Search Results - "González, María‐Julieta"

Short Chain Fatty Acids (SCFAs)-Mediated Gut Epithelial and Immune Regulation and Its Relevance for Inflammatory Bowel Diseases by Parada Venegas, Daniela, De la Fuente, Marjorie K, Landskron, Glauben, González, María Julieta, Quera, Rodrigo, Dijkstra, Gerard, Harmsen, Hermie J M, Faber, Klaas Nico, Hermoso, Marcela A

“…Ulcerative colitis (UC) and Crohn's disease (CD), collectively known as Inflammatory Bowel Diseases (IBD), are caused by a complex interplay between genetic,…”
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Tofacitinib counteracts IL-6 overexpression induced by deficient autophagy: implications in Sjögren’s syndrome by Barrera, María-José, Aguilera, Sergio, Castro, Isabel, Matus, Soledad, Carvajal, Patricia, Molina, Claudio, González, Sergio, Jara, Daniela, Hermoso, Marcela, González, María-Julieta

“…Abstract Objective Altered homeostasis of salivary gland (SG) epithelial cells in Sjögren’s syndrome (SS) could be the initiating factor that leads to…”
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Aberrant MUC1 accumulation in salivary glands of Sjögren’s syndrome patients is reversed by TUDCA in vitro by Castro, Isabel, Albornoz, Nicolás, Aguilera, Sergio, Barrera, María-José, González, Sergio, Núñez, Matilde, Carvajal, Patricia, Jara, Daniela, Lagos, Carolina, Molina, Claudio, Urzúa, Ulises, Hermoso, Marcela A, González, María-Julieta

“…Abstract Objectives Xerostomia in SS patients has been associated with low quality and quantity of salivary mucins, which are fundamental for the hydration and…”
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The relationship between chemokines CCL2, CCL3, and CCL4 with the tumor microenvironment and tumor-associated macrophage markers in colorectal cancer by De la Fuente López, Marjorie, Landskron, Glauben, Parada, Daniela, Dubois-Camacho, Karen, Simian, Daniela, Martinez, Maripaz, Romero, Diego, Roa, Juan Carlos, Chahuán, Isidora, Gutiérrez, Rocío, Lopez-K, Francisco, Alvarez, Karin, Kronberg, Udo, López, Sebastian, Sanguinetti, Antonella, Moreno, Natalia, Abedrapo, Mario, González, María-Julieta, Quera, Rodrigo, Hermoso-R, Marcela A

“…A complex network of chemokines can influence cancer progression with the recruitment and activation of hematopoietic cells, including macrophages to the…”
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Type I Interferon Dependent hsa-miR-145-5p Downregulation Modulates MUC1 and TLR4 Overexpression in Salivary Glands From Sjögren’s Syndrome Patients by Jara, Daniela, Carvajal, Patricia, Castro, Isabel, Barrera, María-José, Aguilera, Sergio, González, Sergio, Molina, Claudio, Hermoso, Marcela, González, María-Julieta

“…Sjögren’s syndrome (SS) is an autoimmune disease that mainly affects salivary glands (SG) and is characterized by overactivation of the type I interferon (IFN)…”
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Inhibition of miR-378a-3p by Inflammation Enhances IL-33 Levels: A Novel Mechanism of Alarmin Modulation in Ulcerative Colitis by Dubois-Camacho, Karen, Diaz-Jimenez, David, De la Fuente, Marjorie, Quera, Rodrigo, Simian, Daniela, Martínez, Maripaz, Landskron, Glauben, Olivares-Morales, Mauricio, Cidlowski, John A, Xu, Xiaojiang, Gao, Guangping, Xie, Jun, Chnaiderman, Jonás, Soto-Rifo, Ricardo, González, María-Julieta, Calixto, Andrea, Hermoso, Marcela A

“…Ulcerative colitis (UC) is an inflammatory bowel disease (IBD) characterized by mucosa damage associated with an uncontrolled inflammatory response. This…”
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Endoplasmic reticulum stress in autoimmune diseases: Can altered protein quality control and/or unfolded protein response contribute to autoimmunity? A critical review on Sjögren's syndrome by Barrera, María-José, Aguilera, Sergio, Castro, Isabel, González, Sergio, Carvajal, Patricia, Molina, Claudio, Hermoso, Marcela A., González, María-Julieta

“…For many years, researchers in the field of autoimmunity have focused on the role of the immune components in the etiopathogenesis of autoimmune diseases…”
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Impaired IRE1α/XBP-1 pathway associated to DNA methylation might contribute to salivary gland dysfunction in Sjögren's syndrome patients by Sepúlveda, Denisse, Barrera, María-José, Castro, Isabel, Aguilera, Sergio, Carvajal, Patricia, Lagos, Carolina, González, Sergio, Albornoz, Nicolás, Bahamondes, Verónica, Quest, Andrew F G, Urzúa, Ulises, Molina, Claudio, Leyton, Cecilia, Hermoso, Marcela A, González, María-Julieta

“…Abstract Objectives Labial salivary glands (LSGs) of SS patients show alterations related to endoplasmic reticulum stress. Glandular dysfunction could be…”
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Characterization of the novel ST2/IL‐33 system in patients with inflammatory bowel disease by Beltrán, Caroll J., Núñez, Lucía E., Díaz‐Jiménez, David, Farfan, Nancy, Candia, Enzo, Heine, Claudio, López, Francisco, González, María Julieta, Quera, Rodrigo, Hermoso, Marcela A.

“…Background: ST2 has been proposed to be a regulator of inflammation and Th1/Th2 balance. ST2L is the IL‐33 membrane receptor and belongs to the IL‐1R family…”
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Diabetes alters the involvement of myofibroblasts during periodontal wound healing by Retamal, Ignacio, Hernández, Romina, Velarde, Victoria, Oyarzún, Alejandro, Martínez, Constanza, Julieta González, María, Martínez, Jorge, Smith, Patricio C.

“…Objectives Myofibroblasts constitute a specific cell phenotype involved in connective tissue healing. Diabetes alters the wound healing response. However, it…”
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Escherichia coli isolates from inflammatory bowel diseases patients survive in macrophages and activate NLRP3 inflammasome by De la Fuente, Marjorie, Franchi, Luigi, Araya, Daniela, Díaz-Jiménez, David, Olivares, Mauricio, Álvarez-Lobos, Manuel, Golenbock, Douglas, González, María-Julieta, López-Kostner, Francisco, Quera, Rodrigo, Núñez, Gabriel, Vidal, Roberto, Hermoso, Marcela A

“…Abstract Crohn's disease (CD) is a multifactorial pathology associated with the presence of adherent-invasive Escherichia coli (AIEC) and NLRP3 polymorphic…”
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Salivary mucins induce a Toll-like receptor 4-mediated pro-inflammatory response in human submandibular salivary cells: are mucins involved in Sjögren's syndrome? by Barrera, María-José, Aguilera, Sergio, Veerman, Enno, Quest, Andrew F G, Díaz-Jiménez, David, Urzúa, Ulises, Cortés, Juan, González, Sergio, Castro, Isabel, Molina, Claudio, Bahamondes, Verónica, Leyton, Cecilia, Hermoso, Marcela A, González, María-Julieta

“…A hallmark characteristic of SS patients is the ectopic presence of the mucins MUC5B and MUC7 in the extracellular matrix of salivary glands that have lost…”
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Pro-inflammatory cytokines enhance ERAD and ATF6α pathway activity in salivary glands of Sjögren's syndrome patients by Barrera, María-José, Aguilera, Sergio, Castro, Isabel, Cortés, Juan, Bahamondes, Verónica, Quest, Andrew F.G, Molina, Claudio, González, Sergio, Hermoso, Marcela, Urzúa, Ulises, Leyton, Cecilia, González, María-Julieta

“…Abstract Salivary gland (SG) acinar-cells are susceptible to endoplasmic reticulum (ER) stress related to their secretory activity and the complexity of…”
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Alterations in type I hemidesmosome components suggestive of epigenetic control in the salivary glands of patients with Sjögren's syndrome by González, Sergio, Aguilera, Sergio, Alliende, Cecilia, Urzúa, Ulises, Quest, Andrew F. G., Herrera, Luisa, Molina, Claudio, Hermoso, Marcela, Ewert, Patricia, Brito, Mónica, Romo, Rafael, Leyton, Cecilia, Pérez, Paola, González, María‐Julieta

“…Objective Acinar cells in the salivary glands of patients with Sjögren's syndrome (SS) display severe alterations in anchorage to the basal lamina…”
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Association of high 5-hydroxymethylcytosine levels with Ten Eleven Translocation 2 overexpression and inflammation in Sjögren's syndrome patients by Lagos, Carolina, Carvajal, Patricia, Castro, Isabel, Jara, Daniela, González, Sergio, Aguilera, Sergio, Barrera, María-José, Quest, Andrew F.G., Bahamondes, Verónica, Molina, Claudio, Urzúa, Ulises, Hermoso, Marcela A., Leyton, Cecilia, González, María-Julieta

“…Here, we determined the 5-hydroxymethylcytosine (5hmC), 5-methylcytosine (5mC), Ten Eleven Translocation (TETs), and DNA methyltransferases (DNMTs) levels in…”
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Synaptotagmin-1 overexpression under inflammatory conditions affects secretion in salivary glands from Sjögren's syndrome patients by Cortés, Juan, Hidalgo, Jorge, Aguilera, Sergio, Castro, Isabel, Brito, Mónica, Urra, Hery, Pérez, Paola, Barrera, María-José, Carvajal, Patricia, Urzúa, Ulises, González, Sergio, Molina, Claudio, Bahamondes, Verónica, Hermoso, Marcela, González, María-Julieta

“…Sjögren's syndrome (SS) is an autoimmune exocrinopathy associated with severe secretory alterations by disruption of the glandular architecture integrity,…”
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Interleukin 33/ST2 Axis Components Are Associated to Desmoplasia, a Metastasis-Related Factor in Colorectal Cancer by Landskron, Glauben, De la Fuente López, Marjorie, Dubois-Camacho, Karen, Díaz-Jiménez, David, Orellana-Serradell, Octavio, Romero, Diego, Sepúlveda, Santiago A, Salazar, Christian, Parada-Venegas, Daniela, Quera, Rodrigo, Simian, Daniela, González, María-Julieta, López-Köstner, Francisco, Kronberg, Udo, Abedrapo, Mario, Gallegos, Iván, Contreras, Héctor R, Peña, Cristina, Díaz-Araya, Guillermo, Roa, Juan Carlos, Hermoso, Marcela A

“…In colorectal cancer (CRC), cancer-associated fibroblasts (CAFs) are the most abundant component from the tumor microenvironment (TM). CAFs facilitate tumor…”
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White matter microstructural damage in early treated phenylketonuric patients by González, María Julieta, Polo, Mónica Rebollo, Ripollés, Pablo, Gassió, Rosa, Ormazabal, Aída, Sierra, Cristina, Roura, Roser Colomé, Artuch, Rafael, Campistol, Jaume

“…Despite dietary intervention, individuals with early treated phenylketonuria (ETPKU) could present neurocognitive deficits and white matter (WM) abnormalities…”
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Glucose deprivation causes oxidative stress and stimulates aggresome formation and autophagy in cultured cardiac myocytes by Marambio, Paola, Toro, Barbra, Sanhueza, Carlos, Troncoso, Rodrigo, Parra, Valentina, Verdejo, Hugo, García, Lorena, Quiroga, Clara, Munafo, Daniela, Díaz-Elizondo, Jessica, Bravo, Roberto, González, María-Julieta, Diaz-Araya, Guilermo, Pedrozo, Zully, Chiong, Mario, Colombo, María Isabel, Lavandero, Sergio

“…Aggresomes are dynamic structures formed when the ubiquitin–proteasome system is overwhelmed with aggregation-prone proteins. In this process, small protein…”
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Metalloproteinase-dependent TLR2 ectodomain shedding is involved in soluble toll-like receptor 2 (sTLR2) production by Langjahr, Patricia, Díaz-Jiménez, David, De la Fuente, Marjorie, Rubio, Estefhany, Golenbock, Douglas, Bronfman, Francisca C, Quera, Rodrigo, González, María-Julieta, Hermoso, Marcela A

“…Toll-like receptor (TLR) 2, a type I membrane receptor that plays a key role in innate immunity, recognizes conserved molecules in pathogens, and triggering an…”
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