Search Results - "Gonzalez Suarez, Eva"

Constitutive activation of RANK disrupts mammary cell fate leading to tumorigenesis by Pellegrini, Pasquale, Cordero, Alex, Gallego, Marta Ines, Dougall, William C., Purificación, Muñoz, Pujana, Miguel Angel, Gonzalez‐Suarez, Eva

“…Receptor Activator of NF‐kappa B (RANK) pathway controls mammary gland development in mice but its role in mammary stem cell fate remains undefined. We show…”
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RANK is a poor prognosis marker and a therapeutic target in ER‐negative postmenopausal breast cancer by Ciscar, Marina, Trinidad, Eva M, Perez‐Chacon, Gema, Alsaleem, Mansour, Jimenez, Maria, Jimenez‐Santos, Maria J, Perez‐Montoyo, Hector, Sanz‐Moreno, Adrian, Vethencourt, Andrea, Toss, Michael, Petit, Anna, Soler‐Monso, Maria T, Lopez, Victor, Gomez‐Miragaya, Jorge, Gomez‐Aleza, Clara, Dobrolecki, Lacey E, Lewis, Michael T, Bruna, Alejandra, Mouron, Silvana, Quintela‐Fandino, Miguel, Al‐Shahrour, Fatima, Martinez‐Aranda, Antonio, Sierra, Angels, Green, Andrew R, Rakha, Emad, Gonzalez‐Suarez, Eva

“…Despite strong preclinical data, the therapeutic benefit of the RANKL inhibitor, denosumab, in breast cancer patients, beyond the bone, is unclear. Aiming to…”
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Linkage of DNA Methylation Quantitative Trait Loci to Human Cancer Risk by Heyn, Holger, Sayols, Sergi, Moutinho, Catia, Vidal, Enrique, Sanchez-Mut, Jose V., Stefansson, Olafur A., Nadal, Ernest, Moran, Sebastian, Eyfjord, Jorunn E., Gonzalez-Suarez, Eva, Pujana, Miguel Angel, Esteller, Manel

“…Epigenetic regulation and, in particular, DNA methylation have been linked to the underlying genetic sequence. DNA methylation quantitative trait loci (meQTL)…”
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Bromodomain inhibition shows antitumoral activity in mice and human luminal breast cancer by Pérez-Salvia, Montserrat, Simó-Riudalbas, Laia, Llinàs-Arias, Pere, Roa, Laura, Setien, Fernando, Soler, Marta, de Moura, Manuel Castro, Bradner, James E, Gonzalez-Suarez, Eva, Moutinho, Catia, Esteller, Manel

“…BET bromodomain inhibitors, which have an antitumoral effect against various solid cancer tumor types, have not been studied in detail in luminal breast…”
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RANKL/RANK control Brca1 mutation-driven mammary tumors by Sigl, Verena, Owusu-Boaitey, Kwadwo, Joshi, Purna A, Kavirayani, Anoop, Wirnsberger, Gerald, Novatchkova, Maria, Kozieradzki, Ivona, Schramek, Daniel, Edokobi, Nnamdi, Hersl, Jerome, Sampson, Aishia, Odai-Afotey, Ashley, Lazaro, Conxi, Gonzalez-Suarez, Eva, Pujana, Miguel A, CIMBA, for, Heyn, Holger, Vidal, Enrique, Cruickshank, Jennifer, Berman, Hal, Sarao, Renu, Ticevic, Melita, Uribesalgo, Iris, Tortola, Luigi, Rao, Shuan, Tan, Yen, Pfeiler, Georg, Lee, Eva YHP, Bago-Horvath, Zsuzsanna, Kenner, Lukas, Popper, Helmuth, Singer, Christian, Khokha, Rama, Jones, Laundette P, Penninger, Josef M

“…Breast cancer is the most common female cancer, affecting approximately one in eight women during their life- time. Besides environmental triggers and…”
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BRCA1 CpG island hypermethylation predicts sensitivity to poly(adenosine diphosphate)-ribose polymerase inhibitors by Veeck, Jurgen, Ropero, Santiago, Setien, Fernando, Gonzalez-Suarez, Eva, Osorio, Ana, Benitez, Javier, Herman, James G, Esteller, Manel

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Cancer cell plasticity defines response to immunotherapy in cutaneous squamous cell carcinoma by Lorenzo-Sanz, Laura, Lopez-Cerda, Marta, da Silva-Diz, Victoria, Artés, Marta H., Llop, Sandra, Penin, Rosa M., Bermejo, Josep Oriol, Gonzalez-Suarez, Eva, Esteller, Manel, Viñals, Francesc, Espinosa, Enrique, Oliva, Marc, Piulats, Josep M., Martin-Liberal, Juan, Muñoz, Purificación

“…Immune checkpoint blockade (ICB) approaches have changed the therapeutic landscape for many tumor types. However, half of cutaneous squamous cell carcinoma…”
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RANK signaling increases after anti-HER2 therapy contributing to the emergence of resistance in HER2-positive breast cancer by Sanz-Moreno, Adrián, Palomeras, Sonia, Pedersen, Kim, Morancho, Beatriz, Pascual, Tomas, Galván, Patricia, Benítez, Sandra, Gomez-Miragaya, Jorge, Ciscar, Marina, Jimenez, Maria, Pernas, Sonia, Petit, Anna, Soler-Monsó, María Teresa, Viñas, Gemma, Alsaleem, Mansour, Rakha, Emad A, Green, Andrew R, Santamaria, Patricia G, Mulder, Celine, Lemeer, Simone, Arribas, Joaquin, Prat, Aleix, Puig, Teresa, Gonzalez-Suarez, Eva

“…Around 15-20% of primary breast cancers are characterized by HER2 protein overexpression and/or HER2 gene amplification. Despite the successful development of…”
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Co-targeting RANK pathway treats and prevents acquired resistance to CDK4/6 inhibitors in luminal breast cancer by Gomes, Inês, Gallego-Paez, Lina M., Jiménez, Maria, Santamaria, Patricia G., Mansinho, André, Sousa, Rita, Abreu, Catarina, Suárez, Eva González, Costa, Luis, Casimiro, Sandra

“…The combination of endocrine therapy (ET) and cyclin-dependent kinase 4/6 (CDK4/6) inhibitors (CDK4/6i) was a hallmark in metastatic luminal breast cancer…”
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European Network of Breast Development and Cancer turned 10 years: a growing family of mammary gland researchers by Koledova, Zuzana, Howard, Beatrice A, Englund, Johanna, Bach, Karsten, Bentires-Alj, Mohammed, Gonzalez-Suarez, Eva

“…The European Network for Breast Development and Cancer (ENBDC), a worldwide network ( http://www.enbdc.org/ ), celebrated its tenth anniversary with a…”
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RANK Overexpression in Transgenic Mice with Mouse Mammary Tumor Virus Promoter-Controlled RANK Increases Proliferation and Impairs Alveolar Differentiation in the Mammary Epithelia and Disrupts Lumen Formation in Cultured Epithelial Acini by Gonzalez-Suarez, Eva, Branstetter, Daniel, Armstrong, Allison, Dinh, Huyen, Blumberg, Hal, Dougall, William C.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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BTNL2, a Butyrophilin/B7-Like Molecule, Is a Negative Costimulatory Molecule Modulated in Intestinal Inflammation by Arnett, Heather A, Escobar, Sabine S, Gonzalez-Suarez, Eva, Budelsky, Alison L, Steffen, Lori A, Boiani, Norman, Zhang, Ming, Siu, Gerald, Brewer, Avery W, Viney, Joanne L

“…Butyrophilin-like 2 (BTNL2) is a butyrophilin family member with homology to the B7 costimulatory molecules, polymorphisms of which have been recently…”
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RANK as a therapeutic target in cancer by González‐Suárez, Eva, Sanz‐Moreno, Adrián

“…The RANK signaling pathway has emerged as a new target in breast cancer as receptor activator of nuclear factor κB ligand (RANKL) and its receptor RANK mediate…”
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RANK Induces Epithelial―Mesenchymal Transition and Stemness in Human Mammary Epithelial Cells and Promotes Tumorigenesis and Metastasis by PALAFOX, Marta, FERRER, Irene, TOMETSKO, Mark, BRANSTETTER, Dan, DOUGALL, William C, GONZALEZ-SUAREZ, Eva, PELLEGRINI, Pasquale, VILA, Sergi, HERNANDEZ-ORTEGA, Sara, URRUTICOECHEA, Ander, CLIMEN, Fina, SOLER, Maria Teresa, MUNOZ, Purificación, VINALS, Francesc

“…Paracrine signaling through receptor activator of NF-κB (RANK) pathway mediates the expansion of mammary epithelia that occurs during pregnancy, and activation…”
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Luminal Rank loss decreases cell fitness leading to basal cell bipotency in parous mammary glands by Rocha, Ana Sofia, Collado-Solé, Alejandro, Graña-Castro, Osvaldo, Redondo-Pedraza, Jaime, Soria-Alcaide, Gonzalo, Cordero, Alex, Santamaría, Patricia G., González-Suárez, Eva

“…Rank signaling pathway regulates mammary gland homeostasis and epithelial cell differentiation. Although Rank receptor is expressed by basal cells and luminal…”
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Dual fatty acid synthase and HER2 signaling blockade shows marked antitumor activity against breast cancer models resistant to anti-HER2 drugs by Blancafort, Adriana, Giró-Perafita, Ariadna, Oliveras, Glòria, Palomeras, Sònia, Turrado, Carlos, Campuzano, Òscar, Carrión-Salip, Dolors, Massaguer, Anna, Brugada, Ramon, Palafox, Marta, Gómez-Miragaya, Jorge, González-Suárez, Eva, Puig, Teresa

“…Blocking the enzyme Fatty Acid Synthase (FASN) leads to apoptosis of HER2-positive breast carcinoma cells. The hypothesis is that blocking FASN, in combination…”
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Management of bone health in solid tumours: From bisphosphonates to a monoclonal antibody by von Moos, Roger, Costa, Luis, Gonzalez-Suarez, Eva, Terpos, Evangelos, Niepel, Daniela, Body, Jean–Jacques

“…•Bone is a common site of metastasis, particularly in breast and prostate cancer.•Bisphosphonates reduce skeletal-related events in patients with bone…”
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Resistance to Taxanes in Triple-Negative Breast Cancer Associates with the Dynamics of a CD49f+ Tumor-Initiating Population by Gómez-Miragaya, Jorge, Palafox, Marta, Paré, Laia, Yoldi, Guillermo, Ferrer, Irene, Vila, Sergi, Galván, Patricia, Pellegrini, Pasquale, Pérez-Montoyo, Hector, Igea, Ana, Muñoz, Purificación, Esteller, Manel, Nebreda, Angel R., Urruticoechea, Ander, Morilla, Idoia, Pernas, Sonia, Climent, Fina, Soler-Monso, María Teresa, Petit, Ana, Serra, Violeta, Prat, Aleix, González-Suárez, Eva

“…Taxanes are a mainstay of treatment for breast cancer, but resistance often develops followed by metastatic disease and mortality. Aiming to reveal the…”
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RANK ligand mediates progestin-induced mammary epithelial proliferation and carcinogenesis by Branstetter, Dan, Pinkas, Jan, Dougall, William C, Erwert, Ryan, Miller, Robert, Jacob, Allison P, Jones, Jon, Gonzalez-Suarez, Eva, Roudier-Meyer, Martine P

“…RANK ligand (RANKL), a TNF-related molecule, is essential for osteoclast formation, function and survival through interaction with its receptor RANK. Mammary…”
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Interrogating open issues in cancer precision medicine with patient-derived xenografts by Byrne, Annette T., Alférez, Denis G., Amant, Frédéric, Annibali, Daniela, Arribas, Joaquín, Biankin, Andrew V., Bruna, Alejandra, Budinská, Eva, Caldas, Carlos, Chang, David K., Clarke, Robert B., Clevers, Hans, Coukos, George, Dangles-Marie, Virginie, Eckhardt, S. Gail, Gonzalez-Suarez, Eva, Hermans, Els, Hidalgo, Manuel, Jarzabek, Monika A., de Jong, Steven, Jonkers, Jos, Kemper, Kristel, Lanfrancone, Luisa, Mælandsmo, Gunhild Mari, Marangoni, Elisabetta, Marine, Jean-Christophe, Medico, Enzo, Norum, Jens Henrik, Palmer, Héctor G., Peeper, Daniel S., Pelicci, Pier Giuseppe, Piris-Gimenez, Alejandro, Roman-Roman, Sergio, Rueda, Oscar M., Seoane, Joan, Serra, Violeta, Soucek, Laura, Vanhecke, Dominique, Villanueva, Alberto, Vinolo, Emilie, Bertotti, Andrea, Trusolino, Livio

“…This Opinion article discusses progress and challenges in using patient-derived xenograft (PDX) models in cancer precision medicine. It is primarily…”
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