Search Results - "Gooden, David M"

Determination of glucuronide conjugates of hydroxyl triphenyl phosphate (OH-TPHP) metabolites in human urine and its use as a biomarker of TPHP exposure by Su, Guanyong, Letcher, Robert J., Yu, Hongxia, Gooden, David M., Stapleton, Heather M.

“…In vitro studies using avian hepatocytes or human liver microsomes suggest that hydroxylation is an important pathway in the metabolism of triphenyl phosphate…”
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Cancer-associated Isocitrate Dehydrogenase 1 (IDH1) R132H Mutation and d-2-Hydroxyglutarate Stimulate Glutamine Metabolism under Hypoxia by Reitman, Zachary J., Duncan, Christopher G., Poteet, Ethan, Winters, Ali, Yan, Liang-Jun, Gooden, David M., Spasojevic, Ivan, Boros, Laszlo G., Yang, Shao-Hua, Yan, Hai

“…Mutations in the cytosolic NADP+-dependent isocitrate dehydrogenase (IDH1) occur in several types of cancer, and altered cellular metabolism associated with…”
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Disruption of Wild-Type IDH1 Suppresses D-2-Hydroxyglutarate Production in IDH1-Mutated Gliomas by GENGLIN JIN, REITMAN, Zachary J, BIGNER, Darell D, HAI YAN, DUNCAN, Christopher G, SPASOJEVIC, Ivan, GOODEN, David M, AHMED RASHEED, B, RUI YANG, LOPEZ, Giselle Y, YIPING HE, MCLENDON, Roger E

“…Point mutations at Arg132 of the cytoplasmic NADP(+)-dependent isocitrate dehydrogenase 1 (IDH1) occur frequently in gliomas and result in a gain of function…”
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Small molecule dual-inhibitors of TRPV4 and TRPA1 for attenuation of inflammation and pain by Kanju, Patrick, Chen, Yong, Lee, Whasil, Yeo, Michele, Lee, Suk Hee, Romac, Joelle, Shahid, Rafiq, Fan, Ping, Gooden, David M., Simon, Sidney A., Spasojevic, Ivan, Mook, Robert A., Liddle, Rodger A., Guilak, Farshid, Liedtke, Wolfgang B.

“…TRPV4 ion channels represent osmo-mechano-TRP channels with pleiotropic function and wide-spread expression. One of the critical functions of TRPV4 in this…”
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In Vitro Metabolism of the Flame Retardant Triphenyl Phosphate in Chicken Embryonic Hepatocytes and the Importance of the Hydroxylation Pathway by Su, Guanyong, Letcher, Robert J, Crump, Doug, Gooden, David M, Stapleton, Heather M

“…We report for the first time either in vitro or in vivo the phase I hydroxylation and phase II conjugation metabolic pathways of an organophosphate flame…”
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A Small-Molecule Inhibitor of Isoprenylcysteine Carboxyl Methyltransferase with Antitumor Activity in Cancer Cells by Winter-Vann, Ann M., Baron, Rudi A., Wong, Waihay, dela Cruz, June, York, John D., Gooden, David M., Bergo, Martin O., Young, Stephen G., Toone, Eric J., Casey, Patrick J., Glomset, John A.

“…Many key regulatory proteins, including members of the Ras family of GTPases, are modified at their C terminus by a process termed prenylation. This processing…”
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Facile synthesis of substituted trans-2-arylcyclopropylamine inhibitors of the human histone demethylase LSD1 and monoamine oxidases A and B by Gooden, David M., Schmidt, Dawn M.Z., Pollock, Julie A., Kabadi, Ami M., McCafferty, Dewey G.

“…A facile synthetic route to substituted trans-2-arylcyclopropylamines was developed to provide mechanism-based inhibitors of the flavoenzyme histone…”
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Synthesis and evaluation of radiolabeled AGI-5198 analogues as candidate radiotracers for imaging mutant IDH1 expression in tumors by Chitneni, Satish K., Reitman, Zachary J., Spicehandler, Rebecca, Gooden, David M., Yan, Hai, Zalutsky, Michael R.

“…[Display omitted] Mutations in the metabolic enzyme isocitrate dehydrogenase 1 (IDH1) are commonly found in gliomas. AGI-5198, a potent and selective inhibitor…”
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Psoralen Derivatives with Enhanced Potency by Buhimschi, Alexandru D., Gooden, David M., Jing, Hongwu, Fels, Diane R., Hansen, Katherine S., Beyer, Wayne F., Dewhirst, Mark W., Walder, Harold, Gasparro, Francis P.

“…Psoralen is a furocoumarin natural product that intercalates within DNA and forms covalent adducts when activated by ultraviolet radiation. It is well known…”
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Chemical Regulation of the Protein Quality Control E3 Ubiquitin Ligase C‐Terminus of Hsc70 Interacting Protein (CHIP) by Kanack, Adam J., Olp, Michael D., Newsom, Oliver J., Scaglione, Jamie B., Gooden, David M., McMahon, Kevin, Smith, Brian C., Scaglione, K. Matthew

“…The ubiquitin ligase C‐terminus of Hsc70 interacting protein (CHIP) is an important regulator of proteostasis. Despite playing an important role in maintaining…”
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Targeted Mass Spectrometry-Based Approach for Protein–Ligand Binding Analyses in Complex Biological Mixtures Using a Phenacyl Bromide Modification Strategy by Jin, Lorrain, Wang, Dongyu, Gooden, David M, Ball, Carol H, Fitzgerald, Michael C

“…The characterization of protein folding stability changes on the proteomic scale is useful for protein-target discovery and for the characterization of…”
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A genetically engineered thermally responsive sustained release curcumin depot to treat neuroinflammation by Sinclair, S. Michael, Bhattacharyya, Jayanta, McDaniel, Jonathan R., Gooden, David M., Gopalaswamy, Ramesh, Chilkoti, Ashutosh, Setton, Lori A.

“…Radiculopathy, a painful neuroinflammation that can accompany intervertebral disc herniation, is associated with locally increased levels of the…”
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Radiolabeled inhibitors as probes for imaging mutant IDH1 expression in gliomas: Synthesis and preliminary evaluation of labeled butyl-phenyl sulfonamide analogs by Chitneni, Satish K., Reitman, Zachary J., Gooden, David M., Yan, Hai, Zalutsky, Michael R.

“…Malignant gliomas frequently harbor mutations in the isocitrate dehydrogenase 1 (IDH1) gene. Studies suggest that IDH mutation contributes to tumor…”
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6-(4-(2-{2-[2-(2-Hydroxy-ethoxy)-ethoxy]-ethoxy}-ethyl)-10-oxa-4-aza-tricyclo[5.2.1.02,6]dec-8-ene-3,5-dione) by Gooden, David

“…Microwave irradiation of maleimide with an excess of furan in water exclusively yields the corresponding exo-cycloadduct in good yield (87%) in 1 hour at 90…”
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Correction to “Proteomic Characterization of the Cellular Response to Nitrosative Stress Mediated by S‑Nitrosoglutathione Reductase Inhibition” by Foster, Matthew W, Yang, Zhonghui, Gooden, David M, Thompson, J. Will, Ball, Carol H, Turner, Meredith E, Hou, Yongyong, Pi, Jingbo, Moseley, M. Arthur, Que, Loretta G

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Identification of a novel Smoothened antagonist that potently suppresses Hedgehog signaling by Wang, Jiangbo, Mook, Robert A., Lu, Jiuyi, Gooden, David M., Ribeiro, Anthony, Guo, Anchen, Barak, Larry S., Kim Lyerly, H., Chen, Wei

“…The Hedgehog signaling pathway plays an essential role in embryo development and adult tissue homeostasis, in regulating stem cells and is abnormally activated…”
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Proteomic Characterization of the Cellular Response to Nitrosative Stress Mediated by S-Nitrosoglutathione Reductase Inhibition by Foster, Matthew W, Yang, Zhonghui, Gooden, David M, Thompson, J. Will, Ball, Carol H, Turner, Meredith E, Hou, Yongyong, Pi, Jingbo, Moseley, M. Arthur, Que, Loretta G

“…The S-nitrosoglutathione-metabolizing enzyme, GSNO reductase (GSNOR), has emerged as an important regulator of protein S-nitrosylation. GSNOR ablation is…”
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Studies on the biosynthesis of the lipodepsipeptide antibiotic Ramoplanin A2 by Hoertz, Amanda J., Hamburger, James B., Gooden, David M., Bednar, Maria M., McCafferty, Dewey G.

“…Ramoplanin, a non-ribosomally synthesized peptide antibiotic, is highly effective against several drug-resistant Gram-positive bacteria, including…”
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Additivity and the Physical Basis of Multivalency Effects:  A Thermodynamic Investigation of the Calcium EDTA Interaction by Christensen, Trine, Gooden, David M, Kung, Joyce E, Toone, Eric J

“…To better understand the origin of multivalency effects in ligand binding, the binding of a series of mono-, bi-, tri- and tetravalent carboxylate ligands to…”
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Identification of Novel Mast Cell Activators Using Cell-Based High-Throughput Screening by Choi, Hae Woong, Chan, Cliburn, Shterev, Ivo D, Lynch, Heather E, Robinette, Taylor J, Johnson-Weaver, Brandi T, Shi, Jianling, Sempowski, Gregory D, Kim, So Young, Dickson, John K, Gooden, David M, Abraham, Soman N, Staats, Herman F

“…Mast cells (MCs) are known to regulate innate and adaptive immunity. MC activators have recently been described as safe and effective vaccine adjuvants. Many…”
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