Search Results - "Gong, Baoqing"

Synthesis and SAR of 2-arylbenzoxazoles, benzothiazoles and benzimidazoles as inhibitors of lysophosphatidic acid acyltransferase-β by Gong, Baoqing, Hong, Feng, Kohm, Cory, Bonham, Lynn, Klein, Peter

“…2-Arylbenzoxazoles, benzothiazoles and benzimidazoles were identified as new classes of potent, isoform specific inhibitors of lysophosphatidic acid…”
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Antitumor activity of lysophosphatidic acid acyltransferase-β inhibitors, a novel class of agents, in multiple myeloma by HIDESHIMA, Teru, CHAUHAN, Dharminder, MUNSHI, Nikhil, RICHARDSON, Paul G, SINGER, Jack W, ANDERSON, Kenneth C, HAYASHI, Toshiaki, PODAR, Klaus, AKIYAMA, Masaharu, MITSIADES, Constantine, MITSIADES, Nicholas, BAOQING GONG, BONHAM, Lynn, DE VRIES, Peter

“…In this study, we examined the effects of isoform-specific functional inhibitors of lysophosphatidic acid acyltransferase (LPAAT), which converts…”
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In Vitro Antimalarial Activity of Chalcones and Their Derivatives by Li, Rongshi, Kenyon, George L, Cohen, Fred E, Chen, Xiaowu, Gong, Baoqing, Dominguez, Jose N, Davidson, Eugene, Kurzban, Gary, Miller, Robert E, Nuzum, Edwin O, Rosenthal, Philip J, McKerrow, James H

“…A series of chalcones and their derivatives have been synthesized and identified as novel potential antimalarials using both molecular modeling and in vitro…”
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Synthesis, SAR, and antitumor properties of diamino-C, N-diarylpyrimidine positional isomers: inhibitors of lysophosphatidic acid acyltransferase-β by BAOQING GONG, FENG HONG, KOHM, Cory, JENKINS, Scott, TULINSKY, John, BHATT, Rama, DE VRIES, Peter, SINGER, Jack W, KLEIN, Peter

“…2,4-Diamino-N(4),6-diarylpyrimidines were identified as potent, isoform specific inhibitors of lysophosphatidic acid acyltransferase-beta (LPAAT-beta). Active…”
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A new and efficient method for the resolution of 2,2'-dihydroxy-1,1'-binaphthyl by Gong, Baoqing, Chen, Wanyi, Hu, Bingfang

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Chiral Synthesis via Organoboranes. 40. Selective Reductions. 55. A Simple One-Pot Synthesis of the Enantiomers of Trifluoromethyloxirane. A General Synthesis in High Optical Purities of .alpha.-Trifluoromethyl Secondary Alcohols via the Ring-Cleavage Reactions of the Epoxide by Ramachandran, P. Veeraraghavan, Gong, Baoqing, Brown, Herbert C

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A Practical Synthesis of a Chiral Analogue of FTY720 by Jiang, Xinglong, Gong, Baoqing, Prasad, Kapa, Repič, Oljan

“…A practical synthesis of 1 involving a catalytic enantioselective construction of the quaternary carbon from imine 10 (derived from 13 and 14) and alkyl iodide…”
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The influence of fluorine on the asymmetric reduction of fluoromethyl ketones by Ramachandran, P. Veeraraghavan, Gong, Baoqing, Teodorović, Aleksandar V.

“…A comparative study of the asymmetric reduction of representative aryl and alkyl α-fluoro- and α-chloromethyl ketones using (−)-diisopinocampheylchloroborane…”
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Relationship between the structure and enantioselectivity in the asymmetric reduction of 2′,6′-disubstituted acetophenones with DIP-ChlorideTM. An ab initio study by Ramachandran, P.Veeraraghavan, Gong, Baoqing, Brown, Herbert C., Francisco, Joseph S.

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Relationship between the structure and enantioselectivity in the asymmetric reduction of 2 ′,6 ′-disubstituted acetophenones with DIP-Chloride TM. An ab initio study by Ramachandran, P.Veeraraghavan, Gong, Baoqing, Brown, Herbert C., Francisco, Joseph S.

“…The % ee achieved in the asymmetric reduction of ring-substituted acetophenones is related to the dihedral angle between the plane of the aromatic ring the…”
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Structure-based design of parasitic protease inhibitors by Li, Rongshi, Chen, Xiaowu, Gong, Baoqing, Selzer, Paul M., Li, Zhe, Davidson, Eugene, Kurzban, Gary, Miller, Robert E., Nuzum, Edwin O., McKerrow, James H., Fletterick, Robert J., Gillmor, Sarah A., Craik, Charles S., Kuntz, Irwin D., Cohen, Fred E., Kenyon, George L.

“…To streamline the preclinical phase of pharmaceutical development, we have explored the utility of structural data on the molecular target and synergy between…”
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