Search Results - "Goodchild, Samuel J"

Cannabidiol increases gramicidin current in human embryonic kidney cells: An observational study by Ghovanloo, Mohammad-Reza, Goodchild, Samuel J, Ruben, Peter C

“…Gramicidin is a monomeric protein that is thought to non-selectively conduct cationic currents and water. Linear gramicidin is considered an antibiotic. This…”
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Sequence of Gating Charge Movement and Pore Gating in hERG Activation and Deactivation Pathways by Goodchild, Samuel J., Macdonald, Logan C., Fedida, David

“…KV11.1 voltage-gated K+ channels are noted for unusually slow activation, fast inactivation, and slow deactivation kinetics, which tune channel activity to…”
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Selective NaV1.7 Antagonists with Long Residence Time Show Improved Efficacy against Inflammatory and Neuropathic Pain by Bankar, Girish, Goodchild, Samuel J., Howard, Sarah, Nelkenbrecher, Karen, Waldbrook, Matthew, Dourado, Michelle, Shuart, Noah G., Lin, Sophia, Young, Clint, Xie, Zhiwei, Khakh, Kuldip, Chang, Elaine, Sojo, Luis E., Lindgren, Andrea, Chowdhury, Sultan, Decker, Shannon, Grimwood, Michael, Andrez, Jean-Christophe, Dehnhardt, Christoph M., Pang, Jodie, Chang, Jae H., Safina, Brian S., Sutherlin, Daniel P., Johnson, James P., Hackos, David H., Robinette, C. Lee, Cohen, Charles J.

“…Selective block of NaV1.7 promises to produce non-narcotic analgesic activity without motor or cognitive impairment. Several NaV1.7-selective blockers have…”
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Local anesthetic inhibition of a bacterial sodium channel by Lee, Sora, Goodchild, Samuel J, Ahern, Christopher A

“…Recent structural breakthroughs with the voltage-gated sodium channel from Arcobacter butzleri suggest that such bacterial channels may provide a structural…”
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Non-psychotropic phytocannabinoid interactions with voltage-gated sodium channels: An update on cannabidiol and cannabigerol by Ghovanloo, Mohammad-Reza, Dib-Hajj, Sulayman D, Goodchild, Samuel J, Ruben, Peter C, Waxman, Stephen G

“…Phytocannabinoids, found in the plant, , are an important class of natural compounds with physiological effects. These compounds can be generally divided into…”
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Pharmacological determination of the fractional block of Nav channels required to impair neuronal excitability and ex vivo seizures by Thouta, Samrat, Waldbrook, Matthew G, Lin, Sophia, Mahadevan, Arjun, Mezeyova, Janette, Soriano, Maegan, Versi, Pareesa, Goodchild, Samuel J, Parrish, R Ryley

“…Voltage-gated sodium channels (Nav) are essential for the initiation and propagation of action potentials in neurons. Of the nine human channel subtypes,…”
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Expanding the genotype-phenotype spectrum in SCN8A-related disorders by Hebbar, Malavika, Al-Taweel, Nawaf, Gill, Inderpal, Boelman, Cyrus, Dean, Richard A, Goodchild, Samuel J, Mezeyova, Janette, Shuart, Noah Gregory, Johnson, Jr, J P, Lee, James, Michoulas, Aspasia, Huh, Linda L, Armstrong, Linlea, Connolly, Mary B, Demos, Michelle K

“…SCN8A-related disorders are a group of variable conditions caused by pathogenic variations in SCN8A. Online Mendelian Inheritance in Man (OMIM) terms them as…”
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Allosteric Block of KCa2 Channels by Apamin by Lamy, Cédric, Goodchild, Samuel J., Weatherall, Kate L., Jane, David E., Liégeois, Jean-François, Seutin, Vincent, Marrion, Neil V.

“…Activation of small conductance calcium-activated potassium (KCa2) channels can regulate neuronal firing and synaptic plasticity. They are characterized by…”
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Blockade of Permeation by Potassium but Normal Gating of the G628S Nonconducting hERG Channel Mutant by Es-Salah-Lamoureux, Zeineb, Xiong, Ping Yu, Goodchild, Samuel J., Ahern, Christopher A., Fedida, David

“…G628S is a mutation in the signature sequence that forms the selectivity filter of the human ether-a-go-go-related gene (hERG) channel (GFG) and is associated…”
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Inhibitory effects of cannabidiol on voltage-dependent sodium currents by Ghovanloo, Mohammad-Reza, Shuart, Noah Gregory, Mezeyova, Janette, Dean, Richard A., Ruben, Peter C., Goodchild, Samuel J.

“…Cannabis sativa contains many related compounds known as phytocannabinoids. The main psychoactive and nonpsychoactive compounds are Δ9-tetrahydrocannabinol…”
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Molecular and functional determinants of local anesthetic inhibition of NaChBac by Lee, Sora, Goodchild, Samuel J., Ahern, Christopher A.

“…In our recent publication, we describe the local anesthetic (LA) inhibition of the prokaryotic voltage gated sodium channel NaChBac. Despite the numerous…”
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Cannabidiol inhibits the skeletal muscle Nav1.4 by blocking its pore and by altering membrane elasticity by Ghovanloo, Mohammad-Reza, Choudhury, Koushik, Bandaru, Tagore S, Fouda, Mohamed A, Rayani, Kaveh, Rusinova, Radda, Phaterpekar, Tejas, Nelkenbrecher, Karen, Watkins, Abeline R, Poburko, Damon, Thewalt, Jenifer, Andersen, Olaf S, Delemotte, Lucie, Goodchild, Samuel J, Ruben, Peter C

“…Cannabidiol (CBD) is the primary nonpsychotropic phytocannabinoid found in Cannabis sativa, which has been proposed to be therapeutic against many conditions,…”
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The contribution of Na V 1.6 to the efficacy of voltage-gated sodium channel inhibitors in wild type and Na V 1.6 gain-of-function (GOF) mouse seizure control by Johnson, Jr, James P, Focken, Thilo, Karimi Tari, Parisa, Dube, Celine, Goodchild, Samuel J, Andrez, Jean-Christophe, Bankar, Girish, Burford, Kristen, Chang, Elaine, Chowdhury, Sultan, Christabel, Jessica, Dean, Richard, de Boer, Gina, Dehnhardt, Christoph, Gong, Wei, Grimwood, Michael, Hussainkhel, Angela, Jia, Qi, Khakh, Kuldip, Lee, Stephanie, Li, Jenny, Lin, Sophia, Lindgren, Andrea, Lofstrand, Verner, Mezeyova, Janette, Nelkenbrecher, Karen, Shuart, Noah Gregory, Sojo, Luis, Sun, Shaoyi, Waldbrook, Matthew, Wesolowski, Steven, Wilson, Michael, Xie, Zhiwei, Zenova, Alla, Zhang, Wei, Scott, Fiona L, Cutts, Alison J, Sherrington, Robin P, Winquist, Raymond, Cohen, Charles J, Empfield, James R

“…Inhibitors of voltage-gated sodium channels (Na s) are important anti-epileptic drugs, but the contribution of specific channel isoforms is unknown since…”
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The contribution of NaV1.6 to the efficacy of voltage‐gated sodium channel inhibitors in wild type and NaV1.6 gain‐of‐function (GOF) mouse seizure control by Johnson, James P., Focken, Thilo, Karimi Tari, Parisa, Dube, Celine, Goodchild, Samuel J., Andrez, Jean‐Christophe, Bankar, Girish, Burford, Kristen, Chang, Elaine, Chowdhury, Sultan, Christabel, Jessica, Dean, Richard, Boer, Gina, Dehnhardt, Christoph, Gong, Wei, Grimwood, Michael, Hussainkhel, Angela, Jia, Qi, Khakh, Kuldip, Lee, Stephanie, Li, Jenny, Lin, Sophia, Lindgren, Andrea, Lofstrand, Verner, Mezeyova, Janette, Nelkenbrecher, Karen, Shuart, Noah Gregory, Sojo, Luis, Sun, Shaoyi, Waldbrook, Matthew, Wesolowski, Steven, Wilson, Michael, Xie, Zhiwei, Zenova, Alla, Zhang, Wei, Scott, Fiona L., Cutts, Alison J., Sherrington, Robin P., Winquist, Raymond, Cohen, Charles J., Empfield, James R.

“…Background and Purpose Inhibitors of voltage‐gated sodium channels (NaVs) are important anti‐epileptic drugs, but the contribution of specific channel isoforms…”
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Identification of CNS-Penetrant Aryl Sulfonamides as Isoform-Selective NaV1.6 Inhibitors with Efficacy in Mouse Models of Epilepsy by Focken, Thilo, Burford, Kristen, Grimwood, Michael E, Zenova, Alla, Andrez, Jean-Christophe, Gong, Wei, Wilson, Michael, Taron, Matt, Decker, Shannon, Lofstrand, Verner, Chowdhury, Sultan, Shuart, Noah, Lin, Sophia, Goodchild, Samuel J, Young, Clint, Soriano, Maegan, Tari, Parisa K, Waldbrook, Matthew, Nelkenbrecher, Karen, Kwan, Rainbow, Lindgren, Andrea, de Boer, Gina, Lee, Stephanie, Sojo, Luis, DeVita, Robert J, Cohen, Charles J, Wesolowski, Steven S, Johnson, J. P, Dehnhardt, Christoph M, Empfield, James R

“…Nonselective antagonists of voltage-gated sodium (NaV) channels have been long used for the treatment of epilepsies. The efficacy of these drugs is thought to…”
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Molecular Pharmacology of Selective NaV1.6 and Dual NaV1.6/NaV1.2 Channel Inhibitors that Suppress Excitatory Neuronal Activity Ex Vivo by Goodchild, Samuel J., Shuart, Noah Gregory, Williams, Aaron D., Ye, Wenlei, Parrish, R. Ryley, Soriano, Maegan, Thouta, Samrat, Mezeyova, Janette, Waldbrook, Matthew, Dean, Richard, Focken, Thilo, Ghovanloo, Mohammad-Reza, Ruben, Peter C., Scott, Fiona, Cohen, Charles J., Empfield, James, Johnson, JP

“…Voltage-gated sodium channel (NaV) inhibitors are used to treat neurological disorders of hyperexcitability such as epilepsy. These drugs act by attenuating…”
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Small conductance calcium-activated potassium channels: from structure to function by Weatherall, Kate L, Goodchild, Samuel J, Jane, David E, Marrion, Neil V

“…The cloning of K(Ca)2 channels revealed three subtypes, with each displaying distinct but partially overlapping expression distributions in the mammalian CNS…”
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Identification of aryl sulfonamides as novel and potent inhibitors of NaV1.5 by Sun, Shaoyi, Jia, Qi, Zenova, Alla Y., Lin, Sophia, Hussainkhel, Angela, Mezeyova, Janette, Chang, Elaine, Goodchild, Samuel J., Xie, Zhiwei, Lindgren, Andrea, de Boer, Gina, Kwan, Rainbow, Khakh, Kuldip, Sojo, Luis, Bichler, Paul, Johnson, J.P., Empfield, James R., Cohen, Charles J., Dehnhardt, Christoph M., Dean, Richard

“…[Display omitted] •A series of novel aryl sulfonamide NaV1.5 inhibitors were described.•Compound (-)-6 is a potent NaV1.5 inhibitor with high selectivity over…”
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NBI-921352, a first-in-class, NaV1.6 selective, sodium channel inhibitor that prevents seizures in Scn8a gain-of-function mice, and wild-type mice and rats by Johnson, JP, Focken, Thilo, Khakh, Kuldip, Tari, Parisa Karimi, Dube, Celine, Goodchild, Samuel J, Andrez, Jean-Christophe, Bankar, Girish, Bogucki, David, Burford, Kristen, Chang, Elaine, Chowdhury, Sultan, Dean, Richard, de Boer, Gina, Decker, Shannon, Dehnhardt, Christoph, Feng, Mandy, Gong, Wei, Grimwood, Michael, Hasan, Abid, Hussainkhel, Angela, Jia, Qi, Lee, Stephanie, Li, Jenny, Lin, Sophia, Lindgren, Andrea, Lofstrand, Verner, Mezeyova, Janette, Namdari, Rostam, Nelkenbrecher, Karen, Shuart, Noah Gregory, Sojo, Luis, Sun, Shaoyi, Taron, Matthew, Waldbrook, Matthew, Weeratunge, Diana, Wesolowski, Steven, Williams, Aaron, Wilson, Michael, Xie, Zhiwei, Yoo, Rhena, Young, Clint, Zenova, Alla, Zhang, Wei, Cutts, Alison J, Sherrington, Robin P, Pimstone, Simon N, Winquist, Raymond, Cohen, Charles J, Empfield, James R

“…NBI-921352 (formerly XEN901) is a novel sodium channel inhibitor designed to specifically target Na V 1.6 channels. Such a molecule provides a…”
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Molecular Pharmacology of Selective Na V 1.6 and Dual Na V 1.6/Na V 1.2 Channel Inhibitors that Suppress Excitatory Neuronal Activity Ex Vivo by Goodchild, Samuel J, Shuart, Noah Gregory, Williams, Aaron D, Ye, Wenlei, Parrish, R Ryley, Soriano, Maegan, Thouta, Samrat, Mezeyova, Janette, Waldbrook, Matthew, Dean, Richard, Focken, Thilo, Ghovanloo, Mohammad-Reza, Ruben, Peter C, Scott, Fiona, Cohen, Charles J, Empfield, James, Johnson, J P

“…Voltage-gated sodium channel (Na ) inhibitors are used to treat neurological disorders of hyperexcitability such as epilepsy. These drugs act by attenuating…”
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