Search Results - "Gonzalez, Raymond"

Rapid and Definitive Identification of Cyclic Peptide Soft Spots by Isotope-Labeled Reductive Dimethylation and Mass Spectrometry Fragmentation by Feng, Yu, Qirjollari, Athanasia, Fawaz, Maria V., Cancilla, Mark T., Gonzalez, Raymond J., Pearson, Kara

“…Cyclic peptides are an emerging therapeutic modality over the past few decades. To identify drug candidates with sufficient proteolytic stability for oral…”
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The application of cytokeratin-18 as a biomarker for drug-induced liver injury by Korver, Samantha, Bowen, Joanne, Pearson, Kara, Gonzalez, Raymond J., French, Neil, Park, Kevin, Jenkins, Rosalind, Goldring, Christopher

“…Drug-induced liver injury (DILI) is a frequent and dangerous adverse effect faced during preclinical and clinical drug therapy. DILI is a leading cause of…”
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Enriching metabolite fractions for assessment of AHR activation potential: a proof of concept study by Erdemir, Ili, Feng, Yu, Liu, Liping, Hao, Rachel, Pearson, Kara, Gonzalez, Raymond

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Universal Accessible Biomarkers of Drug-Induced Tissue Injury and Systemic Inflammation in Rat: Performance Assessment of TIMP-1, A2M, AGP, NGAL, and Albumin by Vlasakova, Katerina, Bourque, Jennifer, Bailey, Wendy J, Patel, Shetal, Besteman, Elizabeth G, Gonzalez, Raymond J, Sistare, Frank D, Glaab, Warren E

“…The ability to monitor for general drug-induced tissue injury (DITI) or systemic inflammation in any tissue using blood-based accessible biomarkers would…”
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Leveraging High-Resolution Ion Mobility-Mass Spectrometry for Cyclic Peptide Soft Spot Identification by Fawaz, Maria, Sun, Congliang, Feng, Yu, Qirjollari, Athanasia, Josien, Hubert, DeBord, Daniel, Simone, Ashli, Williamson, David L., Pearson, Kara, Gonzalez, Raymond J., Vasicek, Lisa, Cancilla, Mark T., Wang, Weixun, Spellman, Daniel S., Kedia, Komal

“…Cyclic peptides are an important class of molecules that gained significant attention in the field of drug discovery due to their unique pharmacological…”
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Educational tug-of-war: internal and external accountability of principals in varied contexts by Gonzalez, Raymond A., Firestone, William A.

“…Purpose - Principals face shifting accountability pressures from many sources. The most notable recent change in the USA has been the growing pressure from…”
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Use of a Bile Salt Export Pump Knockdown Rat Susceptibility Model to Interrogate Mechanism of Drug-Induced Liver Toxicity by Li, Yutai, Evers, Raymond, Hafey, Michael J, Cheon, Kyeongmi, Duong, Hong, Lynch, Donna, LaFranco-Scheuch, Lisa, Pacchione, Stephen, Tamburino, Alex M, Tanis, Keith Q, Geddes, Kristin, Holder, Daniel, Zhang, Nanyan Rena, Kang, Wen, Gonzalez, Raymond J, Galijatovic-Idrizbegovic, Alema, Pearson, Kara M, Lebron, Jose A, Glaab, Warren E, Sistare, Frank D

“…Abstract Inhibition of the bile salt export pump (BSEP) may be associated with clinical drug-induced liver injury, but is poorly predicted by preclinical…”
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P223 - PPB: Considerations for safety studies and data interpretation by Pajkovic, Natasa, Kuo, Yuhsin, Bennet, Amrith, Gonzalez, Raymond, Bernard, Laïla, Poignant, Frédéric, Miller, Randy

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A performance evaluation of three drug-induced liver injury biomarkers in the rat: alpha-glutathione S-transferase, arginase 1, and 4-hydroxyphenyl-pyruvate dioxygenase by Bailey, Wendy J, Holder, Dan, Patel, Hima, Devlin, Pam, Gonzalez, Raymond J, Hamilton, Valerie, Muniappa, Nagaraja, Hamlin, Diane M, Thomas, Craig E, Sistare, Frank D, Glaab, Warren E

“…Alanine aminotransferase (ALT) activity is the most frequently relied upon reference standard for monitoring liver injury in humans and nonclinical species…”
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Nonclinical Safety Biomarkers of Drug-induced Vascular Injury: Current Status and Blueprint for the Future by Mikaelian, Igor, Cameron, Mark, Dalmas, Deidre A., Enerson, Bradley E., Gonzalez, Raymond J., Guionaud, Silvia, Hoffmann, Peter K., King, Nicholas M. P., Lawton, Michael P., Scicchitano, Marshall S., Smith, Holly W., Thomas, Roberta A., Weaver, James L., Zabka, Tanja S.

“…Better biomarkers are needed to identify, characterize, and/or monitor drug-induced vascular injury (DIVI) in nonclinical species and patients. The Predictive…”
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Vascular Imaging of Matrix Metalloproteinase Activity as an Informative Preclinical Biomarker of Drug-induced Vascular Injury by Gonzalez, Raymond J., Lin, Shu-An, Bednar, Bohumil, Connolly, Brett, LaFranco-Scheuch, Lisa, Mesfin, Gebre M., Philip, Thomas, Patel, Shetal, Johnson, Timothy, Sistare, Frank D., Glaab, Warren E.

“…Lack of biomarkers specific to and either predictive or diagnostic of drug-induced vascular injury (DIVI) continues to be a major obstacle during drug…”
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Optical Imaging Biomarkers of Drug-Induced Vascular Injury by Lin, Shu-An, Suresch, Donna L., Connolly, Brett, Mesfin, Gebre, Gonzalez, Raymond J., Patel, Manishkumar R., Shevell, Diane, Johnson, Timothy, Bednar, Bohumil

“…Drug-induced vascular injury (DIVI), defined as arterial medial degeneration/necrosis usually associated with perivascular inflammation, is frequently observed…”
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Maux de l’âme et mots du corps : témoignages de la captivité aux XVIe et XVIIe siècles by Gonzalez Raymond, Anita

“…La lecture des procès intentés par le tribunal du Saint-Office espagnol contre les renégats, anciens captifs ayant renié leur foi pour devenir musulmans en…”
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Employment Outcomes Post Bariatric Surgery: A Systematic Review by Ghulmi, Lima, Gamboa, Cheyenne, Kim, Pearl, Bhari, Kelisha, Martinez, Raymond Gonzalez, Grelle, Allie

“…This research explores the relationship between employment rates post-bariatric surgery and the potential impact of occupational therapy (OT) on employment…”
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Expression and activities of several drug-metabolizing enzymes in LLC-PK1 cells by Gonzalez, Raymond J., Tarloff, Joan B.

“…LLC-PK1 cells are frequently used in toxicology research, but little information is available concerning the capacity of these cells to metabolize xenobiotics…”
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Can Galactose Be Converted to Glucose in HepG2 Cells? Improving the in Vitro Mitochondrial Toxicity Assay for the Assessment of Drug Induced Liver Injury by Xu, Qiuwei, Liu, Liping, Vu, Heather, Kuhls, Matthew, Aslamkhan, Amy G, Liaw, Andy, Yu, Yan, Kaczor, Allen, Ruth, Michael, Wei, Christina, Imredy, John, Lebron, Jose, Pearson, Kara, Gonzalez, Raymond, Mitra, Kaushik, Sistare, Frank D

“…Human hepatocellular carcinoma cells, HepG2, are often used for drug mediated mitochondrial toxicity assessments. Glucose in HepG2 culture media is replaced by…”
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Developing a T cell:Dendritic cell co-culture system to predict idiosyncratic drug induced hypersensitivity reactions by Oropallo, Michael A, Shang, Jackie, Ke, Zhenlian, Gonzalez, Raymond James, Sistare, Frank D., Lebron, Jose, Monroe, James J.

“…Abstract Idiosyncratic drug induced hypersensitivy reactions (IDHR)s pose a significant safety risk to patients. Indeed, IDHRs have been associated with…”
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OPTICAL MONITORING OF THE BROAD-LINE RADIO GALAXY 3C 390.3 by DIETRICH, Matthias, PETERSON, Bradley M, GRIER, Catherine J, BENTZ, Misty C, EASTMAN, Jason, FRANK, Stephan, GONZALEZ, Raymond, MARSHALL, Jennifer L, DEPOY, Darren L, PRIETO, Jose L

“…We have undertaken a new ground-based monitoring campaign on the broad-line radio galaxy 3C 390.3 to improve the measurement of the size of the broad…”
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Maux de l’âme et mots du corps : témoignages de la captivité aux XVIe et XVIIe siècles by Anita Gonzalez-Raymond

“…This paper will explore three archival and documentary corpora, such as the trials of renegades (former captives who had recanted their faith to become Muslims…”
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Maux de l’âme et mots du corps : témoignages de la captivité aux XVIe et XVIIe siècles1 by Gonzalez-Raymond, Anita

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