Search Results - "Gonzalez‐Buendia, Lucia"
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Proliferative vitreoretinopathy: A new concept of disease pathogenesis and practical consequences
Published in Progress in retinal and eye research (01-03-2016)“…During the last four decades, proliferative vitreoretinopathy (PVR) has defied the efforts of many researchers to prevent its occurrence or development. Thus,…”
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RIPK necrotic cell death pathway in both donor photoreceptor and host immune cells synergize to affect photoreceptor graft survival
Published in The FASEB journal (01-04-2023)“…Photoreceptor transplant has been put forward as a repair strategy to tackle degenerated retinas. Nonetheless, cell death and immune rejection seriously limit…”
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TNF‐α signaling regulates RUNX1 function in endothelial cells
Published in The FASEB journal (01-02-2021)“…Runt‐related transcription factor 1 (RUNX1) acts as a mediator of aberrant retinal angiogenesis and has been implicated in the progression of proliferative…”
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Local photoreceptor cell death differences in the murine model of retinal detachment
Published in Scientific reports (22-09-2021)“…To investigate local cell death differences in the attached and detached retina at different regions in a murine experimental retinal detachment model…”
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APOE Christchurch‐mimetic therapeutic antibody reduces APOE‐mediated toxicity and tau phosphorylation
Published in Alzheimer's & dementia (01-02-2024)“…INTRODUCTION We discovered that the APOE3 Christchurch (APOE3Ch) variant may provide resistance to Alzheimer's disease (AD). This resistance may be due to…”
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Peripheral monocytes and neutrophils promote photoreceptor cell death in an experimental retinal detachment model
Published in Cell death & disease (16-12-2023)“…Photoreceptor cell death and immune cell infiltration are two major events that contribute to retinal degeneration. However, the relationship between these two…”
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ATN grading system in a dome‐shaped macula and ridge shaped macula high lymyopic cohort
Published in Acta ophthalmologica (Oxford, England) (01-12-2022)“…Purpose: The purpose of this study was to analyse the ATN grading in highly myopic patients with dome‐shaped macula (DSM) and ridge‐shaped macula (RSM)…”
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Predictive models of long-term anatomic outcome in age-related macular degeneration treated with as-needed Ranibizumab
Published in BMC ophthalmology (18-08-2017)“…To analyze predictors and develop predictive models of anatomic outcome in neovascular age-related macular degeneration (AMD) treated with as-needed…”
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Topical Nanoemulsion of an Runt-related Transcription Factor 1 Inhibitor for the Treatment of Pathologic Ocular Angiogenesis
Published in Ophthalmology science (Online) (01-09-2022)“…To test the efficacy of runt-related transcription factor 1 (RUNX1) inhibition with topical nanoemulsion containing Ro5-3335 (eNano-Ro5) in experimental ocular…”
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Functional characterization of rs2229094 (T>C) polymorphism in the tumor necrosis factor locus and lymphotoxin alpha expression in human retina: the Retina 4 project
Published in Clinical ophthalmology (Auckland, N.Z.) (01-01-2017)“…The objective of this study is to determine the expression and localization of lymphotoxin alpha (LTA) in human retinas and the functionality of one of its…”
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Resilience to autosomal dominant Alzheimer’s disease in a Reelin-COLBOS heterozygous man
Published in Nature medicine (01-05-2023)“…We characterized the world’s second case with ascertained extreme resilience to autosomal dominant Alzheimer’s disease (ADAD). Side-by-side comparisons of this…”
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Treatment of Experimental Choroidal Neovascularization via RUNX1 Inhibition
Published in The American journal of pathology (01-03-2021)“…Choroidal neovascularization (CNV) is a prevalent cause of vision loss in patients with age-related macular degeneration. Runt-related transcription factor 1…”
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Topical delivery of a small molecule RUNX1 transcription factor inhibitor for the treatment of proliferative vitreoretinopathy
Published in Scientific reports (30-11-2020)“…Proliferative vitreoretinopathy (PVR) is the leading cause of retinal detachment surgery failure. Despite significant advances in vitreoretinal surgery, it…”
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ACUTE RETINAL DAMAGE AFTER USING A TOXIC PERFLUORO-OCTANE FOR VITREO-RETINAL SURGERY
Published in Retina (Philadelphia, Pa.) (01-06-2017)“…To describe a series of retinal acute toxicity cases with severe visual loss after intraocular use of a toxic perfluoro-octane (PFO). The clinical presentation…”
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Functional characterization of rs2229094
Published in Clinical ophthalmology (Auckland, N.Z.) (01-01-2017)“…Purpose: The objective of this study is to determine the expression and localization of lymphotoxin alpha (LTA) in human retinas and the functionality of one…”
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Monochromatic higher order aberrations in highly myopic eyes with Staphyloma
Published in BMC ophthalmology (18-05-2021)“…Prevalence of high myopia is continuously increasing, thus, patients affected with staphyloma are abundant worldwide. Assessment of the quality of vision in…”
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Dome-Shaped Macula versus Ridge-Shaped Macula Eyes in High Myopia Based on the 12-line Radial Optical Coherence Tomography Scan Pattern. Differences in Clinical Features
Published in Diagnostics (Basel) (11-10-2021)“…Purpose: To study clinical features in patients with ridge-shaped macula (RSM) compared with those with dome-shaped macula (DSM) having been previously…”
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Atrophic, Tractional, and Neovascular Grading System in a Dome-Shaped Macula and Ridge-Shaped Macula Highly Myopic Cohort
Published in Ophthalmologica (Basel) (2023)“…The aim of this study was to analyze the atrophic, tractional, and neovascular (ATN) components grading in highly myopic patients with dome-shaped macula (DSM)…”
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