Search Results - "González‐Gualda, Estela"

Targeting senescent cells in translational medicine by Paez‐Ribes, Marta, González‐Gualda, Estela, Doherty, Gary J, Muñoz‐Espín, Daniel

“…Organismal ageing is a complex process driving progressive impairment of functionality and regenerative potential of tissues. Cellular senescence is a state of…”
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Galacto‐conjugation of Navitoclax as an efficient strategy to increase senolytic specificity and reduce platelet toxicity by González‐Gualda, Estela, Pàez‐Ribes, Marta, Lozano‐Torres, Beatriz, Macias, David, Wilson, Joseph R., González‐López, Cristina, Ou, Hui‐Ling, Mirón‐Barroso, Sofía, Zhang, Zhenguang, Lérida‐Viso, Araceli, Blandez, Juan F., Bernardos, Andrea, Sancenón, Félix, Rovira, Miguel, Fruk, Ljiljana, Martins, Carla P., Serrano, Manuel, Doherty, Gary J., Martínez‐Máñez, Ramón, Muñoz‐Espín, Daniel

“…Pharmacologically active compounds with preferential cytotoxic activity for senescent cells, known as senolytics, can ameliorate or even revert pathological…”
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A guide to assessing cellular senescence in vitro and in vivo by González‐Gualda, Estela, Baker, Andrew G., Fruk, Ljiljana, Muñoz‐Espín, Daniel

“…Cellular senescence is a complex cell response to damage and stress that can impact the surrounding tissue. Senescent cells no longer proliferate and undergo…”
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An Indocyanine Green‐Based Nanoprobe for In Vivo Detection of Cellular Senescence by Baker, Andrew G., Hartono, Muhamad, Ou, Hui‐Ling, Popov, Andrea Bistrović, Brown, Emma L., Joseph, James, Golinska, Monika, González‐Gualda, Estela, Macias, David, Ge, Jianfeng, Denholm, Mary, Morsli, Samir, Sanghera, Chandan, Else, Thomas R., Greer, Heather F., Vernet, Aude, Bohndiek, Sarah E., Muñoz‐Espín, Daniel, Fruk, Ljiljana

“…There is an urgent need to improve conventional cancer‐treatments by preventing detrimental side effects, cancer recurrence and metastases. Recent studies have…”
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A Two-Photon Probe Based on Naphthalimide-Styrene Fluorophore for the In Vivo Tracking of Cellular Senescence by Lozano-Torres, Beatriz, Blandez, Juan F, Galiana, Irene, Lopez-Dominguez, José A, Rovira, Miguel, Paez-Ribes, Marta, González-Gualda, Estela, Muñoz-Espín, Daniel, Serrano, Manuel, Sancenón, Félix, Martínez-Máñez, Ramón

“…Cellular senescence is a state of stable cell cycle arrest that can negatively affect the regenerative capacities of tissues and can contribute to inflammation…”
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An Indocyanine Green‐Based Nanoprobe for In Vivo Detection of Cellular Senescence by Baker, Andrew G., Hartono, Muhamad, Ou, Hui‐Ling, Popov, Andrea Bistrović, Brown, Emma L., Joseph, James, Golinska, Monika, González‐Gualda, Estela, Macias, David, Ge, Jianfeng, Denholm, Mary, Morsli, Samir, Sanghera, Chandan, Else, Thomas R., Greer, Heather F., Vernet, Aude, Bohndiek, Sarah E., Muñoz‐Espín, Daniel, Fruk, Ljiljana

“…There is an urgent need to improve conventional cancer‐treatments by preventing detrimental side effects, cancer recurrence and metastases. Recent studies have…”
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Inexhaustible hair-cell regeneration in young and aged zebrafish by Pinto-Teixeira, Filipe, Viader-Llargués, Oriol, Torres-Mejía, Elen, Turan, Melissa, González-Gualda, Estela, Pola-Morell, Laura, López-Schier, Hernán

“…Animals have evolved two general strategies to counter injury and maintain physiological function. The most prevalent is protection by isolating vital organs…”
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Abstract 5504: A tumor-promoting senescent secretome triggered by platinum chemotherapy exploits a targetable TGFβR1/Akt-mTOR axis in lung cancer by González-Gualda, Estela, Macias, David, Morsli, Samir, Martín, José Ezequiel, Ou, Hui-Ling, Denholm, Mary, Olan, Ioana, Hoffmann, Reuben, Dane, Mark, Veroutis, Dimitris, Medrano, Guillermo, Mulero, Francisca, Martins, Carla P., Barbacid, Mariano, Gorgoulis, Vassilis, Korkola, James E., Rassl, Doris M., Doherty, Gary J., Rintoul, Robert C., Narita, Masashi, Muñoz-Espín, Daniel

“…Abstract Background Platinum-based chemotherapy is commonly used for the treatment of non-small cell lung cancer (NSCLC), yet clinical outcomes and survival…”
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Metastatic-niche labelling reveals parenchymal cells with stem features by Ombrato, Luigi, Nolan, Emma, Kurelac, Ivana, Mavousian, Antranik, Bridgeman, Victoria Louise, Heinze, Ivonne, Chakravarty, Probir, Horswell, Stuart, Gonzalez-Gualda, Estela, Matacchione, Giulia, Weston, Anne, Kirkpatrick, Joanna, Husain, Ehab, Speirs, Valerie, Collinson, Lucy, Ori, Alessandro, Lee, Joo-Hyeon, Malanchi, Ilaria

“…Direct investigation of the early cellular changes induced by metastatic cells within the surrounding tissue remains a challenge. Here we present a system in…”
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Clearance of senescent macrophages ameliorates tumorigenesis in KRAS-driven lung cancer by Haston, Scott, Gonzalez-Gualda, Estela, Morsli, Samir, Ge, Jianfeng, Reen, Virinder, Calderwood, Alexander, Moutsopoulos, Ilias, Panousopoulos, Leonidas, Deletic, Polina, Carreno, Gabriela, Guiho, Romain, Manshaei, Saba, Gonzalez-Meljem, Jose Mario, Lim, Hui Yuan, Simpson, Daniel J., Birch, Jodie, Pallikonda, Husayn A., Chandra, Tamir, Macias, David, Doherty, Gary J., Rassl, Doris M., Rintoul, Robert C., Signore, Massimo, Mohorianu, Irina, Akbar, Arne N., Gil, Jesús, Muñoz-Espín, Daniel, Martinez-Barbera, Juan Pedro

“…The accumulation of senescent cells in the tumor microenvironment can drive tumorigenesis in a paracrine manner through the senescence-associated secretory…”
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CRISPR-Mediated Reactivation of DKK3 Expression Attenuates TGF-β Signaling in Prostate Cancer by Kardooni, Hoda, Gonzalez-Gualda, Estela, Stylianakis, Emmanouil, Saffaran, Sina, Waxman, Jonathan, Kypta, Robert M

“…The gene encodes a secreted protein, Dkk-3, that inhibits prostate tumor growth and metastasis. is downregulated by promoter methylation in many types of…”
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Author Correction: Metastatic-niche labelling reveals parenchymal cells with stem features by Ombrato, Luigi, Nolan, Emma, Kurelac, Ivana, Mavousian, Antranik, Bridgeman, Victoria Louise, Heinze, Ivonne, Chakravarty, Probir, Horswell, Stuart, Gonzalez-Gualda, Estela, Matacchione, Giulia, Weston, Anne, Kirkpatrick, Joanna, Husain, Ehab, Speirs, Valerie, Collinson, Lucy, Ori, Alessandro, Lee, Joo-Hyeon, Malanchi, Ilaria

“…An Amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Metastatic niche labelling reveals tissue parenchyma stem cell features by Ombrato, Luigi, Nolan, Emma, Kurelac, Ivana, Mavousian, Antranik, Bridgeman, Victoria, Heinze, Ivonne, Chakravarty, Probir, Horswell, Stuart, Gonzalez-Gualda, Estela, Matacchione, Giulia, Weston, Anne, Kirkpatrick, Joanna, Husain, Ehab, Speirs, Valerie, Collinson, Lucy, Ori, Alessandro, Lee, Joo-Hyeon, Malanchi, Ilaria

“…To date, a direct investigation of the early cellular changes induced by metastatic cells within the surrounding tissue is difficult to achieve. We present the…”
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