Search Results - "Gonzalez Deniselle, Maria Claudia"

Therapeutic effects of progesterone in animal models of neurological disorders by De Nicola, Alejandro F, Coronel, Florencia, Garay, Laura I, Gargiulo-Monachelli, Gisella, Gonzalez Deniselle, Maria Claudia, Gonzalez, Susana L, Labombarda, Florencia, Meyer, Maria, Guennoun, Rachida, Schumacher, Michael

“…Substantial evidence supports that progesterone exerts many functions in the central and peripheral nervous system unrelated to its classical role in…”
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Early Signs of Neuroinflammation in the Postnatal Wobbler Mouse Model of Amyotrophic Lateral Sclerosis by Meyer, Maria, Lima, Analia, Deniselle, Maria Claudia Gonzalez, De Nicola, Alejandro F.

“…The Wobbler mouse is an accepted model of sporadic amyotrophic lateral sclerosis. The spinal cord of clinically symptomatic animals (3–5 months old) shows…”
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Insights into the Therapeutic Potential of Glucocorticoid Receptor Modulators for Neurodegenerative Diseases by De Nicola, Alejandro F, Meyer, Maria, Guennoun, Rachida, Schumacher, Michael, Hunt, Hazel, Belanoff, Joseph, de Kloet, E Ronald, Gonzalez Deniselle, Maria Claudia

“…Glucocorticoids are crucial for stress-coping, resilience, and adaptation. However, if the stress hormones become dysregulated, the vulnerability to…”
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Testosterone Reduces Myelin Abnormalities in the Wobbler Mouse Model of Amyotrophic Lateral Sclerosis by Esperante, Ivan J, Meyer, Maria, Banzan, Carolina, Kruse, Maria Sol, Lima, Analia, Roig, Paulina, Guennoun, Rachida, Schumacher, Michael, De Nicola, Alejandro F, Gonzalez Deniselle, Maria Claudia

“…Amyotrophic lateral sclerosis (ALS) is a fatal motoneuron degenerative disease that is associated with demyelination. The ( ) mouse exhibits motoneuron…”
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Stress-induced Neuroinflammation of the Spinal Cord is Restrained by Cort113176 (Dazucorilant), A Specific Glucocorticoid Receptor Modulator by Meyer, Maria, Meijer, Onno, Hunt, Hazel, Belanoff, Joseph, Lima, Analia, de Kloet, E. Ronald, Gonzalez Deniselle, Maria Claudia, De Nicola, Alejandro F.

“…Glucocorticoids exert antiinflammatory, antiproliferative and immunosupressive effects. Paradoxically they may also enhance inflammation particularly in the…”
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Progesterone and Allopregnanolone Neuroprotective Effects in the Wobbler Mouse Model of Amyotrophic Lateral Sclerosis by De Nicola, Alejandro F., Meyer, María, Garay, Laura, Kruse, Maria Sol, Schumacher, Michael, Guennoun, Rachida, Gonzalez Deniselle, Maria Claudia

“…Progesterone regulates a number of processes in neurons and glial cells not directly involved in reproduction or sex behavior. Several neuroprotective effects…”
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Long-term effects of the glucocorticoid receptor modulator CORT113176 in murine motoneuron degeneration by Meyer, Maria, Kruse, Maria Sol, Garay, Laura, Lima, Analia, Roig, Paulina, Hunt, Hazel, Belanoff, Joseph, de Kloet, E. Ronald, Deniselle, Maria Claudia Gonzalez, De Nicola, Alejandro F.

“…•Wobbler mice present motoneuron degeneration and hyperadrenocorticism.•CORT113176 is a high affinity specific glucocorticoid receptor antagonist.•Prolonged…”
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Protective effects of the neurosteroid allopregnanolone in a mouse model of spontaneous motoneuron degeneration by Meyer, Maria, Garay, Laura I., Kruse, María Sol, Lara, Agustina, Gargiulo-Monachelli, Gisella, Schumacher, Michael, Guennoun, Rachida, Coirini, Hector, De Nicola, Alejandro F., Gonzalez Deniselle, Maria Claudia

“…•Progesterone and allopregnanolone effects were evaluated in a model of motoneuron degeneration.•Both steroids increased protective signals such as pAKT and…”
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Comparative effects of progesterone and the synthetic progestin norethindrone on neuroprotection in a model of spontaneous motoneuron degeneration by Gargiulo-Monachelli, Gisella, Meyer, Maria, Lara, Agustina, Garay, Laura, Lima, Analia, Roig, Paulina, De Nicola, Alejandro F., Gonzalez Deniselle, Maria Claudia

“…•Progesterone (PROG) and norethindrone (NOR) effects were tested in Wobbler spinal cord.•PROG prevented neuropathology of motoneurons and glia and enhanced…”
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Progesterone neuroprotection in traumatic CNS injury and motoneuron degeneration by De Nicola, Alejandro F, Labombarda, Florencia, Deniselle, Maria Claudia Gonzalez, Gonzalez, Susana L, Garay, Laura, Meyer, Maria, Gargiulo, Gisella, Guennoun, Rachida, Schumacher, Michael

“…Abstract Studies on the neuroprotective and promyelinating effects of progesterone in the nervous system are of great interest due to their potential clinical…”
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Steroid Profiling in Male Wobbler Mouse, a Model of Amyotrophic Lateral Sclerosis by Gonzalez Deniselle, Maria Claudia, Liere, Philippe, Pianos, Antoine, Meyer, Maria, Aprahamian, Fanny, Cambourg, Annie, Di Giorgio, Noelia P, Schumacher, Michael, De Nicola, Alejandro F, Guennoun, Rachida

“…The Wobbler mouse is an animal model for human motoneuron diseases, especially amyotrophic lateral sclerosis (ALS), used in the investigation of both pathology…”
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Neuroprotective Effects of Testosterone in Male Wobbler Mouse, a Model of Amyotrophic Lateral Sclerosis by Lara, Agustina, Esperante, Iván, Meyer, Maria, Liere, Philippe, Di Giorgio, Noelia, Schumacher, Michael, Guennoun, Rachida, Gargiulo-Monachelli, Gisella, De Nicola, Alejandro Federico, Gonzalez Deniselle, Maria Claudia

“…Patients suffering of amyotrophic lateral sclerosis (ALS) present motoneuron degeneration leading to muscle atrophy, dysphagia, and dysarthria. The Wobbler…”
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Effects of progesterone in the spinal cord of a mouse model of multiple sclerosis by Garay, Laura, Deniselle, Maria Claudia Gonzalez, Lima, Analia, Roig, Paulina, De Nicola, Alejandro F.

“…The spinal cord is a target of progesterone (PROG), as demonstrated by the expression of intracellular and membrane PROG receptors and by its myelinating and…”
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The selective glucocorticoid receptor modulator CORT108297 restores faulty hippocampal parameters in Wobbler and corticosterone-treated mice by Meyer, Maria, Gonzalez Deniselle, Maria Claudia, Hunt, Hazel, de Kloet, E Ronald, De Nicola, Alejandro F

“…Mutant Wobbler mice are models for human amyotrophic lateral sclerosis (ALS). In addition to spinal cord degeneration, Wobbler mice show high levels of blood…”
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Progesterone prevents mitochondrial dysfunction in the spinal cord of wobbler mice by Deniselle, Maria Claudia Gonzalez, Carreras, Maria Cecilia, Garay, Laura, Gargiulo-Monachelli, Gisella, Meyer, Maria, Poderoso, Juan Jose, De Nicola, Alejandro F.

“…J. Neurochem. (2012) 122, 185–195. In the Wobbler mouse, a mutation of the Vps54 protein increases oxidative stress in spinal motoneurons, associated to toxic…”
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Protective effects of progesterone administration on axonal pathology in mice with experimental autoimmune encephalomyelitis by Garay, Laura, Deniselle, Maria Claudia Gonzalez, Meyer, Maria, Costa, Juan José Lopez, Lima, Analia, Roig, Paulina, DeNicola, Alejandro F

“…Abstract Experimental autoimmune encephalomyelitis (EAE), an induced model of Multiple Sclerosis presents spinal cord demyelination, axonal pathology and…”
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Progesterone Effects on Neuronal Ultrastructure and Expression of Microtubule-associated Protein 2 (MAP2) in Rats with Acute Spinal Cord Injury by González, Susana L, López-Costa, Juan José, Labombarda, Florencia, Deniselle, Maria Claudia González, Guennoun, Rachida, Schumacher, Michael, De Nicola, Alejandro F

“…(1) Following acute spinal cord injury, progesterone modulates several molecules essential for motoneuron function, although the morphological substrates for…”
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Long-Term Memory Function Impairments following Sucrose Exposure in Juvenile versus Adult Rats by Coirini, Héctor, Rey, Mariana, Gonzalez Deniselle, María Claudia, Kruse, María Sol

“…We previously described that excessive consumption of sucrose during youth produces fear memory and anxiety-like behavior in adulthood. Here, we evaluated…”
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Progesterone modulates brain-derived neurotrophic factor and choline acetyltransferase in degenerating Wobbler motoneurons by Gonzalez Deniselle, Maria Claudia, Garay, Laura, Gonzalez, Susana, Saravia, Flavia, Labombarda, Florencia, Guennoun, Rachida, Schumacher, Michael, De Nicola, Alejandro F.

“…Progesterone (PROG) shows neuroprotective effects in nervous system diseases. The Wobbler mouse, a model of motoneuron degeneration, suffers a mutation of the…”
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Steroid protection in the experimental autoimmune encephalomyelitis model of multiple sclerosis by Garay, Laura, Gonzalez Deniselle, Maria Claudia, Gierman, Lobke, Meyer, Maria, Lima, Analia, Roig, Paulina, De Nicola, Alejandro F

“…Based on evidence that pregnant women with multiple sclerosis (MS) show a decline in the relapse rate during the third trimester and an increase during the…”
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