Search Results - "Goodrich, L. R."

A pilot study to determine the optimal dose of scAAVIL-1ra in a large animal model of post-traumatic osteoarthritis by Thampi, P., Seabaugh, K. A., Pezzanite, L. M., Chu, C. R., Phillips, J. N., Grieger, J. C., McIlwraith, C. W., Samulski, R. J., Goodrich, L. R.

“…Gene therapy approaches using adeno-associated viral vectors have been successfully tested in the equine post-traumatic osteoarthritis (PTOA) model. Owing to…”
Get full text

scAAVIL-1ra dosing trial in a large animal model and validation of long-term expression with repeat administration for osteoarthritis therapy by Goodrich, L R, Grieger, J C, Phillips, J N, Khan, N, Gray, S J, McIlwraith, C W, Samulski, R J

“…A gene therapeutic approach to treat osteoarthritis (OA) appears to be on the horizon for millions of people who suffer from this disease. Previously we…”
Get full text

Equine bone marrow-derived mesenchymal stromal cells (BMDMSCs) from the ilium and sternum: Are there differences? by Adams, M. K., Goodrich, L. R., Rao, S., Olea-Popelka, F., Phillips, N., Kisiday, J. D., Mcilwraith, C. W.

“…Summary Reasons for performing study The 2 sites of bone marrow harvest for isolation of mesenchymal stromal cells (MSC) in the horse are the sternum and…”
Get full text

Dynamic compression plate (DCP) fixation of propagating medial condylar fractures of the third metacarpal/metatarsal bone in 30 racehorses: Retrospective analysis (1990–2005) by Goodrich, L. R, Nixon, A. J, Conway, J. D, Morley, P. S, Bladon, B. M, Hogan, P. M

“…REASONS FOR PERFORMING STUDY: An in‐depth review of dynamic compression plate (DCP) fixation of propagating medial condyle fractures of the third metacarpus or…”
Get full text

Ex vivo serotype-specific transduction of equine joint tissue by self-complementary adeno-associated viral vectors by Goodrich, L R, Choi, V W, Carbone, B A Duda, McIlwraith, C W, Samulski, R J

“…Cell transplantation for the treatment of joint disease is an important clinical tool. Genetic modification of cells before transplantation has shown enhanced…”
Get more information

Comparison of lameness outcomes in horses with acute or chronic digital lameness that underwent magnetic resonance imaging by Koch, DW, Barrett, MF, Jackman, BR, MacDonald, D, Goodrich, LR

“…Aims: To compare the outcome, in terms of lameness score or return to athletic function, of horses with acute vs. chronic digital lameness that underwent…”
Get full text

Direct adenovirus-mediated IGF-I gene transduction of synovium induces persisting synovial fluid IGF-I ligand elevations by GOODRICH, L. R, BROWER-TOLAND, B. D, WARNICK, L, ROBBINS, P. D, EVANS, C. H, NIXON, A. J

“…Insulin-like growth factor-I (IGF-I) is one of the most influential growth factors in cartilage repair. Maintenance of adequate IGF-I levels after articular…”
Get full text

Allogeneic vs. autologous intra‐articular mesenchymal stem cell injection within normal horses: Clinical and cytological comparisons suggest safety by Colbath, A. C., Dow, S. W., Hopkins, L. S., Phillips, J. N., McIlwraith, C. W., Goodrich, L. R.

“…Summary Background Allogeneic bone marrow‐derived mesenchymal stem cells (BMDMSCs) could provide multiple advantages over autologous BMDMSCs, including…”
Get full text

Recent advances in articular cartilage evaluation using computed tomography and magnetic resonance imaging by Nelson, B. B., Kawcak, C. E., Barrett, M. F., McIlwraith, C. W., Grinstaff, M. W., Goodrich, L. R.

“…Summary Articular cartilage is a critical joint tissue and its evaluation remains a diagnostic challenge in horses. Coupled with a poor capacity for healing,…”
Get full text

Use of contrast media in computed tomography and magnetic resonance imaging in horses: Techniques, adverse events and opportunities by Nelson, B. B., Goodrich, L. R., Barrett, M. F., Grinstaff, M. W., Kawcak, C. E.

“…Summary The use of contrast media in computed tomography (CT) and magnetic resonance imaging (MRI) is increasing in horses. These contrast‐enhanced imaging…”
Get full text

A comparison of arthroscopy to ultrasonography for identification of pathology of the equine stifle by Adrian, A. M., Barrett, M. F., Werpy, N. M., Kawcak, C. E., Chapman, P. L., Goodrich, L. R.

“…Summary Reasons for performing study To evaluate and compare the diagnostic capability of arthroscopy and ultrasonography for the detection of pathological…”
Get full text

Genetic modification of chondrocytes with insulin-like growth factor-1 enhances cartilage healing in an equine model by GOODRICH, L. R, HIDAKA, C, ROBBINS, P. D, EVANS, C. H, NIXON, A. J

“…Gene therapy with insulin-like growth factor-1 (IGF-1) increases matrix production and enhances chondrocyte proliferation and survival in vitro. The purpose of…”
Get full text

Arthroscopic reattachment of osteochondritis dissecans lesions using resorbable polydioxanone pins by Nixon, A.J, Fortier, L.A, Goodrich, L.R, Ducharme, N.G

“…Reasons for performing study: Debridement of osteochondritis dissecans (OCD) cartilage lesions results in fibrocartilage and imperfect hyaline repair tissue,…”
Get full text

Comparison of subjective lameness evaluation, force platforms and an inertial-sensor system to identify mild lameness in an equine osteoarthritis model by Donnell, J.R., Frisbie, D.D., King, M.R., Goodrich, L.R., Haussler, K.K.

“…•Objective and subjective evaluations were compared to identify mild lameness in horses.•A well-developed controlled model of osteoarthritis was used to induce…”
Get full text

Evaluation of equine articular cartilage degeneration after mechanical impact injury using cationic contrast-enhanced computed tomography by Nelson, B.B., Mäkelä, J.T.A., Lawson, T.B., Patwa, A.N., Barrett, M.F., McIlwraith, C.W., Hurtig, M.B., Snyder, B.D., Moorman, V.J., Grinstaff, M.W., Goodrich, L.R., Kawcak, C.E.

“…Cationic agent contrast-enhanced computed tomography (cationic CECT) characterizes articular cartilage ex vivo, however, its capacity to detect post-traumatic…”
Get full text

Antimicrobial delivery by intrasynovial catheterisation with systemic administration for equine synovial trauma and sepsis by Stewart, A.A, Goodrich, L.R, Byron, C.R, Evans, R.B, Stewart, M.C

“…Objective  To present the technique for intra‐articular catheter placement and report the clinical outcomes of 38 cases of equine synovial trauma and/or…”
Get full text

Radiographic localisation of the entheses of the equine stifle by Aldrich, E. D., Goodrich, L. R., Monahan, M. K., Conway, J. D., Valdés‐Martínez, A.

“…Summary Reason for performing study Injury to the tendons and ligaments of the equine stifle is a common cause of lameness in horses. Individual radiographic…”
Get full text

Adeno-associated virus gene therapy vector scAAVIGF-I for transduction of equine articular chondrocytes and RNA-seq analysis by Hemphill, D.D, McIlwraith, C.W, Slayden, R.A, Samulski, R.J, Goodrich, L.R

“…Summary Objective IGF-I is one of several anabolic factors being investigated for the treatment of osteoarthritis (OA). Due to the short biological half-life,…”
Get full text

optimised injection technique for the navicular bursa that avoids the deep digital flexor tendon by Daniel, A. J., Goodrich, L. R., Barrett, M. F., Werpy, N. M., Morley, P. S., McIlwraith, C. W.

“…REASONS FOR PERFORMING STUDY: Injection of the navicular bursa is commonly performed from the palmar aspect of the limb, which results in penetration of the…”
Get full text

Incidence of support limb laminitis in horses treated with half limb, full limb or transfixation pin casts: A retrospective study of 113 horses (2000-2009) by VIRGIN, J. E., GOODRICH, L. R., BAXTER, G. M., RAO, S.

“…Summary Reasons for performing study: To determine the incidence of support limb laminitis among horses treated with half limb, full limb or transfixation pin…”
Get full text