Search Results - "González Ros, J. M"

Occupancy of Nonannular Lipid Binding Sites on KcsA Greatly Increases the Stability of the Tetrameric Protein by Triano, I, Barrera, F. N, Renart, M. L, Molina, M. L, Fernández-Ballester, G, Poveda, J. A, Fernández, A. M, Encinar, J. A, Ferrer-Montiel, A. V, Otzen, D, González-Ros, J. M

“…KcsA, a homotetrameric potassium channel from prokaryotes, contains noncovalently bound lipids appearing in the X-ray crystallographic structure of the…”
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Contribution of Ion Binding Affinity to Ion Selectivity and Permeation in KcsA, a Model Potassium Channel by Renart, M. L, Montoya, E, Fernández, A. M, Molina, M. L, Poveda, J. A, Encinar, J. A, Ayala, J. L, Ferrer-Montiel, A. V, Gómez, J, Morales, A, González Ros, J. M

“…Ion permeation and selectivity, key features in ion channel function, are believed to arise from a complex ensemble of energetic and kinetic variables. Here we…”
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Ion Binding to KcsA: Implications in Ion Selectivity and Channel Gating by Renart, M. L, Triano, I, Poveda, J. A, Encinar, J. A, Fernández, A. M, Ferrer-Montiel, A. V, Gómez, J, González Ros, J. M

“…Binding of K+ and Na+ to the potassium channel KcsA has been characterized from the stabilization observed in the heat-induced denaturation of the protein as…”
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Lipid modulation of ion channels through specific binding sites by Poveda, J.A., Giudici, A.M., Renart, M.L., Molina, M.L., Montoya, E., Fernández-Carvajal, A., Fernández-Ballester, G., Encinar, J.A., González-Ros, J.M.

“…Ion channel conformational changes within the lipid membrane are a key requirement to control ion passage. Thus, it seems reasonable to assume that lipid…”
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Influence of C-Terminal Protein Domains and Protein−Lipid Interactions on Tetramerization and Stability of the Potassium Channel KcsA by Molina, M. L, Encinar, J. A, Barrera, F. N, Fernández-Ballester, G, Riquelme, G, González-Ros, J. M

“…KcsA is a prokaryotic potassium channel formed by the assembly of four identical subunits around a central aqueous pore. Although the high-resolution X-ray…”
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Protein-promoted membrane domains by Poveda, J.A., Fernández, A.M., Encinar, J.A., González-Ros, J.M.

“…The current notion of biological membranes encompasses a very complex structure, made of dynamically changing compartments or domains where different membrane…”
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Structure and Interaction with Membrane Model Systems of a Peptide Derived from the Major Epitope Region of HIV Protein gp41: Implications on Viral Fusion Mechanism by Contreras, Lellys M, Aranda, Francisco J, Gavilanes, Francisco, González-Ros, José M, Villalaín, José

“…The HIV-1 gp41 envelope protein mediates entry of the virus into the target cell by promoting membrane fusion. With a view toward possible new insights into…”
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Arginine-rich peptides are blockers of VR-1 channels with analgesic activity by Planells-Cases, R., Aracil, A., Merino, J.M., Gallar, J., Pérez-Payá, E., Belmonte, C., González-Ros, J.M., Ferrer-Montiel, A.V.

“…Vanilloid receptors (VRs) play a fundamental role in the transduction of peripheral tissue injury and/or inflammation responses. Molecules that antagonize VR…”
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Protein orientation affects the efficiency of functional protein transplantation into the xenopus oocyte membrane by Ivorra, I, Fernández, A, Gal, B, Aleu, J, González-Ros, J M, Ferragut, J A, Morales, A

“…Xenopus oocytes incorporate into their plasma membrane nicotinic acetylcholine receptors (nAChRs) after intracellular injection of lipid vesicles bearing this…”
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Tyrosine Phosphorylation of the Inactivating Peptide of the Shaker B Potassium Channel:  A Structural−Functional Correlate by Encinar, J. A, Fernández, A. M, Molina, M. L, Molina, A, Poveda, J. A, Albar, J. P, López-Barneo, J, Gavilanes, F, Ferrer-Montiel, A. V, González-Ros, J. M

“…A synthetic peptide patterned after the sequence of the inactivating “ball” domain of the Shaker B K+ channel restores fast (N-type) inactivation in mutant…”
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Probing the Channel-Bound Shaker B Inactivating Peptide by Stereoisomeric Substitution at a Strategic Tyrosine Residue by Encinar, J. A, Fernández, A. M, Poveda, J. A, Molina, M. L, Albar, J. P, Gavilanes, F, Gonzalez-Ros, J. M

“…A synthetic peptide patterned after the sequence of the inactivating ball domain of the Shaker B K+ channel, the ShB peptide, fully restores fast inactivation…”
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The influence of a membrane environment on the structure and stability of a prokaryotic potassium channel, KcsA by Encinar, J.A., Molina, M.L., Poveda, J.A., Barrera, F.N., Renart, M.L., Fernández, A.M., González-Ros, J.M.

“…The lack of a membrane environment in membrane protein crystals is considered one of the major limiting factors to fully imply X-ray structural data to explain…”
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Altered Drug Membrane Permeability in a Multidrug-Resistant Leishmania tropica Line by Chiquero, M.Jesús, Pérez-Victoria, José M, O’Valle, Francisco, González-Ros, José M, del Moral, Raimundo G, Ferragut, José A, Castanys, Santiago, Gamarro, Francisco

“…We selected a Leishmania tropica cell line resistant to daunomycin (DNM) that presents a multidrug-resistant (MDR) phenotype characterized by overexpression of…”
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Salmonid viral haemorrhagic septicaemia virus: fusion-related enhancement of virus infectivity by peptides derived from viral glycoprotein G or a combinatorial library by Mas, V, Perez, L, Encinar, J.A, Pastor, M.T, Rocha, A, Perez-Paya, E, Ferrer-Montiel, A, Gonzalez Ros, J.M, Estepa, A, Coll, J.M

“…To search for enhancers and/or inhibitors of viral haemorrhagic septicaemia virus (VHSV, a salmonid rhabdovirus) infectivity, a total of 51 peptides from a…”
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Incorporation of Reconstituted Acetylcholine Receptors from Torpedo Into the Xenopus Oocyte Membrane by Morales, A., Aleu, J., Ivorra, I., Ferragut, J. A., Gonzalez-Ros, J. M., Miledi, R.

“…Xenopus oocytes are a valuable aid for studying the molecular structure and function of ionic channels and neurotransmitter receptors. Their use has recently…”
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Thermal stability of hepatitis B surface antigen S proteins by Gómez-Gutiérrez, J, Rodríguez-Crespo, I, González-Ros, J M, Ferragut, J A, Paul, D A, Peterson, D L, Gavilanes, F

“…Thermal stability of hepatitis B surface antigen (HBsAg) has been studied by analyzing alterations in the native secondary structure and the antigenic…”
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Effect of the inactivating "ball" peptide of Shaker B on intermediate conductance Ca2+-dependent inwardly rectifying K+ channels of HeLa cells by Riquelme, G., Fernández, A. M., Encinar, J. A., González-Ros, J. M., Sepúlveda, F. V.

“…The patch-clamp technique was used to study the effect of intracellularly added inactivating "ball" peptide (BP) of the Shaker B K^sup +^ channel upon Ca^sup…”
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Phospholipid Interactions of a Peptide from the Fusion-Related Domain of the Glycoprotein of VHSV, a Fish Rhabdovirus by Nuñez, E., Fernandez, A.M., Estepa, A., Gonzalez-Ros, J.M., Gavilanes, F., Coll, J.M.

“…Previous studies mapped a p2 domain (aa 82–109) which binds phosphatidylserine (PS) (Estepa and Coll, 1996a) and contains three contiguous hydrophobic amino…”
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Protein stability and interaction of the nicotinic acetylcholine receptor with cholinergic ligands studied by Fourier-transform infrared spectroscopy by FERNANDEZ-BALLESTER, G, CASTRESANA, J, ARRONDO, J.-L. R, FERRAGUT, J. A, GONZALEZ-ROS, J. M

“…Based on the conformational dependence of the amide-I i.r. band, this paper explores the use of Fourier-transform i.r. spectroscopy methods to probe structural…”
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Botulinum toxin type A inhibits Ca(2+)-dependent transport of acetylcholine in reconstituted giant liposomes made from presynaptic membranes from cholinergic nerve terminals by López-Alonso, E, Canaves, J, Arribas, M, Casanova, A, Marsal, J, González-Ros, J M, Solsona, C

“…Giant liposomes were made from a mixture of asolectin phospholipid vesicles and presynaptic plasma membranes isolated from Torpedo cholinergic nerve endings…”
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