Search Results - "Gonzalez‐Molina, Jordi"

Mesenchymal Stem Cells Sense the Toughness of Nanomaterials and Interfaces by Peng, Lihui, Matellan, Carlos, Bosch‐Fortea, Minerva, Gonzalez‐Molina, Jordi, Frigerio, Matteo, Salentinig, Stefan, del Rio Hernandez, Armando, Gautrot, Julien E.

“…Stem cells are known to sense and respond to the mechanical properties of biomaterials. In turn, cells exert forces on their environment that can lead to…”
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MMP14 expression and collagen remodelling support uterine leiomyosarcoma aggressiveness by Gonzalez‐Molina, Jordi, Hahn, Paula, Falcão, Raul Maia, Gultekin, Okan, Kokaraki, Georgia, Zanfagnin, Valentina, Braz Petta, Tirzah, Lehti, Kaisa, Carlson, Joseph W.

“…Fibrillar collagen deposition, stiffness and downstream signalling support the development of leiomyomas (LMs), common benign mesenchymal tumours of the…”
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Mechanical Confinement and DDR1 Signaling Synergize to Regulate Collagen‐Induced Apoptosis in Rhabdomyosarcoma Cells by Gonzalez‐Molina, Jordi, Kirchhof, Katharina Miria, Rathod, Bhavik, Moyano‐Galceran, Lidia, Calvo‐Noriega, Maria, Kokaraki, Georgia, Bjørkøy, Astrid, Ehnman, Monika, Carlson, Joseph W., Lehti, Kaisa

“…Fibrillar collagens promote cell proliferation, migration, and survival in various epithelial cancers and are generally associated with tumor aggressiveness…”
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Co-evolution of matrisome and adaptive adhesion dynamics drives ovarian cancer chemoresistance by Pietilä, Elina A., Gonzalez-Molina, Jordi, Moyano-Galceran, Lidia, Jamalzadeh, Sanaz, Zhang, Kaiyang, Lehtinen, Laura, Turunen, S. Pauliina, Martins, Tomás A., Gultekin, Okan, Lamminen, Tarja, Kaipio, Katja, Joneborg, Ulrika, Hynninen, Johanna, Hietanen, Sakari, Grénman, Seija, Lehtonen, Rainer, Hautaniemi, Sampsa, Carpén, Olli, Carlson, Joseph W., Lehti, Kaisa

“…Due to its dynamic nature, the evolution of cancer cell-extracellular matrix (ECM) crosstalk, critically affecting metastasis and treatment resistance, remains…”
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Extracellular fluid viscosity enhances liver cancer cell mechanosensing and migration by Gonzalez-Molina, Jordi, Zhang, Xiaoli, Borghesan, Michela, Mendonça da Silva, Joana, Awan, Maooz, Fuller, Barry, Gavara, Núria, Selden, Clare

“…The extracellular fluid (ECF) is a crowded environment containing macromolecules that determine its characteristic density, osmotic pressure, and viscosity,…”
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Chemotherapy as a regulator of extracellular matrix-cell communication: Implications in therapy resistance by Gonzalez-Molina, Jordi, Moyano-Galceran, Lidia, Single, Andrew, Gultekin, Okan, Alsalhi, Shno, Lehti, Kaisa

“…The development of most solid cancers, including pancreatic, breast, lung, liver, and ovarian cancer, involves a desmoplastic reaction: a process of major…”
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MMP14 in Sarcoma: A Regulator of Tumor Microenvironment Communication in Connective Tissues by Gonzalez-Molina, Jordi, Gramolelli, Silvia, Liao, Zehuan, Carlson, Joseph W, Ojala, Päivi M, Lehti, Kaisa

“…Sarcomas are deadly malignant tumors of mesenchymal origin occurring at all ages. The expression and function of the membrane-type matrix metalloproteinase…”
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FOXP3+ T cells in uterine sarcomas are associated with favorable prognosis, low extracellular matrix expression and reduced YAP activation by Gultekin, Okan, Gonzalez-Molina, Jordi, Hardell, Elin, Moyano-Galceran, Lidia, Mitsios, Nicholas, Mulder, Jan, Kokaraki, Georgia, Isaksson, Anders, Sarhan, Dhifaf, Lehti, Kaisa, Carlson, Joseph W.

“…Uterine sarcomas are rare but deadly malignancies without effective treatment. Immunotherapy is a promising new approach to treat these tumors but has shown…”
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The extracellular matrix – immune microenvironment crosstalk in cancer therapy: Challenges and opportunities by Closset, Lara, Gultekin, Okan, Salehi, Sahar, Sarhan, Dhifaf, Lehti, Kaisa, Gonzalez-Molina, Jordi

“…•The mutual regulation between the extracellular matrix and immune cells has central functions in cancer progression and immunotherapy response.•Classical…”
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A clinical-scale BioArtificial Liver, developed for GMP, improved clinical parameters of liver function in porcine liver failure by Selden, Clare, Bundy, James, Erro, Eloy, Puschmann, Eva, Miller, Malcolm, Kahn, Delawir, Hodgson, Humphrey, Fuller, Barry, Gonzalez-Molina, Jordi, Le Lay, Aurelie, Gibbons, Stephanie, Chalmers, Sherri, Modi, Sunil, Thomas, Amy, Kilbride, Peter, Isaacs, Agnes, Ginsburg, Richard, Ilsley, Helen, Thomson, David, Chinnery, Galya, Mankahla, Ncedile, Loo, Lizel, Spearman, C. Wendy

“…Liver failure, whether arising directly from acute liver failure or from decompensated chronic liver disease is an increasing problem worldwide and results in…”
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The extracellular fluid macromolecular composition differentially affects cell-substrate adhesion and cell morphology by Gonzalez-Molina, Jordi, Mendonça da Silva, Joana, Fuller, Barry, Selden, Clare

“…Soluble macromolecules present in the tumour microenvironment (TME) alter the physical characteristics of the extracellular fluid and can affect cancer cell…”
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Integrated Molecular Analysis of Undifferentiated Uterine Sarcomas Reveals Clinically Relevant Molecular Subtypes by Binzer-Panchal, Amrei, Hardell, Elin, Viklund, Björn, Ghaderi, Mehran, Bosse, Tjalling, Nucci, Marisa R, Lee, Cheng-Han, Hollfelder, Nina, Corcoran, Pádraic, Gonzalez-Molina, Jordi, Moyano-Galceran, Lidia, Bell, Debra A, Schoolmeester, John K, Måsbäck, Anna, Kristensen, Gunnar B, Davidson, Ben, Lehti, Kaisa, Isaksson, Anders, Carlson, Joseph W

“…Undifferentiated uterine sarcomas (UUS) are rare, extremely deadly, sarcomas with no effective treatment. The goal of this study was to identify novel…”
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Abstract 6096: The microarchitecture and fibrillar collagen expression of leiomyosarcoma are associated with malignancy by Gonzalez-Molina, Jordi, Hahn, Paula, Falcão, Raul Maia, Kokaraki, Georgia, de Souza, Jorge Estefano, Lajus, Tirzah Braz Petta, Lehti, Kaisa, Carlson, Joseph W.

“…Abstract The expression, abundance, and microarchitecture of fibrillar collagens are associated with tumor development and aggressiveness in various…”
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Use of non-adherent hydrogels to control the behaviour of human hepatocarcinoma cell lines by Jordi, Gonzalez-Molina, Natasha, Maurmann, Clare, Selden

“…Abstract only…”
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Cell-biomaterial mechanical interactions: from cancer mechanobiology to cell therapies by Gonzalez-Molina, Jordi

“…The physical characteristics of the cell microenvironment greatly affect cellular processes such as survival, proliferation, migration, and differentiation…”
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Impact of Storage at -80°C on Encapsulated Liver Spheroids After Liquid Nitrogen Storage by Kilbride, Peter, Gonzalez-Molina, Jordi, Maurmann, Natasha, Mendonça da Silva, Joana, Gibbons, Stephanie, Selden, Clare, Fuller, Barry, Morris, John

“…For many bioengineered tissues to have practical clinical application, cryopreservation for use on demand is essential. This study examined different thermal…”
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