Search Results - "Gonzalez, Ian E"

The IKK‐related kinase TBK1 activates mTORC1 directly in response to growth factors and innate immune agonists by Bodur, Cagri, Kazyken, Dubek, Huang, Kezhen, Ekim Ustunel, Bilgen, Siroky, Kate A, Tooley, Aaron Seth, Gonzalez, Ian E, Foley, Daniel H, Acosta‐Jaquez, Hugo A, Barnes, Tammy M, Steinl, Gabrielle K, Cho, Kae‐Won, Lumeng, Carey N, Riddle, Steven M, Myers, Martin G, Fingar, Diane C

“…The innate immune kinase TBK1 initiates inflammatory responses to combat infectious pathogens by driving production of type I interferons. TBK1 also controls…”
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Leptin action through hypothalamic nitric oxide synthase-1–expressing neurons controls energy balance by Leshan, Rebecca L, Greenwald-Yarnell, Megan, Patterson, Christa M, Gonzalez, Ian E, Myers, Martin G

“…The adipocyte-derived hormone leptin acts on the brain to signal the long-term status of energy balance in the body. Martin Myers and his colleagues narrow…”
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Ventral Tegmental Area Neurotensin Signaling Links the Lateral Hypothalamus to Locomotor Activity and Striatal Dopamine Efflux in Male Mice by Patterson, Christa M, Wong, Jenny-Marie T, Leinninger, Gina M, Allison, Margaret B, Mabrouk, Omar S, Kasper, Chelsea L, Gonzalez, Ian E, Mackenzie, Alexander, Jones, Justin C, Kennedy, Robert T, Myers, Martin G

“…Projections from the lateral hypothalamic area (LHA) innervate components of the mesolimbic dopamine (MLDA) system, including the ventral tegmental area (VTA)…”
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Leptin action via LepR-b Tyr1077 contributes to the control of energy balance and female reproduction by Patterson, Christa M, Villanueva, Eneida C, Greenwald-Yarnell, Megan, Rajala, Michael, Gonzalez, Ian E, Saini, Natinder, Jones, Justin, Myers, Martin G

“…Abstract Leptin action in the brain signals the repletion of adipose energy stores, suppressing feeding and permitting energy expenditure on a variety of…”
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The innate immune kinase TBK1 directly increases mTORC2 activity and downstream signaling to Akt by Tooley, Aaron Seth, Kazyken, Dubek, Bodur, Cagri, Gonzalez, Ian E., Fingar, Diane C.

“…TBK1 responds to microbes to initiate cellular responses critical for host innate immune defense. We found previously that TBK1 phosphorylates mTOR…”
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215-LB: Ablation of Nos-1 Neurons in the PVH Reveals an Essential Role in Sustaining Metabolic Homeostasis, Independent of Melanocortin Function by FAULKNER, LATRICE D., GONZALEZ, IAN E., OLSON, DAVID, MEEK, THOMAS H.

“…The paraventricular hypothalamus (PVH) is vital for energy balance regulation, as developmental or mechanical lesions targeting the PVH lead to massive…”
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Melanocortin 3 receptor-expressing neurons in the ventromedial hypothalamus promote glucose disposal by Sutton, Amy K., Goforth, Paulette B., Gonzalez, Ian E., Dell’Orco, James, Pei, Hongjuan, Myers, Martin G., Olson, David P.

“…The ventromedial hypothalamus (VMH) is a critical neural node that senses blood glucose and promotes glucose utilization or mobilization during hypoglycemia…”
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Paraventricular Calcitonin Receptor–Expressing Neurons Modulate Energy Homeostasis in Male Mice by Gonzalez, Ian E, Ramirez-Matias, Julliana, Lu, Chunxia, Pan, Warren, Zhu, Allen, Myers, Martin G, Olson, David P

“…The paraventricular nucleus of the hypothalamus (PVH) is a heterogeneous collection of neurons that play important roles in modulating feeding and energy…”
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Paraventricular, subparaventricular and periventricular hypothalamic IRS4-expressing neurons are required for normal energy balance by Sutton, Amy K., Gonzalez, Ian E., Sadagurski, Marianna, Rajala, Michael, Lu, Chunxia, Allison, Margaret B., Adams, Jessica M., Myers, Martin G., White, Morris F., Olson, David P.

“…Understanding the neural components modulating feeding-related behavior and energy expenditure is crucial to combating obesity and its comorbidities. Neurons…”
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Sa1754 Isolation of Ribosome Associated mRNA As a Tool to Study Transcriptional Changes in Paneth Cells by Rajala, Michael, Patterson, Christa M, Gonzalez, Ian E, Carulli, Alexis J, Olson, David P, Myers, Martin

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Leptin action via hypothalamic nitric oxide synthase-1 neurons controls energy balance by Leshan, Rebecca L., Greenwald-Yarnell, Megan, Patterson, Christa M., Gonzalez, Ian E., Myers, Martin G.

“…Few effective measures exist to combat the worldwide obesity epidemic 1 , and the identification of potential therapeutic targets requires a deeper…”
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