Search Results - "Goodrich, James A"

Unexpected roles for core promoter recognition factors in cell-type-specific transcription and gene regulation by Tjian, Robert, Goodrich, James A

“…Key Points The control of transcription initiation is a primary mechanism for regulating gene expression, especially in governing developmental and…”
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DICER1 Loss and Alu RNA Induce Age-Related Macular Degeneration via the NLRP3 Inflammasome and MyD88 by Tarallo, Valeria, Hirano, Yoshio, Gelfand, Bradley D., Dridi, Sami, Kerur, Nagaraj, Kim, Younghee, Cho, Won Gil, Kaneko, Hiroki, Fowler, Benjamin J., Bogdanovich, Sasha, Albuquerque, Romulo J.C., Hauswirth, William W., Chiodo, Vince A., Kugel, Jennifer F., Goodrich, James A., Ponicsan, Steven L., Chaudhuri, Gautam, Murphy, Michael P., Dunaief, Joshua L., Ambati, Balamurali K., Ogura, Yuichiro, Yoo, Jae Wook, Lee, Dong-ki, Provost, Patrick, Hinton, David R., Núñez, Gabriel, Baffi, Judit Z., Kleinman, Mark E., Ambati, Jayakrishna

“…Alu RNA accumulation due to DICER1 deficiency in the retinal pigmented epithelium (RPE) is implicated in geographic atrophy (GA), an advanced form…”
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XPB, a subunit of TFIIH, is a target of the natural product triptolide by Liu, Jun O, Titov, Denis V, Gilman, Benjamin, He, Qing-Li, Bhat, Shridhar, Low, Woon-Kai, Dang, Yongjun, Smeaton, Michael, Demain, Arnold L, Miller, Paul S, Kugel, Jennifer F, Goodrich, James A

“…Triptolide is a bioactive natural product isolated from plants used in traditional Chinese medicine. A target identification approach shows that triptolide…”
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Non-coding-RNA regulators of RNA polymerase II transcription by Goodrich, James A, Kugel, Jennifer F

“…Several non-coding RNAs (ncRNAs) that regulate eukaryotic mRNA transcription have recently been discovered. Their mechanisms of action and biological roles are…”
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Interactions of HMGB Proteins with the Genome and the Impact on Disease by Voong, Calvin K, Goodrich, James A, Kugel, Jennifer F

“…High Mobility Group Box (HMGB) proteins are small architectural DNA binding proteins that regulate multiple genomic processes such as DNA damage repair,…”
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B2 RNA and Alu RNA Repress Transcription by Disrupting Contacts between RNA Polymerase II and Promoter DNA within Assembled Complexes by Yakovchuk, Petro, Goodrich, James A., Kugel, Jennifer F., Roeder, Robert G.

“…Noncoding RNAs (ncRNAs) are now recognized as transregulators of eukaryotic transcription, a role once attributed exclusively to protein factors. Two ncRNAs in…”
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Single molecule studies characterize the kinetic mechanism of tetrameric p53 binding to different native response elements by Suwita, Johannes P, Voong, Calvin K, Ly, Elina, Goodrich, James A, Kugel, Jennifer F

“…The transcriptional activator p53 is a tumor suppressor protein that controls cellular pathways important for cell fate decisions, including cell cycle arrest,…”
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Finding the start site: redefining the human initiator element by Kugel, Jennifer F, Goodrich, James A

“…Transcription by RNA polymerase II (Pol II) is dictated in part by core promoter elements, which are DNA sequences flanking the transcription start site (TSS)…”
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Mechanisms and Functions of the RNA Polymerase II General Transcription Machinery during the Transcription Cycle by Archuleta, Stephen R, Goodrich, James A, Kugel, Jennifer F

“…Central to the development and survival of all organisms is the regulation of gene expression, which begins with the process of transcription catalyzed by RNA…”
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The HMGB1 C-Terminal Tail Regulates DNA Bending by Blair, Rebecca H., Horn, Abigail E., Pazhani, Yogitha, Grado, Lizbeth, Goodrich, James A., Kugel, Jennifer F.

“…High mobility group box protein 1 (HMGB1) is an architectural protein that facilitates the formation of protein–DNA assemblies involved in transcription,…”
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Short‐term exposure to ethanol induces transcriptional changes in nontumorigenic breast cells by Miller, Georgiana M., Brant, Tyler S., Goodrich, James A., Kugel, Jennifer F.

“…Breast cancer is a leading cause of cancer‐related deaths in women. Many genetic and behavioral risk factors can contribute to the initiation and progression…”
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ERK1/2 activation is a therapeutic target in age-related macular degeneration by Dridi, Sami, Hirano, Yoshio, Tarallo, Valeria, Kim, Younghee, Fowler, Benjamin J, Ambati, Balamurali K, Bogdanovich, Sasha, Chiodo, Vince A, Hauswirth, William W, Kugel, Jennifer F, Goodrich, James A, Ponicsan, Steven L, Hinton, David R, Kleinman, Mark E, Baffi, Judit Z, Gelfand, Bradley D, Ambati, Jayakrishna

“…Deficient expression of the RNase III DICER1, which leads to the accumulation of cytotoxic Alu RNA, has been implicated in degeneration of the retinal…”
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Differences in UV-C LED Inactivation of Legionella pneumophila Serogroups in Drinking Water by Buse, Helen Y, Hall, John S, Hunter, Gary L, Goodrich, James A

“…(Lp) is an opportunistic pathogen that causes respiratory infections primarily through inhalation of contaminated aerosols. Lp can colonize premise plumbing…”
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Characterization of the structure, function, and mechanism of B2 RNA, an ncRNA repressor of RNA polymerase II transcription by Espinoza, Celso A, Goodrich, James A, Kugel, Jennifer F

“…We previously found that the SINE-encoded mouse B2 RNA binds RNA polymerase II and represses mRNA transcription during the cellular heat-shock response. In…”
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Actin is part of pre-initiation complexes and is necessary for transcription by RNA polymerase II by de Lanerolle, Primal, Hofmann, Wilma A, Stojiljkovic, Ljuba, Fuchsova, Beata, Vargas, Gabriela M, Mavrommatis, Evangelos, Philimonenko, Vlada, Kysela, Katarina, Goodrich, James A, Lessard, James L, Hope, Thomas J, Hozak, Pavel

“…Actin is abundant in the nucleus and has been implicated in transcription; however, the nature of this involvement has not been established. Here we…”
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B2 RNA binds directly to RNA polymerase II to repress transcript synthesis by Kugel, Jennifer F, Goodrich, James A, Espinoza, Celso A, Allen, Tiffany A, Hieb, Aaron R

“…B2 RNA is a small noncoding RNA polymerase III transcript that represses mRNA transcription in response to heat shock in mouse cells. Here we define the…”
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Protein-protein interaction assays: eliminating false positive interactions by Goodrich, James A, Nguyen, Tuan N

“…Many methods commonly used to identify and characterize interactions between two or more proteins are variations of the immobilized protein-protein interaction…”
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Selection and characterization of a DNA aptamer that can discriminate between cJun/cJun and cJun/cFos by Walters, Ryan D, McSwiggen, David T, Goodrich, James A, Kugel, Jennifer F

“…The AP-1 family of transcriptional activators plays pivotal roles in regulating a wide range of biological processes from the immune response to tumorigenesis…”
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The Herpes Simplex Virus 1 Protein ICP4 Acts as both an Activator and a Repressor of Host Genome Transcription during Infection by Rivas, Thomas, Goodrich, James A., Kugel, Jennifer F.

“…Infection by herpes simplex virus 1 (HSV-1) impacts nearly all steps of host cell gene expression. The regulatory mechanisms by which this occurs, and the…”
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TFIIF Facilitates Dissociation of RNA Polymerase II from Noncoding RNAs That Lack a Repression Domain by Wagner, Stacey D., Kugel, Jennifer F., Goodrich, James A.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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