Search Results - "González, Mariano M."

Cross-class metallo-β-lactamase inhibition by bisthiazolidines reveals multiple binding modes by Hinchliffe, Philip, González, Mariano M., Mojica, Maria F., González, Javier M., Castillo, Valerie, Saiz, Cecilia, Kosmopoulou, Magda, Tooke, Catherine L., Llarrull, Leticia I., Mahler, Graciela, Bonomo, Robert A., Vila, Alejandro J., Spencer, James

“…Metallo-β-lactamases (MBLs) hydrolyze almost all β-lactam antibiotics and are unaffected by clinically available β-lactamase inhibitors (βLIs). Active-site…”
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In-cell kinetic stability is an essential trait in metallo-β-lactamase evolution by González, Lisandro J., Bahr, Guillermo, González, Mariano M., Bonomo, Robert A., Vila, Alejandro J.

“…Protein stability is an essential property for biological function. In contrast to the vast knowledge on protein stability in vitro, little is known about the…”
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Optimization of Conformational Dynamics in an Epistatic Evolutionary Trajectory by González, Mariano M, Abriata, Luciano A, Tomatis, Pablo E, Vila, Alejandro J

“…The understanding of protein evolution depends on the ability to relate the impact of mutations on molecular traits to organismal fitness. Biological activity…”
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A general reaction mechanism for carbapenem hydrolysis by mononuclear and binuclear metallo-β-lactamases by Lisa, María-Natalia, Palacios, Antonela R., Aitha, Mahesh, González, Mariano M., Moreno, Diego M., Crowder, Michael W., Bonomo, Robert A., Spencer, James, Tierney, David L., Llarrull, Leticia I., Vila, Alejandro J.

“…Carbapenem-resistant Enterobacteriaceae threaten human health, since carbapenems are last resort drugs for infections by such organisms. Metallo-β-lactamases…”
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Bisthiazolidines: A Substrate-Mimicking Scaffold as an Inhibitor of the NDM‑1 Carbapenemase by González, Mariano M, Kosmopoulou, Magda, Mojica, Maria F, Castillo, Valerie, Hinchliffe, Philip, Pettinati, Ilaria, Brem, Jürgen, Schofield, Christopher J, Mahler, Graciela, Bonomo, Robert A, Llarrull, Leticia I, Spencer, James, Vila, Alejandro J

“…Pathogenic Gram-negative bacteria resistant to almost all β-lactam antibiotics are a major public health threat. Zn­(II)-dependent or metallo-β-lactamases…”
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Enantioselective synthesis of new oxazolidinylthiazolidines as enzyme inhibitors by Saiz, Cecilia, Villamil, Valentina, González, Mariano M., Rossi, Ma. Agustina, Martínez, Lorena, Suescun, Leopoldo, Vila, Alejandro J., Mahler, Graciela

“…[Display omitted] The synthesis of new oxazolidinylthiazolidines bicycles, oxygen analogues of bisthiazolidines, also known as metallo-β-lactamase inhibitors…”
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Cross-class metallo-[Beta]-lactamase inhibition by bisthiazolidines reveals multiple binding modes by Hinchliffe, Philip, González, Mariano M, Mojica, Maria F, González, Javier M, Castillo, Valerie, Saiz, Cecilia, Kosmopoulou, Magda, Tooke, Catherine L, Llarrull, Leticia I, Mahler, Graciela, Bonomo, Robert A, Vila, Alejandro J, Spencer, James

“…Tre-2/USP6, BUB2, cdc16 domain family member 1 (the TBC domain is the GTPase activating protein domain) (TBC1D1) is a Rab GTPase activating protein that is…”
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Spontaneous esophageal perforation (Boerhaave syndrome) successfully treated with an over-the-scope clip and fully covered metal stent by González-Haba, Mariano, MD, Ferguson, Mark K., MD, Gelrud, Andres, MD, MMS

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