Search Results - "Goodman, Krista"

Discovery of GSK2193874: An Orally Active, Potent, and Selective Blocker of Transient Receptor Potential Vanilloid 4 by Cheung, Mui, Bao, Weike, Behm, David J, Brooks, Carl A, Bury, Michael J, Dowdell, Sarah E, Eidam, Hilary S, Fox, Ryan M, Goodman, Krista B, Holt, Dennis A, Lee, Dennis, Roethke, Theresa J, Willette, Robert N, Xu, Xiaoping, Ye, Guosen, Thorneloe, Kevin S

“…Transient Receptor Potential Vanilloid 4 (TRPV4) is a member of the Transient Receptor Potential (TRP) superfamily of cation channels. TRPV4 is expressed in…”
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Discovery of GSK2798745: A Clinical Candidate for Inhibition of Transient Receptor Potential Vanilloid 4 (TRPV4) by Brooks, Carl A, Barton, Linda S, Behm, David J, Eidam, Hilary S, Fox, Ryan M, Hammond, Marlys, Hoang, Tram H, Holt, Dennis A, Hilfiker, Mark A, Lawhorn, Brian G, Patterson, Jaclyn R, Stoy, Patrick, Roethke, Theresa J, Ye, Guosen, Zhao, Steve, Thorneloe, Kevin S, Goodman, Krista B, Cheung, Mui

“…GSK2798745, a clinical candidate, was identified as an inhibitor of the transient receptor potential vanilloid 4 (TRPV4) ion channel for the treatment of…”
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1433 Targeting peptidyl-prolyl isomerase Pin1 to modulate cancer-associated fibroblast phenotype and TGF-beta signaling by Chow, Melvyn, O’Shea, Morgan, Tasdemir, Doga, Starobinets, Hanna, Brown, Kristin, Sabatos-Peyton, Catherine, Corse, Emily, Hayes, Sebastian, Goodman, Krista

“…BackgroundCancer-associated fibroblasts present a significant barrier to standard of care immunotherapy through multiple mechanisms including deposition of…”
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NADPH oxidase-dependent and -independent mechanisms of reported inhibitors of reactive oxygen generation by Gatto, Jr, Gregory J, Ao, Zhaohui, Kearse, Michael G, Zhou, Mei, Morales, Cyndi R, Daniels, Erin, Bradley, Benjamin T, Goserud, Matthew T, Goodman, Krista B, Douglas, Stephen A, Harpel, Mark R, Johns, Douglas G

“…NADPH oxidase isoform-2 (NOX2) generates reactive oxygen species (ROS) that contribute to neurodegenerative and cardiovascular pathologies. However, validation…”
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An orally active TRPV4 channel blocker prevents and resolves pulmonary edema induced by heart failure by Thorneloe, Kevin S, Cheung, Mui, Bao, Weike, Alsaid, Hasan, Lenhard, Stephen, Jian, Ming-Yuan, Costell, Melissa, Maniscalco-Hauk, Kristeen, Krawiec, John A, Olzinski, Alan, Gordon, Earl, Lozinskaya, Irina, Elefante, Lou, Qin, Pu, Matasic, Daniel S, James, Chris, Tunstead, James, Donovan, Brian, Kallal, Lorena, Waszkiewicz, Anna, Vaidya, Kalindi, Davenport, Elizabeth A, Larkin, Jonathan, Burgert, Mark, Casillas, Linda N, Marquis, Robert W, Ye, Guosen, Eidam, Hilary S, Goodman, Krista B, Toomey, John R, Roethke, Theresa J, Jucker, Beat M, Schnackenberg, Christine G, Townsley, Mary I, Lepore, John J, Willette, Robert N

“…Pulmonary edema resulting from high pulmonary venous pressure (PVP) is a major cause of morbidity and mortality in heart failure (HF) patients, but current…”
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Potent, Selective and Orally Bioavailable Dihydropyrimidine Inhibitors of Rho Kinase (ROCK1) as Potential Therapeutic Agents for Cardiovascular Diseases by Sehon, Clark A, Wang, Gren Z, Viet, Andrew Q, Goodman, Krista B, Dowdell, Sarah E, Elkins, Patricia A, Semus, Simon F, Evans, Christopher, Jolivette, Larry J, Kirkpatrick, Robert B, Dul, Edward, Khandekar, Sanjay S, Yi, Tracey, Wright, Lois L, Smith, Gary K, Behm, David J, Bentley, Ross, Doe, Christopher P, Hu, Erding, Lee, Dennis

“…Recent studies using known Rho-associated kinase isoform 1 (ROCK1) inhibitors along with cellular and molecular biology data have revealed a pivotal role of…”
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Development of Dihydropyridone Indazole Amides as Selective Rho-Kinase Inhibitors by Goodman, Krista B, Cui, Haifeng, Dowdell, Sarah E, Gaitanopoulos, Dimitri E, Ivy, Robert L, Sehon, Clark A, Stavenger, Robert A, Wang, Gren Z, Viet, Andrew Q, Xu, Weiwei, Ye, Guosen, Semus, Simon F, Evans, Christopher, Fries, Harvey E, Jolivette, Larry J, Kirkpatrick, Robert B, Dul, Edward, Khandekar, Sanjay S, Yi, Tracey, Jung, David K, Wright, Lois L, Smith, Gary K, Behm, David J, Bentley, Ross, Doe, Christopher P, Hu, Erding, Lee, Dennis

“…Rho kinase (ROCK1) mediates vascular smooth muscle contraction and is a potential target for the treatment of hypertension and related disorders. Indazole…”
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Pharmacological Inhibition of C-C Chemokine Receptor 2 Decreases Macrophage Infiltration in the Aortic Root of the Human C-C Chemokine Receptor 2/Apolipoprotein E−/− Mouse: Magnetic Resonance Imaging Assessment by Olzinski, Alan R, Turner, Gregory H, Bernard, Roberta E, Karr, Heather, Cornejo, Carla A, Aravindhan, Karpagam, Hoang, Bao, Ringenberg, Michael A, Qin, Pu, Goodman, Krista B, Willette, Robert N, Macphee, Colin H, Jucker, Beat M, Sehon, Clark A, Gough, Peter J

“…PURPOSE—This study assessed the pharmacological effect of a novel selective C-C chemokine receptor (CCR) 2 antagonist (GSK1344386B) on monocyte/macrophage…”
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Discovery of Aminofurazan-azabenzimidazoles as Inhibitors of Rho-Kinase with High Kinase Selectivity and Antihypertensive Activity by Stavenger, Robert A, Cui, Haifeng, Dowdell, Sarah E, Franz, Robert G, Gaitanopoulos, Dimitri E, Goodman, Krista B, Hilfiker, Mark A, Ivy, Robert L, Leber, Jack D, Marino, Joseph P, Oh, Hye-Ja, Viet, Andrew Q, Xu, Weiwei, Ye, Guosen, Zhang, Daohua, Zhao, Yongdong, Jolivette, Larry J, Head, Martha S, Semus, Simon F, Elkins, Patricia A, Kirkpatrick, Robert B, Dul, Edward, Khandekar, Sanjay S, Yi, Tracey, Jung, David K, Wright, Lois L, Smith, Gary K, Behm, David J, Doe, Christopher P, Bentley, Ross, Chen, Zunxuan X, Hu, Erding, Lee, Dennis

“…The discovery, proposed binding mode, and optimization of a novel class of Rho-kinase inhibitors are presented. Appropriate substitution on the 6-position of…”
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CCR2 receptor antagonists: Optimization of biaryl sulfonamides to increase activity in whole blood by Wang, Gren Z., Haile, Pamela A., Daniel, Tom, Belot, Benjamin, Viet, Andrew Q., Goodman, Krista B., Sha, Deyou, Dowdell, Sarah E., Varga, Norbert, Hong, Xuan, Chakravorty, Subhas, Webb, Christine, Cornejo, Carla, Olzinski, Alan, Bernard, Roberta, Evans, Christopher, Emmons, Amanda, Briand, Jacques, Chung, Chun-Wa, Quek, Ruben, Lee, Dennis, Gough, Peter J., Sehon, Clark A.

“…A series of biarylsulfonamides was identified as hCCR2 receptor antagonist but suffered from high plasma protein binding resulting in a >100 fold shift in…”
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Aminomethylpiperazines as selective urotensin antagonists by Hilfiker, Mark A., Zhang, Daohua, Dowdell, Sarah E., Goodman, Krista B., McAtee, John J., Dodson, Jason W., Viet, Andrew Q., Wang, Gren Z., Sehon, Clark A., Behm, David J., Wu, Zining, Carballo, Luz H., Douglas, Stephen A., Neeb, Michael J.

“…Aminomethylpiperazines, reported previously as being κ-opioid receptor agonists, have been developed into selective, high affinity human urotensin-II…”
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Development of potent and selective small-molecule human Urotensin-II antagonists by McAtee, John J., Dodson, Jason W., Dowdell, Sarah E., Girard, Gerald R., Goodman, Krista B., Hilfiker, Mark A., Sehon, Clark A., Sha, Deyou, Wang, Gren Z., Wang, Ning, Viet, Andrew Q., Zhang, Daohua, Aiyar, Nambi V., Behm, David J., Carballo, Luz H., Evans, Christopher A., Fries, Harvey E., Nagilla, Rakesh, Roethke, Theresa J., Xu, Xiaoping, Yuan, Catherine C.K., Douglas, Stephen A., Neeb, Michael J.

“…This work describes the development of potent and selective human Urotensin-II antagonists starting from lead compound 1. Several problems relating to oral…”
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Potent and selective small-molecule human urotensin-II antagonists with improved pharmacokinetic profiles by McAtee, John J., Dodson, Jason W., Dowdell, Sarah E., Erhard, Karl, Girard, Gerald R., Goodman, Krista B., Hilfiker, Mark A., Jin, Jian, Sehon, Clark A., Sha, Deyou, Shi, Dongchuan, Wang, Feng, Wang, Gren Z., Wang, Ning, Wang, Yonghui, Viet, Andrew Q., Yuan, Catherine C.K., Zhang, Daohua, Aiyar, Nambi V., Behm, David J., Carballo, Luz H., Evans, Christopher A., Fries, Harvey E., Nagilla, Rakesh, Roethke, Theresa J., Xu, Xiaoping, Douglas, Stephen A., Neeb, Michael J.

“…Redesign of the potent human urotensin-II antagonist 1 with the 2-pyrrolidinylmethyl-3-phenyl-piperidine core to a new chemical series with a substituted…”
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Discovery of potent, selective sulfonylfuran urea endothelial lipase inhibitors by Goodman, Krista B., Bury, Michael J., Cheung, Mui, Cichy-Knight, Maria A., Dowdell, Sarah E., Dunn, Allison K., Lee, Dennis, Lieby, Jeffrey A., Moore, Michael L., Scherzer, Daryl A., Sha, Deyou, Suarez, Dominic P., Murphy, Dennis J., Harpel, Mark R., Manas, Eric S., McNulty, Dean E., Annan, Roland S., Matico, Rosalie E., Schwartz, Benjamin K., Trill, John J., Sweitzer, Thomas D., Wang, Da-yuan, Keller, Paul M., Krawiec, John A., Jaye, Michael C.

“…A series of potent, selective sulfonylfuran urea endothelial lipase inhibitors is reported. Mechanism of action studies are also discussed. Endothelial lipase…”
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ZUMA-8: A phase 1/2 multicenter study evaluating KTE-X19 in patients (pts) with relapsed/refractory (R/R) chronic lymphocytic leukemia (CLL) by Flinn, Ian, Marris, Michael, Wierda, William G., Coutre, Steven, Pagel, John M., Byrd, John C., Goyal, Lovely, Goodman, Krista, Zheng, Yan, Milletti, Francesca, Murugappan, Swaminathan, Brown, Jennifer R.

“…Abstract only TPS7566 Background: Despite treatment advances, CLL is largely incurable. First-line targeted therapy with ibrutinib mostly produces durable…”
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Relation of Childhood Sexual Abuse, Intimate Partner Violence, and Depression to Risk Factors for HIV Among Black Men Who Have Sex With Men in 6 US Cities by Williams, John K, Wilton, Leo, Magnus, Manya, Wang, Lei, Wang, Jing, Dyer, Typhanye Penniman, Koblin, Beryl A, Hucks-Ortiz, Christopher, Fields, Sheldon D, Shoptaw, Steve, Stephenson, Rob, O'Cleirigh, Conall, Cummings, Vanessa

“…We assessed the relation of childhood sexual abuse (CSA), intimate partner violence (IPV), and depression to HIV sexual risk behaviors among Black men who have…”
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Identification of a Human Whole Blood-Based Endothelial Cell Impedance Assay for Assessing Clinical Transient Receptor Potential Vanilloid 4 Target Engagement Ex Vivo by Xu, Xiaoping, Goyal, Navin, Costell, Melissa H, Roethke, Theresa, James, Christian H, Thorneloe, Kevin S, Patterson, Jaclyn, Stoy, Patrick, Goodman, Krista, Sprecher, Dennis L, Behm, David J

“…Transient receptor potential vanilloid 4 (TRPV4) channels expressed on pulmonary endothelial cells are activated by elevated pulmonary vascular pressure,…”
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Abstract 5574: Degradation of PIP4K2C by novel bivalent functional degrader LRK-A induces tumor regression in CRC by Corse, Emily, Goodman, Krista, O'Shea, Morgan, Ye, Guosen, Chow, Melvyn, Arnold, Julie, Giacalone, Vincent, Hayes, Sebastian, Dube, Erica, Alnemy, Sydney, Adigun, Oluwatimileyin Akinrinmade, Brown, Kristin, d'Hennezel, Eva, Sabatos-Peyton, Catherine

“…Abstract Phosphatidylinositol 5-phosphate 4-kinase, type II, gamma (PIP4K2C) is a lipid kinase with critical roles in vesicular trafficking,…”
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Engaging, Recruiting, and Retaining Black Men Who Have Sex With Men in Research Studies: Don’t Underestimate the Importance of Staffing—Lessons Learned From HPTN 061, the BROTHERS Study by Magnus, Manya, Franks, Julie, Griffith, Sam, Arnold, Michael P., Goodman, Krista, Wheeler, Darrell P.

“…HIV/AIDS in the United States continues to primarily impact men who have sex with men (MSM), with disproportionately high rates among black MSM. The purpose of…”
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Quality home visits: Activities to promote meaningful interactions by Hughes‐Belding, Kere, Peterson, Carla A., Clucas Walter, Melissa, Rowe, Neil, Fan, Liuran, Dooley, Leslie J., Steffensmeier, Chloe, Wang, Wen, Bao, Juan, Goodman, Krista

“…ABSTRACT Examination of and support for specific practices that promote high‐quality home visiting are essential as family support programs continue to expand…”
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