Search Results - "Good, James"

State of the Art in Respiratory Syncytial Virus Drug Discovery and Development by Cockerill, G. Stuart, Good, James A. D, Mathews, Neil

“…Respiratory syncytial virus (RSV) is a globally prevalent viral infection with limited treatment options which hospitalizes millions each year. Treatment…”
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Persistence of asthma requires multiple feedback circuits involving type 2 innate lymphoid cells and IL-33 by Christianson, Christina A., PhD, Goplen, Nicholas P., MS, Zafar, Iram, MS, Irvin, Chaoyu, MS, Good, James T., MD, Rollins, Donald R., MD, Gorentla, Balachandra, PhD, Liu, Weimin, PhD, Gorska, Magdalena M., MD, PhD, Chu, HongWei, MD, Martin, Richard J., MD, Alam, Rafeul, MD, PhD

“…Background Asthma in a mouse model spontaneously resolves after cessation of allergen exposure. We developed a mouse model in which asthma features persisted…”
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Adhesive fiber stratification in uropathogenic Escherichia coli biofilms unveils oxygen-mediated control of type 1 pili by Floyd, Kyle A, Moore, Jessica L, Eberly, Allison R, Good, James A D, Shaffer, Carrie L, Zaver, Himesh, Almqvist, Fredrik, Skaar, Eric P, Caprioli, Richard M, Hadjifrangiskou, Maria

“…Bacterial biofilms account for a significant number of hospital-acquired infections and complicate treatment options, because bacteria within biofilms are…”
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The Effects of Airway Microbiome on Corticosteroid Responsiveness in Asthma by GOLEVA, Elena, JACKSON, Leisa P, KIRK HARRIS, J, ROBERTSON, Charles E, RAND SUTHERLAND, E, HALL, Clifton F, GOOD, James T, GELFAND, Erwin W, MARTIN, Richard J, LEUNG, Donald Y. M

“…The role of airway microbiome in corticosteroid response in asthma is unknown. To examine airway microbiome composition in patients with…”
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Discovery of Sisunatovir (RV521), an Inhibitor of Respiratory Syncytial Virus Fusion by Cockerill, G. Stuart, Angell, Richard M, Bedernjak, Alexandre, Chuckowree, Irina, Fraser, Ian, Gascon-Simorte, Jose, Gilman, Morgan S. A, Good, James A. D, Harland, Rachel, Johnson, Sara M, Ludes-Meyers, John H, Littler, Edward, Lumley, James, Lunn, Graham, Mathews, Neil, McLellan, Jason S, Paradowski, Michael, Peeples, Mark E, Scott, Claire, Tait, Dereck, Taylor, Geraldine, Thom, Michelle, Thomas, Elaine, Villalonga Barber, Carol, Ward, Simon E, Watterson, Daniel, Williams, Gareth, Young, Paul, Powell, Kenneth

“…RV521 is an orally bioavailable inhibitor of respiratory syncytial virus (RSV) fusion that was identified after a lead optimization process based upon hits…”
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Mechanism of Th2/Th17-predominant and Neutrophilic, Th2/Th17-low Subtypes of Asthma by Liu, Weimin, Liu, Sucai, Verma, Mukesh, Zafar, Iram, Good, James T, Rollins, Donald, Groshong, Stephen, Gorska, Magdalena M, Martin, Richard J, Alam, Rafeul

“…Abstract Background The mechanism of Th2/Th17-predominant and Th2/Th17-low asthma is unknown. Objective To study the immune mechanism of Th2/Th17-predominant…”
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Thiazolino 2‑Pyridone Amide Inhibitors of Chlamydia trachomatis Infectivity by Good, James A. D, Silver, Jim, Núñez-Otero, Carlos, Bahnan, Wael, Krishnan, K. Syam, Salin, Olli, Engström, Patrik, Svensson, Richard, Artursson, Per, Gylfe, Åsa, Bergström, Sven, Almqvist, Fredrik

“…The bacterial pathogen Chlamydia trachomatis is a global health burden currently treated with broad-spectrum antibiotics which disrupt commensal bacteria. We…”
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Steroid resistance of airway type 2 innate lymphoid cells from patients with severe asthma: The role of thymic stromal lymphopoietin by Liu, Sucai, PhD, Verma, Mukesh, PhD, Michalec, Lidia, PhD, Liu, Weimin, PhD, Sripada, Anand, PhD, Rollins, Donald, MD, Good, James, MD, Ito, Yoko, PhD, Chu, HongWei, PhD, Gorska, Magdalena M., MD, PhD, Martin, Richard J., MD, Alam, Rafeul, MD, PhD

“…Background Type 2 innate lymphoid cells (ILC2s) represent an important type 2 immune cell. Glucocorticoid regulation of human ILC2s is largely unknown…”
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Durvalumab for recurrent or metastatic head and neck squamous cell carcinoma: Results from a single-arm, phase II study in patients with ≥25% tumour cell PD-L1 expression who have progressed on platinum-based chemotherapy by Zandberg, Dan P., Algazi, Alain P., Jimeno, Antonio, Good, James S., Fayette, Jérôme, Bouganim, Nathaniel, Ready, Neal E., Clement, Paul M., Even, Caroline, Jang, Raymond W., Wong, Stuart, Keilholz, Ulrich, Gilbert, Jill, Fenton, Moon, Braña, Irene, Henry, Stephanie, Remenar, Eva, Papai, Zsuzsanna, Siu, Lillian L., Jarkowski, Anthony, Armstrong, Jon M., Asubonteng, Kobby, Fan, Jean, Melillo, Giovanni, Mesía, Ricard

“…Patients with recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC) progressing on platinum-based chemotherapy have poor prognoses and limited…”
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Thiazolino 2‑Pyridone Amide Isosteres As Inhibitors of Chlamydia trachomatis Infectivity by Good, James A. D, Kulén, Martina, Silver, Jim, Krishnan, K. Syam, Bahnan, Wael, Núñez-Otero, Carlos, Nilsson, Ingela, Wede, Emma, de Groot, Esmee, Gylfe, Åsa, Bergström, Sven, Almqvist, Fredrik

“…Chlamydia trachomatis is a global health burden due to its prevalence as a sexually transmitted disease and as the causative agent of the eye infection…”
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Chemical disarming of isoniazid resistance in Mycobacterium tuberculosis by Flentie, Kelly, Harrison, Gregory A., Tükenmez, Hasan, Livny, Jonathan, Good, James A. D., Sarkar, Souvik, Zhu, Dennis X., Kinsella, Rachel L., Weiss, Leslie A., Solomon, Samantha D., Schene, Miranda E., Hansen, Mette R., Cairns, Andrew G., Kulén, Martina, Wixe, Torbjörn, Lindgren, Anders E. G., Chorell, Erik, Bengtsson, Christoffer, Krishnan, K. Syam, Hultgren, Scott J., Larsson, Christer, Almqvist, Fredrik, Stallings, Christina L.

“…Mycobacterium tuberculosis (Mtb) killed more people in 2017 than any other single infectious agent. This dangerous pathogen is able to withstand stresses…”
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Impact of winding on nanoimprinted surfaces in roll‐to‐roll nanoimprint lithography by Jambhapuram, Manogna, Good, James K., Azoug, Aurélie

“…Roll‐to‐Roll manufacturing aims at scaling ultraviolet‐ and thermally cured nanoimprint lithography (UV‐NIL, T‐NIL) to commercial production speeds and…”
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Design, Synthesis, and Evaluation of Novel Δ2‑Thiazolino 2‑Pyridone Derivatives That Potentiate Isoniazid Activity in an Isoniazid-Resistant Mycobacterium tuberculosis Mutant by Sarkar, Souvik, Mayer Bridwell, Anne E., Good, James A. D., Wang, Erin R., McKee, Samuel R., Valenta, Joy, Harrison, Gregory A., Flentie, Kelly N., Henry, Frederick L., Wixe, Torbjörn, Demirel, Peter, Vagolu, Siva K., Chatagnon, Jonathan, Machelart, Arnaud, Brodin, Priscille, Tønjum, Tone, Stallings, Christina L., Almqvist, Fredrik

“…Mycobacterium tuberculosis (Mtb) drug resistance poses an alarming threat to global tuberculosis control. We previously reported that C10, a ring-fused…”
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Airway and serum biochemical correlates of refractory neutrophilic asthma by Alam, Rafeul, MD, PhD, Good, James, MD, Rollins, Donald, MD, Verma, Mukesh, PhD, Chu, HongWei, MD, Pham, Tuyet-Hang, MT, Martin, Richard J., MD

“…Background Despite progress in the diagnosis and management of asthma, many patients have poorly controlled or refractory asthma (RA). The mechanism of this RA…”
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Gefapixant, a P2X3 receptor antagonist, for the treatment of refractory or unexplained chronic cough: a randomised, double-blind, controlled, parallel-group, phase 2b trial by Smith, Jaclyn A, Kitt, Michael M, Morice, Alyn H, Birring, Surinder S, McGarvey, Lorcan P, Sher, Mandel R, Li, Yu-Ping, Wu, Wen-Chi, Xu, Zhi Jin, Muccino, David R, Ford, Anthony P, Smith, Jaclyn, McGarvey, Lorcan, Birring, Surinder, Hull, James, Carr, Warner W, Goldsobel, Alan B, Gross, Gary N, Holcomb, John R, Hussain, Iftikhar, Sher, Mandel, Spangenthal, Selwyn, Storms, William, Morice, Alyn, Elkayam, David, Steven, Gary C, Krainson, James, Fakih, Faisal Alfonso, Matz, Jonathan, Brooks, Gregory Daniel, Casale, Thomas, Berman, Gary D, Condemi, John J, Greos, Leon S, Gogate, Shaila U, Sher, Ellen R, Friesen, Jason H, Schenkel, Eric J, Bernstein, David Isaac, Corren, Jonathan, Sundar, Krishna, Gotfried, Mark H, Montanaro, Anthony, Lumry, William R, Amar, Niran J, Kaplan, Michael S, Prenner, Bruce M, Murphy, Thomas R, Good, James S, Parker, Sean, Harrison, Tim, Pavord, Ian, Brightling, Christopher, Djukanovic, Ratko, McQuaid, Douglas, Denenberg, Michael, Ettinger, Neil A, Iyer, Vivek

“…Gefapixant is a P2X3 receptor antagonist that has shown promise for the treatment of refractory and unexplained chronic cough. The aim of this study was to…”
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Triphenylbutanamines: Kinesin Spindle Protein Inhibitors with in Vivo Antitumor Activity by Wang, Fang, Good, James A. D, Rath, Oliver, Kaan, Hung Yi Kristal, Sutcliffe, Oliver B, Mackay, Simon P, Kozielski, Frank

“…The human mitotic kinesin Eg5 represents a novel mitotic spindle target for cancer chemotherapy. We previously identified S-trityl-l-cysteine (STLC) and…”
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Attenuating Listeria monocytogenes Virulence by Targeting the Regulatory Protein PrfA by Good, James A D, Andersson, Christopher, Hansen, Sabine, Wall, Jessica, Krishnan, K Syam, Begum, Afshan, Grundström, Christin, Niemiec, Moritz S, Vaitkevicius, Karolis, Chorell, Erik, Wittung-Stafshede, Pernilla, Sauer, Uwe H, Sauer-Eriksson, A Elisabeth, Almqvist, Fredrik, Johansson, Jörgen

“…The transcriptional activator PrfA, a member of the Crp/Fnr family, controls the expression of some key virulence factors necessary for infection by the human…”
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Optimized S‑Trityl‑l‑cysteine-Based Inhibitors of Kinesin Spindle Protein with Potent in Vivo Antitumor Activity in Lung Cancer Xenograft Models by Good, James A. D, Wang, Fang, Rath, Oliver, Kaan, Hung Yi Kristal, Talapatra, Sandeep K, Podgórski, Dawid, MacKay, Simon P, Kozielski, Frank

“…The mitotic kinesin Eg5 is critical for the assembly of the mitotic spindle and is a promising chemotherapy target. Previously, we identified…”
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New insights in the diagnosis of chronic refractory cough by Good, James T., Rollins, Donald R., Kolakowski, Christena A., Stevens, Allen D., Denson, Joshua L., Martin, Richard J.

“…Chronic Refractory Cough (CRC) is a common condition that significantly impairs patients' quality of life. Unfortunately, in many situations patients continue…”
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Optimal identification of human conventional and nonconventional (CRTH2–IL7Rα–) ILC2s using additional surface markers by Liu, Sucai, Sirohi, Kapil, Verma, Mukesh, McKay, Jerome, Michalec, Lidia, Sripada, Anand, Danhorn, Tomas, Rollins, Donald, Good, James, Gorska, Magdalena M., Martin, Richard J., Alam, Rafeul

“…Human type 2 innate lymphoid cells (ILC2s) are identified by coupled detection of CRTH2 and IL7Rα on lineage negative (Lin–) cells. Type 2 cytokine production…”
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