Search Results - "Goodrum, J F"

Cholesterol from degenerating nerve myelin becomes associated with lipoproteins containing apolipoprotein E by Goodrum, J F

“…Apolipoprotein E is synthesized and secreted by rat sciatic nerve consequent to several types of injury. It has been proposed that endoneurial apolipoprotein…”
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Role of organotellurium species in tellurium neuropathy by GOODRUM, J. F

“…Exposure of weanling rats to a diet containing 1% elemental tellurium causes segmental demyelination of peripheral nerve, and an inhibition of squalene…”
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Cholesterol synthesis is down-regulated during regeneration of peripheral nerve by Goodrum, J F

“…The discovery of apolipoprotein E synthesis and secretion by injured peripheral nerve to the hypothesis that endoneurial apolipoprotein E serves to salvage…”
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Cholesterol synthesis in regenerating peripheral nerve is not influenced by serum cholesterol levels by Goodrum, J F

“…Following a nerve crush, cholesterol from degenerating myelin is retained within the nerve and reutilized for new myelin synthesis during nerve regeneration,…”
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Control of Cholesterol Biosynthesis in Schwann Cells by Fu, Qiang, Goodrum, Jeffry F., Hayes, Carol, Hostettler, Janell D., Toews, Arrel D., Morell, Pierre

“…: Cholesterol accounts for over one‐fourth of total myelin lipids. We found that, during development of the rat sciatic nerve, expression of mRNA for…”
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The Cell Biology of Myelin Degeneration and Regeneration in the Peripheral Nervous System by Goodrum, Jeffry F, Bouldin, Thomas W

“…Keywords: Lipoproteins, Macrophage, Myelin lipids, Peripheral nerve, Schwann cell, Wallerian degeneration…”
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Neurofilament and tubulin mRNA expression in Schwann cells by Roberson, M D, Toews, A D, Goodrum, J F, Morell, P

“…Feeding of elemental tellurium to weanling rats blocks synthesis of cholesterol (a major component of myelin), and causes demyelination of the sciatic nerve…”
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Fate of myelin lipids during degeneration and regeneration of peripheral nerve: an autoradiographic study by Goodrum, JF, Earnhardt, T, Goines, N, Bouldin, TW

“…Four weeks after labeling myelin lipids with an intraneural injection of 3H-acetate, sciatic nerves were crushed, and the distribution of radiolabeled myelin…”
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Primary demyelination induced by exposure to tellurium alters Schwann cell gene expression: a model for intracellular targeting of NGF receptor by Toews, AD, Griffiths, IR, Kyriakides, E, Goodrum, JF, Eckermann, CE, Morell, P, Thomson, CE

“…Exposure of developing rats to tellurium results in a highly synchronous segmental demyelination of peripheral nerves with sparing of axons; this demyelination…”
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Nerve regeneration occurs in the absence of apolipoprotein E in mice by Popko, B, Goodrum, J F, Bouldin, T W, Zhang, S H, Maeda, N

“…The concentration of apolipoprotein E (apoE), a high-affinity ligand for the low-density lipoprotein receptor, increases dramatically in peripheral nerve…”
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Tellurium-induced neuropathy: metabolic alterations associated with demyelination and remyelination in rat sciatic nerve by Harry, G J, Goodrum, J F, Bouldin, T W, Wagner-Recio, M, Toews, A D, Morell, P

“…Rats fed a diet containing 1.25% elemental tellurium initiated on postnatal day 20 undergo a transient neuropathy characterized by synchronous demyelination of…”
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Fatty acids from degenerating myelin lipids are conserved and reutilized for myelin synthesis during regeneration in peripheral nerve by Goodrum, J F, Weaver, J E, Goines, N D, Bouldin, T W

“…Following nerve crush, cholesterol from degenerating myelin is conserved and reutilized for new myelin synthesis during nerve regeneration. The possibility…”
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Tellurium-induced alterations in 3-hydroxy-3-methylglutaryl-CoA reductase gene expression and enzyme activity: differential effects in sciatic nerve and liver suggest tissue-specific regulation of cholesterol synthesis by Toews, A D, Goodrum, J F, Lee, S Y, Eckermann, C, Morell, P

“…The demyelination of peripheral nerves that results from exposure of developing rats to tellurium is due to inhibition of squalene epoxidase, a step in…”
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Gene expression during tellurium-induced primary demyelination by Morell, P, Toews, A D, Wagner, M, Goodrum, J F

“…A compound may be "developmentally neurotoxic" because it interferes with a metabolic step exclusively or preferentially expressed during development in a…”
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Acrylamide-induced increases in deposition of axonally transported glycoproteins in rat sciatic nerve by Harry, G J, Goodrum, J F, Bouldin, T W, Toews, A D, Morell, P

“…The axonal transport of proteins, glycoproteins, and gangliosides in sensory neurons of the sciatic nerve was examined in adult rats exposed to acrylamide via…”
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Tellurium causes dose-dependent coordinate down-regulation of myelin gene expression by Toews, Arrel D, Roe, Elaine B, Goodrum, J.F, Bouldin, T.W, Weaver, J, Goines, N.D, Morell, P

“…Exposure of developing rats to a diet containing elemental tellurium systemically inhibits cholesterol synthesis at the level of squalene epoxidase. At high…”
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Analysis of the apparent biphasic axonal transport kinetics of fucosylated glycoproteins by Goodrum, JF, Morell, P

“…Following intraocular injection of [3H]fucose, which labels many glycoproteins of retinal ganglion cells, the accumulation of transported radioactivity…”
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Lipid metabolism during early stages of Wallerian degeneration in the rat sciatic nerve by White, F V, Toews, A D, Goodrum, J F, Novicki, D L, Bouldin, T W, Morell, P

“…We examined changes in biosynthetic capacity of sciatic nerve during the early stages of Wallerian degeneration, utilizing a model that permits exclusion of…”
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Lipid droplets in Schwann cells during tellurium neuropathy are derived from newly synthesized lipid by Goodrum, J F, Earnhardt, T S, Goines, N D, Bouldin, T W

“…Exposure of weanling rats to a diet containing elemental tellurium results in a peripheral neuropathy characterized by segmental demyelination and minimal…”
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Macrophage-like cells from explant cultures of rat sciatic nerve produce apolipoprotein E by Goodrum, J F, Novicki, D L

“…Apolipoprotein E is synthesized and secreted by degenerating peripheral nerve, but the role of resident endoneurial cells in this process is not clear. To…”
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