Search Results - "Goo, Leslie"

Early development of broadly neutralizing antibodies in HIV-1–infected infants by Goo, Leslie, Chohan, Vrasha, Nduati, Ruth, Overbaugh, Julie

“…Antibodies capable of neutralizing a broad array of HIV-1 viral isolates from different clades have been isolated from some chronically infected individuals,…”
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Broadly Neutralizing Activity of Zika Virus-Immune Sera Identifies a Single Viral Serotype by Dowd, Kimberly A., DeMaso, Christina R., Pelc, Rebecca S., Speer, Scott D., Smith, Alexander R.Y., Goo, Leslie, Platt, Derek J., Mascola, John R., Graham, Barney S., Mulligan, Mark J., Diamond, Michael S., Ledgerwood, Julie E., Pierson, Theodore C.

“…Recent epidemics of Zika virus (ZIKV) have been associated with congenital malformation during pregnancy and Guillain-Barré syndrome. There are two ZIKV…”
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A single mutation in the envelope protein modulates flavivirus antigenicity, stability, and pathogenesis by Goo, Leslie, VanBlargan, Laura A, Dowd, Kimberly A, Diamond, Michael S, Pierson, Theodore C

“…The structural flexibility or 'breathing' of the envelope (E) protein of flaviviruses allows virions to sample an ensemble of conformations at equilibrium. The…”
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A Virus-Like Particle Vaccine Elicits Broad Neutralizing Antibody Responses in Humans to All Chikungunya Virus Genotypes by Goo, Leslie, Dowd, Kimberly A., Lin, Tsai-Yu, Mascola, John R., Graham, Barney S., Ledgerwood, Julie E., Pierson, Theodore C.

“…Chikungunya virus (CHIKV) is an alphavirus that has emerged as a global health burden. There are 3 CHIKV genotypes: Asian, West African, and…”
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A (class-)switch in the antibody response may distinguish primary from secondary dengue virus infection by Levoir, Lisa, Goo, Leslie

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Defining the impact of flavivirus envelope protein glycosylation site mutations on sensitivity to broadly neutralizing antibodies by Contreras, Maya, Stuart, Jackson B, Levoir, Lisa M, Belmont, Laura, Goo, Leslie

“…Antibodies targeting an envelope dimer epitope (EDE) cross-neutralize Zika virus (ZIKV) and dengue virus (DENV) and have thus inspired an epitope-focused…”
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Single B cell transcriptomics identifies multiple isotypes of broadly neutralizing antibodies against flaviviruses by Lubow, Jay, Levoir, Lisa M, Ralph, Duncan K, Belmont, Laura, Contreras, Maya, Cartwright-Acar, Catiana H, Kikawa, Caroline, Kannan, Shruthi, Davidson, Edgar, Duran, Veronica, Rebellon-Sanchez, David E, Sanz, Ana M, Rosso, Fernando, Doranz, Benjamin J, Einav, Shirit, Matsen Iv, Frederick A, Goo, Leslie

“…Sequential dengue virus (DENV) infections often generate neutralizing antibodies against all four DENV serotypes and sometimes, Zika virus. Characterizing…”
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Broadly neutralizing human antibodies against dengue virus identified by single B cell transcriptomics by Durham, Natasha D, Agrawal, Aditi, Waltari, Eric, Croote, Derek, Zanini, Fabio, Fouch, Mallorie, Davidson, Edgar, Smith, Olivia, Carabajal, Esteban, Pak, John E, Doranz, Benjamin J, Robinson, Makeda, Sanz, Ana M, Albornoz, Ludwig L, Rosso, Fernando, Einav, Shirit, Quake, Stephen R, McCutcheon, Krista M, Goo, Leslie

“…Eliciting broadly neutralizing antibodies (bNAbs) against the four dengue virus serotypes (DENV1-4) that are spreading into new territories is an important…”
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Zika Virus Is Not Uniquely Stable at Physiological Temperatures Compared to Other Flaviviruses by Goo, Leslie, Dowd, Kimberly A, Smith, Alexander R Y, Pelc, Rebecca S, DeMaso, Christina R, Pierson, Theodore C

“…Zika virus (ZIKV) is a flavivirus that has emerged as a global health threat due in part to its association with congenital abnormalities. Other globally…”
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Neutralizing Antibody Escape during HIV-1 Mother-to-Child Transmission Involves Conformational Masking of Distal Epitopes in Envelope by GOO, Leslie, MILLIGAN, Caitlin, SIMONICH, Cassandra A, NDUATI, Ruth, OVERBAUGH, Julie

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A Combination of Broadly Neutralizing HIV-1 Monoclonal Antibodies Targeting Distinct Epitopes Effectively Neutralizes Variants Found in Early Infection by GOO, Leslie, JALALIAN-LECHAK, Zahra, RICHARDSON, Barbra A, OVERBAUGH, Julie

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HIV-1 maternal and infant variants show similar sensitivity to broadly neutralizing antibodies, but sensitivity varies by subtype by MABUKA, Jennifer, GOO, Leslie, OMENDA, Maxwel M, NDUATI, Ruth, OVERBAUGH, Julie

“…To protect against HIV infection, passively transferred and/or vaccine-elicited neutralizing antibodies (NAbs) need to effectively target diverse subtypes that…”
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Effects of Identity Minimization on Moloney Murine Leukemia Virus Template Recognition and Frequent Tertiary Template-Directed Insertions during Nonhomologous Recombination by DUGGAL, Nisha K, GOO, Leslie, KING, Steven R, TELESNITSKY, Alice

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Deconstructing the Antiviral Neutralizing-Antibody Response: Implications for Vaccine Development and Immunity by VanBlargan, Laura A, Goo, Leslie, Pierson, Theodore C

“…The antibody response plays a key role in protection against viral infections. While antiviral antibodies may reduce the viral burden via several mechanisms,…”
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Virus-inclusive single-cell RNA sequencing reveals the molecular signature of progression to severe dengue by Zanini, Fabio, Robinson, Makeda L., Croote, Derek, Sahoo, Malaya Kumar, Sanz, Ana Maria, Ortiz-Lasso, Eliana, Albornoz, Ludwig Luis, Rosso, Fernando, Montoya, Jose G., Goo, Leslie, Pinsky, Benjamin A., Quake, Stephen R., Einav, Shirit

“…Dengue virus (DENV) infection can result in severe complications. However, the understanding of the molecular correlates of severity is limited, partly due to…”
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HIV-1 neutralizing antibodies induced by native-like envelope trimers by Sanders, Rogier W., van Gils, Marit J., Derking, Ronald, Sok, Devin, Ketas, Thomas J., Burger, Judith A., Ozorowski, Gabriel, Cupo, Albert, Simonich, Cassandra, Goo, Leslie, Arendt, Heather, Kim, Helen J., Lee, Jeong Hyun, Pugach, Pavel, Williams, Melissa, Debnath, Gargi, Moldt, Brian, van Breemen, Mariëlle J., Isik, Gözde, Medina-Ramírez, Max, Back, Jaap Willem, Koff, Wayne C., Julien, Jean-Philippe, Rakasz, Eva G., Seaman, Michael S., Guttman, Miklos, Lee, Kelly K., Klasse, Per Johan, LaBranche, Celia, Schief, William R., Wilson, Ian A., Overbaugh, Julie, Burton, Dennis R., Ward, Andrew B., Montefiori, David C., Dean, Hansi, Moore, John P.

“…Steps in the right direction HIV-1 mutates rapidly, making it difficult to design a vaccine that will protect people against all of the virus' iterations. A…”
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The effect of single mutations in Zika virus envelope on escape from broadly neutralizing antibodies by Kikawa, Caroline, Cartwright-Acar, Catiana H, Stuart, Jackson B, Contreras, Maya, Levoir, Lisa M, Evans, Matthew J, Bloom, Jesse D, Goo, Leslie

“…The wide endemic range of mosquito-vectored flaviviruses-such as Zika virus and dengue virus serotypes 1-4-places hundreds of millions of people at risk of…”
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The Zika virus envelope protein glycan loop regulates virion antigenicity by Goo, Leslie, DeMaso, Christina R., Pelc, Rebecca S., Ledgerwood, Julie E., Graham, Barney S., Kuhn, Richard J., Pierson, Theodore C.

“…Because antibodies are an important component of flavivirus immunity, understanding the antigenic structure of flaviviruses is critical. Compared to dengue…”
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Dengue virus: Bumps in the road to therapeutic antibodies by Goo, Leslie, Pierson, Theodore C

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Bumps in the road to therapeutic antibodies by Goo, Leslie, Pierson, Theodore C.

“…A human antibody against dengue virus serotype 2 has been shown to protect mice against disease. Structures of the antibody bound to the virus illuminate how…”
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