Aptamer-based biosensors for the diagnosis of sepsis

Sepsis, the syndrome of infection complicated by acute organ dysfunction, is a serious and growing global problem, which not only leads to enormous economic losses but also becomes one of the leading causes of mortality in the intensive care unit. The detection of sepsis-related pathogens and biomar...

Full description

Saved in:

Bibliographic Details
Published in:	Journal of nanobiotechnology Vol. 19; no. 1; pp. 216 - 22
Main Authors:	Liu, Lubin, Han, Zeyu, An, Fei, Gong, Xuening, Zhao, Chenguang, Zheng, Weiping, Mei, Li, Zhou, Qihui
Format:	Journal Article
Language:	English
Published:	England BioMed Central Ltd 19-07-2021 BioMed Central BMC
Subjects:	Acids Antibiotics Aptamer-based biosensors Aptamers Aptamers, Nucleotide Bacteria Bibliometrics Biomarkers Biosensing Techniques Biosensors CRISPR Cytokines Diagnosis Disease prevention Economic impact Humans Laboratories Ligands Methods Molecular diagnostic techniques Mortality Nanomaterials Nanostructures Nucleic acid aptamers Review Selectivity Sensors Sepsis Sepsis - diagnosis Signal transduction Staphylococcus infections Streptococcus infections Tumor necrosis factor-TNF China Aptamer-based biosensors Nanomaterials Sepsis Diagnosis
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Sepsis, the syndrome of infection complicated by acute organ dysfunction, is a serious and growing global problem, which not only leads to enormous economic losses but also becomes one of the leading causes of mortality in the intensive care unit. The detection of sepsis-related pathogens and biomarkers in the early stage plays a critical role in selecting appropriate antibiotics or other drugs, thereby preventing the emergence of dangerous phases and saving human lives. There are numerous demerits in conventional detection strategies, such as high cost, low efficiency, as well as lacking of sensitivity and selectivity. Recently, the aptamer-based biosensor is an emerging strategy for reasonable sepsis diagnosis because of its accessibility, rapidity, and stability. In this review, we first introduce the screening of suitable aptamer. Further, recent advances of aptamer-based biosensors in the detection of bacteria and biomarkers for the diagnosis of sepsis are summarized. Finally, the review proposes a brief forecast of challenges and future directions with highly promising aptamer-based biosensors.
ISSN:	1477-3155 1477-3155
DOI:	10.1186/s12951-021-00959-5