Search Results - "Goodman, Simon. L."

The antibody horror show: an introductory guide for the perplexed by Goodman, Simon. L.

“…•Commercial antibodies are vital to biological research but still trouble users.•Unique identifiability of antibody and supplier, and batch validation are…”
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Structure and mechanics of integrin-based cell adhesion by Arnaout, M Amin, Goodman, Simon L, Xiong, Jian-Ping

“…Integrins are α/β heterodimeric adhesion glycoprotein receptors that regulate a wide variety of dynamic cellular processes such as cell migration,…”
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Crystal Structure of the Extracellular Segment of Integrin αVβ3 in Complex with an Arg-Gly-Asp Ligand by XIONG, Jian-Ping, STEHLE, Thilo, RONGGUANG ZHANG, JOACHIMIAK, Andrzej, FRECH, Matthias, GOODMAN, Simon L, ARNAOUT, M. Amin

“…The structural basis for the divalent cation-dependent binding of heterodimeric αβ integrins to their ligands, which contain the prototypical Arg-Gly-Asp…”
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Cilengitide inhibits progression of experimental breast cancer bone metastases as imaged noninvasively using VCT, MRI and DCE‐MRI in a longitudinal in vivo study by Bäuerle, Tobias, Komljenovic, Dorde, Merz, Maximilian, Berger, Martin R., Goodman, Simon L., Semmler, Wolfhard

“…The aim of this study was to investigate the effect of inhibiting αvβ3/αvβ5 integrins by cilengitide in experimentally induced breast cancer bone metastases…”
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Radiation sensitization of glioblastoma by cilengitide has unanticipated schedule‐dependency by Mikkelsen, Tom, Brodie, Chaya, Finniss, Susan, Berens, Michael E., Rennert, Jessica L., Nelson, Kevin, Lemke, Nancy, Brown, Stephen L., Hahn, Diane, Neuteboom, Berend, Goodman, Simon L.

“…We investigated whether cilengitide could amplify the antitumor effects of radiotherapy in an orthotopic rat glioma xenograft model. Cilengitide is a specific…”
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Integrins as therapeutic targets by Goodman, Simon L, Picard, Martin

“…Integrins are a large family of molecules that are central regulators in multicellular biology. They orchestrate cell–cell and cell–extracellular matrix (ECM)…”
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Multimeric Cyclic RGD Peptides as Potential Tools for Tumor Targeting: Solid-Phase Peptide Synthesis and Chemoselective Oxime Ligation by Thumshirn, Georgette, Hersel, Ulrich, Goodman, Simon L., Kessler, Horst

“…The αvβ3 integrin receptor plays an important role in human metastasis and tumor‐induced angiogenesis. Targeting this receptor may provide information about…”
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Integrins αvβ3 and αvβ5 as prognostic, diagnostic, and therapeutic targets in gastric cancer by Böger, Christine, Warneke, Viktoria S., Behrens, Hans-Michael, Kalthoff, Holger, Goodman, Simon L., Becker, Thomas, Röcken, Christoph

“…Background We investigated the expression of two α v integrins, α v β 3 and α v β 5 , in gastric cancer (GC) by testing the following hypotheses: that these…”
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The Antibody Society's antibody validation webinar series by Voskuil, Jan L.A., Bandrowski, Anita, Begley, C. Glenn, Bradbury, Andrew R.M., Chalmers, Andrew D., Gomes, Aldrin V., Hardcastle, Travis, Lund-Johansen, Fridtjof, Plückthun, Andreas, Roncador, Giovanna, Solache, Alejandra, Taussig, Michael J., Trimmer, James S., Williams, Cecilia, Goodman, Simon L.

“…In the wake of the reproducibility crisis and numerous discussions on how commercially available antibodies as research tool contribute to it, The Antibody…”
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Matched rabbit monoclonal antibodies against αv-series integrins reveal a novel αvβ3-LIBS epitope, and permit routine staining of archival paraffin samples of human tumors by Goodman, Simon L, Grote, Hans Juergen, Wilm, Claudia

“…The relationship between integrin expression and function in pathologies is often contentious as comparisons between human pathological expression and…”
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Pharmacological inhibition of the vitronectin receptor abrogates PDGF-BB-induced hepatic stellate cell migration and activation in vitro by Patsenker, Eleonora, Popov, Yury, Wiesner, Matthias, Goodman, Simon L, Schuppan, Detlef

“…Background/Aims Activated hepatic stellate cells (HSC) play a central role in the development of liver fibrosis. Platelet-derived growth factor (PDGF)-BB and…”
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The path to VICTORy - a beginner's guide to success using commercial research antibodies by Goodman, Simon L

“…Commercial research antibodies are crucial tools in modern cell biology and biochemistry. In the USA some $2 billion a year are spent on them, but many are…”
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Integrins as Therapeutic Targets: Successes and Cancers by Raab-Westphal, Sabine, Marshall, John F, Goodman, Simon L

“…Integrins are transmembrane receptors that are central to the biology of many human pathologies. Classically mediating cell-extracellular matrix and cell-cell…”
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A Novel Adaptation of the Integrin PSI Domain Revealed from Its Crystal Structure by Xiong, Jian-Ping, Stehle, Thilo, Goodman, Simon L., Arnaout, M. Amin

“…Integrin β-subunits contain an N-terminal PSI (for plexin-semaphorin-integrin) domain that contributes to integrin activation and harbors the PI(A) alloantigen…”
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αv‐Integrin isoform expression in primary human tumors and brain metastases by Vogetseder, Alexander, Thies, Svenja, Ingold, Barbara, Roth, Patrick, Weller, Michael, Schraml, Peter, Goodman, Simon L., Moch, Holger

“…To determine whether metastasis to brain is associated with altered expression patterns of integrins, we investigated the expression of αvβ3, αvβ5, αvβ6 and…”
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Invasion patterns in brain metastases of solid cancers by Berghoff, Anna S, Rajky, Orsolya, Winkler, Frank, Bartsch, Rupert, Furtner, Julia, Hainfellner, Johannes A, Goodman, Simon L, Weller, Michael, Schittenhelm, Jens, Preusser, Matthias

“…Brain metastases are generally considered to be well demarcated from the surrounding brain parenchyma, although infiltrative growth patterns have been…”
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Inhibition of Integrin αvβ6 on Cholangiocytes Blocks Transforming Growth Factor-β Activation and Retards Biliary Fibrosis Progression by Patsenker, Eleonora, Popov, Yury, Stickel, Felix, Jonczyk, Alfred, Goodman, Simon L, Schuppan, Detlef

“…Background & Aims: Integrin αvβ6 is highly expressed on certain activated epithelia, where it mediates attachment to fibronectin and serves as coreceptor for…”
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Integrin control of the transforming growth factor-β pathway in glioblastoma by ROTH, Patrick, SILGINER, Manuela, WELLER, Michael, GOODMAN, Simon L, HASENBACH, Kathy, THIES, Svenja, MAURER, Gabriele, SCHRAML, Peter, TABATABAI, Ghazaleh, MOCH, Holger, TRITSCHLER, Isabel

“…Transforming growth factor-β is a central mediator of the malignant phenotype of glioblastoma, the most common and malignant form of intrinsic brain tumours…”
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Pharmacological inhibition of integrin αvβ3 aggravates experimental liver fibrosis and suppresses hepatic angiogenesis by Patsenker, Eleonora, Popov, Yury, Stickel, Felix, Schneider, Vreni, Ledermann, Monika, Sägesser, Hans, Niedobitek, Gerald, Goodman, Simon L., Schuppan, Detlef

“…The vitronectin receptor integrin αvβ3 promotes angiogenesis by mediating migration and proliferation of endothelial cells, but also drives fibrogenic…”
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Monitoring multiple angiogenesis‐related molecules in the blood of cancer patients shows a correlation between VEGF‐A and MMP‐9 levels before treatment and divergent changes after surgical vs. conservative therapy by Zaman, Khalil, Driscoll, Robert, Hahn, Diane, Werffeli, Patricia, Goodman, Simon L., Bauer, Jean, Leyvraz, Serge, Lejeune, Ferdy, Stupp, Roger, Rüegg, Curzio

“…Anti‐angiogenic therapies are currently in cancer clinical trials, but to date there are no established tests for evaluating the angiogenic status of a…”
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