Search Results - "Goodlett, C R"

Alcohol-Induced Purkinje Cell Loss with a Single Binge Exposure in Neonatal Rats: A Stereological Study of Temporal Windows of Vulnerability by Goodlett, Charles R., Eilers, Amy T.

“…Previous research has shown that the early neonatal period of rats is one of enhanced vulnerability to cerebellar Purkinje cell loss associated with binge‐like…”
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Neonatal Binge Ethanol Exposure Using Intubation: Timing and Dose Effects on Place Learning by Goodlett, Charles R, Johnson, Timothy B

“…Neonatal rats were given ethanol using an acute intubation procedure that resulted in daily binge-like exposure with minimal effects on somatic growth…”
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Neonatal Ethanol Exposure Impairs Eyeblink Conditioning in Weanling Rats by Stanton, Mark E., Goodlett, Charles R.

“…Eyeblink conditioning depends on an identified brainstem‐cerebellar circuit and may be useful in functional studies of early cerebellar damage produced by…”
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Therapeutic effects of complex motor training on motor performance deficits induced by neonatal binge-like alcohol exposure in rats: I. Behavioral results by Klintsova, Anna Y, Cowell, Rita M, Swain, Rodney A, Napper, Ruth M.A, Goodlett, Charles R, Greenough, William T

“…The effects of complex motor task learning on subsequent motor performance of adult rats exposed to alcohol on postnatal days 4 through 9 were studied. Male…”
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Binge Neonatal Alcohol Intubations Induce Dose-Dependent Loss of Purkinje Cells by Goodlett, Charles R., Pearlman, Aaron D., Lundahl, Kristy R.

“…Previous work using artificial rearing methods to administer alcohol to neonatal rats identified postnatal days (PD) 4–6 as a period of enhanced vulnerability…”
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Binge-Like Alcohol Exposure of Neonatal Rats Via Intragastric Intubation Induces Both Purkinje Cell Loss and Cortical Astrogliosis by Goodlett, Charles R., Peterson, Stephanie D., Lundahl, Kristy R., Pearlman, Aaron D.

“…Binge‐like alcohol exposure in neonatal rats on postnatal days 4 to 9 via artificial rearing results in a well‐documented transient astrogliosis in the…”
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Sex Differences in Vulnerability to Developmental Spatial Learning Deficits Induced by Limited Binge Alcohol Exposure in Neonatal Rats by GOODLETT, CHARLES R., PETERSON, STEPHANIE D.

“…The two main objectives of this study were (1) to replicate previous findings that 6 days of binge-like exposure to alcohol during the neonatal brain growth…”
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Alcohol exposure alters cell cycle and apoptotic events during early neurulation by Anthony, Bruce, Zhou, Feng C., Ogawa, Tetsuo, Goodlett, Charles R., Ruiz, Joseph

“…Background: Fetal alcohol exposure causes growth deficits, microencephaly, and neurological abnormalities. Although the effects of alcohol on developmental…”
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Prenatal alcohol exposure retards the migration and development of serotonin neurons in fetal C57BL mice by Zhou, F.C., Sari, Y., Zhang, J.K., Goodlett, C.R., Li, T.-K.

“…Incomplete neural tube fusion (iNTF), induced by alcohol, in midline floor and roof plates was found in our recent study. In this study, serotonin (5-HT)…”
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Therapeutic motor training increases parallel fiber synapse number per Purkinje neuron in cerebellar cortex of rats given postnatal binge alcohol exposure : Preliminary report by KLINTSOVA, A. Y, MATTHEWS, J. T, GOODLETT, C. R, NAPPER, R. M. A, GREENOUGH, W. T

“…Because therapeutic approaches to fetal alcohol effects in humans have been rare, this study explored the rehabilitative effect of complex motor training on an…”
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Cell population depletion associated with fetal alcohol brain damage: mechanisms of BAC-dependent cell loss by West, J R, Goodlett, C R, Bonthius, D J, Hamre, K M, Marcussen, B L

“…Neuronal death is one of the most serious consequences of alcohol exposure during development. Studies described in this paper used a neonatal rat model to…”
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Dissociation of spatial navigation and visual guidance performance in Purkinje cell degeneration (pcd) mutant mice by Goodlett, C R, Hamre, K M, West, J R

“…Spatial learning in rodents requires normal functioning of hippocampal and cortical structures. Recent data suggest that the cerebellum may also be essential…”
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A single day of alcohol exposure during the brain growth spurt induces brain weight restriction and cerebellar Purkinje cell loss by Goodlett, C R, Marcussen, B L, West, J R

“…The period of rapid brain growth that occurs relatively late in development has been shown to be vulnerable to alcohol-induced brain growth deficits and neuron…”
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NMDA prevents alcohol-induced neuronal cell death of cerebellar granule cells in culture by Pantazis, N J, Dohrman, D P, Luo, J, Thomas, J D, Goodlett, C R, West, J R

“…Neuronal cell loss is one of the most debilitating effects of alcohol exposure during development of the nervous system. In this study, primary cultures of…”
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Vulnerability of cerebellar granule cells to alcohol-induced cell death diminishes with time in culture by Pantazis, N J, Dohrman, D P, Goodlett, C R, Cook, R T, West, J R

“…This study examined the effects of alcohol exposure on the viability of cerebellar granule cells in culture. Continuous alcohol exposure, starting 1 day after…”
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Therapeutic effects of complex motor training on motor performance deficits induced by neonatal binge-like alcohol exposure in rats:: II. A quantitative stereological study of synaptic plasticity in female rat cerebellum by Klintsova, Anna Y., Scamra, Carly, Hoffman, Melissa, Napper, Ruth M.A., Goodlett, Charles R., Greenough, William T.

“…Twenty days of complex motor skill training in adult rats was previously demonstrated to rehabilitate motor performance deficits induced by binge alcohol…”
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Blood alcohol concentration and severity of microencephaly in neonatal rats depend on the pattern of alcohol administration by Bonthius, D J, Goodlett, C R, West, J R

“…A rat model of third trimester fetal alcohol exposure was used to examine how the pattern of administration of a daily alcohol dose influences the pattern of…”
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Impaired spatial navigation in adult female but not adult male rats exposed to alcohol during the brain growth spurt by Kelly, S J, Goodlett, C R, Hulsether, S A, West, J R

“…Two groups of male and female rats were given the same dose of alcohol using an artificial rearing procedure on postnatal days 4-10. One group received the…”
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Neonatal ethanol produces cerebellar deep nuclear cell loss and correlated disruption of eyeblink conditioning in adult rats by Green, John T, Tran, Tuan, Steinmetz, Joseph E, Goodlett, Charles R

“…Binge-like neonatal exposure to ethanol (EtOH) in rats, during the period of brain development comparable to that of the human third trimester, produces…”
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Forebrain ischemia induces selective behavioral impairments associated with hippocampal injury in rats by GIONET, T. X, THOMAS, J. D, WARNER, D. S, GOODLETT, C. R, WASSERMAN, E. A, WEST, J. R

“…Two groups of rats were tested on a variety of motor and cognitive tasks after either 10 minutes of two-vessel occlusion forebrain ischemia (n = 8) or sham…”
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