Search Results - "Gonzalez Santana, Andres"

The Staudinger/aza-Wittig/Grignard reaction as key step for the concise synthesis of 1-C-Alkyl-iminoalditol glycomimetics by Zoidl, Manuel, Gonzalez Santana, Andres, Torvisco, Ana, Tysoe, Christina, Siriwardena, Aloysius, Withers, Stephen G., Wrodnigg, Tanja M.

“…•The Staudinger/aza-Wittig Grignard reaction cascade is a concise synthetic method for the synthesis of biologically active 1-C-alkyl iminoalditol…”
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Ligand-Directed Chemistry on Glycoside Hydrolases - A Proof of Concept Study by Prasch, Herwig, Wolfsgruber, Andreas, Thonhofer, Martin, Culum, André, Mandl, Christoph, Weber, Patrick, Zündel, Melanie, Nasseri, Seyed A, Gonzalez Santana, Andres, Tegl, Gregor, Nidetzky, Bernd, Gruber, Karl, Stütz, Arnold E, Withers, Stephen G, Wrodnigg, Tanja M

“…Selective covalent labelling of enzymes using small molecule probes has advanced the scopes of protein profiling. The covalent bond formation to a specific…”
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Mechanistic Insights into the Chaperoning of Human Lysosomal-Galactosidase Activity: Highly Functionalized Aminocyclopentanes and C -5a-Substituted Derivatives of 4- epi -Isofagomine by Weber, Patrick, Thonhofer, Martin, Averill, Summer, Davies, Gideon J, Santana, Andres Gonzalez, Müller, Philipp, Nasseri, Seyed A, Offen, Wendy A, Pabst, Bettina M, Paschke, Eduard, Schalli, Michael, Torvisco, Ana, Tschernutter, Marion, Tysoe, Christina, Windischhofer, Werner, Withers, Stephen G, Wolfsgruber, Andreas, Wrodnigg, Tanja M, Stütz, Arnold E

“…Glycosidase inhibitors have shown great potential as pharmacological chaperones for lysosomal storage diseases. In light of this, a series of new…”
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C-5a-substituted validamine type glycosidase inhibitors by Schalli, Michael, Wolfsgruber, Andreas, Gonzalez Santana, Andres, Tysoe, Christina, Fischer, Roland, Stütz, Arnold E., Thonhofer, Martin, Withers, Stephen G.

“…A series of N-alkyl derivatives of the D-galactosidase inhibitor 1,4-di-epi-validamine featuring lipophilic substituents at position C-5a was prepared and…”
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Transglycosylation products generated by Talaromyces amestolkiae GH3 β-glucosidases: effect of hydroxytyrosol, vanillin and its glucosides on breast cancer cells by Méndez-Líter, Juan Antonio, Tundidor, Isabel, Nieto-Domínguez, Manuel, de Toro, Beatriz Fernández, González Santana, Andrés, de Eugenio, Laura Isabel, Prieto, Alicia, Asensio, Juan Luis, Cañada, Francisco Javier, Sánchez, Cristina, Martínez, María Jesús

“…Transglycosylation represents one of the most promising approaches for obtaining novel glycosides, and plant phenols and polyphenols are emerging as one of the…”
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Synthesis of C-5a-substituted derivatives of 4-epi-isofagomine: notable β-galactosidase inhibitors and activity promotors of GM1-gangliosidosis related human lysosomal β-galactosidase mutant R201C by Thonhofer, Martin, Weber, Patrick, Gonzalez Santana, Andres, Tysoe, Christina, Fischer, Roland, Pabst, Bettina M., Paschke, Eduard, Schalli, Michael, Stütz, Arnold E., Tschernutter, Marion, Windischhofer, Werner, Withers, Stephen G.

“…[Display omitted] •The first synthesis of (5aS)-chain extended 4-epi-isofagomines.•New compounds are powerful β-galactosidase inhibitors.•Residual human…”
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5-Fluoro derivatives of 4-epi-isofagomine as d-galactosidase inhibitors and potential pharmacological chaperones for GM1-gangliosidosis as well as Fabry's disease by Thonhofer, Martin, Gonzalez Santana, Andres, Fischer, Roland, Torvisco Gomez, Ana, Saf, Robert, Schalli, Michael, Stütz, Arnold E., Withers, Stephen G.

“…•The first synthesis of 5-fluoro-isoimino sugars.•The tertiary fluorine substituent is located at the branching point.•Compounds exhibit improved…”
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Synthesis of C-5a-chain extended derivatives of 4-epi-isofagomine: Powerful β-galactosidase inhibitors and low concentration activators of GM1-gangliosidosis-related human lysosomal β-galactosidase by Thonhofer, Martin, Weber, Patrick, Santana, Andres Gonzalez, Fischer, Roland, Pabst, Bettina M., Paschke, Eduard, Schalli, Michael, Stütz, Arnold E., Tschernutter, Marion, Windischhofer, Werner, Withers, Stephen G.

“…[Display omitted] From an easily available partially protected formal derivative of 1-deoxymannojirimycin, by hydroxymethyl chain-branching and further…”
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Synthesis of C-5a-chain extended derivatives of 4-epi-isofagomine: Powerful beta -galactosidase inhibitors and low concentration activators of G sub(M1)-gangliosidosis-related human lysosomal beta -galactosidase by Thonhofer, Martin, Weber, Patrick, Santana, Andres Gonzalez, Fischer, Roland, Pabst, Bettina M, Paschke, Eduard, Schalli, Michael, Stuetz, Arnold E, Tschernutter, Marion, Windischhofer, Werner, Withers, Stephen G

“…From an easily available partially protected formal derivative of 1-deoxymannojirimycin, by hydroxymethyl chain-branching and further elaboration, lipophilic…”
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A glucotolerant β-glucosidase from the fungus Talaromyces amestolkiae and its conversion into a glycosynthase for glycosylation of phenolic compounds by Méndez-Líter, Juan Antonio, Nieto-Domínguez, Manuel, Fernández de Toro, Beatriz, González Santana, Andrés, Prieto, Alicia, Asensio, Juan Luis, Cañada, Francisco Javier, de Eugenio, Laura Isabel, Martínez, María Jesús

“…The interest for finding novel β-glucosidases that can improve the yields to produce second-generation (2G) biofuels is still very high. One of the most…”
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Aromatic Interactions in Glycochemistry: From Molecular Recognition to Catalysis by Santana, Andrés González, Díaz-Casado, Laura, Montalvillo, Laura, Jiménez-Moreno, Ester, Mann, Enrique, Asensio, Juan Luis

“…Aromatic platforms are ubiquitous recognition motifs occurring in protein carbohydrate- binding domains (CBDs), RNA receptors and enzymes. They stabilize the…”
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A glucotolerant [beta]-glucosidase from the fungus Talaromyces amestolkiae and its conversion into a glycosynthase for glycosylation of phenolic compounds by Méndez-Líter, Juan Antonio, Nieto-Domínguez, Manuel, Fernández de Toro, Beatriz, González Santana, Andrés, Prieto, Alicia, Asensio, Juan Luis, Caéada, Francisco Javier, de Eugenio, Laura Isabel, Martínez, María Jesús

“…The interest for finding novel [beta]-glucosidases that can improve the yields to produce second-generation (2G) biofuels is still very high. One of the most…”
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Transglycosylation products generated by Talaromyces amestolkiae GH3 [beta]-glucosidases: effect of hydroxytyrosol, vanillin and its glucosides on breast cancer cells by Méndez-Líter, Juan Antonio, Tundidor, Isabel, Nieto-Domínguez, Manuel, de Toro, Beatriz Fernández, González Santana, Andrés, de Eugenio, Laura Isabel, Prieto, Alicia, Asensio, Juan Luis, Caéada, Francisco Javier, Sánchez, Cristina, Martínez, María Jesús

“…Transglycosylation represents one of the most promising approaches for obtaining novel glycosides, and plant phenols and polyphenols are emerging as one of the…”
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