Search Results - "Gong, Sitang"
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Characteristics of pediatric SARS-CoV-2 infection and potential evidence for persistent fecal viral shedding
Published in Nature medicine (01-04-2020)“…We report epidemiological and clinical investigations on ten pediatric SARS-CoV-2 infection cases confirmed by real-time reverse transcription PCR assay of…”
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2
PKN2 in colon cancer cells inhibits M2 phenotype polarization of tumor-associated macrophages via regulating DUSP6-Erk1/2 pathway
Published in Molecular cancer (24-01-2018)“…Protein kinase N2 (PKN2) is a PKC-related serine/threonine-protein kinase. PKN2 is required for tumor cell migration, invasion and apoptosis. However, the…”
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3
Mucosal Profiling of Pediatric-Onset Colitis and IBD Reveals Common Pathogenics and Therapeutic Pathways
Published in Cell (14-11-2019)“…Pediatric-onset colitis and inflammatory bowel disease (IBD) have significant effects on the growth of infants and children, but the etiopathogenesis…”
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4
Functional and structural characterization of a two-MAb cocktail for delayed treatment of enterovirus D68 infections
Published in Nature communications (18-05-2021)“…Enterovirus D68 (EV-D68) is an emerging pathogen associated with respiratory diseases and/or acute flaccid myelitis. Here, two MAbs, 2H12 and 8F12, raised…”
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5
Identification of candidate diagnostic and prognostic biomarkers for pancreatic carcinoma
Published in EBioMedicine (01-02-2019)“…Pancreatic carcinoma (PC) is one of the most aggressive cancers affecting human health. It is essential to identify candidate biomarkers for the diagnosis and…”
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6
SLAMF7 regulates the inflammatory response in macrophages during polymicrobial sepsis
Published in The Journal of clinical investigation (15-03-2023)“…Uncontrolled inflammation occurred in sepsis results in multiple organ injuries and shock, which contributes to the death of patients with sepsis. However, the…”
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7
MiR-1 suppresses tumor cell proliferation in colorectal cancer by inhibition of Smad3-mediated tumor glycolysis
Published in Cell death & disease (04-05-2017)“…Aberrant expression of microRNA (miR)-1 has been observed in many human malignancies. However, the function and underlying mechanism of miR-1 remains elusive…”
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8
Salmonella effector SopB reorganizes cytoskeletal vimentin to maintain replication vacuoles for efficient infection
Published in Nature communications (30-01-2023)“…A variety of intracellular bacteria modulate the host cytoskeleton to establish subcellular niches for replication. However, the role of intermediate…”
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9
Mast cells-derived MiR-223 destroys intestinal barrier function by inhibition of CLDN8 expression in intestinal epithelial cells
Published in Biological research (24-03-2020)“…Mast cells (MCs) have been found to play a critical role during development of inflammatory bowel disease (IBD) that characterized by dysregulation of…”
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10
GITR Promotes the Polarization of TFH-Like Cells in Helicobacter pylori -Positive Gastritis
Published in Frontiers in immunology (10-09-2021)“…Gastric CD4 T cells contribute to ( )-induced gastritis by amplifying mucosal inflammation and exacerbating mucosal injuries. However, the pathogenic CD4 T…”
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11
Aminophylline suppresses chronic renal failure progression by activating SIRT1/AMPK/mTOR-dependent autophagy
Published in Acta biochimica et biophysica Sinica (28-05-2024)“…Chronic renal failure (CRF) is a severe syndrome affecting the urinary system for which there are no effective therapeutics. In this study, we investigate the…”
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12
Human Norovirus NTPase Antagonizes Interferon-β Production by Interacting With IkB Kinase ε
Published in Frontiers in microbiology (15-07-2021)“…Human norovirus (HuNoV) is the leading cause of epidemic acute gastroenteritis worldwide. Type I interferons (IFN)-α/β are highly potent cytokines that are…”
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13
Zika Virus Infection Induces Acute Kidney Injury Through Activating NLRP3 Inflammasome Via Suppressing Bcl-2
Published in Frontiers in immunology (14-08-2019)“…Zika virus (ZIKV) is a newly emerging flavivirus that broadly exhibits in various bodily tissues and fluids, especially in the brain, and ZIKV infection often…”
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14
Vitronectin Destroyed Intestinal Epithelial Cell Differentiation through Activation of PDE4-Mediated Ferroptosis in Inflammatory Bowel Disease
Published in Mediators of inflammation (19-07-2023)“…Objective. Vitronectin (VTN) has been reported to trigger cell pyroptosis to aggravate inflammation in our previous study. However, the function of VTN in…”
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15
Sorbitol Destroyed Intestinal Microfold Cells (M Cells) Development through Inhibition of PDE4-Mediated RANKL Expression
Published in Mediators of inflammation (02-05-2024)“…Objective. Microfold cells (M cells) are specific intestinal epithelial cells for monitoring and transcytosis of antigens, microorganisms, and pathogens in the…”
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Deficiency of GntR Family Regulator MSMEG_5174 Promotes Mycobacterium smegmatis Resistance to Aminoglycosides via Manipulating Purine Metabolism
Published in Frontiers in microbiology (11-07-2022)“…The increasing incidence of drug-resistant tuberculosis is still an emergency for global public health and a major obstacle to tuberculosis treatment…”
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17
Lactose intolerance and gastrointestinal cow's milk allergy in infants and children - common misconceptions revisited
Published in The World Allergy Organization journal (12-12-2017)“…Lactose is the main carbohydrate in human and mammalian milk. Lactose requires enzymatic hydrolysis by lactase into D-glucose and D-galactose before it can be…”
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Monocarboxylate Transporter 4 Triggered Cell Pyroptosis to Aggravate Intestinal Inflammation in Inflammatory Bowel Disease
Published in Frontiers in immunology (19-05-2021)“…NLRP3 inflammasome has emerged as a crucial regulator of inflammatory bowel disease (IBD) characterized by a chronic inflammatory disease of the…”
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A Mouse Model of Enterovirus D68 Infection for Assessment of the Efficacy of Inactivated Vaccine
Published in Viruses (30-01-2018)“…In recent years, enterovirus D68 (EVD68) has been reported increasingly to be associated with severe respiratory tract infections and acute flaccid myelitis…”
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20
Prognostic Value of the Glasgow Prognostic Score or Modified Glasgow Prognostic Score for Patients with Colorectal Cancer Receiving Various Treatments: a Systematic Review and Meta-Analysis
Published in Cellular physiology and biochemistry (01-01-2018)“…Background/Aims: Increasing evidence indicates that the systemic inflammatory response plays a vital role in carcinogenesis. The Glasgow Prognostic Score or…”
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