Search Results - "González‐Sancho, José Manuel"

The human PKP2/plakophilin‐2 gene is induced by Wnt/β‐catenin in normal and colon cancer‐associated fibroblasts by Niell, Núria, Larriba, María Jesús, Ferrer‐Mayorga, Gemma, Sánchez‐Pérez, Isabel, Cantero, Ramón, Real, Francisco X., del Peso, Luis, Muñoz, Alberto, González‐Sancho, José Manuel

“…Colorectal cancer results from the malignant transformation of colonic epithelial cells. Stromal fibroblasts are the main component of the tumour…”
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Vitamin D regulates the phenotype of human breast cancer cells by Pendás-Franco, Natalia, González-Sancho, José Manuel, Suárez, Yajaira, Aguilera, Oscar, Steinmeyer, Andreas, Gamallo, Carlos, Berciano, María T., Lafarga, Miguel, Muñoz, Alberto

“…1α,25-dihydroxyvitamin D 3 (1,25(OH) 2D 3), the most active vitamin D metabolite, regulates proliferation, survival, and differentiation in many cell types…”
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Epigenetic repression of ROR2 has a Wnt-mediated, pro-tumourigenic role in colon cancer by Lara, Ester, Calvanese, Vincenzo, Huidobro, Covadonga, Fernández, Agustin F, Moncada-Pazos, Angela, Obaya, Alvaro J, Aguilera, Oscar, González-Sancho, José Manuel, Sánchez, Laura, Astudillo, Aurora, Muñoz, Alberto, López-Otín, Carlos, Esteller, Manel, Fraga, Mario F

“…Wnt factors control cell differentiation through semi-independent molecular cascades known as the beta-catenin-dependent (canonical) and -independent…”
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Vitamin D opposes multilineage cell differentiation induced by Notch inhibition and BMP4 pathway activation in human colon organoids by Bustamante-Madrid, Pilar, Barbáchano, Antonio, Albandea-Rodríguez, David, Rodríguez-Cobos, Javier, Rodríguez-Salas, Nuria, Prieto, Isabel, Burgos, Aurora, Martínez de Villarreal, Jaime, Real, Francisco X., González-Sancho, José Manuel, Larriba, María Jesús, Lafarga, Miguel, Muñoz, Alberto, Fernández-Barral, Asunción

“…Understanding the mechanisms involved in colonic epithelial differentiation is key to unraveling the alterations causing inflammatory conditions and cancer…”
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The Wnt antagonist DICKKOPF-1 gene is a downstream target of β-catenin/TCF and is downregulated in human colon cancer by GONZALEZ-SANCHO, José Manuel, AGUILERA, Oscar, GARCIA, José Miguel, PENDAS-FRANCO, Natalia, PENA, Cristina, CAL, Santiago, GARCIA DE HERREROS, Antonio, BONILLA, Félix, MUNOZ, Alberto

“…Wnt glycoproteins regulate homeostasis and development by binding to membrane Frizzled-LRP5/6 receptor complexes. Wnt signaling includes a canonical pathway…”
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The inhibition of Wnt/β-catenin signalling by 1α,25-dihydroxyvitamin D3 is abrogated by Snail1 in human colon cancer cells by Larriba, María Jesús, Valle, Noelia, Pálmer, Héctor G, Ordóñez-Morán, Paloma, Álvarez-Díaz, Silvia, Becker, Karl-Friedrich, Gamallo, Carlos, de Herreros, Antonio García, González-Sancho, José Manuel, Muñoz, Alberto

“…The Wnt/β-catenin signalling pathway is activated in 90% of human colon cancers by nuclear accumulation of β-catenin protein due to its own mutation or to that…”
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Glucocorticoids Antagonize AP-1 by Inhibiting the Activation/Phosphorylation of JNK without Affecting Its Subcellular Distribution by González, María Victoria, Jiménez, Benilde, Berciano, María T., González-Sancho, José Manuel, Caelles, Carme, Lafarga, Miguel, Muñoz, Alberto

“…The immunosuppressive and antiinflammatory actions of glucocorticoid hormones are mediated by their transrepression of activating protein-1 (AP-1) and nuclear…”
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WNT-3A regulates an Axin1/NRF2 complex that regulates antioxidant metabolism in hepatocytes by Rada, Patricia, Rojo, Ana I, Offergeld, Anika, Feng, Gui Jie, Velasco-Martín, Juan P, González-Sancho, José Manuel, Valverde, Ángela M, Dale, Trevor, Regadera, Javier, Cuadrado, Antonio

“…Nuclear factor (erythroid-derived 2)-like 2 (NRF2) is a master regulator of oxidant and xenobiotic metabolism, but it is unknown how it is regulated to provide…”
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The Wnt antagonist DICKKOPF-1 gene is induced by 1α,25-dihydroxyvitamin D3 associated to the differentiation of human colon cancer cells by Aguilera, Oscar, Peña, Cristina, García, José Miguel, Larriba, María Jesús, Ordóñez-Morán, Paloma, Navarro, Diego, Barbáchano, Antonio, López de Silanes, Isabel, Ballestar, Esteban, Fraga, Mario F., Esteller, Manel, Gamallo, Carlos, Bonilla, Félix, González-Sancho, José Manuel, Muñoz, Alberto

“…The Wnt–β-catenin pathway is aberrantly activated in most colon cancers. DICKKOPF-1 (DKK-1) gene encodes an extracellular Wnt inhibitor that blocks the…”
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Clinico-Pathological Features, Outcomes and Impacts of COVID-19 Pandemic on Patients with Early-Onset Colorectal Cancer: A Single-Institution Experience by Martinez-Perez, Daniel, Viñal, David, Peña-Lopez, Jesús, Jimenez-Bou, Diego, Ruiz-Gutierrez, Iciar, Martinez-Recio, Sergio, Alameda-Guijarro, María, Rueda-Lara, Antonio, Martin-Montalvo, Gema, Ghanem, Ismael, Custodio, Ana Belén, Trilla-Fuertes, Lucia, Gamez-Pozo, Angelo, Barbachano, Antonio, Rodriguez-Cobos, Javier, Bustamante-Madrid, Pilar, Fernandez-Barral, Asuncion, Burgos, Aurora, Prieto-Nieto, Maria Isabel, Pastrian, Laura Guerra, González-Sancho, José Manuel, Muñoz, Alberto, Feliu, Jaime, Rodríguez-Salas, Nuria

“…Background: The rising incidence of colorectal cancer (CRC) among young patients is alarming. We aim to characterize the clinico-pathological features and…”
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Nuclear DICKKOPF-1 as a biomarker of chemoresistance and poor clinical outcome in colorectal cancer by Aguilera, Óscar, González-Sancho, José Manuel, Zazo, Sandra, Rincón, Raúl, Fernández, Agustín F, Tapia, Olga, Canals, Francesc, Morte, Beatriz, Calvanese, Vincenzo, Orgaz, José L, Niell, Núria, Aguilar, Susana, Freije, José M, Graña, Osvaldo, Pisano, David G, Borrero, Aurea, Martínez-Useros, Javier, Jiménez, Benilde, Fraga, Mario F, García-Foncillas, Jesús, López-Otín, Carlos, Lafarga, Miguel, Rojo, Federico, Muñoz, Alberto

“…Sporadic colorectal cancer (CRC) insurgence and progression depend on the activation of Wnt/β-catenin signaling. Dickkopf (DKK)-1 is an extracellular inhibitor…”
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From molecular basis to clinical insights: a challenging future for the vitamin D endocrine system in colorectal cancer by Pereira, Fábio, Fernández-Barral, Asunción, Larriba, María Jesús, Barbáchano, Antonio, González-Sancho, José Manuel

“…Colorectal cancer (CRC) is one of the most life-threatening neoplasias in terms of incidence and mortality worldwide. Vitamin D deficiency has been associated…”
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Vitamin D and Wnt3A have additive and partially overlapping modulatory effects on gene expression and phenotype in human colon fibroblasts by Ferrer-Mayorga, Gemma, Niell, Núria, Cantero, Ramón, González-Sancho, José Manuel, del Peso, Luis, Muñoz, Alberto, Larriba, María Jesús

“…The Wnt/β-catenin signalling pathway is essential for intestinal epithelium homeostasis, but its aberrant activation is a hallmark of colorectal cancer (CRC)…”
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The use of an active learning approach to teach metabolism to students of nutrition and dietetics by González‐Sancho, José Manuel, Sánchez‐Pacheco, Aurora, Lasa, Marina, Molina, Susana, Vara, Francisco, Peso, Luis

“…This article describes the transition from a traditional instructor‐centered course, based on lectures, to a student‐centered course based on active learning…”
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Vitamin D and Wnt/β-catenin Pathway in Colon Cancer : Role and Regulation of DICKKOPF Genes by PENDAS-FRANCO, Natalia, AGUILERA, Oscar, PEREIRA, Fabio, GONZALEZ-SANCHO, José Manuel, MUNOZ, Alberto

“…Colorectal cancer is a major health problem worldwide. Aberrant activation of the Wingless-type mouse mammary tumour virus integration site family…”
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Vitamin D3 promotes the differentiation of colon carcinoma cells by the induction of E-cadherin and the inhibition of β -catenin signaling by Pálmer, Héctor G., González-Sancho, José Manuel, Espada, Jesús, Berciano, María T., Puig, Isabel, Baulida, Josep, Quintanilla, Miguel, Cano, Amparo, de Herreros, Antonio García, Lafarga, Miguel, Muñoz, Alberto

“…The β-catenin signaling pathway is deregulated in nearly all colon cancers. Nonhypercalcemic vitamin D3 (1α,25-dehydroxyvitamin D3) analogues are candidate…”
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Vitamin D Is a Multilevel Repressor of Wnt/β-Catenin Signaling in Cancer Cells by Larriba, María Jesús, González-Sancho, José Manuel, Barbáchano, Antonio, Niell, Núria, Ferrer-Mayorga, Gemma, Muñoz, Alberto

“…The Wnt/β-catenin signaling pathway is abnormally activated in most colorectal cancers and in a proportion of other neoplasias. This activation initiates or…”
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Inhibition of proliferation and expression of T1 and cyclin D1 genes by thyroid hormone in mammary epithelial cells by González-Sancho, José Manuel, Figueroa, Angélica, López-Barahona, Mónica, López, Eva, Beug, Hartmut, Muñoz, Alberto

“…The relationship between thyroid hormone (triiodothyronine, T3) and breast cancer is unclear. We studied the effect of the c‐erbA/TRα proto‐oncogene encoding a…”
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High dose brachytherapy (real time) in patients with intermediate- or high-risk prostate cancer: technical description and preliminary experience by Prada Gómez, Pedro J, de la Rua Calderón, Angeles, Romo Fonseca, Inmaculada, Evia Suárez, Miguel, Abascal García, José Manuel, Juan Rijo, Germán, Fernández García, José, González Sancho, José Manuel, Abascal García, Ramón, Rodríguez-Fernández, Reinerio

“…It has been well documented that the outcome of prostate cancer treatment depends on the dose administered. Hence, techniques have been developed that allow…”
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Retinoic acid and 1,25-dihydroxyvitamin D3 inhibit tenascin-C expression in rat glioma C6 cells by Alvarez-Dolado, Manuel, González-Sancho, José Manuel, Navarro-Yubero, Cristina, García-Fernández, Luis F., Muñoz, Alberto

“…Tenascin‐C (Tn‐C) is an extracellular matrix protein with growth‐, invasive‐, and angiogenesis‐promoting activities. Tn‐C is upregulated during wound healing,…”
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