Search Results - "González Pérez, Marta"

Design, Synthesis, and Biological Evaluation of First-in-Class Dual Acting Histone Deacetylases (HDACs) and Phosphodiesterase 5 (PDE5) Inhibitors for the Treatment of Alzheimer’s Disease by Rabal, Obdulia, Sánchez-Arias, Juan A, Cuadrado-Tejedor, Mar, de Miguel, Irene, Pérez-González, Marta, García-Barroso, Carolina, Ugarte, Ana, Estella-Hermoso de Mendoza, Ander, Sáez, Elena, Espelosin, Maria, Ursua, Susana, Haizhong, Tan, Wei, Wu, Musheng, Xu, Garcia-Osta, Ana, Oyarzabal, Julen

“…Simultaneous inhibition of phosphodiesterase 5 (PDE5) and histone deacetylases (HDAC) has recently been validated as a potentially novel therapeutic approach…”
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Editorial: New insights into the role of neuroinflammation and glial cells in the development of neurological disorders by Pérez-González, Marta, Solas, Maite, Wu, Yixing, Mela, Virginia

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Survival prediction and treatment optimization of multiple myeloma patients using machine-learning models based on clinical and gene expression data by Mosquera Orgueira, Adrián, González Pérez, Marta Sonia, Díaz Arias, José Ángel, Antelo Rodríguez, Beatriz, Alonso Vence, Natalia, Bendaña López, Ángeles, Abuín Blanco, Aitor, Bao Pérez, Laura, Peleteiro Raíndo, Andrés, Cid López, Miguel, Pérez Encinas, Manuel Mateo, Bello López, José Luis, Mateos Manteca, Maria Victoria

“…Multiple myeloma (MM) remains mostly an incurable disease with a heterogeneous clinical evolution. Despite the availability of several prognostic scores,…”
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Identifying the Main Functional Pathways Associated with Cognitive Resilience to Alzheimer’s Disease by Pérez-González, Marta, Badesso, Sara, Lorenzo, Elena, Guruceaga, Elizabeth, Pérez-Mediavilla, Alberto, García-Osta, Ana, Cuadrado-Tejedor, Mar

“…Understanding the mechanisms involved in cognitive resilience in Alzheimer’s disease (AD) represents a promising strategy to identify novel treatments for…”
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Correction: Gene expression profiling identifies FLT3 mutation-like cases in wild-type FLT3 acute myeloid leukemia by Mosquera Orgueira, Adrián, Peleteiro Raíndo, Andrés, Cid López, Miguel, Antelo Rodríguez, Beatriz, Díaz Arias, José Ángel, Ferreiro Ferro, Roi, Alonso Vence, Natalia, Bendaña López, Ángeles, Abuín Blanco, Aitor, Bao Pérez, Laura, Melero Valentín, Paula, Sonia González Pérez, Marta, Cerchione, Claudio, Martinelli, Giovanni, Montesinos Fernández, Pau, Mateo Pérez Encinas, Manuel, Luis Bello López, José

“…[This corrects the article DOI: 10.1371/journal.pone.0247093.]…”
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Amyloid-Driven Tau Accumulation on Mitochondria Potentially Leads to Cognitive Deterioration in Alzheimer's Disease by Cuadrado-Tejedor, Mar, Pérez-González, Marta, Alfaro-Ruiz, Rocío, Badesso, Sara, Sucunza, Diego, Espelosin, María, Ursúa, Susana, Lachen-Montes, Mercedes, Fernández-Irigoyen, Joaquín, Santamaria, Enrique, Luján, Rafael, García-Osta, Ana

“…Despite the well-accepted role of the two main neuropathological markers (β-amyloid and tau) in the progression of Alzheimer's disease, the interaction and…”
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Taking Advantage of the Selectivity of Histone Deacetylases and Phosphodiesterase Inhibitors to Design Better Therapeutic Strategies to Treat Alzheimer's Disease by Cuadrado-Tejedor, Mar, Pérez-González, Marta, García-Muñoz, Cristina, Muruzabal, Damián, García-Barroso, Carolina, Rabal, Obdulia, Segura, Víctor, Sánchez-Arias, Juan A, Oyarzabal, Julen, Garcia-Osta, Ana

“…The discouraging results with therapies for Alzheimer's disease (AD) in clinical trials, highlights the urgent need to adopt new approaches. Like other complex…”
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Multitarget Approach for the Treatment of Alzheimer’s Disease: Inhibition of Phosphodiesterase 9 (PDE9) and Histone Deacetylases (HDACs) Covering Diverse Selectivity Profiles by Rabal, Obdulia, Sánchez-Arias, Juan A, Cuadrado-Tejedor, Mar, de Miguel, Irene, Pérez-González, Marta, García-Barroso, Carolina, Ugarte, Ana, Estella-Hermoso de Mendoza, Ander, Sáez, Elena, Espelosin, Maria, Ursua, Susana, Tan, Haizhong, Wu, Wei, Xu, Musheng, Pineda-Lucena, Antonio, Garcia-Osta, Ana, Oyarzabal, Julen

“…Here, we present a series of dual-target phosphodiesterase 9 (PDE9) and histone deacetylase (HDAC) inhibitors devised as pharmacological tool compounds for…”
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Gene expression profiling identifies FLT3 mutation-like cases in wild-type FLT3 acute myeloid leukemia by Mosquera Orgueira, Adrián, Peleteiro Raíndo, Andrés, Cid López, Miguel, Antelo Rodríguez, Beatriz, Díaz Arias, José Ángel, Ferreiro Ferro, Roi, Alonso Vence, Natalia, Bendaña López, Ángeles, Abuín Blanco, Aitor, Bao Pérez, Laura, Melero Valentín, Paula, González Pérez, Marta Sonia, Cerchione, Claudio, Martinelli, Giovanni, Montesinos Fernández, Pau, Pérez Encinas, Manuel Mateo, Bello López, José Luis

“…FLT3 mutation is present in 25-30% of all acute myeloid leukemias (AML), and it is associated with adverse outcome. FLT3 inhibitors have shown improved…”
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Discovery of in Vivo Chemical Probes for Treating Alzheimer’s Disease: Dual Phosphodiesterase 5 (PDE5) and Class I Histone Deacetylase Selective Inhibitors by Rabal, Obdulia, Sánchez-Arias, Juan A, Cuadrado-Tejedor, Mar, de Miguel, Irene, Pérez-González, Marta, García-Barroso, Carolina, Ugarte, Ana, Estella-Hermoso de Mendoza, Ander, Sáez, Elena, Espelosin, Maria, Ursua, Susana, Haizhong, Tan, Wei, Wu, Musheng, Xu, Garcia-Osta, Ana, Oyarzabal, Julen

“…In order to determine the contributions of histone deacetylase (HDAC) isoforms to the beneficial effects of dual phosphodiesterase 5 (PDE5) and pan-HDAC…”
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Impact of Scaffold Exploration on Novel Dual-Acting Histone Deacetylases and Phosphodiesterase 5 Inhibitors for the Treatment of Alzheimer’s Disease by Sánchez-Arias, Juan A, Rabal, Obdulia, Cuadrado-Tejedor, Mar, de Miguel, Irene, Pérez-González, Marta, Ugarte, Ana, Sáez, Elena, Espelosin, Maria, Ursua, Susana, Haizhong, Tan, Wei, Wu, Musheng, Xu, Garcia-Osta, Ana, Oyarzabal, Julen

“…A novel systems therapeutics approach, involving simultaneous inhibition of phosphodiesterase 5 (PDE5) and histone deacetylase (HDAC), has been validated as a…”
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Unsupervised machine learning improves risk stratification in newly diagnosed multiple myeloma: an analysis of the Spanish Myeloma Group by Mosquera Orgueira, Adrian, González Pérez, Marta Sonia, Diaz Arias, Jose, Rosiñol, Laura, Oriol, Albert, Teruel, Ana Isabel, Martinez Lopez, Joaquin, Palomera, Luis, Granell, Miguel, Blanchard, Maria Jesus, de la Rubia, Javier, López de la Guia, Ana, Rios, Rafael, Sureda, Anna, Hernandez, Miguel Teodoro, Bengoechea, Enrique, Calasanz, María José, Gutierrez, Norma, Martin, Maria Luis, Blade, Joan, Lahuerta, Juan-Jose, San Miguel, Jesús, Mateos, Maria Victoria

“…The International Staging System (ISS) and the Revised International Staging System (R-ISS) are commonly used prognostic scores in multiple myeloma (MM). These…”
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Cognitive impairments in a Down syndrome model with abnormal hippocampal and prefrontal dynamics and cytoarchitecture by Muza, Phillip M., Bush, Daniel, Pérez-González, Marta, Zouhair, Ines, Cleverley, Karen, Sopena, Miriam L., Aoidi, Rifdat, West, Steven J., Good, Mark, Tybulewicz, Victor L.J., Walker, Matthew C., Fisher, Elizabeth M.C., Chang, Pishan

“…The Dp(10)2Yey mouse carries a ∼2.3-Mb intra-chromosomal duplication of mouse chromosome 10 (Mmu10) that has homology to human chromosome 21, making it an…”
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Improved personalized survival prediction of patients with diffuse large B-cell Lymphoma using gene expression profiling by Mosquera Orgueira, Adrián, Díaz Arias, José Ángel, Cid López, Miguel, Peleteiro Raíndo, Andrés, Antelo Rodríguez, Beatriz, Aliste Santos, Carlos, Alonso Vence, Natalia, Bendaña López, Ángeles, Abuín Blanco, Aitor, Bao Pérez, Laura, González Pérez, Marta Sonia, Pérez Encinas, Manuel Mateo, Fraga Rodríguez, Máximo Francisco, Bello López, José Luis

“…Thirty to forty percent of patients with Diffuse Large B-cell Lymphoma (DLBCL) have an adverse clinical evolution. The increased understanding of DLBCL biology…”
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Time to Treatment Prediction in Chronic Lymphocytic Leukemia Based on New Transcriptional Patterns by Mosquera Orgueira, Adrián, Antelo Rodríguez, Beatriz, Alonso Vence, Natalia, Bendaña López, Ángeles, Díaz Arias, José Ángel, Díaz Varela, Nicolás, González Pérez, Marta Sonia, Pérez Encinas, Manuel Mateo, Bello López, José Luis

“…Chronic lymphocytic leukemia (CLL) is the most frequent lymphoproliferative syndrome in western countries. CLL evolution is frequently indolent, and treatment…”
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Personalized Survival Prediction of Patients With Acute Myeloblastic Leukemia Using Gene Expression Profiling by Mosquera Orgueira, Adrián, Peleteiro Raíndo, Andrés, Cid López, Miguel, Díaz Arias, José Ángel, González Pérez, Marta Sonia, Antelo Rodríguez, Beatriz, Alonso Vence, Natalia, Bao Pérez, Laura, Ferreiro Ferro, Roi, Albors Ferreiro, Manuel, Abuín Blanco, Aitor, Fontanes Trabazo, Emilia, Cerchione, Claudio, Martinnelli, Giovanni, Montesinos Fernández, Pau, Mateo Pérez Encinas, Manuel, Luis Bello López, José

“…Acute Myeloid Leukemia (AML) is a heterogeneous neoplasm characterized by cytogenetic and molecular alterations that drive patient prognosis. Currently…”
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Evaluation of the Stellae-123 prognostic gene expression signature in acute myeloid leukemia by Mosquera Orgueira, Adrián, Peleteiro Raíndo, Andrés, Díaz Arias, José Ángel, Antelo Rodríguez, Beatriz, López Riñón, Mónica, Cerchione, Claudio, de la Fuente Burguera, Adolfo, González Pérez, Marta Sonia, Martinelli, Giovanni, Montesinos Fernández, Pau, Pérez Encinas, Manuel Mateo

“…Risk stratification in acute myeloid leukemia (AML) has been extensively improved thanks to the incorporation of recurrent cytogenomic alterations into risk…”
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Detection of Rare Germline Variants in the Genomes of Patients with B-Cell Neoplasms by Mosquera Orgueira, Adrián, Cid López, Miguel, Peleteiro Raíndo, Andrés, Díaz Arias, José Ángel, Antelo Rodríguez, Beatriz, Bao Pérez, Laura, Alonso Vence, Natalia, Bendaña López, Ángeles, Abuin Blanco, Aitor, Melero Valentín, Paula, Ferreiro Ferro, Roi, Aliste Santos, Carlos, Fraga Rodríguez, Máximo Francisco, González Pérez, Marta Sonia, Pérez Encinas, Manuel Mateo, Bello López, José Luis

“…There is growing evidence indicating the implication of germline variation in cancer predisposition and prognostication. Here, we describe an analysis of…”
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Personally Tailored Survival Prediction of Patients With Follicular Lymphoma Using Machine Learning Transcriptome-Based Models by Mosquera Orgueira, Adrián, Cid López, Miguel, Peleteiro Raíndo, Andrés, Abuín Blanco, Aitor, Díaz Arias, Jose Ángel, González Pérez, Marta Sonia, Antelo Rodríguez, Beatriz, Bao Pérez, Laura, Ferreiro Ferro, Roi, Aliste Santos, Carlos, Pérez Encinas, Manuel Mateo, Fraga Rodríguez, Máximo Francisco, Cerchione, Claudio, Mozas, Pablo, Bello López, José Luis

“…Follicular Lymphoma (FL) has a 10-year mortality rate of 20%, and this is mostly related to lymphoma progression and transformation to higher grades. In the…”
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FLT3 inhibitors in the treatment of acute myeloid leukemia: current status and future perspectives by Mosquera Orgueira, Adrián, Bao Pérez, Laura, Mosquera Torre, Alicia, Peleteiro Raíndo, Andrés, Cid López, Miguel, Díaz Arias, José Á, Ferreiro Ferro, Roi, Antelo Rodríguez, Beatriz, González Pérez, Marta S, Albors Ferreiro, Manuel, Alonso Vence, Natalia, Pérez Encinas, Manuel M, Bello López, José L, Martinelli, Giovanni, Cerchione, Claudio

“…Mutations in the FMS-like tyrosine kinase 3 (FLT3) gene arise in 25-30% of all acute myeloid leukemia (AML) patients. These mutations lead to constitutive…”
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