Search Results - "Gonsiorek, W"

Expansion of SAR studies on triaryl bis sulfone cannabinoid CB2 receptor ligands by Tong, Ling, Shankar, B.B., Chen, Lei, Rizvi, Razia, Kelly, Joseph, Gilbert, Eric, Huang, Chunli, Yang, De-Yi, Kozlowski, Joseph A., Shih, N.-Y., Gonsiorek, W., Hipkin, R. William, Malikzay, Asra, Lunn, Charles A., Lundell, Daniel J.

“…SAR exploration on triaryl bis sulfone A led us to structurally novel and diverse CB2 selective ligands B. We report further expansion of the structure…”
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Human interferon-inducible 10-kDa protein and human interferon-inducible T cell alpha chemoattractant are allotopic ligands for human CXCR3: differential binding to receptor states by Cox, M A, Jenh, C H, Gonsiorek, W, Fine, J, Narula, S K, Zavodny, P J, Hipkin, R W

“…The human CXC chemokines IP-10 (10-kDa interferon-inducible protein), MIG (monokine induced by human interferon-gamma), and I-TAC (interferon-inducible T cell…”
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Sch35966 is a potent, selective agonist at the peripheral cannabinoid receptor (CB2) in rodents and primates by Gonsiorek, W, Lunn, C A, Fan, X, Deno, G, Kozlowski, J, Hipkin, R W

“…Background and purpose: The peripheral cannabinoid receptor (CB2) is expressed on peripheral immune cells and is thought to have a role in the…”
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Discovery and Characterization of Vicriviroc (SCH 417690), a CCR5 Antagonist with Potent Activity against Human Immunodeficiency Virus Type 1 by STRIZKI, Julie M, TREMBLAY, Cecile, TAGAT, Jayaram R, COX, Kathleen, PRIESTLEY, Tony, SOROTA, Steve, WEI HUANG, HIRSCH, Martin, REYES, Gregory R, BAROUDY, Bahige M, XU, Serena, WOJCIK, Lisa, WAGNER, Nicole, GONSIOREK, Waldemar, HIPKIN, R. William, CHOU, Chuan-Chu, PUGLIESE-SIVO, Catherine, YUSHI XIAO

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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A new sesterterpene, Sch 599473, from a marine sponge, Ircinia sp by Yang, Shu-Wei, Chan, Tze-Ming, Pomponi, Shirley A, Gonsiorek, Waldemar, Chen, Guodong, Wright, Amy E, Hipkin, William, Patel, Mahesh, Gullo, Vincent, Pramanik, Birendra, Zavodny, Paul, Chu, Min

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Endocannabinoid 2-arachidonyl glycerol is a full agonist through human type 2 cannabinoid receptor: antagonism by anandamide by Gonsiorek, W, Lunn, C, Fan, X, Narula, S, Lundell, D, Hipkin, R W

“…The endocannabinoids anandamide and 2-arachidonyl glycerol (2-AG) bind to G protein-coupled central and peripheral cannabinoid receptors CB1 and CB2,…”
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A novel cannabinoid peripheral cannabinoid receptor-selective inverse agonist blocks leukocyte recruitment in vivo by Lunn, Charles A, Fine, Jay S, Rojas-Triana, Alberto, Jackson, James V, Fan, Xuedong, Kung, Ted T, Gonsiorek, Waldemar, Schwarz, Martin A, Lavey, Brian, Kozlowski, Joseph A, Narula, Satwant K, Lundell, Daniel J, Hipkin, R William, Bober, Loretta A

“…The expression of the cannabinoid peripheral cannabinoid receptor (CB(2)) receptor on peripheral immune cells suggests that compounds specific for CB(2) might…”
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Cloning and characterization of a novel human histamine receptor by Morse, K L, Behan, J, Laz, T M, West, Jr, R E, Greenfeder, S A, Anthes, J C, Umland, S, Wan, Y, Hipkin, R W, Gonsiorek, W, Shin, N, Gustafson, E L, Qiao, X, Wang, S, Hedrick, J A, Greene, J, Bayne, M, Monsma, Jr, F J

“…Histamine exerts its numerous physiological functions through interaction with G protein-coupled receptors. Three such receptors have been defined at both the…”
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Expansion of SAR studies on triaryl bis sulfone cannabinoid CB sub(2) receptor ligands by Tong, Ling, Shankar, B B, Chen, Lei, Rizvi, Razia, Kelly, Joseph, Gilbert, Eric, Huang, Chunli, Yang, De-Yi, Kozlowski, Joseph A, Shih, N-Y, Gonsiorek, W, Hipkin, RWilliam, Malikzay, Asra, Lunn, Charles A, Lundell, Daniel J

“…We report further expansion of the structure activity relationship (SAR) on the triaryl bis sulfone class of compounds ( I), which are potent CB sub(2)…”
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Triaryl bis-sulfones as a new class of cannabinoid CB2 receptor inhibitors: identification of a lead and initial SAR studies by Lavey, Brian J., Kozlowski, Joseph A., Hipkin, R. William, Gonsiorek, Waldemar, Lundell, Daniel J., Piwinski, John J., Narula, Satwant, Lunn, Charles A.

“…A novel class of cannabinoid CB2 receptor ligands is described. The compounds are nanomolar inhibitors of the CB2 receptor and can show high selectivity over…”
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Triaryl bis-sulfones as cannabinoid-2 receptor ligands: SAR studies by Shankar, Bandarpalle B., Lavey, Brian J., Zhou, Guowei, Spitler, James A., Tong, Ling, Rizvi, Razia, Yang, De-Yi, Wolin, Ronald, Kozlowski, Joseph A., Shih, Neng-Yang, Wu, Jie, Hipkin, R. William, Gonsiorek, Waldemar, Lunn, Charles A.

“…SAR studies on recently reported triaryl bis-sulfone cannabinoid CB2 receptor ligands are described. Modification of aryl substitution and their respective…”
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The study of CXCR3 and CCR7 pharmacology using [ 35S]GTPγS exchange assays in cell membranes and permeabilized peripheral blood lymphocytes by Gonsiorek, Waldemar, Zavodny, Paul, Hipkin, R.William

“…The GTPγS exchange assay is a functional model corresponding to the first step of G protein-coupled receptor activation. We provide simple methodologies and…”
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Pharmacological characterization of the chemokine receptor, hCCR1 in a stable transfectant and differentiated HL‐60 cells: antagonism of hCCR1 activation by MIP‐1β by Chou, Chuan‐Chu, Fine, Jay S, Pugliese‐Sivo, Catherine, Gonsiorek, Waldemar, Davies, Liza, Deno, Gregory, Petro, Mary, Schwarz, Martin, Zavodny, Paul J, Hipkin, R William

“…C‐C chemokine receptor‐1 (CCR1) has been implicated in mediating a variety of inflammatory conditions including multiple sclerosis and organ rejection…”
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Cloning and pharmacological characterization of CXCR1 and CXCR2 from Macaca fascicularis by Hipkin, R William, Deno, Gregory, Fine, Jay, Sun, Yongliang, Wilburn, Brian, Fan, Xuedong, Gonsiorek, Waldemar, Wiekowski, Maria T

“…Two genes with high sequence homology to human CXCR1 (hCXCR1) and CXCR2 (hCXCR2) were cloned from blood of cynomolgus monkey (Macaca fascicularis). Comparison…”
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HUMAN B CELL-ATTRACTING CHEMOKINE 1 (BCA-1; CXCL13) IS AN AGONIST FOR THE HUMAN CXCR3 RECEPTOR by Jenh, Chung-Her, Cox, Mary Ann, Hipkin, William, Lu, Tianhong, Pugliese-Sivo, Catherine, Gonsiorek, Waldemar, Chou, Chuan-Chu, Narula, Satwant K., Zavodny, Paul J.

“…The CXC chemokine CXCL13, known as BCA-1 (B cell-attracting chemokine 1) or BLC (B-lymphocyte chemoattractant), has been identified as an efficacious…”
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Kinetic studies of desensitization and resensitization of the relaxation response to beta-2 adrenoceptor agonists in isolated guinea pig trachea by Wachsman, D E, Kavaler, J P, Sugár, I P, Schachter, E N, Gonsiorek, W, Maayani, S

“…Activation of beta-2 adrenoceptors (BAR) in smooth muscle preparations is associated with a rapid, reversible and incomplete receptor desensitization,…”
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