Search Results - "Gonzalez, Sonia Martinez"

Identification of novel PI3K inhibitors through a scaffold hopping strategy by Martínez González, Sonia, Hernández, Ana Isabel, Álvarez, Rosa María, Rodríguez, Antonio, Ramos-Lima, Francisco, Bischoff, James R., Albarrán, María Isabel, Cebriá, Antonio, Hernández-Encinas, Elena, García-Arocha, Jennifer, Cebrián, David, Blanco-Aparicio, Carmen, Pastor, Joaquín

“…[Display omitted] A scaffold hopping strategy, including intellectual property availability assessment, was successfully applied for the discovery of novel…”
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Imidazo[1,2-a]pyrazines as novel PI3K inhibitors by Martínez González, Sonia, Hernández, Ana Isabel, Varela, Carmen, Rodríguez-Arístegui, Sonsoles, Alvarez, Rosa María, García, Ana Belén, Lorenzo, Milagros, Rivero, Virginia, Oyarzabal, Julen, Rabal, Obdulia, Bischoff, James R., Albarrán, Maribel, Cebriá, Antonio, Alfonso, Patricia, Link, Wolfgang, Fominaya, Jesús, Pastor, Joaquín

“…Phosphoinositide-3-kinase (PI3K) is an important target for cancer therapeutics due to the deregulation of its signaling pathway in a wide variety of human…”
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Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor by Martínez González, Sonia, Hernández, Ana Isabel, Varela, Carmen, Rodríguez-Arístegui, Sonsoles, Lorenzo, Milagros, Rodríguez, Antonio, Rivero, Virginia, Martín, José Ignacio, Saluste, Carl Gustav, Ramos-Lima, Francisco, Cendón, Elena, Cebrián, David, Aguirre, Enara, Gomez-Casero, Elena, Albarrán, Maribel, Alfonso, Patricia, García-Serelde, Beatriz, Oyarzabal, Julen, Rabal, Obdulia, Mulero, Francisca, Gonzalez-Granda, Teresa, Link, Wolfgang, Fominaya, Jesús, Barbacid, Mariano, Bischoff, James R., Pizcueta, Pilar, Pastor, Joaquín

“…Phosphoinositide-3-kinase (PI3K) is an important target for cancer therapeutics due to the deregulation of this signaling pathway in a wide variety of human…”
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Rapid identification of ETP-46992, orally bioavailable PI3K inhibitor, selective versus mTOR by Martínez González, Sonia, Hernández, Ana Isabel, Varela, Carmen, Lorenzo, Milagros, Ramos-Lima, Francisco, Cendón, Elena, Cebrián, David, Aguirre, Enara, Gomez-Casero, Elena, Albarrán, M.I., Alfonso, Patricia, García-Serelde, Beatriz, Mateos, Genoveva, Oyarzabal, Julen, Rabal, Obdulia, Mulero, Francisca, Gonzalez-Granda, Teresa, Link, Wolfgang, Fominaya, Jesús, Barbacid, Mariano, Bischoff, James R., Pizcueta, Pilar, Blanco-Aparicio, Carmen, Pastor, Joaquín

“…Phosphoinositide-3-kinases (PI3K) are a family of lipid kinases mediating numerous cell processes such as proliferation, migration and differentiation. PI3K is…”
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Omipalisib inspired macrocycles as dual PI3K/mTOR inhibitors by Álvarez, Rosa M., García, Ana Belén, Riesco-Fagundo, Concepción, Martín, José I., Varela, Carmen, Rodríguez Hergueta, Antonio, González Cantalapiedra, Esther, Oyarzabal, Julen, Di Geronimo, Bruno, Lorenzo, Milagros, Albarrán, M Isabel, Cebriá, Antonio, Cebrián, David, Martínez-González, Sonia, Blanco-Aparicio, Carmen, Pastor, Joaquín

“…Activation of the phosphatidylinositol 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) signaling pathway occurs frequently in a wide range of human…”
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Discovery of novel triazolo[4,3-b]pyridazin-3-yl-quinoline derivatives as PIM inhibitors by Martínez-González, Sonia, Rodríguez-Arístegui, Sonsoles, Gómez de la Oliva, Cristina Ana, Hernández, Ana Isabel, González Cantalapiedra, Esther, Varela, Carmen, García, Ana Belén, Rabal, Obdulia, Oyarzabal, Julen, Bischoff, James R., Klett, Javier, Albarrán, María Isabel, Cebriá, Antonio, Ajenjo, Nuria, García-Serelde, Beatriz, Gómez-Casero, Elena, Cuadrado-Urbano, Manuel, Cebrián, David, Blanco-Aparicio, Carmen, Pastor, Joaquín

“…PIM kinase family (PIM-1, PIM-2 and PIM-3) is an appealing target for the discovery and development of selective inhibitors, useful in various disease…”
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Callosal agenesis, chorioretinal lacunae, absence of infantile spasms, and normal development: Aicardi syndrome without epilepsy? by Viñas, Jose Maria Prats, Gonzalez, María Jesús Martinez, Ribes, Ainhoa Garcia, Gonzalez, Sonia Martinez, Fernandez, Ricardo Martinez

“…Aicardi syndrome is defined by the clinical triad of infantile spasms, agenesis of the corpus callosum, and pathognomonic chorioretinal lacunae. Almost all…”
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Generation of tricyclic imidazo[1,2-a]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy by Martínez González, Sonia, Rodríguez-Arístegui, Sonsoles, Hernández, Ana Isabel, Varela, Carmen, González Cantalapiedra, Esther, Álvarez, Rosa María, Rodríguez Hergueta, Antonio, Bischoff, James R., Albarrán, María Isabel, Cebriá, Antonio, Cendón, Elena, Cebrián, David, Alfonso, Patricia, Pastor, Joaquín

“…[Display omitted] The involvement of the phosphoinositide 3-kinases (PI3Ks) in several diseases, especially in the oncology area, has singled it as one of the…”
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Design and Synthesis of a Series of Piperazine‐1‐carboxamidine Derivatives with Antifungal Activity Resulting from Accumulation of Endogenous Reactive Oxygen Species by François, Isabelle E., Thevissen, Karin, Pellens, Klaartje, Meert, Els M., Heeres, Jan, Freyne, Eddy, Coesemans, Erwin, Viellevoye, Marcel, Deroose, Frederik, Martinez Gonzalez, Sonia, Pastor, Joaquin, Corens, David, Meerpoel, Lieven, Borgers, Marcel, Ausma, Jannie, Dispersyn, Gerrit D., Cammue, Bruno P.

“…In this study, we screened a library of 500 compounds for fungicidal activity via induction of endogenous reactive oxygen species (ROS) accumulation…”
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Primary care in Spain and England; learning from the differences. Opinions of Spanish general practitioners with experience in both countries by Ayerbe García-Monzón, Luis, Milazzo Loma-Osorio, Jorge, Pérez-Piñar López, María, González Martínez, Sonia, González López, Esteban

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Macrocyclization as a Source of Desired Polypharmacology. Discovery of Triple PI3K/mTOR/PIM Inhibitors by Martínez-González, Sonia, Alvarez, Rosa M, Martín, José I, García, Ana Belén, Riesco-Fagundo, Concepción, Varela, Carmen, Rodríguez Hergueta, Antonio, González Cantalapiedra, Esther, Albarrán, M. I, Gómez-Casero, Elena, Cebriá, Antonio, Aguirre, Enara, Ajenjo, Nuria, Cebrián, David, Di Geronimo, Bruno, Cunningham, Darren, O’Neill, Michael, Dave, Harish P. G, Blanco-Aparicio, Carmen, Pastor, Joaquín

“…The PI3K/AKT/mTOR and PIM kinase pathways contribute to the development of several hallmarks of cancer. Cotargeting of these pathways has exhibited promising…”
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Abstract 4337: Novel potent and selective orally available CDK8/19 kinase inhibitors by Blanco Aparicio, Carmen, Renner, Oliver, Gomez-Casero, Elena, Albarran, Maria Isabel, Cebria, Antonio, Barrera, Borja, Aguirre, Enara, Rodriguez de Miguel, Maria del Carmen, Urbano, Manuel, Hernandez, Ana Isabel, Gomez de la Oliva, Cristina, Rivero, Virginia, Riesco, Rosario Concepcion, Martinez Gonzalez, Sonia, Pastor, Joaquin

“…Abstract CDK8 and its paralog CDK19 are cyclin-dependent kinases and together with CDK7 and CDK9 belongs to the group of C-terminal domain (CTD) kinases that…”
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Pyrido[2,3-b][1,5]benzoxazepin-5(6H)-one derivatives as CDK8 inhibitors by Martínez-González, Sonia, García, Ana Belén, Albarrán, M. Isabel, Cebriá, Antonio, Amezquita-Alves, Adrián, García-Campos, Francisco Javier, Martínez-Gago, Jaime, Martínez-Torrecuadrada, Jorge, Muñoz, I.G., Blanco-Aparicio, Carmen, Pastor, Joaquín

“…CDK8 is a cyclin-dependent kinase that forms part of the mediator complex, and modulates the transcriptional output from distinct transcription factors…”
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Is peripheral and/or catheter blood necessary for performing haemoculture in haemodialysis patients whose central venous catheter presents bacteraemia? by Betancor-Jiménez, Juan F, Alonso-Almán, Francisco, Parodis-López, Yanet, Quintana-Viñau, Beatriz, González-Martinez, Sonia, García-Laverick, Cristina, Pérez-Borges, Patricia, Rodríguez-Pérez, Jose C

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Induction of Lysosome Membrane Permeabilization as a Therapeutic Strategy to Target Pancreatic Cancer Stem Cells by Cash, Timothy P., Alcalá, Sonia, Rico-Ferreira, María del Rosario, Hernández-Encinas, Elena, García, Jennifer, Albarrán, María Isabel, Valle, Sandra, Muñoz, Javier, Martínez-González, Sonia, Blanco-Aparicio, Carmen, Pastor, Joaquín, Serrano, Manuel, Sainz, Bruno

“…Despite significant efforts to improve pancreatic ductal adenocarcinoma (PDAC) clinical outcomes, overall survival remains dismal. The poor response to current…”
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Callosal agenesis, chorioretinal lacunae, absence of infantile spasms, and normal development: Aicardi syndrome without epilepsy? by Viñas, Jose Maria Prats, Gonzalez, María Jesús Martinez, Ribes, Ainhoa Garcia, Gonzalez, Sonia Martinez, Fernandez, Ricardo Martinez

“…Aicardi syndrome is defined by the clinical triad of infantile spasms, agenesis of the corpus callosum, and pathognomonic chorioretinal lacunae. Almost all…”
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La aplicación de la biotecnología en el diagnóstico de enfermedades de importancia en salud pública en México by Martínez-González, Sonia -Mirén, Martínez Rodríguez, Maria Concepción

“…Aunque las últimas técnicas de diagnóstico de la biotecnología médica son aplicadas en México, existe aún un porcentaje importante de personas que no tienen…”
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Corrigendum to <’ Omipalisib inspired macrocycles as dual PI3K/mTOR inhibitors’ [Eur. J. Med. Chem. 211 (2021), 113109] by Alvarez, Rosa M., García, Ana Belén, Riesco-Fagundo, Concepción, Martín, José I., Varela, Carmen, Rodríguez Hergueta, Antonio, González Cantalapiedra, Esther, Oyarzabal, Julen, Di Geronimo, Bruno, Lorenzo, Milagros, Albarrán, M Isabel, Cebriá, Antonio, Cebrián, David, Martínez-González, Sonia, Blanco-Aparicio, Carmen, Pastor, Joaquín

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La aplicación de la biotecnología en el diagnóstico de enfermedades de importancia en salud pública en México by Martínez Rodríguez, Maria Concepción, Martínez González, Sonia -Mirén

“…  Although the diagnostic techniques of medical biotechnology are being applied in Mexico, there is still a significant percentage of people who do not have…”
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Atención primaria en España e Inglaterra; aprender de las diferencias. Opinión de médicos de familia españoles con experiencia en ambos países by Ayerbe García-Monzón, Luis, Milazzo Loma-Osorio, Jorge, Pérez-Piñar López, María, González Martínez, Sonia, González López, Esteban

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