parker, Anthony W., Matousek, Pavel, Goodship, Allen E.

“…Fragility fractures, those fractures which result from low level trauma, have a large and growing socio‐economic cost in countries with aging populations…”
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Raman spectroscopy reveals differences in collagen secondary structure which relate to the levels of mineralisation in bones that have evolved for different functions by Buckley, Kevin, Matousek, Pavel, Parker, Anthony W., Goodship, Allen E.

“…Bone is a composite material comprising a collagen fibril scaffold surrounded by crystals of carbonated‐hydroxyapatite mineral. It is well established that the…”
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Decomposition of in vivo spatially offset Raman spectroscopy data using multivariate analysis techniques by Buckley, Kevin, Kerns, Jemma G., Parker, Anthony W., Goodship, Allen E., Matousek, Pavel

“…The decomposition of spatially offset Raman spectra for complex multilayer systems, such as biological tissues, requires advanced techniques such as…”
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Is the Collagen Primed for Mineralization in Specific Regions of the Turkey Tendon? An Investigation of the Protein–Mineral Interface Using Raman Spectroscopy by Kerns, Jemma G, Buckley, Kevin, Churchwell, John, Parker, Anthony W, Matousek, Pavel, Goodship, Allen E

“…The tendons in the turkey leg have specific well-defined areas which become mineralized as the animal ages and they are a thoroughly characterized model system…”
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Photon migration of Raman signal in bone as measured with spatially offset Raman spectroscopy by Sowoidnich, Kay, Churchwell, John H., Buckley, Kevin, Goodship, Allen E., Parker, Anthony W., Matousek, Pavel

“…Spatially offset Raman spectroscopy (SORS) is currently being developed as an in vivo tool for bone disease detection, but to date, information about the…”
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