Search Results - "Good, Theresa A."

Protein folding and assembly in confined environments: Implications for protein aggregation in hydrogels and tissues by Simpson, Laura W., Good, Theresa A., Leach, Jennie B.

“…In the biological milieu of a cell, soluble crowding molecules and rigid confined environments strongly influence whether the protein is properly folded,…”
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Impact of Four Common Hydrogels on Amyloid‑β (Aβ) Aggregation and Cytotoxicity: Implications for 3D Models of Alzheimer’s Disease by Simpson, Laura W, Szeto, Gregory L, Boukari, Hacene, Good, Theresa A, Leach, Jennie B

“…The physiochemical properties of hydrogels utilized in 3D culture can be used to modulate cell phenotype and morphology with a striking resemblance to cellular…”
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Collagen hydrogel confinement of Amyloid-β (Aβ) accelerates aggregation and reduces cytotoxic effects by Simpson, Laura W., Szeto, Gregory L., Boukari, Hacene, Good, Theresa A., Leach, Jennie B.

“…Alzheimer's disease (AD) is the most common form of dementia and is associated with the accumulation of amyloid-β (Aβ), a peptide whose aggregation has been…”
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Role of aggregation conditions in structure, stability, and toxicity of intermediates in the Aβ fibril formation pathway by Lee, Sungmun, Fernandez, Erik J., Good, Theresa A.

“…β‐amyloid peptide (Aβ) is one of the main protein components of senile plaques associated with Alzheimer's disease (AD). Aβ readily aggregates to forms fibrils…”
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Nanofluidic Biosensing for β-Amyloid Detection Using Surface Enhanced Raman Spectroscopy by Chou, I-Hsien, Benford, Melodie, Beier, Hope T, Coté, Gerard L, Wang, Miao, Jing, Nan, Kameoka, Jun, Good, Theresa A

“…Trace detection of the conformational transition of β-amyloid peptide (Aβ) from a predominantly α-helical structure to β-sheet could have a large impact in…”
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Two Disaccharides and Trimethylamine N-Oxide Affect Aβ Aggregation Differently, but All Attenuate Oligomer-Induced Membrane Permeability by Qi, Wei, Zhang, Aming, Good, Theresa A, Fernandez, Erik J

“…Interaction between aggregates of amyloid beta protein (Aβ) and membranes has been hypothesized by many to be a key event in the mechanism of neurotoxicity…”
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The influence of phospholipid membranes on bovine calcitonin secondary structure and amyloid formation by Wang, Steven S.‐S., Good, Theresa A., Rymer, Dawn L.

“…Calcitonin, a peptide hormone associated with medullary carcinoma of the thyroid, has the potential to form amyloid fibrils and may be a valuable model for…”
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Pulsatile shear stress leads to DNA fragmentation in human SH-SY5Y neuroblastoma cell line by Triyoso, Dina H., Good, Theresa A.

“…Using an in vitro model of shear stress-induced cell injury we demonstrate that application of shear to differentiated human SH-SY5Y cells leads to cell death…”
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Structurally distinct toxicity inhibitors bind at common loci on β‐amyloid fibril by Keshet, Ben, Gray, Jeffrey J., Good, Theresa A.

“…The accumulation of aggregated β‐Amyloid (Aβ) in the brain is a hallmark of Alzheimer's disease and is thought to play a role in the neurotoxicity associated…”
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Modeling allosteric regulation of de novo pyrimidine biosynthesis in Escherichia coli by Rodríguez, Mauricio, Good, Theresa A., Wales, Melinda E., Hua, Jean P., Wild, James R.

“…With the emergence of multifaceted bioinformatics-derived data, it is becoming possible to merge biochemical and physiological information to develop a new…”
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The effect of oxidation on the mechanical response and microstructure of porcine aortas by Stephen, Elizabeth A., Venkatasubramaniam, Arundhathi, Good, Theresa A., Timmie Topoleski, L. D.

“…Reactive oxygen species (ROS), a product of many cellular functions, has been implicated in many age‐related pathophysiological processes, including…”
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The effect of glycation on arterial microstructure and mechanical response by Stephen, Elizabeth A., Venkatasubramaniam, Arundhathi, Good, Theresa A., Topoleski, L. D. T.

“…Like engineered materials, an artery's biomechanical behavior and function depend on its microstructure. Glycation is associated with both normal aging and…”
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Attenuation of β-amyloid-induced toxicity by sialic-acid-conjugated dendrimers: Role of sialic acid attachment by Patel, Dhara A, Henry, James E, Good, Theresa A

“…Abstract β-Amyloid (Aβ) is the primary protein component of senile plaques in Alzheimer's disease and is believed to be associated with neurotoxicity in the…”
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Can size alone explain some of the differences in toxicity between β-amyloid oligomers and fibrils by Keshet, Ben, Yang, In Hong, Good, Theresa A

“…β-Amyloid (Aβ) peptide is believed to play a key role in the mechanism of Alzheimer's disease (AD). Aβ tends to aggregate to form amyloid fibrils. A variety of…”
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Effect of β -amyloid Block of the Fast-Inactivating K+Channel on Intracellular Ca2+and Excitability in a Modeled Neuron by Good, Theresa A., Murphy, Regina M.

“…β -Amyloid peptide (Aβ ), one of the primary protein components of senile plaques found in Alzheimer disease, is believed to be toxic to neurons by a mechanism…”
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Simultaneous monitoring of peptide aggregate distributions, structure, and kinetics using amide hydrogen exchange: Application to Aβ(1-40) fibrillogenesis by Qi, Wei, Zhang, Aming, Patel, Dhara, Lee, Sungmun, Harrington, Jamie L, Zhao, Liming, Schaefer, David, Good, Theresa A, Fernandez, Erik J

“…Increasing evidence indicates that soluble aggregates of amyloid beta protein (Aβ) are neurotoxic. However, difficulty in isolating these unstable, dynamic…”
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Kinetic study of β-amyloid residue accessibility using reductive alkylation and mass spectrometry by Ramos, Irina, Fabris, Dan, Qi, Wei, Fernandez, Erik J, Good, Theresa A

“…Beta-amyloid peptide (Aβ) is the major protein constituent found in senile plaques in Alzheimer's disease (AD). It is believed that Aβ plays a role in…”
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Development of photocrosslinked sialic acid containing polymers for use in Aβ toxicity attenuation by Cowan, Christopher B, Coté, Gerard L, Good, Theresa A

“…Abstract β-Amyloid peptide (Aβ), the primary protein component in senile plaques associated with Alzheimer's disease (AD), has been implicated in neurotoxicity…”
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Application of Surface-Enhanced Raman Spectroscopy for Detection of Beta Amyloid Using Nanoshells by Beier, Hope T., Cowan, Christopher B., Chou, I-Hsien, Pallikal, James, Henry, James E., Benford, Melodie E., Jackson, Joseph B., Good, Theresa A., Coté, Gerard L.

“…Currently, no methods exist for the definitive diagnosis of AD premortem. β-amyloid, the primary component of the senile plaques found in patients with this…”
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Exploring the mechanism of β-amyloid toxicity attenuation by multivalent sialic acid polymers through the use of mathematical models by Cowan, Christopher B., Patel, Dhara A., Good, Theresa A.

“…β-Amyloid peptide (Aβ), the primary protein component in senile plaques associated with Alzheimer's disease (AD), has been implicated in neurotoxicity…”
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