Search Results - "Gong, Danyang"

Genome-wide identification of interferon-sensitive mutations enables influenza vaccine design by Du, Yushen, Xin, Li, Shi, Yuan, Zhang, Tian-Hao, Wu, Nicholas C, Dai, Lei, Gong, Danyang, Brar, Gurpreet, Shu, Sara, Luo, Jiadi, Reiley, William, Tseng, Yen-Wen, Bai, Hongyan, Wu, Ting-Ting, Wang, Jieru, Shu, Yuelong, Sun, Ren

“…In conventional attenuated viral vaccines, immunogenicity is often suboptimal. Here we present a systematic approach for vaccine development that eliminates…”
Get full text

Self-Organized Cerebral Organoids with Human-Specific Features Predict Effective Drugs to Combat Zika Virus Infection by Watanabe, Momoko, Buth, Jessie E., Vishlaghi, Neda, de la Torre-Ubieta, Luis, Taxidis, Jiannis, Khakh, Baljit S., Coppola, Giovanni, Pearson, Caroline A., Yamauchi, Ken, Gong, Danyang, Dai, Xinghong, Damoiseaux, Robert, Aliyari, Roghiyh, Liebscher, Simone, Schenke-Layland, Katja, Caneda, Christine, Huang, Eric J., Zhang, Ye, Cheng, Genhong, Geschwind, Daniel H., Golshani, Peyman, Sun, Ren, Novitch, Bennett G.

“…The human cerebral cortex possesses distinct structural and functional features that are not found in the lower species traditionally used to model brain…”
Get full text

Differential Metabolic Reprogramming by Zika Virus Promotes Cell Death in Human versus Mosquito Cells by Thaker, Shivani K., Chapa, Travis, Garcia, Gustavo, Gong, Danyang, Schmid, Ernst W., Arumugaswami, Vaithilingaraja, Sun, Ren, Christofk, Heather R.

“…Zika virus is a pathogen that poses serious consequences, including congenital microcephaly. Although many viruses reprogram host cell metabolism, whether Zika…”
Get full text

25-Hydroxycholesterol Protects Host against Zika Virus Infection and Its Associated Microcephaly in a Mouse Model by Li, Chunfeng, Deng, Yong-Qiang, Wang, Shuo, Ma, Feng, Aliyari, Roghiyh, Huang, Xing-Yao, Zhang, Na-Na, Watanabe, Momoko, Dong, Hao-Long, Liu, Ping, Li, Xiao-Feng, Ye, Qing, Tian, Min, Hong, Shuai, Fan, Junwan, Zhao, Hui, Li, Lili, Vishlaghi, Neda, Buth, Jessie E., Au, Connie, Liu, Ying, Lu, Ning, Du, Peishuang, Qin, F. Xiao-Feng, Zhang, Bo, Gong, Danyang, Dai, Xinghong, Sun, Ren, Novitch, Bennett G., Xu, Zhiheng, Qin, Cheng-Feng, Cheng, Genhong

“…Zika virus (ZIKV) has become a public health threat due to its global transmission and link to severe congenital disorders. The host immune responses to ZIKV…”
Get full text

Zika Virus Mucosal Infection Provides Protective Immunity by Martínez, Laura E, Garcia, Jr, Gustavo, Contreras, Deisy, Gong, Danyang, Sun, Ren, Arumugaswami, Vaithilingaraja

“…Zika virus (ZIKV) is a major human pathogen. ZIKV can replicate in female and male reproductive organs, thus facilitating the human-human transmission cycle…”
Get full text

mRNA display with library of even-distribution reveals cellular interactors of influenza virus NS1 by Du, Yushen, Hultquist, Judd F., Zhou, Quan, Olson, Anders, Tseng, Yenwen, Zhang, Tian-hao, Hong, Mengying, Tang, Kejun, Chen, Liubo, Meng, Xiangzhi, McGregor, Michael J., Dai, Lei, Gong, Danyang, Martin-Sancho, Laura, Chanda, Sumit, Li, Xinming, Bensenger, Steve, Krogan, Nevan J., Sun, Ren

“…A comprehensive examination of protein-protein interactions (PPIs) is fundamental for the understanding of cellular machineries. However, limitations in…”
Get full text

Enhancing the Prefusion Conformational Stability of SARS-CoV-2 Spike Protein Through Structure-Guided Design by Riley, Timothy P, Chou, Hui-Ting, Hu, Ruozhen, Bzymek, Krzysztof P, Correia, Ana R, Partin, Alexander C, Li, Danqing, Gong, Danyang, Wang, Zhulun, Yu, Xinchao, Manzanillo, Paolo, Garces, Fernando

“…The worldwide pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is unprecedented and the impact on public health and the…”
Get full text

RIOK3 is an adaptor protein required for IRF3-mediated antiviral type I interferon production by Feng, Jun, De Jesus, Paul D, Su, Victoria, Han, Stephanie, Gong, Danyang, Wu, Nicholas C, Tian, Yuan, Li, Xudong, Wu, Ting-Ting, Chanda, Sumit K, Sun, Ren

“…Detection of cytosolic nucleic acids by pattern recognition receptors leads to the induction of type I interferons (IFNs) and elicits the innate immune…”
Get full text

Functional Constraint Profiling of a Viral Protein Reveals Discordance of Evolutionary Conservation and Functionality by Wu, Nicholas C, Olson, C Anders, Du, Yushen, Le, Shuai, Tran, Kevin, Remenyi, Roland, Gong, Danyang, Al-Mawsawi, Laith Q, Qi, Hangfei, Wu, Ting-Ting, Sun, Ren

“…Viruses often encode proteins with multiple functions due to their compact genomes. Existing approaches to identify functional residues largely rely on…”
Get full text

CryoEM and mutagenesis reveal that the smallest capsid protein cements and stabilizes Kaposi's sarcoma-associated herpesvirus capsid by Dai, Xinghong, Gong, Danyang, Xiao, Yuchen, Wu, Ting-Ting, Sun, Ren, Zhou, Z. Hong

“…With just one eighth the size of the major capsid protein (MCP), the smallest capsid protein (SCP) of human tumor herpesviruses—Kaposi's sarcoma-associated…”
Get full text

ZAP Inhibits Murine Gammaherpesvirus 68 ORF64 Expression and Is Antagonized by RTA by Xuan, Yifang, Gong, Danyang, Qi, Jing, Han, Chuanhui, Deng, Hongyu, Gao, Guangxia

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Rational selection of building blocks for the assembly of bispecific antibodies by Gong, Danyang, Riley, Timothy P, Bzymek, Krzysztof P, Correia, Ana R, Li, Danqing, Spahr, Christopher, Robinson, John H, Case, Ryan B, Wang, Zhulun, Garces, Fernando

“…Bispecific antibodies, engineered to recognize two targets simultaneously, demonstrate exceptional clinical potential for the therapeutic intervention of…”
Get full text

Kaposi's sarcoma-associated herpesvirus ORF18 and ORF30 are essential for late gene expression during lytic replication by Gong, Danyang, Wu, Nicholas C, Xie, Yafang, Feng, Jun, Tong, Leming, Brulois, Kevin F, Luan, Harding, Du, Yushen, Jung, Jae U, Wang, Cun-yu, Kang, Mo Kwan, Park, No-Hee, Sun, Ren, Wu, Ting-Ting

“…Kaposi's sarcoma-associated herpesvirus (KSHV) is associated with several human malignances. As saliva is likely the major vehicle for KSHV transmission, we…”
Get full text

A CRISPR Activation Screen Identifies an Atypical Rho GTPase That Enhances Zika Viral Entry by Luu, Anh Phuong, Yao, Zhenlan, Ramachandran, Sangeetha, Azzopardi, Stephanie A, Miles, Linde A, Schneider, William M, Hoffmann, H-Heinrich, Bozzacco, Leonia, Garcia, Jr, Gustavo, Gong, Danyang, Damoiseaux, Robert, Tang, Hengli, Morizono, Kouki, Rudin, Charles M, Sun, Ren, Arumugaswami, Vaithilingaraja, Poirier, John T, MacDonald, Margaret R, Rice, Charles M, Li, Melody M H

“…Zika virus (ZIKV) is a re-emerging flavivirus that has caused large-scale epidemics. Infection during pregnancy can lead to neurologic developmental…”
Get full text

Structures of capsid and capsid-associated tegument complex inside the Epstein–Barr virus by Liu, Wei, Cui, Yanxiang, Wang, Caiyan, Li, Zihang, Gong, Danyang, Dai, Xinghong, Bi, Guo-Qiang, Sun, Ren, Zhou, Z. Hong

“…As the first discovered human cancer virus, Epstein–Barr virus (EBV) causes Burkitt’s lymphoma and nasopharyngeal carcinoma. Isolating virions for determining…”
Get full text

Correction: Functional Constraint Profiling of a Viral Protein Reveals Discordance of Evolutionary Conservation and Functionality by Wu, Nicholas C, Olson, C Anders, Du, Yushen, Le, Shuai, Tran, Kevin, Remenyi, Roland, Gong, Danyang, Al-Mawsawi, Laith Q, Qi, Hangfei, Wu, Ting-Ting, Sun, Ren

“…[This corrects the article DOI: 10.1371/journal.pgen.1005310.]…”
Get full text

Next generation Fc scaffold for multispecific antibodies by Estes, Bram, Sudom, Athena, Gong, Danyang, Whittington, Douglas A., Li, Vivian, Mohr, Christopher, Li, Danqing, Riley, Timothy P., Shi, Stone D.-H., Zhang, Jun, Garces, Fernando, Wang, Zhulun

“…Bispecific antibodies (Bispecifics) demonstrate exceptional clinical potential to address some of the most complex diseases. However, Bispecific production in…”
Get full text

Protocol for high-throughput cloning, expression, purification, and evaluation of bispecific antibodies by Li, Danqing, Partin, Alexander C., Zhao, Liangjun, Chen, Irwin, Michaels, Mark L., Wang, Zhulun, Garces, Fernando, Gong, Danyang, Riley, Timothy P.

“…Bispecific antibodies are a powerful new class of therapeutics, but their development often requires enormous amounts of time and resources. Here, we describe…”
Get full text

Replication and Transcription Activator (RTA) of Murine Gammaherpesvirus 68 Binds to an RTA-Responsive Element and Activates the Expression of ORF18 by Hong, Yun, Qi, Jing, Gong, Danyang, Han, Chuanhui, Deng, Hongyu

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Annotating Protein Functional Residues by Coupling High-Throughput Fitness Profile and Homologous-Structure Analysis by Du, Yushen, Wu, Nicholas C, Jiang, Lin, Zhang, Tianhao, Gong, Danyang, Shu, Sara, Wu, Ting-Ting, Sun, Ren

“…Identification and annotation of functional residues are fundamental questions in protein sequence analysis. Sequence and structure conservation provides…”
Get full text