Search Results - "Gonzales, Mitzi M"

Biological aging processes underlying cognitive decline and neurodegenerative disease by Gonzales, Mitzi M, Garbarino, Valentina R, Pollet, Erin, Palavicini, Juan P, Kellogg, Jr, Dean L, Kraig, Ellen, Orr, Miranda E

“…Alzheimer's disease and related dementias (ADRD) are among the top contributors to disability and mortality in later life. As with many chronic conditions,…”
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Central artery stiffness, neuropsychological function, and cerebral perfusion in sedentary and endurance-trained middle-aged adults by Tarumi, Takashi, Gonzales, Mitzi M, Fallow, Bennett, Nualnim, Nantinee, Pyron, Martha, Tanaka, Hirofumi, Haley, Andreana P

“…BACKGROUND:Midlife vascular disease risk is a strong risk factor for late-life dementia. Central arterial stiffness, a hallmark of vascular aging, is…”
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Extending human healthspan and longevity: a symposium report by DeVito, Loren M., Barzilai, Nir, Cuervo, Ana Maria, Niedernhofer, Laura J., Milman, Sofiya, Levine, Morgan, Promislow, Daniel, Ferrucci, Luigi, Kuchel, George A., Mannick, Joan, Justice, Jamie, Gonzales, Mitzi M., Kirkland, James L., Cohen, Pinchas, Campisi, Judith

“…For many years, it was believed that the aging process was inevitable and that age‐related diseases could not be prevented or reversed. The geroscience…”
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Revisiting Apathy in Alzheimer’s Disease: From Conceptualization to Therapeutic Approaches by Teixeira, Antonio L., Gonzales, Mitzi M., de Souza, Leonardo Cruz, Weisenbach, Sara L.

“…Apathy is a neurobehavioral syndrome characterized by impaired motivation for goal-directed behaviors and cognitive activity, alongside blunted affect. Apathy…”
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Depressive symptoms in older adult couples: Associations with dyadic physical health, social engagement, and close friends by Miller, Lyndsey M, Steele, Joel S, Wu, Chao-Yi, Kaye, Jeffrey, Dodge, Hiroko H, Gonzales, Mitzi M, Lyons, Karen S

“…The objective of this study was to examine associations between level of depressive symptoms in older adult spouse/partner couples and their physical health…”
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Cortical Atrophy is Associated with Accelerated Cognitive Decline in Mild Cognitive Impairment with Subsyndromal Depression by Gonzales, Mitzi M., Ph.D, Insel, Philip S., M.S, Nelson, Craig, M.D, Tosun, Duygu, Ph.D, Mattsson, Niklas, M.D., Ph.D, Mueller, Susanne G., M.D, Sacuiu, Simona, M.D., Ph.D, Bickford, David, B.A, Weiner, Michael W., M.D, Mackin, R. Scott, Ph.D

“…Abstract Objectives: To investigate the association between cognitive decline and cortical atrophy in individuals with mild cognitive impairment (MCI) and…”
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The association of circulating endocannabinoids with neuroimaging and blood biomarkers of neuro-injury by Vered, Shiraz, Beiser, Alexa S, Sulimani, Liron, Sznitman, Sharon, Gonzales, Mitzi M, Aparicio, Hugo J, DeCarli, Charles, Scott, Matthew R, Ghosh, Saptaparni, Lewitus, Gil M, Meiri, David, Seshadri, Sudha, Weinstein, Galit

“…Preclinical studies highlight the importance of endogenous cannabinoids (endocannabinoids; eCBs) in neurodegeneration. Yet, prior observational studies focused…”
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45 Senolytic Therapy Transiently Reduces Inflammatory Markers in Primary Blood Mononuclear Cells of Individuals with Early Alzheimer’s Disease: Exploring the Conserved Transcriptional Response to Adversity as a Biomarker for Disease State by Garbarino, Valentina R., Xu, Peng, Zhang, Bin, Biggs, Glenn, Gonzales, Mitzi M., Orr, Miranda E.

“…OBJECTIVES/GOALS: Determine if the Conserved Transcriptional Response to Adversity transcriptomic profile established in primary blood mononuclear cells (PBMC)…”
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Cognitive screening with functional assessment improves diagnostic accuracy and attenuates bias by González, David Andrés, Gonzales, Mitzi M., Jennette, Kyle J., Soble, Jason R., Fongang, Bernard

“…Introduction Cognitive screening measures often lack sensitivity and are hampered by inequities across ethnoracial groups. A multitrait multimethod (MTMM)…”
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Blood biomarkers for dementia in Hispanic and non‐Hispanic White adults by Gonzales, Mitzi M., Short, Meghan I., Satizabal, Claudia L., O’ Bryant, Sid, Tracy, Russel P., Zare, Habil, Seshadri, Sudha

“…Introduction The study evaluated if blood markers reflecting diverse biological pathways differentiate clinical diagnostic groups among Hispanic and…”
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Identifying Blood Biomarkers for Dementia Using Machine Learning Methods in the Framingham Heart Study by Lin, Honghuang, Himali, Jayandra J, Satizabal, Claudia L, Beiser, Alexa S, Levy, Daniel, Benjamin, Emelia J, Gonzales, Mitzi M, Ghosh, Saptaparni, Vasan, Ramachandran S, Seshadri, Sudha, McGrath, Emer R

“…Blood biomarkers for dementia have the potential to identify preclinical disease and improve participant selection for clinical trials. Machine learning is an…”
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A population‐based meta‐analysis of circulating GFAP for cognition and dementia risk by Gonzales, Mitzi M., Wiedner, Crystal, Wang, Chen‐Pin, Liu, Qianqian, Bis, Joshua C., Li, Zhiguang, Himali, Jayandra J., Ghosh, Saptaparni, Thomas, Emy A., Parent, Danielle M., Kautz, Tiffany F., Pase, Matthew P., Aparicio, Hugo J., Djoussé, Luc, Mukamal, Kenneth J., Psaty, Bruce M., Longstreth, William T., Mosley, Thomas H., Gudnason, Vilmundur, Mbangdadji, Djass, Lopez, Oscar L., Yaffe, Kristine, Sidney, Stephen, Bryan, R. Nick, Nasrallah, Ilya M., DeCarli, Charles S., Beiser, Alexa S., Launer, Lenore J., Fornage, Myriam, Tracy, Russell P., Seshadri, Sudha, Satizabal, Claudia L.

“…Objective Expression of glial fibrillary acidic protein (GFAP), a marker of reactive astrocytosis, colocalizes with neuropathology in the brain. Blood levels…”
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Association of Loneliness With 10-Year Dementia Risk and Early Markers of Vulnerability for Neurocognitive Decline by Salinas, Joel, Beiser, Alexa S., Samra, Jasmeet K., O'Donnell, Adrienne, DeCarli, Charles S., Gonzales, Mitzi M., Aparicio, Hugo J., Seshadri, Sudha

“…Loneliness is common, and its prevalence is rising. The relationship of loneliness with subsequent dementia and the early preclinical course of Alzheimer…”
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Senolytic therapy in mild Alzheimer’s disease: a phase 1 feasibility trial by Gonzales, Mitzi M., Garbarino, Valentina R., Kautz, Tiffany F., Palavicini, Juan Pablo, Lopez-Cruzan, Marisa, Dehkordi, Shiva Kazempour, Mathews, Julia J., Zare, Habil, Xu, Peng, Zhang, Bin, Franklin, Crystal, Habes, Mohamad, Craft, Suzanne, Petersen, Ronald C., Tchkonia, Tamara, Kirkland, James L., Salardini, Arash, Seshadri, Sudha, Musi, Nicolas, Orr, Miranda E.

“…Cellular senescence contributes to Alzheimer’s disease (AD) pathogenesis. An open-label, proof-of-concept, phase I clinical trial of orally delivered senolytic…”
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Apathy as a Predictor of Conversion from Mild Cognitive Impairment to Alzheimer's Disease: A Texas Alzheimer's Research and Care Consortium (TARCC) Cohort-Based Analysis by Salem, Haitham, Suchting, Robert, Gonzales, Mitzi M, Seshadri, Sudha, Teixeira, Antonio L

“…Apathy is among the neuropsychiatric symptoms frequently observed in people with cognitive impairment. It has been postulated to be a potential predictor of…”
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Brief Report: An Evaluation of Item Bias on the Functional Activities Questionnaire by González, David Andrés, Clark, Michael J, Gonzales, Mitzi M, Benge, Jared

“…Abstract Objective To evaluate whether the Functional Activities Questionnaire (FAQ), a commonly used measure of functional status in neurodegenerative disease…”
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Comprehensive Evaluation of the Functional Activities Questionnaire (FAQ) and Its Reliability and Validity by González, David Andrés, Gonzales, Mitzi M., Resch, Zachary J., Sullivan, A. Campbell, Soble, Jason R.

“…The Functional Activities Questionnaire (FAQ) is a collateral-report measure of difficulties in activities of daily living. Despite its widespread use,…”
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A geroscience motivated approach to treat Alzheimer’s disease: Senolytics move to clinical trials by Gonzales, Mitzi M., Krishnamurthy, Sudarshan, Garbarino, Valentina, Daeihagh, Ali S., Gillispie, Gregory J., Deep, Gagan, Craft, Suzanne, Orr, Miranda E.

“…•A poor understanding of mechanisms driving Alzheimer’s disease pathogenesis presents obstacles for drug development.•Cellular senescence is a promising target…”
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Factors Associated with Apathy in Alzheimer's Disease: A Cross-Sectional Analysis of the Texas Alzheimer's Research and Care Consortium (TARCC) Study by Teixeira, Antonio L, Salem, Haitham, Martins, Lais B, Gonzales, Mitzi M, Seshadri, Sudha, Suchting, Robert

“…Apathy is among the most frequent neuropsychiatric syndromes in Alzheimer's disease (AD). To determine the prevalence of apathy and the associated clinical and…”
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Impaired Kidney Function, Cerebral Small Vessel Disease and Cognitive Disorders: The Framingham Heart Study by Kelly, Dearbhla M, Pinheiro, Adlin A, Koini, Marisa, Anderson, Christopher D, Aparicio, Hugo, Hofer, Edith, Kern, Daniela, Blacker, Deborah, DeCarli, Charles, Hwang, Shih-Jen, Viswanathan, Anand, Gonzales, Mitzi M, Beiser, Alexa S, Seshadri, Sudha, Schmidt, Reinhold, Demissie, Serkalem, Romero, Jose R

“…It remains unclear if the relation of chronic kidney disease (CKD) with cognitive dysfunction is independent of blood pressure (BP). We evaluated kidney…”
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