Search Results - "Gonsky, R."

Down Syndrome Phenotypes: The Consequences of Chromosomal Imbalance by Korenberg, J. R., X.-N. Chen, Schipper, R., Sun, Z., Gonsky, R., Gerwehr, S., Carpenter, N., Daumer, C., Dignan, P., Disteche, C., Graham, J. M., Hudgins, L., McGillivray, B., Miyazaki, K., Ogasawara, N., Park, J. P., Pagon, R., Pueschel, S., Sack, G., Say, B., Schuffenhauer, S., Soukup, S., Yamanaka, T.

“…Down syndrome (DS) is a major cause of mental retardation and congenital heart disease. Besides a characteristic set of facial and physical features, DS is…”
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An IFNG SNP with an estrogen-like response element selectively enhances promoter expression in peripheral but not lamina propria T cells by Gonsky, R, Deem, R L, Bream, J H, Young, H A, Targan, S R

“…This study examines mucosa-specific regulatory pathways involved in modulation of interferon-gamma (IFN-gamma) in lamina propria T cells. Previous studies…”
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From Amplification to Gene in Thyroid Cancer: A High-Resolution Mapped Bacterial-Artificial-Chromosome Resource for Cancer Chromosome Aberrations Guides Gene Discovery after Comparative Genome Hybridization by Chen, X.-N., Knauf, J.A., Gonsky, R., Wang, M., Lai, E.H., Chissoe, S., Fagin, J.A., Korenberg, J.R.

“…Chromosome rearrangements associated with neoplasms provide a rich resource for definition of the pathways of tumorigenesis. The power of comparative genome…”
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Identification of Rapid Turnover Transcripts Overexpressed in Thyroid Tumors and Thyroid Cancer Cell Lines: Use of a Targeted Differential RNA Display Method to Select for mRNA Subsets by Gonsky, Rivkah, Knauf, Jeffrey A., Elisei, Rosella, Wang, Jian Wei, Su, Susan, Fagin, James A.

“…The mRNAs of transiently expressed proteins such as cytokines and proto-oncogenes are commonly subject to rapid transcriptional activation and degradation…”
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DOP29 Elevation of a novel blood-based gene signature in a severe Crohn’s disease (CD) subtype preceding surgery defines and predicts a post-surgical decrease in pro-inflammatory pathway activation by Gonsky, R, Fleshner, P, Botwin, G, Biener-Ramanujan, E, McGovern, D, Targan, S

“…Abstract Background CD is defined by transmural inflammation leading to inflammatory, stricturing and/or penetrating phenotypes. Identifying underlying…”
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TLR4 and MD-2 Expression Is Regulated by Immune-mediated Signals in Human Intestinal Epithelial Cells by Abreu, Maria T., Arnold, Elizabeth T., Thomas, Lisa S., Gonsky, Rivkah, Zhou, Yuehua, Hu, Bing, Arditi, Moshe

“…The normal intestinal epithelium is not inflamed despite contact with a high density of commensal bacteria. Intestinal epithelial cells (IEC) express low…”
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Binding of ATP and messenger RNA by the beta-subunit of eukaryotic initiation factor 2 by Gonsky, R, Itamar, D, Harary, R, Kaempfer, R

“…In addition to forming a ternary complex with Met-tRNA(f) and GTP, eukaryotic initiation factor 2 (eIF-2) recognizes a specific site in mRNA molecules. Both…”
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Distinct Methylation of IFNG in the Gut by Gonsky, Rivkah, Deem, Richard L, Targan, Stephan R

“…Mucosal expression of proinflammatory cytokines plays a pivotal role in inflammatory bowel disease (IBD) pathogenesis. Epigenetic remodeling of chromatin via…”
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Distinct IFNG methylation in a subset of ulcerative colitis patients based on reactivity to microbial antigens by Gonsky, Rivkah, Deem, Richard L., Landers, Carol J., Derkowski, Carrie A., Berel, Dror, McGovern, Dermot P.B., Targan, Stephan R.

“…Background: High antibody reactivity toward microbial antigens in Crohn's disease (CD) patients is predictive of a more aggressive disease course. However, few…”
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A Distal Region in the Interferon-γ Gene Is a Site of Epigenetic Remodeling and Transcriptional Regulation by Interleukin-2 by Bream, Jay H., Hodge, Deborah L., Gonsky, Rivkah, Spolski, Rosanne, Leonard, Warren J., Krebs, Stephanie, Targan, Stephan, Morinobu, Akio, O'Shea, John J., Young, Howard A.

“…Interferon-γ (IFN-γ) is a multifunctional cytokine that defines the development of Th1 cells and is critical for host defense against intracellular pathogens…”
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Binding of ATP to eukaryotic initiation factor 2. Differential modulation of mRNA-binding activity and GTP-dependent binding of methionyl-tRNAMetf by Gonsky, R, Lebendiker, M A, Harary, R, Banai, Y, Kaempfer, R

“…Eukaryotic initiation factor 2 (eIF-2) is shown to bind ATP with high affinity. Binding of ATP to eIF-2 induces loss of the ability to form a ternary complex…”
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Clonal origin of pituitary adenomas by Herman, V, Fagin, J, Gonsky, R, Kovacs, K, Melmed, S

“…As the pathogenesis of pituitary adenomas remains unclear, the tumor clonal composition of these common neoplasms was studied. Clonality was determined in…”
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Enhancer role of STAT5 in CD2 activation of IFN-gamma gene expression by Gonsky, Rivkah, Deem, Richard L, Bream, Jay, Young, Howard A, Targan, Stephan R

“…IFN-gamma is an important immunoregulatory protein with tightly controlled expression in activated T and NK cells. Three potential STAT binding regions have…”
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A comparison of engine and air-driven instrumentation methods with hand instrumentation by Bolanos, O R, Sinai, I H, Gonsky, M R, Srinivasan, R

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Involvement of Protein Kinase C epsilon (PKC epsilon ) in Thyroid Cell Death: A Truncated Chimeric PKC epsilon Cloned from a Thyroid Cancer Cell Line Protects Thyroid Cells from Apoptosis by Knauf, JA, Elisei, R, Mochly-Rosen, D, Liron, T, Chen, X, Gonsky, R, Korenberg, J R, Fagin, JA

“…The protein kinase C (PKC) family has been implicated in the regulation of apoptosis. However, the contribution of individual PKC isozymes to this process is…”
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Molecular screening of pituitary adenomas for gene mutations and rearrangements by Herman, V, Drazin, N Z, Gonsky, R, Melmed, S

“…Although pituitary tumors arise as benign monoclonal neoplasms, genetic alterations have not readily been identified in these adenomas. We studied restriction…”
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Dampened SOCS: An altered balance between STAT activating and SOCS inhibitory signals regulate interferon-γ expression in LPMC by GONSKY, R, DEEM, R, YOUNG, H, TARGAN, S

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Reexpression of thyroid peroxidase in a derivative of an undifferentiated thyroid carcinoma cell line by introduction of wild-type p53 by FAGIN, J. A, SHIH-HUEY TANG, ZEKI, K, DI LAURO, R, FUSCO, A, GONSKY, R

“…Loss of function of p53 is believed to result in transformation through impairment of its properties as a transcription factor, which interferes with the…”
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CD2 mediates activation of the IFN‐γ intronic STAT binding region in mucosal T cells by Gonsky, Rivkah, Deem, Richard L., Young, Howard A., Targan, Stephan R.

“…The pathways leading to activation of mucosal lamina propria (LP) T cells differ from those of peripheral T cells. LP T cells exhibit enhanced IFN‐γ secretion…”
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Reduced Expression of Nuclear Cyclic Adenosine 5′-Monophospate Response Element-Binding Proteins and IFN-γ Promoter Function in Disease Due to an Intracellular Pathogen by Samten, Buka, Ghosh, Paritosh, Yi, Ae-Kyung, Weis, Stephen E., Lakey, David L., Gonsky, Rivkah, Pendurthi, Usha, Wizel, Benjamin, Zhang, Yueru, Zhang, Ming, Gong, Jianhua, Fernandez, Marilyn, Safi, Hassan, Vankayalapati, Ramakrishna, Young, Howard A., Barnes, Peter F.

“…Mycobacterium tuberculosis-induced IFN-γ protein and mRNA expression have been shown to be reduced in tuberculosis patients, compared with healthy tuberculin…”
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