Search Results - "Goodnow, Christopher C."

Clonal redemption of autoantibodies by somatic hypermutation away from self-reactivity during human immunization by Reed, Joanne H, Jackson, Jennifer, Christ, Daniel, Goodnow, Christopher C

“…Clonal anergy is an enigmatic self-tolerance mechanism because no apparent purpose is served by retaining functionally silenced B cells bearing autoantibodies…”
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High-throughput targeted long-read single cell sequencing reveals the clonal and transcriptional landscape of lymphocytes by Singh, Mandeep, Al-Eryani, Ghamdan, Carswell, Shaun, Ferguson, James M., Blackburn, James, Barton, Kirston, Roden, Daniel, Luciani, Fabio, Giang Phan, Tri, Junankar, Simon, Jackson, Katherine, Goodnow, Christopher C., Smith, Martin A., Swarbrick, Alexander

“…High-throughput single-cell RNA sequencing is a powerful technique but only generates short reads from one end of a cDNA template, limiting the reconstruction…”
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Clonal redemption and clonal anergy as mechanisms to balance B cell tolerance and immunity by Burnett, Deborah L., Reed, Joanne H., Christ, Daniel, Goodnow, Christopher C.

“…The adaptive immune system is tasked with producing antibodies that recognize a wide scope of potential pathogens, including those never before encountered,…”
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Calling differentially methylated regions from whole genome bisulphite sequencing with DMRcate by Peters, Timothy J, Buckley, Michael J, Chen, Yunshun, Smyth, Gordon K, Goodnow, Christopher C, Clark, Susan J

“…Abstract Whole genome bisulphite sequencing (WGBS) permits the genome-wide study of single molecule methylation patterns. One of the key goals of mammalian…”
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Germinal center antibody mutation trajectories are determined by rapid self/foreign discrimination by Burnett, Deborah L, Langley, David B, Schofield, Peter, Hermes, Jana R, Chan, Tyani D, Jackson, Jennifer, Bourne, Katherine, Reed, Joanne H, Patterson, Kate, Porebski, Benjamin T, Brink, Robert, Christ, Daniel, Goodnow, Christopher C

“…Antibodies have the specificity to differentiate foreign antigens that mimic self antigens, but it remains unclear how such specificity is acquired. In a mouse…”
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Comparison of predicted and actual consequences of missense mutations by Miosge, Lisa A., Field, Matthew A., Sontani, Yovina, Cho, Vicky, Johnson, Simon, Palkova, Anna, Balakishnan, Bhavani, Liang, Rong, Zhang, Yafei, Lyon, Stephen, Beutler, Bruce, Whittle, Belinda, Bertram, Edward M., Enders, Anselm, Goodnow, Christopher C., Andrews, T. Daniel

“…Each person’s genome sequence has thousands of missense variants. Practical interpretation of their functional significance must rely on computational…”
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Redemption of autoantibodies on anergic B cells by variable-region glycosylation and mutation away from self-reactivity by Sabouri, Zahra, Schofield, Peter, Horikawa, Keisuke, Spierings, Emily, Kipling, David, Randall, Katrina L, Langley, David, Roome, Brendan, Vazquez-Lombardi, Rodrigo, Rouet, Romain, Hermes, Jana, Chan, Tyani D, Brink, Robert, Dunn-Walters, Deborah K, Christ, Daniel, Goodnow, Christopher C

“…The best-understood mechanisms for achieving antibody self/non-self discrimination discard self-reactive antibodies before they can be tested for binding…”
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HENMT1 and piRNA Stability Are Required for Adult Male Germ Cell Transposon Repression and to Define the Spermatogenic Program in the Mouse by Lim, Shu Ly, Qu, Zhi Peng, Kortschak, R Daniel, Lawrence, David M, Geoghegan, Joel, Hempfling, Anna-Lena, Bergmann, Martin, Goodnow, Christopher C, Ormandy, Christopher J, Wong, Lee, Mann, Jeff, Scott, Hamish S, Jamsai, Duangporn, Adelson, David L, O'Bryan, Moira K

“…piRNAs are critical for transposable element (TE) repression and germ cell survival during the early phases of spermatogenesis, however, their role in adult…”
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Two levels of protection for the B cell genome during somatic hypermutation by Schatz, David G, Liu, Man, Duke, Jamie L, Richter, Daniel J, Vinuesa, Carola G, Goodnow, Christopher C, Kleinstein, Steven H

“…Somatic hypermutation introduces point mutations into immunoglobulin genes in germinal centre B cells during an immune response. The reaction is initiated by…”
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Roquin-2 Shares Functions with Its Paralog Roquin-1 in the Repression of mRNAs Controlling T Follicular Helper Cells and Systemic Inflammation by Pratama, Alvin, Ramiscal, Roybel R., Silva, Diego G., Das, Souvik K., Athanasopoulos, Vicki, Fitch, Jessica, Botelho, Natalia K., Chang, Pheh-Ping, Hu, Xin, Hogan, Jennifer J., Maña, Paula, Bernal, David, Korner, Heinrich, Yu, Di, Goodnow, Christopher C., Cook, Matthew C., Vinuesa, Carola G.

“…Accumulation of T follicular helper (Tfh) cells and proinflammatory cytokines drive autoantibody-mediated diseases. The RNA-binding protein Roquin-1 (Rc3h1)…”
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SAMD9L autoinflammatory or ataxia pancytopenia disease mutations activate cell-autonomous translational repression by Russell, Amanda J., Gray, Paul E., Ziegler, John B., Kim, Yae Jean, Smith, Sandy, Sewell, William A., Goodnow, Christopher C.

“…Sterile α motif domain-containing protein 9-like (SAMD9L) is encoded by a hallmark interferon-induced gene with a role in controlling virus replication that is…”
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IgD attenuates the IgM-induced anergy response in transitional and mature B cells by Sabouri, Zahra, Perotti, Samuel, Spierings, Emily, Humburg, Peter, Yabas, Mehmet, Bergmann, Hannes, Horikawa, Keisuke, Roots, Carla, Lambe, Samantha, Young, Clara, Andrews, T. Dan, Field, Matthew, Enders, Anselm, Reed, Joanne H., Goodnow, Christopher C.

“…Self-tolerance by clonal anergy of B cells is marked by an increase in IgD and decrease in IgM antigen receptor surface expression, yet the function of IgD on…”
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Loss-of-function of Fbxo10, encoding a post-translational regulator of BCL2 in lymphomas, has no discernible effect on BCL2 or B lymphocyte accumulation in mice by Masle-Farquhar, Etienne, Russell, Amanda, Li, Yangguang, Zhu, Fen, Rui, Lixin, Brink, Robert, Goodnow, Christopher C

“…Regulation of the anti-apoptotic BCL2 protein determines cell survival and is frequently abnormal in B cell lymphomas. An evolutionarily conserved…”
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DNA Hypermethylation Encroachment at CpG Island Borders in Cancer Is Predisposed by H3K4 Monomethylation Patterns by Skvortsova, Ksenia, Masle-Farquhar, Etienne, Luu, Phuc-Loi, Song, Jenny Z., Qu, Wenjia, Zotenko, Elena, Gould, Cathryn M., Du, Qian, Peters, Timothy J., Colino-Sanguino, Yolanda, Pidsley, Ruth, Nair, Shalima S., Khoury, Amanda, Smith, Grady C., Miosge, Lisa A., Reed, Joanne H., Kench, James G., Rubin, Mark A., Horvath, Lisa, Bogdanovic, Ozren, Lim, Sue Mei, Polo, Jose M., Goodnow, Christopher C., Stirzaker, Clare, Clark, Susan J.

“…Promoter CpG islands are typically unmethylated in normal cells, but in cancer a proportion are subject to hypermethylation. Using methylome sequencing we…”
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Cellular and genetic mechanisms of self tolerance and autoimmunity by Goodnow, Christopher C, Sprent, Jonathon, de St Groth, Barbara Fazekas, Vinuesa, Carola G

“…The mammalian immune system has an extraordinary potential for making receptors that sense and neutralize any chemical entity entering the body. Inevitably,…”
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Developmental kinetics, turnover, and stimulatory capacity of thymic epithelial cells by Gray, Daniel H.D., Seach, Natalie, Ueno, Tomoo, Milton, Morag K., Liston, Adrian, Lew, Andrew M., Goodnow, Christopher C., Boyd, Richard L.

“…Despite the importance of thymic stromal cells to T-cell development, relatively little is known about their biology. Here, we use single-cell analysis of…”
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Murine LRBA deficiency causes CTLA‐4 deficiency in Tregs without progression to immune dysregulation by Burnett, Deborah L, Parish, Ian A, Masle‐Farquhar, Etienne, Brink, Robert, Goodnow, Christopher C

“…Inherited mutations in lipopolysaccharide‐responsive beige‐like anchor (LRBA) cause a recessive human immune dysregulation syndrome with memory B‐cell and…”
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CD83 increases MHC II and CD86 on dendritic cells by opposing IL-10-driven MARCH1-mediated ubiquitination and degradation by Tze, Lina E, Horikawa, Keisuke, Domaschenz, Heather, Howard, Debbie R, Roots, Carla M, Rigby, Robert J, Way, David A, Ohmura-Hoshino, Mari, Ishido, Satoshi, Andoniou, Christopher E, Degli-Esposti, Mariapia A, Goodnow, Christopher C

“…Effective vaccine adjuvants must induce expression of major histocompatibility (MHC) class II proteins and the costimulatory molecule CD86 on dendritic cells…”
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Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis by Heazlewood, Chad K, Cook, Matthew C, Eri, Rajaraman, Price, Gareth R, Tauro, Sharyn B, Taupin, Douglas, Thornton, David J, Png, Chin Wen, Crockford, Tanya L, Cornall, Richard J, Adams, Rachel, Kato, Masato, Nelms, Keats A, Hong, Nancy A, Florin, Timothy H J, Goodnow, Christopher C, McGuckin, Michael A

“…MUC2 mucin produced by intestinal goblet cells is the major component of the intestinal mucus barrier. The inflammatory bowel disease ulcerative colitis is…”
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Aire regulates the transfer of antigen from mTECs to dendritic cells for induction of thymic tolerance by Hubert, François-Xavier, Kinkel, Sarah A., Davey, Gayle M., Phipson, Belinda, Mueller, Scott N., Liston, Adrian, Proietto, Anna I., Cannon, Ping Z.F., Forehan, Simon, Smyth, Gordon K., Wu, Li, Goodnow, Christopher C., Carbone, Francis R., Scott, Hamish S., Heath, William R.

“…To investigate the role of Aire in thymic selection, we examined the cellular requirements for generation of ovalbumin (OVA)–specific CD4 and CD8 T cells in…”
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