Search Results - "Goodman, L."

Separating host and microbiome contributions to drug pharmacokinetics and toxicity by Zimmermann, Michael, Zimmermann-Kogadeeva, Maria, Wegmann, Rebekka, Goodman, Andrew L

“…The gut microbiota is implicated in the metabolism of many medical drugs, with consequences for interpersonal variation in drug efficacy and toxicity. However,…”
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Vitamin B12 as a Modulator of Gut Microbial Ecology by Degnan, Patrick H., Taga, Michiko E., Goodman, Andrew L.

“…The microbial mechanisms and key metabolites that shape the composition of the human gut microbiota are largely unknown, impeding efforts to manipulate…”
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Vaccine side-effects and SARS-CoV-2 infection after vaccination in users of the COVID Symptom Study app in the UK: a prospective observational study by Menni, Cristina, Klaser, Kerstin, May, Anna, Polidori, Lorenzo, Capdevila, Joan, Louca, Panayiotis, Sudre, Carole H, Nguyen, Long H, Drew, David A, Merino, Jordi, Hu, Christina, Selvachandran, Somesh, Antonelli, Michela, Murray, Benjamin, Canas, Liane S, Molteni, Erika, Graham, Mark S, Modat, Marc, Joshi, Amit D, Mangino, Massimo, Hammers, Alexander, Goodman, Anna L, Chan, Andrew T, Wolf, Jonathan, Steves, Claire J, Valdes, Ana M, Ourselin, Sebastien, Spector, Tim D

“…The Pfizer-BioNTech (BNT162b2) and the Oxford-AstraZeneca (ChAdOx1 nCoV-19) COVID-19 vaccines have shown excellent safety and efficacy in phase 3 trials. We…”
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Minireview: Kisspeptin/Neurokinin B/Dynorphin (KNDy) Cells of the Arcuate Nucleus: A Central Node in the Control of Gonadotropin-Releasing Hormone Secretion by Lehman, Michael N, Coolen, Lique M, Goodman, Robert L

“…Recently, a subset of neurons was identified in the arcuate nucleus of the hypothalamus that colocalize three neuropeptides, kisspeptin, neurokinin B, and…”
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Sphingolipids produced by gut bacteria enter host metabolic pathways impacting ceramide levels by Johnson, Elizabeth L., Heaver, Stacey L., Waters, Jillian L., Kim, Benjamin I., Bretin, Alexis, Goodman, Andrew L., Gewirtz, Andrew T., Worgall, Tilla S., Ley, Ruth E.

“…Gut microbes are linked to host metabolism, but specific mechanisms remain to be uncovered. Ceramides, a type of sphingolipid (SL), have been implicated in the…”
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The Long-Term Stability of the Human Gut Microbiota by Faith, Jeremiah J., Guruge, Janaki L., Charbonneau, Mark, Subramanian, Sathish, Seedorf, Henning, Goodman, Andrew L., Clemente, Jose C., Knight, Rob, Heath, Andrew C., Leibel, Rudolph L., Rosenbaum, Michael, Gordon, Jeffrey I.

“…A low-error 16S ribosomal RNA amplicon sequencing method, in combination with whole-genome sequencing of >500 cultured isolates, was used to characterize…”
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Mechanisms of Toll-like Receptor 4 Endocytosis Reveal a Common Immune-Evasion Strategy Used by Pathogenic and Commensal Bacteria by Tan, Yunhao, Zanoni, Ivan, Cullen, Thomas W., Goodman, Andrew L., Kagan, Jonathan C.

“…Microbe-induced receptor trafficking has emerged as an essential means to promote innate immune signal transduction. Upon detection of bacterial…”
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Uterine transplant: from imagination to implementation by Goodman, LR

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Human nutrition, the gut microbiome and the immune system by Kau, Andrew L., Ahern, Philip P., Griffin, Nicholas W., Goodman, Andrew L., Gordon, Jeffrey I.

“…Marked changes in socio-economic status, cultural traditions, population growth and agriculture are affecting diets worldwide. Understanding how our diet and…”
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Neuroendocrine control of gonadotropin‐releasing hormone: Pulsatile and surge modes of secretion by Goodman, Robert L., Herbison, Allan E., Lehman, Michael N., Navarro, Victor M.

“…The concept that different systems control episodic and surge secretion of gonadotropin‐releasing hormone (GnRH) was well established by the time that GnRH was…”
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Translocation of a gut pathobiont drives autoimmunity in mice and humans by Manfredo Vieira, S, Hiltensperger, M, Kumar, V, Zegarra-Ruiz, D, Dehner, C, Khan, N, Costa, F R C, Tiniakou, E, Greiling, T, Ruff, W, Barbieri, A, Kriegel, C, Mehta, S S, Knight, J R, Jain, D, Goodman, A L, Kriegel, M A

“…Despite multiple associations between the microbiota and immune diseases, their role in autoimmunity is poorly understood. We found that translocation of a gut…”
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The antibody horror show: an introductory guide for the perplexed by Goodman, Simon. L.

“…•Commercial antibodies are vital to biological research but still trouble users.•Unique identifiability of antibody and supplier, and batch validation are…”
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B vitamin acquisition by gut commensal bacteria by Putnam, Emily E, Goodman, Andrew L

“…About the Authors: Emily E. Putnam Affiliation: Department of Microbial Pathogenesis and Microbial Sciences Institute, Yale University School of Medicine, New…”
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FlyBase: introduction of the Drosophila melanogaster Release 6 reference genome assembly and large-scale migration of genome annotations by dos Santos, Gilberto, Schroeder, Andrew J, Goodman, Joshua L, Strelets, Victor B, Crosby, Madeline A, Thurmond, Jim, Emmert, David B, Gelbart, William M

“…Release 6, the latest reference genome assembly of the fruit fly Drosophila melanogaster, was released by the Berkeley Drosophila Genome Project in 2014; it…”
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FlyBase: updates to the Drosophila melanogaster knowledge base by Larkin, Aoife, Marygold, Steven J, Antonazzo, Giulia, Attrill, Helen, dos Santos, Gilberto, Garapati, Phani V, Goodman, Joshua L, Gramates, L Sian, Millburn, Gillian, Strelets, Victor B, Tabone, Christopher J, Thurmond, Jim

“…Abstract FlyBase (flybase.org) is an essential online database for researchers using Drosophila melanogaster as a model organism, facilitating access to a…”
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Carbapenem and colistin resistance in Enterobacteriaceae in Southeast Asia: Review and mapping of emerging and overlapping challenges by Malchione, Marissa D., Torres, Laura M., Hartley, David M., Koch, Michala, Goodman, Jesse L.

“…•Data from 258 studies on carbapenem and polymyxin resistance in Southeast Asia were analysed.•Carbapenem-resistant E. coli and Klebsiella were reported in 8…”
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Antimicrobial peptide resistance mediates resilience of prominent gut commensals during inflammation by Cullen, T. W., Schofield, W. B., Barry, N. A., Putnam, E. E., Rundell, E. A., Trent, M. S., Degnan, P. H., Booth, C. J., Yu, H., Goodman, A. L.

“…Resilience to host inflammation and other perturbations is a fundamental property of gut microbial communities, yet the underlying mechanisms are not well…”
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Metabolic and fitness determinants for in vitro growth and intestinal colonization of the bacterial pathogen Campylobacter jejuni by Gao, Beile, Vorwerk, Hanne, Huber, Claudia, Lara-Tejero, Maria, Mohr, Juliane, Goodman, Andrew L, Eisenreich, Wolfgang, Galán, Jorge E, Hofreuter, Dirk

“…Campylobacter jejuni is one of the leading infectious causes of food-borne illness around the world. Its ability to persistently colonize the intestinal tract…”
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Extensive personal human gut microbiota culture collections characterized and manipulated in gnotobiotic mice by Goodman, Andrew L, Kallstrom, George, Faith, Jeremiah J, Reyes, Alejandro, Moore, Aimee, Dantas, Gautam, Gordon, Jeffrey I

“…The proportion of the human gut bacterial community that is recalcitrant to culture remains poorly defined. In this report, we combine high-throughput…”
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Immunoglobulin A Coating Identifies Colitogenic Bacteria in Inflammatory Bowel Disease by Palm, Noah W., de Zoete, Marcel R., Cullen, Thomas W., Barry, Natasha A., Stefanowski, Jonathan, Hao, Liming, Degnan, Patrick H., Hu, Jianzhong, Peter, Inga, Zhang, Wei, Ruggiero, Elizabeth, Cho, Judy H., Goodman, Andrew L., Flavell, Richard A.

“…Specific members of the intestinal microbiota dramatically affect inflammatory bowel disease (IBD) in mice. In humans, however, identifying bacteria that…”
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