Search Results - "González Zaldivar, Yanetza"

Gene Therapy for Polyglutamine Spinocerebellar Ataxias: Advances, Challenges, and Perspectives by Vázquez‐Mojena, Yaimeé, León‐Arcia, Karen, González‐Zaldivar, Yanetza, Rodríguez‐Labrada, Roberto, Velázquez‐Pérez, Luis

“…ABSTRACT Polyglutamine spinocerebellar ataxias (SCAs) comprise a heterogeneous group of six autosomal dominant ataxias caused by cytosine–adenine–guanine…”
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Neurorehabilitation therapy in spinocerebellar ataxia type 2: A 24‐week, rater‐blinded, randomized, controlled trial by Rodríguez‐Díaz, Julio Cesar, Velázquez‐Pérez, Luis, Rodríguez Labrada, Roberto, Aguilera Rodríguez, Raúl, Laffita Pérez, Dalina, Canales Ochoa, Nalia, Medrano Montero, Jacqueline, Estupiñán Rodríguez, Annelié, Osorio Borjas, Marcos, Góngora Marrero, Mariela, Reynaldo Cejas, Lorenzo, González Zaldivar, Yanetza, Almaguer Gotay, Dennis

“…ABSTRACT Background: Neurorehabilitation has become in a widely used approach in spinocerebellar ataxias, but there are scarce powerful clinical studies…”
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Spinocerebellar ataxia type 2: Measures of saccade changes improve power for clinical trials by Rodríguez-Labrada, Roberto, Velázquez-Pérez, Luis, Auburger, Georg, Ziemann, Ulf, Canales-Ochoa, Nalia, Medrano-Montero, Jacqueline, Vázquez-Mojena, Yaimeé, González-Zaldivar, Yanetza

“…ABSTRACT Background Saccadic eye movement abnormalities are common in patients with spinocerebellar ataxia type 2, but it is unclear how these alterations…”
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On the Cut-Off Value of the Anteroposterior Diameter of the Midbrain Atrophy in Spinocerebellar Ataxia Type 2 Patients by Álvarez-Cuesta, José Alberto, Mora-Batista, Camilo, Reyes-Carreto, Ramón, Carrillo-Rodes, Frank Jesus, Fitz, Sergio J Torralbaz, González-Zaldivar, Yanetza, Vargas-De-León, Cruz

“…(1) Background: Spinocerebellar ataxias (SCA) is a term that refers to a group of hereditary ataxias, which are neurological diseases characterized by…”
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Cognitive Decline Is Closely Associated with Ataxia Severity in Spinocerebellar Ataxia Type 2: a Validation Study of the Schmahmann Syndrome Scale by Rodríguez-Labrada, Roberto, Batista-Izquierdo, Alejandro, González-Melix, Zuleyra, Reynado-Cejas, Lorenzo, Vázquez-Mojena, Yaimeé, Sanz, Yuri Arsenio, Canales-Ochoa, Nalia, González-Zaldívar, Yanetza, Dogan, Imis, Reetz, Kathrin, Velázquez-Pérez, Luis

“…The cerebellar cognitive affective syndrome scale (CCAS-S) was designed to detect specific cognitive dysfunctions in cerebellar patients but is scarcely…”
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Early corticospinal tract damage in prodromal SCA2 revealed by EEG-EMG and EMG-EMG coherence by Velázquez-Pérez, Luis, Tünnerhoff, Johannes, Rodríguez-Labrada, Roberto, Torres-Vega, Reidenis, Ruiz-Gonzalez, Yusely, Belardinelli, Paolo, Medrano-Montero, Jacqueline, Canales-Ochoa, Nalia, González-Zaldivar, Yanetza, Vazquez-Mojena, Yaimeé, Auburger, Georg, Ziemann, Ulf

“…•Corticospinal tract integrity was tested using EEG-EMG and EMG-EMG coherence.•SCA2 patients and prodromal SCA2 mutation carriers had reduced EEG-EMG and…”
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Sleep spindles and K-complex activities are decreased in spinocerebellar ataxia type 2: relationship to memory and motor performances by Rodríguez-Labrada, Roberto, Galicia-Polo, Lourdes, Canales-Ochoa, Nalia, Voss, Ursula, Tuin, Inca, Peña-Acosta, Arnoy, Estupiñán-Rodriguez, Annelié, Medrano-Montero, Jacqueline, Vázquez-Mojena, Yaimeé, González-Zaldivar, Yanetza, Auburger, Georg, Velázquez-Pérez, Luis

“…Sleep spindles and K-complexes are electroencephalographic hallmarks of non-rapid eye movement (non-REM) sleep that provide valuable information into brain…”
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Peripheral Inflammation Links with the Severity of Clinical Phenotype in Spinocerebellar Ataxia 2 by Vázquez‐Mojena, Yaimeé, Rodríguez‐Córdova, Yanetsy, Dominguez‐Barrios, Yennis, León‐Arcia, Karen, Miranda‐Becerra, David, Gonzalez‐Zaldivar, Yanetza, Guerra‐Bustillos, Guillermo, Ziemann, Ulf, Auburger, Georg, Rodríguez‐Labrada, Roberto, Robinson‐Agramonte, María de los Ángeles, Velázquez‐Pérez, Luis

“…ABSTRACT Background The role of peripheral inflammation in spinocerebellar ataxia type 2 (SCA2) is unknown. Objective The objective of this study was to…”
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Weight loss is correlated with disease severity in Spinocerebellar ataxia type 2: a cross-sectional cohort study by Rodriguez-Graña, Tania, Rodríguez-Labrada, Roberto, Santana-Porbén, Sergio, Reynaldo-Cejas, Lorenzo, Medrano-Montero, Jacqueline, Canales-Ochoa, Nalia, Silva-Ricardo, Yanelis, Torres-Vega, Reidenis, González-Zaldivar, Yanetza, Almaguer-Gotay, Dennis, Auburger, Georg, Velázquez-Pérez, Luis

“…Body weight changes occur frequently during advanced stages of Spinocerebellar Ataxia type 2 (SCA2), nevertheless limited information exists on biomarkers of…”
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Redox Imbalance Associates with Clinical Worsening in Spinocerebellar Ataxia Type 2 by Dennis, Almaguer-Gotay, Almaguer-Mederos, Luis E., Raúl, Rodríguez-Aguilera, Roberto, Rodríguez-Labrada, Luis, Velázquez-Pérez, Dany, Cuello-Almarales, Yanetza, González-Zaldívar, Yaimeé, Vázquez-Mojena, Annelié, Estupiñán-Domínguez, Arnoy, Peña-Acosta, Reydenis, Torres-Vega

“…Background. Spinocerebellar ataxia type 2 (SCA2) is a neurodegenerative disease presenting with redox imbalance. However, the nature and implications of redox…”
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Corticomuscular Coherence: a Novel Tool to Assess the Pyramidal Tract Dysfunction in Spinocerebellar Ataxia Type 2 by Velázquez-Pérez, Luis, Tünnerhoff, Johannes, Rodríguez-Labrada, Roberto, Torres-Vega, Reidenis, Belardinelli, Paolo, Medrano-Montero, Jacqueline, Peña-Acosta, Arnoy, Canales-Ochoa, Nalia, Vázquez-Mojena, Yaimeé, González-Zaldivar, Yanetza, Auburger, Georg, Ziemann, Ulf

“…Clinical signs of corticospinal tract dysfunction are a common feature of spinocerebellar ataxia type 2 (SCA2) patients. The objective of this study is to…”
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Executive deficit in spinocerebellar ataxia type 2 is related to expanded CAG repeats: Evidence from antisaccadic eye movements by Rodríguez-Labrada, Roberto, Velázquez-Pérez, Luis, Aguilera-Rodríguez, Raúl, Seifried-Oberschmidt, Carola, Peña-Acosta, Arnoy, Canales-Ochoa, Nalia, Medrano-Montero, Jacqueline, Estupiñan-Rodríguez, Annelié, Vázquez-Mojena, Yaimeé, González-Zaldivar, Yanetza, Laffita Mesa, Jose M.

“…Although antisaccadic task is a sensitive research tool in psychopathology, it has not been systematically studied in patients with spinocerebellar ataxia type…”
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De novo mutations in ataxin-2 gene and ALS risk by Laffita-Mesa, José Miguel, Rodríguez Pupo, Jorge Michel, Moreno Sera, Raciel, Vázquez Mojena, Yaimee, Kourí, Vivian, Laguna-Salvia, Leonides, Martínez-Godales, Michael, Valdevila Figueira, José A, Bauer, Peter O, Rodríguez-Labrada, Roberto, González Zaldívar, Yanetza, Paucar, Martin, Svenningsson, Per, Velázquez Pérez, Luís

“…Pathogenic CAG repeat expansion in the ataxin-2 gene (ATXN2) is the genetic cause of spinocerebellar ataxia type 2 (SCA2). Recently, it has been associated…”
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Testosterone Levels Are Decreased and Associated with Disease Duration in Male Spinocerebellar Ataxia Type 2 Patients by Almaguer-Mederos, Luis E., Aguilera-Rodríguez, Raúl, Almaguer-Gotay, Dennis, Hechavarría-Barzaga, Kenia, Álvarez-Sosa, Amarilis, Chapman-Rodríguez, Yamilé, Silva-Ricardo, Yanelis, González-Zaldivar, Yanetza, Vázquez-Mojena, Yaimé, Cuello-Almarales, Dany, Rodríguez-Estupiñán, Annelié

“…Spinocerebellar ataxia type 2 (SCA2) is a progressive neurodegenerative disorder due to an unstable expansion of a CAG repeat in the ATXN2 gene. Despite…”
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Normal ATXN2 alleles influences on the age at onset in spinocerebellar ataxia type 2 by Almaguer‐Mederos, Luis E., Aguilera‐Rodríguez, Raúl, Cuello‐Almarales, Dany, Almaguer‐Gotay, Dennis, González‐Zaldívar, Yanetza, Vázquez‐Mojena, Yaimé, Santos‐Falcón, Nieves, Sánchez‐Cruz, Gilberto, Velázquez‐Pérez, Luis

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Molecular epidemiology of spinocerebellar ataxias in Cuba: Insights into SCA2 founder effect in Holguin by Velázquez Pérez, Luis, Cruz, Gilberto Sánchez, Santos Falcón, Nieves, Enrique Almaguer Mederos, Luis, Escalona Batallan, Karel, Rodríguez Labrada, Roberto, Paneque Herrera, Milena, Laffita Mesa, José Miguel, Rodríguez Díaz, Julio C., Rodríguez, Raúl Aguilera, González Zaldivar, Yanetza, Coello Almarales, Dany, Almaguer Gotay, Dennis, Jorge Cedeño, Humberto

“…The objective of this study was to determine the prevalence of hereditary ataxias in Cuba, with a special focus on the clinical and molecular features of SCA2…”
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Epigenetics DNA methylation in the core ataxin-2 gene promoter: novel physiological and pathological implications by Laffita-Mesa, José Miguel, Bauer, Peter O., Kourí, Vivian, Peña Serrano, Leodani, Roskams, Jane, Almaguer Gotay, Dennis, Montes Brown, Julio Cesar, Martínez Rodríguez, Pedro Ariel, González-Zaldívar, Yanetza, Almaguer Mederos, Luís, Cuello-Almarales, Dany, Aguiar Santiago, Jorge

“…Pathogenic CAG (cytosine-adenine-guanine) expansions beyond certain thresholds in the ataxin-2 (ATXN2) gene cause spinocerebellar ataxia type 2 (SCA2) and were…”
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Spinocerebellar Ataxia Type 2 Is Associated with the Extracellular Loss of Superoxide Dismutase but Not Catalase Activity by Almaguer-Gotay, Dennis, Almaguer-Mederos, Luis E, Aguilera-Rodríguez, Raul, Rodríguez-Labrada, Roberto, Cuello-Almarales, Dany, Estupiñán-Domínguez, Annelié, Velázquez-Pérez, Luis C, González-Zaldívar, Yanetza, Vázquez-Mojena, Yaimé

“…Spinocerebellar ataxia type 2 (SCA2) is an inherited and still incurable neurodegenerative disorder. Evidence suggests that pro-oxidant agents as well as…”
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Uncommon features in Cuban families affected with Friedreich ataxia by Cruz-Mariño, Tania, González-Zaldivar, Yanetza, Laffita-Mesa, Jose Miguel, Almaguer-Mederos, Luis, Aguilera-Rodríguez, Raul, Almaguer-Gotay, Dennis, Rodríguez-Labrada, Roberto, Canales-Ochoa, Nalia, MacLeod, Patrick, Velázquez-Pérez, Luis

“…This report describes two families who presented with autosomal recessive ataxia. By means of Polymerase Chain Reaction (PCR) molecular testing we identified…”
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Couples at risk for spinocerebellar ataxia type 2: the Cuban prenatal diagnosis experience by Cruz-Mariño, Tania, Velázquez-Pérez, Luis, González-Zaldivar, Yanetza, Aguilera-Rodríguez, Raúl, Velázquez-Santos, Miguel, Vázquez-Mojena, Yaimé, Estupiñán-Rodríguez, Annelié, Reynaldo-Armiñán, Rubén, Almaguer-Mederos, Luis Enrique, Laffita-Mesa, José Miguel, Tamayo-Chiang, Victor, Paneque, Milena

“…Cuba reports the highest worldwide prevalence of spinocerebellar ataxia type 2 (SCA2) and the greatest number of descendants at risk. A protocol for genetic…”
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