Disruptive environmental chemicals and cellular mechanisms that confer resistance to cell death

Cell death is a process of dying within biological cells that are ceasing to function. This process is essential in regulating organism development, tissue homeostasis, and to eliminate cells in the body that are irreparably damaged. In general, dysfunction in normal cellular death is tightly linked...

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Published in:	Carcinogenesis (New York) Vol. 36 Suppl 1; no. Suppl 1; pp. S89 - S110
Main Authors:	Narayanan, Kannan Badri, Ali, Manaf, Barclay, Barry J, Cheng, Qiang Shawn, D'Abronzo, Leandro, Dornetshuber-Fleiss, Rita, Ghosh, Paramita M, Gonzalez Guzman, Michael J, Lee, Tae-Jin, Leung, Po Sing, Li, Lin, Luanpitpong, Suidjit, Ratovitski, Edward, Rojanasakul, Yon, Romano, Maria Fiammetta, Romano, Simona, Sinha, Ranjeet K, Yedjou, Clement, Al-Mulla, Fahd, Al-Temaimi, Rabeah, Amedei, Amedeo, Brown, Dustin G, Ryan, Elizabeth P, Colacci, Annamaria, Hamid, Roslida A, Mondello, Chiara, Raju, Jayadev, Salem, Hosni K, Woodrick, Jordan, Scovassi, A Ivana, Singh, Neetu, Vaccari, Monica, Roy, Rabindra, Forte, Stefano, Memeo, Lorenzo, Kim, Seo Yun, Bisson, William H, Lowe, Leroy, Park, Hyun Ho
Format:	Journal Article
Language:	English
Published:	England Oxford University Press 01-06-2015
Subjects:	Animals Carcinogenesis - chemically induced Carcinogens, Environmental - adverse effects Cell Death - drug effects Environmental Exposure - adverse effects Hazardous Substances - adverse effects Homeostasis - drug effects Humans Neoplasms - chemically induced Neoplasms - etiology Review
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Summary:	Cell death is a process of dying within biological cells that are ceasing to function. This process is essential in regulating organism development, tissue homeostasis, and to eliminate cells in the body that are irreparably damaged. In general, dysfunction in normal cellular death is tightly linked to cancer progression. Specifically, the up-regulation of pro-survival factors, including oncogenic factors and antiapoptotic signaling pathways, and the down-regulation of pro-apoptotic factors, including tumor suppressive factors, confers resistance to cell death in tumor cells, which supports the emergence of a fully immortalized cellular phenotype. This review considers the potential relevance of ubiquitous environmental chemical exposures that have been shown to disrupt key pathways and mechanisms associated with this sort of dysfunction. Specifically, bisphenol A, chlorothalonil, dibutyl phthalate, dichlorvos, lindane, linuron, methoxychlor and oxyfluorfen are discussed as prototypical chemical disruptors; as their effects relate to resistance to cell death, as constituents within environmental mixtures and as potential contributors to environmental carcinogenesis.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-2
ISSN:	0143-3334 1460-2180
DOI:	10.1093/carcin/bgv032