Search Results - "Gong, Xianqiong"

Therapeutic benefits of apocynin in mice with lipopolysaccharide/D-galactosamine-induced acute liver injury via suppression of the late stage pro-apoptotic AMPK/JNK pathway by Peng, Xianwen, Yang, Yongqiang, Tang, Li, Wan, Jingyuan, Dai, Jie, Li, Longjiang, Huang, Jiayi, Shen, Yi, Lin, Ling, Gong, Xianqiong, Zhang, Li

“…[Display omitted] •The NOX inhibitor apocynin attenuated LPS/D-Gal-induced oxidative injury.•Apocynin alleviated liver injury and improved survival of…”
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Deletion of GPR81 activates CREB/Smad7 pathway and alleviates liver fibrosis in mice by Zhi, Ying, Fan, Kerui, Liu, Shuang, Hu, Kai, Zan, Xinyan, Lin, Ling, Yang, Yongqiang, Gong, Xianqiong, Chen, Kun, Tang, Li, Li, Longjiang, Huang, Jiayi, Zhang, Shujun, Zhang, Li

“…Enhanced glycolysis is a crucial metabolic event that drives the development of liver fibrosis, but the molecular mechanisms have not been fully understood…”
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Negative regulation of pro-apoptotic AMPK/JNK pathway by itaconate in mice with fulminant liver injury by Fan, Kerui, Chen, Kun, Zan, Xinyan, Zhi, Ying, Zhang, Xue, Zhang, Xinyue, Qiu, Jinghuan, Liu, Gang, Li, Longjiang, Tang, Li, Hu, Kai, Wan, Jingyuan, Gong, Xianqiong, Yang, Yongqiang, Zhang, Li

“…Accumulating evidence indicates that metabolic responses are deeply integrated into signal transduction, which provides novel opportunities for the metabolic…”
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A Mechanistic Assessment of the Discordance between Normal Serum Alanine Aminotransferase Levels and Altered Liver Histology in Chronic Hepatitis B by Gong, Xianqiong, Yang, Jiaen, Tang, Jinmo, Gu, Chong, Huang, Lijian, Zheng, Ying, Liang, Huiqing, Wang, Min, Wu, Chuncheng, Chen, Yue, Zhang, Manying, Yu, Zhijian, Mao, Qianguo

“…To understand the mechanisms underlying the discordance between normal serum alanine aminotransferase (ALT) levels and significant alterations in liver…”
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Impacts of small-molecule STAT3 inhibitor SC-43 on toxicity, global proteomics and metabolomics of HepG2 cells by Mao, Ting, He, Peikun, Xu, Zhichao, Lai, Yingying, Huang, Jinlian, Yu, Zhijian, Li, Peiyu, Gong, Xianqiong

“…In this study, we aimed to investigate the cytotoxicity and potential mechanisms of SC-43 by analyzing the global proteomics and metabolomics of HepG2 cells…”
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Comprehensive analysis of transcriptomics and metabolomics to understand triptolide-induced liver injury in mice by Zhao, Jie, Xie, Cen, Wang, Kanglong, Takahashi, Shogo, Krausz, Kristopher W., Lu, Dasheng, Wang, Qiong, Luo, Yuhong, Gong, Xianqiong, Mu, Xiyan, Wang, Qiao, Su, Suwen, Gonzalez, Frank J.

“…•An integrated application of transcriptomics and metabolomics methods was conducted to reveal mechanism of triptolide-induced liver…”
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A novel image-based machine learning method assists SERS for multiple types of urological cancers detection by Ge, Houyang, Gao, Xingen, Zhang, Hongyi, Wang, Fuqiang, Gong, Xianqiong, Lin, Juqiang

“…•Label-free SERS method was employed to fast screening of bladder, prostate and kidney cancer simultaneously through blood plasma.•A novel image-based machine…”
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Immune response gene 1 deficiency impairs Nrf2 activation and aggravates liver fibrosis in mice by Fan, Kerui, Zan, Xinyan, Zhi, Ying, Yang, Yongqiang, Hu, Kai, Zhang, Xinyue, Zhang, Xue, Zhao, Shuang, Chen, Kun, Gong, Xianqiong, Tian, Rui, Zhang, Li

“…A growing body of evidence suggests that metabolic events play essential roles in the development of liver fibrosis. Immune response gene 1 (IRG1) catalyzes…”
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Immune response gene 1 deficiency aggravates high fat diet-induced nonalcoholic fatty liver disease via promotion of redox-sensitive AKT suppression by Zhang, Xue, Zhi, Ying, Zan, Xinyan, Fan, Kerui, Chen, Kun, Zhao, Shuang, Dai, Xinyi, Li, Longjiang, Yang, Yongqiang, Hu, Kai, Gong, Xianqiong, Zhang, Li

“…Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disorder worldwide. Immune response gene 1 (IRG1) catalyzes the production of…”
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Endogenous AMPK acts as a detrimental factor in fulminant hepatitis via potentiating JNK-dependent hepatocyte apoptosis by Hu, Kai, Gong, Xianqiong, Ai, Qing, Lin, Ling, Dai, Jie, Cai, Lu, Jiang, Rong, Ge, Pu, Zhang, Li

“…The energy sensor AMP-activated protein kinase (AMPK) is crucial for energy homeostasis. Recent studies have revealed that AMPK is involved in various…”
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Protective benefits of AMP-activated protein kinase in hepatic ischemia-reperfusion injury by Zhang, Min, Yang, Dan, Gong, Xianqiong, Ge, Pu, Dai, Jie, Lin, Ling, Zhang, Li

“…Hepatic ischemia-reperfusion injury (HIRI) is a major cause of hepatic failure and death after liver trauma, haemorrhagic shock, resection surgery and liver…”
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Anti-oxidative and anti-inflammatory benefits of the ribonucleoside analogue 5-azacitidine in mice with acetaminophen-induced toxic hepatitis by Yang, Changming, Yi, Jun, Gong, Xianqiong, Ge, Pu, Dai, Jie, Lin, Ling, Xing, Yu, Zhang, Li

“…Toxic hepatitis induced by overdose of acetaminophen (APAP) is one of the major life-threatening problems, oxidative stress and inflammatory injury are the…”
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5-Aminoimidazole-4-carboxamide-1-β-d-ribofuranoside alleviated carbon tetrachloride-induced acute hepatitis in mice by Yang, Changming, Gong, Xianqiong, Ai, Qing, Ge, Pu, Lin, Ling, Zhang, Li

“…AMP-activated protein kinase (AMPK) is one of the principal cellular energy sensors participating in maintenance of energy balance but recent evidences also…”
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In Vitro Inhibition of Growth, Biofilm Formation, and Persisters of Staphylococcus aureus by Pinaverium Bromide by Mao, Ting, Chai, Bao, Xiong, Yanpeng, Wang, Hongyan, Nie, Lei, Peng, Renhai, Li, Peiyu, Yu, Zhijian, Fang, Fang, Gong, Xianqiong

“…Biofilm or persister cells formed by Staphylococcus aureus are closely related to pathogenicity. However, no antimicrobials exist to inhibit biofilm formation…”
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5-Aminoimidazole-4-carboxamide-1-β-D-ribofuranoside-attenuates LPS/D-Gal-induced acute hepatitis in mice by Zhou, Dan, Ai, Qing, Lin, Ling, Gong, Xianqiong, Ge, Pu, Che, Qian, Wan, Jingyuan, Wen, Aiqing, Zhang, Li

“…The AMP-activated protein kinase (AMPK)-mediated energy-sensing signals play important roles in reprogramming the expression of inflammatory genes. In the…”
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Small hepatitis B surface antigen interacts with and modulates enoyl–coenzyme A hydratase expression in hepatoma cells by Gong, Xianqiong, Zhu, Yueyong, Dong, Jing, Chen, Jing, You, Jia, Zheng, Qi, Rao, Zilan, Mao, Qianguo, Jiang, Jiaji

“…Enoyl–coenzyme A hydratase (ECHS1) is a key enzyme in the metabolism of fatty acids in mitochondria. We previously reported that hepatitis B surface antigen…”
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Metformin suppresses intrahepatic coagulation activation in mice with lipopolysaccharide/D-galactosamine-induced fulminant hepatitis by GONG, XIANQIONG, DUAN, RUI, AO, JIN-E, AI, QING, GE, PU, LIN, LING, ZHANG, LI

“…Metformin is a widely-used antidiabetic drug with hypoglycemic activity and previously described anti-inflammatory properties. Previous studies have…”
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Small hepatitis B surface antigen interacts with and modulates enoylâ[euro]"coenzyme A hydratase expression in hepatoma cells by Gong, Xianqiong, Zhu, Yueyong, Dong, Jing, Chen, Jing, You, Jia, Zheng, Qi, Rao, Zilan, Mao, Qianguo, Jiang, Jiaji

“…Enoylâ[euro]"coenzyme A hydratase (ECHS1) is a key enzyme in the metabolism of fatty acids in mitochondria. We previously reported that hepatitis B surface…”
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A Mechanistic Assessment of the Discordance between Normal Serum Alanine Aminotransferase Levels and Altered Liver Histology in Chronic Hepatitis B: e0134532 by Gong, Xianqiong, Yang, Jiaen, Tang, Jinmo, Gu, Chong, Huang, Lijian, Zheng, Ying, Liang, Huiqing, Wang, Min, Wu, Chuncheng, Chen, Yue

“…To understand the mechanisms underlying the discordance between normal serum alanine aminotransferase (ALT) levels and significant alterations in liver…”
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Sustained efficacy of alpha-interferon therapy combined with Yixuesheng Capsule in treatment of chronic hepatitis B by Mao, Qianguo, Su, Yayong, Wu, Chuncheng, Duan, Zhicheng, Tang, Jinmo, Gu, Chongi, Liang, Huiqing, Yang, Jiaen, Huang, Lijian, Zheng, Ying, Wang, Min, Gong, Xianqiong

“…To observe the difference between the combination therapy of alpha-interferon (IFN-alpha) therapy Yixuesheng Capsule and the monotherapy of IFN-alpha in…”
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