Search Results - "Gooding, Clare"

Heteromeric RNP Assembly at LINEs Controls Lineage-Specific RNA Processing by Attig, Jan, Agostini, Federico, Gooding, Clare, Chakrabarti, Anob M., Singh, Aarti, Haberman, Nejc, Zagalak, Julian A., Emmett, Warren, Smith, Christopher W.J., Luscombe, Nicholas M., Ule, Jernej

“…Long mammalian introns make it challenging for the RNA processing machinery to identify exons accurately. We find that LINE-derived sequences (LINEs)…”
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The alternative splicing program of differentiated smooth muscle cells involves concerted non-productive splicing of post-transcriptional regulators by Llorian, Miriam, Gooding, Clare, Bellora, Nicolas, Hallegger, Martina, Buckroyd, Adrian, Wang, Xiao, Rajgor, Dipen, Kayikci, Melis, Feltham, Jack, Ule, Jernej, Eyras, Eduardo, Smith, Christopher W J

“…Alternative splicing (AS) is a key component of gene expression programs that drive cellular differentiation. Smooth muscle cells (SMCs) are important in the…”
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Identification of RBPMS as a mammalian smooth muscle master splicing regulator via proximity of its gene with super-enhancers by Nakagaki-Silva, Erick E, Gooding, Clare, Llorian, Miriam, Jacob, Aishwarya G, Richards, Frederick, Buckroyd, Adrian, Sinha, Sanjay, Smith, Christopher Wj

“…Alternative splicing (AS) programs are primarily controlled by regulatory RNA-binding proteins (RBPs). It has been proposed that a small number of master…”
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Defining the roles and interactions of PTB by Kafasla, Panagiota, Mickleburgh, Ian, Llorian, Miriam, Coelho, Miguel, Gooding, Clare, Cherny, Dmitry, Joshi, Amar, Kotik-Kogan, Olga, Curry, Stephen, Eperon, Ian C, Jackson, Richard J, Smith, Christopher W J

“…PTB (polypyrimidine tract-binding protein) is an abundant and widely expressed RNA-binding protein with four RRM (RNA recognition motif) domains. PTB is…”
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Autoregulation of Polypyrimidine Tract Binding Protein by Alternative Splicing Leading to Nonsense-Mediated Decay by Wollerton, Matthew C, Gooding, Clare, Wagner, Eric J, Garcia-Blanco, Mariano A, Smith, Christopher W.J

“…Polypyrimdine tract binding protein (PTB) is a regulator of alternative splicing, mRNA 3′ end formation, mRNA stability and localization, and IRES-mediated…”
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MBNL1 and PTB cooperate to repress splicing of Tpm1 exon 3 by Gooding, Clare, Edge, Christopher, Lorenz, Mike, Coelho, Miguel B, Winters, Mikael, Kaminski, Clemens F, Cherny, Dmitry, Eperon, Ian C, Smith, Christopher W J

“…Exon 3 of the rat α-tropomyosin (Tpm1) gene is repressed in smooth muscle cells, allowing inclusion of the mutually exclusive partner exon 2. Two key types of…”
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A drug-repositioning screen using splicing-sensitive fluorescent reporters identifies novel modulators of VEGF-A splicing with anti-angiogenic properties by Star, Eleanor, Stevens, Megan, Gooding, Clare, Smith, Christopher W. J., Li, Ling, Ayine, Monica Lamici, Harper, Steve J., Bates, David O., Oltean, Sebastian

“…Alternative splicing of the vascular endothelial growth factor A ( VEGF-A ) terminal exon generates two protein families with differing functions…”
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Approaching Religious Literacy in International Affairs: A Conference Report by Prodromou, Elizabeth H., Gooding, Clare D., Lipton Galbraith, Sasha

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Polypyrimidine Tract Binding Protein Functions as a Repressor To Regulate Alternative Splicing of α-Actinin Mutally Exclusive Exons by Southby, Justine, Gooding, Clare, Smith, Christopher W. J.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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A Novel Polypyrimidine Tract-binding Protein Paralog Expressed in Smooth Muscle Cells by Gooding, Clare, Kemp, Paul, Smith, Christopher W.J.

“…Polypyrimidine tract-binding protein (PTB) is an abundant widespread RNA-binding protein with roles in regulation of pre-mRNA alternative splicing and 3′-end…”
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Cell-type specific regulator RBPMS switches alternative splicing via higher-order oligomerization and heterotypic interactions with other splicing regulators by Yang, Yi, Lee, Giselle C, Nakagaki-Silva, Erick, Huang, Yuling, Peacey, Matthew, Partridge, Ruth, Gooding, Clare, Smith, Christopher W J

“…Abstract Alternative pre-mRNA splicing decisions are regulated by RNA binding proteins (RBPs) that can activate or repress regulated splice sites. Repressive…”
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Phosphorylation of the smooth muscle master splicing regulator RBPMS regulates its splicing activity by Barnhart, Michael D, Yang, Yi, Nakagaki-Silva, Erick E, Hammond, Thomas H, Pizzinga, Mariavittoria, Gooding, Clare, Stott, Katherine, Smith, Christopher W J

“…We previously identified RBPMS as a master regulator of alternative splicing in differentiated smooth muscle cells (SMCs). RBPMS is transcriptionally…”
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Polypyrimidine tract binding protein 1 regulates the activation of mouse CD8 T cells by D'Angeli, Vanessa, Monzón‐Casanova, Elisa, Matheson, Louise S., Gizlenci, Özge, Petkau, Georg, Gooding, Clare, Berrens, Rebecca V., Smith, Christopher W. J., Turner, Martin

“…The RNA‐binding protein polypyrimidine tract binding protein 1 (PTBP1) has been found to have roles in CD4 T‐cell activation, but its function in CD8 T cells…”
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Functional interactions between polypyrimidine tract binding protein and PRI peptide ligand containing proteins by Coelho, Miguel B, Ascher, David B, Gooding, Clare, Lang, Emma, Maude, Hannah, Turner, David, Llorian, Miriam, Pires, Douglas E V, Attig, Jan, Smith, Christopher W J

“…Polypyrimidine tract binding protein (PTBP1) is a heterogeneous nuclear ribonucleoprotein (hnRNP) that plays roles in most stages of the life-cycle of pre-mRNA…”
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Stoichiometry of a regulatory splicing complex revealed by single-molecule analyses by Cherny, Dmitry, Gooding, Clare, Eperon, Giles E, Coelho, Miguel B, Bagshaw, Clive R, Smith, Christopher W J, Eperon, Ian C

“…Splicing is regulated by complex interactions of numerous RNA‐binding proteins. The molecular mechanisms involved remain elusive, in large part because of…”
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A peptide motif in Raver1 mediates splicing repression by interaction with the PTB RRM2 domain by Smith, Christopher W J, Rideau, Alexis P, Gooding, Clare, Simpson, Peter J, Monie, Tom P, Lorenz, Mike, Hüttelmaier, Stefan, Singer, Robert H, Matthews, Stephen, Curry, Stephen

“…Polypyrimidine tract-binding protein (PTB) is a regulatory splicing repressor. Raver1 acts as a PTB corepressor for splicing of alpha-tropomyosin (Tpm1) exon…”
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Dissecting domains necessary for activation and repression of splicing by Muscleblind-like protein 1 by Edge, Christopher, Gooding, Clare, Smith, Christopher W J

“…Alternative splicing contributes to the diversity of the proteome, and provides the cell with an important additional layer of regulation of gene expression…”
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Tropomyosin exons as models for alternative splicing by Gooding, Clare, Smith, Christopher W J

“…Three of the four mammalian tropomyosin (Tm) genes are alternatively spliced, most commonly by mutually exclusive selection from pairs of internal or 3' end…”
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The PTB interacting protein raver1 regulates α-tropomyosin alternative splicing by Gromak, Natalia, Rideau, Alexis, Southby, Justine, Scadden, A. D. J., Gooding, Clare, Hüttelmaier, Stefan, Singer, Robert H., Smith, Christopher W. J.

“…Regulated switching of the mutually exclusive exons 2 and 3 of α‐tropomyosin (TM) involves repression of exon 3 in smooth muscle cells. Polypyrimidine…”
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Repression of alpha-actinin SM exon splicing by assisted binding of PTB to the polypyrimidine tract by Matlin, Arianne J, Southby, Justine, Gooding, Clare, Smith, Christopher W J

“…Polypyrimidine tract binding protein (PTB) acts as a regulatory repressor of a large number of alternatively spliced exons, often requiring multiple binding…”
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