Search Results - "Gooderham, N.J."

K03 – Metabolism, Inflammation and Cancer by Gooderham, N.J.

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Using microRNA profiles to predict and evaluate hepatic carcinogenic potential by Gooderham, N.J., Koufaris, C.

“…•Substantial evidence supports a role for microRNAs in liver carcinogenesis.•In the last few years numerous studies have examined the effects of…”
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Metabolic phenotype-microRNA data fusion analysis of the systemic consequences of Roux-en-Y gastric bypass surgery by Wu, Q, Li, J V, Seyfried, F, le Roux, C W, Ashrafian, H, Athanasiou, T, Fenske, W, Darzi, A, Nicholson, J K, Holmes, E, Gooderham, N J

“…Background/Objectives: Bariatric surgery offers sustained marked weight loss and often remission of type 2 diabetes, yet the mechanisms of establishment of…”
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The cooked meat-derived mammary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) elicits estrogenic-like microRNA responses in breast cancer cells by Papaioannou, M.D., Koufaris, C., Gooderham, N.J.

“…The cooking of meat results in the generation of heterocyclic amines (HCA), the most abundant of which is 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine…”
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Transdifferentiated rat pancreatic progenitor cells (AR42J-B13/H) respond to phenobarbital in a rat hepatocyte-specific manner by Osborne, M, Haltalli, M, Currie, R, Wright, J, Gooderham, N.J

“…Abstract Phenobarbital (PB) is known to produce species-specific effects in the rat and mouse, being carcinogenic in certain mouse strains, but only in rats if…”
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In vitro toxicity study of synthetic and natural alkenyl glucosinolate hydrolysis products on cHo1 and MCL5 cell lines by Kadir, N.H. Abd, Rossiter, J.T., Gooderham, N.J.

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Organ distinctive mutagenicity in MutaTMMouse after short-term exposure to PhIP by Lynch, A.M., Gooderham, N.J., Boobis, A.R.

“…We have investigated PhIP-induced mutagenicity in various tissues (Kidney, liver, large and small intestine) using a transgenic mouse model (MutaTMMouse). In…”
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GRASr2 Evaluation of Aliphatic Acyclic and Alicyclic Terpenoid Tertiary Alcohols and Structurally Related Substances Used as Flavoring Ingredients by Marnett, Lawrence J, Cohen, Samuel M, Fukushima, Shoji, Gooderham, Nigel J, Hecht, Stephen S, Rietjens, Ivonne M.C.M, Smith, Robert L, Adams, Timothy B, Bastaki, Maria, Harman, Christie L, McGowen, Margaret M, Taylor, Sean V

“…This publication is the 1st in a series of publications by the Expert Panel of the Flavor and Extract Manufacturers Assoc. summarizing the Panel's 3rd…”
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The impact of structural and metabolic variation on the toxicity and carcinogenicity of hydroxy- and alkoxy-substituted allyl- and propenylbenzenes by Rietjens, I, Adams, T.B, Bastaki, M, Cohen, S.M, Fukushima, S, Harman, C, Gooderham, N.J, Hecht, S, Marnett, L.J, Smith, R.L, Taylor, S.V

“…The metabolic fate of a compound is determined by numerous factors including its chemical structure. Although the metabolic options for a variety of functional…”
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Mechanisms of action of the carcinogenic heterocyclic amine PhIP by Gooderham, N.J., Creton, S., Lauber, S.N., Zhu, H.

“…Formed during the cooking of meat, the heterocyclic amine 2-amino-1-methyl-6-phenylimidazo[4-5- b]pyridine (PhIP) is mutagenic and carcinogenic. Although the…”
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Cell cycle and gene expression changes in response to 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in human TK6 Cells by Zhu, H., Boobis, A.R., Gooderham, N.J.

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Cell cycle and gene expression changes in response to [formula omitted] (PhIP) in human TK6 Cells by Zhu, H., Boobis, A.R., Gooderham, N.J.

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The Mechanism of Cryptolepine-Induced Cell Death by Ansah, C., ., H. Zhu, ., N.J. Gooderham

“…The objective of the present study was to use morphological and biochemical approaches to characterize the mode of CLP-induced cell death. Using a differential…”
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The phytoalexin resveratrol attenuates 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced mutagenicity in mammalian cells by Boyce, A.P., Price, J., Doehmer, J., Gooderham, N.J.

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Heterocyclic amines and human cancer: Immunohistochemical evidence for potential metabolic competency of the colon by Chana, U., Edwards, R., Lightfoot, T., Garner, C., Boobis, A., Gooderham, N.J.

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Genetic analysis of PHIP intestinal mutations in MutaTMMouse by Lynch, A.M., Gooderham, N.J., Davies, D.S., Boobis, A.R.

“…The mutagenicity of 2-amino-l-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) was investigated in male MutaTMMouse mice administered 20 mg/kg per os for 4 days…”
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Phip protein adduction and mutagenicity in Muta®Mouse by Lynch, A.M., Gooderham, N.J., Boobis, A.H.

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Organ distinctive mutagenicity in Muta TM Mouse after short-term exposure to PhIP by Lynch, A.M., Gooderham, N.J., Boobis, A.R.

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Genetic analysis of PHIP intestinal mutations in Muta TM Mouse by Lynch, A.M., Gooderham, N.J., Davies, D.S., Boobis, A.R.

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Detection and measurement of MeIQx in human urine after ingestion of a cooked meat meal by Murray, S, Gooderham, N J, Boobis, A R, Davies, D S

“…A gas chromatographic-mass spectrometric assay has been developed for the measurement of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in urine. The…”
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