Search Results - "González‐Forero, David"

Targeting autotaxin impacts disease advance in the SOD1‐G93A mouse model of amyotrophic lateral sclerosis by Gento‐Caro, Ángela, Vilches‐Herrando, Esther, Portillo, Federico, González‐Forero, David, Moreno‐López, Bernardo

“…A preclinical strategy to broaden the search of potentially effective treatments in amyotrophic lateral sclerosis (ALS) relies on identifying factors…”
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Interfering with lysophosphatidic acid receptor edg2/lpa1 signalling slows down disease progression in SOD1‐G93A transgenic mice by Gento‐Caro, Ángela, Vilches‐Herrando, Esther, García‐Morales, Victoria, Portillo, Federico, Rodríguez‐Bey, Guillermo, González‐Forero, David, Moreno‐López, Bernardo

“…Aims Alterations in excitability represent an early hallmark in Amyotrophic Lateral Sclerosis (ALS). Therefore, deciphering the factors that impact motor…”
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Sp1-regulated expression of p11 contributes to motor neuron degeneration by membrane insertion of TASK1 by García-Morales, Victoria, Rodríguez-Bey, Guillermo, Gómez-Pérez, Laura, Domínguez-Vías, Germán, González-Forero, David, Portillo, Federico, Campos-Caro, Antonio, Gento-Caro, Ángela, Issaoui, Noura, Soler, Rosa M., Garcera, Ana, Moreno-López, Bernardo

“…Disruption in membrane excitability contributes to malfunction and differential vulnerability of specific neuronal subpopulations in a number of neurological…”
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Membrane-derived phospholipids control synaptic neurotransmission and plasticity by García-Morales, Victoria, Montero, Fernando, González-Forero, David, Rodríguez-Bey, Guillermo, Gómez-Pérez, Laura, Medialdea-Wandossell, María Jesús, Domínguez-Vías, Germán, García-Verdugo, José Manuel, Moreno-López, Bernardo

“…Synaptic communication is a dynamic process that is key to the regulation of neuronal excitability and information processing in the brain. To date, however,…”
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Endogenous Rho-kinase signaling maintains synaptic strength by stabilizing the size of the readily releasable pool of synaptic vesicles by González-Forero, David, Montero, Fernando, García-Morales, Victoria, Domínguez, Germán, Gómez-Pérez, Laura, García-Verdugo, José Manuel, Moreno-López, Bernardo

“…Rho-associated kinase (ROCK) regulates neural cell migration, proliferation and survival, dendritic spine morphology, and axon guidance and regeneration. There…”
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Lysophosphatidic Acid and Several Neurotransmitters Converge on Rho-Kinase 2 Signaling to Manage Motoneuron Excitability by García-Morales, Victoria, Gento-Caro, Ángela, Portillo, Federico, Montero, Fernando, González-Forero, David, Moreno-López, Bernardo

“…Intrinsic membrane excitability (IME) sets up neuronal responsiveness to synaptic drive. Several neurotransmitters and neuromodulators, acting through…”
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Nitric Oxide Induces Pathological Synapse Loss by a Protein Kinase G-, Rho Kinase-Dependent Mechanism Preceded by Myosin Light Chain Phosphorylation by Sunico, Carmen R, Gonzalez-Forero, David, Dominguez, German, Garcia-Verdugo, Jose Manuel, Moreno-Lopez, Bernardo

“…The molecular signaling that underpins synapse loss in neuropathological conditions remains unknown. Concomitant upregulation of the neuronal nitric oxide (NO)…”
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Differential Postnatal Maturation of GABAA, Glycine Receptor, and Mixed Synaptic Currents in Renshaw Cells and Ventral Spinal Interneurons by Gonzalez-Forero, David, Alvarez, Francisco J

“…Renshaw cells (RCs) receive excitatory inputs from motoneurons to which then they inhibit. The gain of this spinal recurrent inhibitory circuit is modulated by…”
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The A-current modulates learning via NMDA receptors containing the NR2B subunit by Fontán-Lozano, Ángela, Suárez-Pereira, Irene, González-Forero, David, Carrión, Angel Manuel

“…Synaptic plasticity involves short- and long-term events, although the molecular mechanisms that underlie these processes are not fully understood. The…”
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Nitric Oxide-Directed Synaptic Remodeling in the Adult Mammal CNS by Sunico, Carmen R, Portillo, Federico, Gonzalez-Forero, David, Moreno-Lopez, Bernardo

“…In adult mammals, learning, memory, and restoration of sensorimotor lost functions imply synaptic reorganization that requires diffusible messengers-mediated…”
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The nitric oxide/cyclic guanosine monophosphate pathway modulates the inspiratory-related activity of hypoglossal motoneurons in the adult rat by Montero, Fernando, Portillo, Federico, González-Forero, David, Moreno-López, Bernardo

“…Motoneurons integrate interneuronal activity into commands for skeletal muscle contraction and relaxation to perform motor actions. Hypoglossal motoneurons…”
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Interfering with lysophosphatidic acid receptor edg2/lpa 1 signalling slows down disease progression in SOD1-G93A transgenic mice by Gento-Caro, Ángela, Vilches-Herrando, Esther, García-Morales, Victoria, Portillo, Federico, Rodríguez-Bey, Guillermo, González-Forero, David, Moreno-López, Bernardo

“…Alterations in excitability represent an early hallmark in Amyotrophic Lateral Sclerosis (ALS). Therefore, deciphering the factors that impact motor neuron…”
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Transynaptic effects of tetanus neurotoxin in the oculomotor system by González-Forero, David, Morcuende, Sara, Alvarez, Francisco J., de la Cruz, Rosa R., Pastor, Ángel M.

“…The question whether general tetanus arises from the independent sum of multiple local tetani or results from the actions of the transynaptic tetanus…”
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ORAL ADMINISTRATION OF A LPA1/EDG2 INHIBITOR POTENTIATES HIGH-FAT DIET-INDUCED NEUROPROTECTION OF LUMBAR MOTONEURONS IN THE SOD1-G93A MOUSE MODEL OF ALS by Sánchez-García, Enrique, Vilches-Herrando, Esther, González-Forero, David, Moreno-López, Bernardo, Gento-Caro, Angela

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EFFECTS OF CHRONIC ADMINISTRATION OF THE AUTOTAXIN INHIBITOR PF8380 ON HIGH-FAT DIET-INDUCED BENEFICIAL EFFECTS ON A MOUSE MODEL OF ALS by Gento-Caro, Angela, Sánchez-García, Enrique, Vilches-Herrando, Esther, Ariza-Molina, Jorge, Moreno-López, Bernardo, González-Forero, David

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SIRNA-INDUCED DOWN-REGULATION OF P11/S100A10 IMPACTS STRENGTH AND USE-DEPENDENT PLASTICITY AT EXCITATORY SYNAPSES IN THE HYPOGLOSSAL NUCLEUS OF THE RAT by Vilches-Herrando, Esther, Gento-Caro, Angela, Sánchez-García, Enrique, González-Forero, David, Moreno-López, Bernardo

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Membrane-Derived Phospholipids Control Synaptic Neurotransmission and Plasticity: e1002153 by García-Morales, Victoria, Montero, Fernando, González-Forero, David, Rodríguez-Bey, Guillermo, Gómez-Pérez, Laura, Medialdea-Wandossell, María Jesús, Domínguez-Vías, Germán, García-Verdugo, José Manuel, Moreno-López, Bernardo

“…Synaptic communication is a dynamic process that is key to the regulation of neuronal excitability and information processing in the brain. To date, however,…”
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Inhibition of Resting Potassium Conductances by Long-Term Activation of the NO/cGMP/Protein Kinase G Pathway: A New Mechanism Regulating Neuronal Excitability by Gonzalez-Forero, David, Portillo, Federico, Gomez, Laura, Montero, Fernando, Kasparov, Sergey, Moreno-Lopez, Bernardo

“…Glutamate-induced excitotoxicity, the most common pathological mechanism leading to neuronal death, may occur even with normal levels of glutamate if it…”
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Nerve injury reduces responses of hypoglossal motoneurones to baseline and chemoreceptor-modulated inspiratory drive in the adult rat by González‐Forero, David, Portillo, Federico, Sunico, Carmen R., Moreno‐López, Bernardo

“…The effects of peripheral nerve lesions on the membrane and synaptic properties of motoneurones have been extensively studied. However, minimal information…”
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Synaptic structural modification following changes in activity induced by tetanus neurotoxin in cat abducens neurons by González-Forero, David, Pastor, Angel M., Delgado-García, Jose María, de la Cruz, Rosa R., Alvarez, Francisco J.

“…A low or a high dose of tetanus neurotoxin (TeNT) injected in the lateral rectus muscle of the cat causes respectively, functional block of inhibitory synapses…”
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