Search Results - "Gonzalvez, François"

Barth syndrome: Cellular compensation of mitochondrial dysfunction and apoptosis inhibition due to changes in cardiolipin remodeling linked to tafazzin (TAZ) gene mutation by Gonzalvez, François, D'Aurelio, Marilena, Boutant, Marie, Moustapha, Aoula, Puech, Jean-Philippe, Landes, Thomas, Arnauné-Pelloquin, Laeticia, Vial, Guillaume, Taleux, Nellie, Slomianny, Christian, Wanders, Ronald J., Houtkooper, Riekelt H., Bellenguer, Pascale, Møller, Ian Max, Gottlieb, Eyal, Vaz, Frederic M., Manfredi, Giovanni, Petit, Patrice X.

“…Cardiolipin is a mitochondrion-specific phospholipid that stabilizes the assembly of respiratory chain complexes, favoring full-yield operation. It also…”
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Caspase-8 binding to cardiolipin in giant unilamellar vesicles provides a functional docking platform for bid by Jalmar, Olivier, François-Moutal, Liberty, García-Sáez, Ana-Jesus, Perry, Mark, Granjon, Thierry, Gonzalvez, François, Gottlieb, Eyal, Ayala-Sanmartin, Jesus, Klösgen, Beate, Schwille, Petra, Petit, Patrice X

“…Caspase-8 is involved in death receptor-mediated apoptosis in type II cells, the proapoptotic programme of which is triggered by truncated Bid. Indeed,…”
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Mechanistic issues of the interaction of the hairpin-forming domain of tBid with mitochondrial cardiolipin by Gonzalvez, François, Pariselli, Fabrizio, Jalmar, Olivier, Dupaigne, Pauline, Sureau, Franck, Dellinger, Marc, Hendrickson, Eric A, Bernard, Sophie, Petit, Patrice X

“…The pro-apoptotic effector Bid induces mitochondrial apoptosis in synergy with Bax and Bak. In response to death receptors activation, Bid is cleaved by…”
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Cardiolipin: Setting the beat of apoptosis by Gonzalvez, François, Gottlieb, Eyal

“…Cardiolipin (CL) is a mitochondria-specific phospholipid which is known to be intimately linked with the mitochondrial bioenergetic machinery. Accumulating…”
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Acquisition of a single EZH2 D1 domain mutation confers acquired resistance to EZH2-targeted inhibitors by Baker, Theresa, Nerle, Sujata, Pritchard, Justin, Zhao, Boyang, Rivera, Victor M, Garner, Andrew, Gonzalvez, Francois

“…Although targeted therapies have revolutionized cancer treatment, overcoming acquired resistance remains a major clinical challenge. EZH2 inhibitors (EZH2i),…”
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Cardiolipin provides an essential activating platform for caspase-8 on mitochondria by Gonzalvez, Francois, Schug, Zachary T, Houtkooper, Riekelt H, MacKenzie, Elaine D, Brooks, David G, Wanders, Ronald J.A, Petit, Patrice X, Vaz, Frédéric M, Gottlieb, Eyal

“…Cardiolipin is a mitochondria-specific phospholipid known to be intimately involved with apoptosis. However, the lack of appropriate cellular models to date…”
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Tumor Regression upon Intratumoral and Subcutaneous Dosing of the STING Agonist ALG-031048 in Mouse Efficacy Models by Jekle, Andreas, Thatikonda, Santosh Kumar, Jaisinghani, Ruchika, Ren, Suping, Kinkade, April, Stevens, Sarah K, Stoycheva, Antitsa, Rajwanshi, Vivek K, Williams, Caroline, Deval, Jerome, Mukherjee, Sucheta, Zhang, Qingling, Chanda, Sushmita, Smith, David B, Blatt, Lawrence M, Symons, Julian A, Gonzalvez, Francois, Beigelman, Leonid

“…Stimulator of interferon genes (STING) agonists have shown potent anti-tumor efficacy in various mouse tumor models and have the potential to overcome…”
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Interaction of the alpha-helical H6 peptide from the pro-apoptotic protein tBid with cardiolipin by Petit, Patrice X, Dupaigne, Pauline, Pariselli, Fabrizio, Gonzalvez, François, Etienne, François, Rameau, Carole, Bernard, Sophie

“…BH3 interacting domain death agonist (Bid), a pro-apoptotic member of the Bcl-2 family of proteins, is activated through cleavage by caspase-8. The active…”
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Abstract 2644: AP32788, a potent, selective inhibitor of EGFR and HER2 oncogenic mutants, including exon 20 insertions, in preclinical models by Gonzalvez, Francois, Zhu, Xiaotian, Huang, Wei-Sheng, Baker, Theresa E., Ning, Yaoyu, Wardwell, Scott D., Nadworny, Sara, Zhang, Sen, Das, Biplab, Gong, Yongjin, Greenfield, Matthew T., Jang, Hyun G., Kohlmann, Anna, Li, Feng, Taslimi, Paul M., Tugnait, Meera, Xu, Yongjin, Ye, Emily Y., Youngsaye, Willmen W., Zech, Stephan G., Zhang, Yun, Zhou, Tianjun, Narasimhan, Narayana I., Dalgarno, David C., Shakespeare, William C., Rivera, Victor M.

“…In non-small cell lung cancer (NSCLC), multiple classes of activating mutations have been identified in EGFR and HER2 that vary widely in their sensitivity to…”
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Mobocertinib (TAK-788): A Targeted Inhibitor of EGFR Exon 20 Insertion Mutants in Non-Small Cell Lung Cancer by Gonzalvez, Francois, Vincent, Sylvie, Baker, Theresa E, Gould, Alexandra E, Li, Shuai, Wardwell, Scott D, Nadworny, Sara, Ning, Yaoyu, Zhang, Sen, Huang, Wei-Sheng, Hu, Yongbo, Li, Feng, Greenfield, Matthew T, Zech, Stephan G, Das, Biplab, Narasimhan, Narayana I, Clackson, Tim, Dalgarno, David, Shakespeare, William C, Fitzgerald, Michael, Chouitar, Johara, Griffin, Robert J, Liu, Shengwu, Wong, Kwok-Kin, Zhu, Xiaotian, Rivera, Victor M

“…Most exon 20 insertion ( ex20ins) driver mutations in non-small cell lung cancer (NSCLC) are insensitive to approved EGFR tyrosine kinase inhibitors (TKI). To…”
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TRAF2 Sets a Threshold for Extrinsic Apoptosis by Tagging Caspase-8 with a Ubiquitin Shutoff Timer by Gonzalvez, Francois, Lawrence, David, Yang, Becky, Yee, Sharon, Pitti, Robert, Marsters, Scot, Pham, Victoria C., Stephan, Jean-Philippe, Lill, Jennie, Ashkenazi, Avi

“…Apoptotic caspase activation mechanisms are well defined, yet inactivation modes remain unclear. The death receptors (DRs), DR4, DR5, and Fas, transduce…”
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Targeting HER2 Exon 20 Insertion-Mutant Lung Adenocarcinoma with a Novel Tyrosine Kinase Inhibitor Mobocertinib by Han, Han, Li, Shuai, Chen, Ting, Fitzgerald, Michael, Liu, Shengwu, Peng, Chengwei, Tang, Kwan Ho, Cao, Shougen, Chouitar, Johara, Wu, Jiansheng, Peng, David, Deng, Jiehui, Gao, Zhendong, Baker, Theresa E, Li, Fei, Zhang, Hua, Pan, Yuanwang, Ding, Hailin, Hu, Hai, Pyon, Val, Thakurdin, Cassandra, Papadopoulos, Eleni, Tang, Sittinon, Gonzalvez, Francois, Chen, Haiquan, Rivera, Victor M, Brake, Rachael, Vincent, Sylvie, Wong, Kwok-Kin

“…No targeted treatments are currently approved for exon 20 insertion-mutant lung adenocarcinoma patients. Mobocertinib (TAK-788) is a potent irreversible…”
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Preclinical pharmacokinetic, pharmacodynamic and efficacy relationships of ALG-093702, a liver targeted PD-L1 small molecule inhibitor, in different in vivo models by Roose, Heleen, Zhang, Qingling, Le, Kha, Jekle, Andreas, Rekstyte-Matiene, Kristina, Stevens, Sarah, Jaisinghani, Ruchika, Liu, Cheng, Chang, Sandra, Stoycheva, Antitsa, Blatt, Lawrence, Beigelman, Leonid, Symons, Julian, Chanda, Sushmita, Gonzalvez, Francois, Wu, Tongfei

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FRI-241 - Preclinical pharmacokinetic, pharmacodynamic and efficacy relationships of ALG-093702, a liver targeted PD-L1 small molecule inhibitor, in different in vivo models by Roose, Heleen, Zhang, Qingling, Le, Kha, Jekle, Andreas, Rekstyte-Matiene, Kristina, Stevens, Sarah, Jaisinghani, Ruchika, Liu, Cheng, Chang, Sandra, Stoycheva, Antitsa, Blatt, Lawrence, Beigelman, Leonid, Symons, Julian, Chanda, Sushmita, Gonzalvez, Francois, Wu, Tongfei

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Discovery of oral PDL1 small molecule inhibitors specifically designed for the treatment of chronic hepatitis B by Wu, Tongfei, Stevens, Sarah, Liu, Cheng, Rekstyte-Matiene, Kristina, Behaeghel, Elke, Mukherjee, Sucheta, Chang, Sandra, Jaisinghani, Ruchika, Stoycheva, Antitsa, Jekle, Andreas, Zhang, Qingling, Gupta, Kusum, Deval, Jerome, Symons, Julian, Blatt, Lawrence, Beigelman, Leonid, Raboisson, Pierre, Gonzalvez, Francois

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Abstract 1758: Discovery of novel potent and selective inhibitors of PRMT5 with anti-tumor activity in hepatocellular carcinoma and lung pre-clinical models by Gonzalvez, Francois, Vandyck, Koen, Debing, Yannick, Gupta, Kusum, Misner, Dinah, Zhang, Qingling, Liu, Jyanwei, Stoycheva, Antitsa, Stevens, Sarah, Symons, Julian, Beigelman, Leonid, Raboisson, Pierre, Deval, Jerome

“…Protein arginine methyltransferase-5 (PRMT5) regulates many essential biological processes by catalyzing the symmetric di-methylation of arginine (sDMA) on a…”
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BID is cleaved by caspase-8 within a native complex on the mitochondrial membrane by Schug, Z T, Gonzalvez, F, Houtkooper, R H, Vaz, F M, Gottlieb, E

“…Caspase-8 stably inserts into the mitochondrial outer membrane during extrinsic apoptosis. Inhibition of caspase-8 enrichment on the mitochondria impairs…”
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Abstract 4520: Preclinical characterization of ALG-031048, a novel STING agonist with potent anti-tumor activity in mice by Jekle, Andreas, Thatikonda, Santosh, Stevens, Sarah, Williams, Caroline, Kinkade, April, Ren, Suping, Jaisinghani, Ruchika, Zhang, Qingling, Misner, Dinah, Stoycheva, Antitsa, Deval, Jerome, Mukherjee, Sucheta, Gonzalvez, Francois, Chanda, Sushmita, Smith, David B., Symons, Julian A., Blatt, Lawrence M., Beigelman, Leonid

“…Introduction: The STING (STimulator of INterferon Genes) protein has been identified as an attractive target for cancer immunotherapy due to its central role…”
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Discovery of mobocertinib, a potent, oral inhibitor of EGFR exon 20 insertion mutations in non–small cell lung cancer by Huang, Wei-Sheng, Li, Feng, Gong, Yongjin, Zhang, Yun, Youngsaye, Willmen, Xu, Yongjin, Zhu, Xiaotian, Greenfield, Matthew T., Kohlmann, Anna, Taslimi, Paul M., Toms, Angela, Zech, Stephan G., Zhou, Tianjun, Das, Biplab, Jang, Hyun G., Tugnait, Meera, Ye, Yihua E., Gonzalvez, Francois, Baker, Theresa E., Nadworny, Sara, Ning, Yaoyu, Wardwell, Scott D., Zhang, Sen, Gould, Alexandra E., Hu, Yongbo, Lane, Weston, Skene, Robert J., Zou, Hua, Clackson, Tim, Narasimhan, Narayana I., Rivera, Victor M., Dalgarno, David C., Shakespeare, William C.

“…[Display omitted] In the treatment of non–small cell lung cancer (NSCLC), patients harboring exon 20 insertion mutations in the epidermal growth factor…”
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Abstract 3597: EZH2 D1 domain mutants confer acquired resistance to EZH2-targeted inhibitors and reprogram B-cell transcription by Gonzalvez, Francois, Baker, Theresa, Pritchard, Justin, Rivera, Victor M., Garner, Andrew

“…Aberrant epigenetic changes play an important role in the onset and progression of numerous tumor types, and targeting enzymes that regulate these processes…”
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