Behavioral effects of the combined use of alcohol and energy drinks on alcohol hangover in an experimental mice model

•Mixing alcohol and energy drinks is common practice among young people.•Neuromuscular coordination and muscle strength were affected by the mixture.•The change in locomotor activity was 6 h longer in mice treated with alcohol and energy drink. In last few years it has been a significant increase in...

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Bibliographic Details
Published in:	Neuroscience letters Vol. 670; pp. 1 - 7
Main Authors:	Asorey, Lucas G., Carbone, Silvia, Gonzalez, Bárbara J., Cutrera, Rodolfo A.
Format:	Journal Article
Language:	English
Published:	Ireland Elsevier B.V 23-03-2018
Subjects:	Alcohol Alcohol hangover Alcoholic Intoxication Animals Anxiety-like behavior Behavior, Animal - drug effects Blood Alcohol Content Energy Drinks Ethanol - pharmacology Locomotor activity Male Mice Models, Animal Motor Activity - drug effects Neuromuscular coordination Alcohol hangover Neuromuscular coordination Alcohol Anxiety-like behavior Mice Energy drinks Locomotor activity
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Summary:	•Mixing alcohol and energy drinks is common practice among young people.•Neuromuscular coordination and muscle strength were affected by the mixture.•The change in locomotor activity was 6 h longer in mice treated with alcohol and energy drink. In last few years it has been a significant increase in the consumption of alcohol combined with energy drink. The aim of this work was to study the effect of this mixture in motor and affective behaviors during an alcohol hangover episode. Male Swiss mice received one of the following treatments: saline + sucrose; saline + energy drink; ethanol + sucrose; ethanol + energy drink. Ethanol dose was 3.8 g/kg BW (i.p.) and energy drink dose was 18 ml/kg BW (gavage) at ZT1 (8 am) (ZT: Zeitgeber time; ZT0: 7 am; lights on). The behavioral tests used were tight rope test to determine motor coordination; hanging wire test to study muscular strength; elevated plus maze and open field tests to evaluate anxiety like-behavior and locomotor activity. Tests were carried out at basal point that matched with lights onset and every 6 h up to 18 h after treatments. Hangover onset was established at ZT7 when blood alcohol concentration (BAC) was almost zero. Our results showed that the mixture of alcohol and energy drink altered significantly motor skills. Specifically, a significant decrease was observed in the performance of the animals in the tightrope and hanging wire tests in groups treated with the mixture of alcohol and energy drink. A significant impairment in the anxiety-like behavior was observed mainly at the beginning of alcohol hangover. These findings suggest that energy drink added to alcohol extends motor disabilities observed during an alcohol hangover episode in comparison with animals that received alcohol alone.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0304-3940 1872-7972
DOI:	10.1016/j.neulet.2018.01.030